SquamousCell LungCarcinomaLooking fortell-tale                Nachosigns         Caballero
P2-N
P1   P2P4   P3
Normal                 P2Intermediate   Tumor
P2-N
Human height followsa normal distribution
Distribution of the number of reads       that align to each gene                            # reads
RNA Seq data  can be modeled using anegative binomial distribution                          # reads
Significance   High     Low -                0          +           Log Fold Change
Genes with significant   count differences betweennormal and intermediate samples                                  Normal ...
CDON counts are significantly smaller   in intermediate than in normal                                 Patient 1          ...
Number of significant genes    71                1267Intermediate         Tumor     vs                vs   Normal         ...
Number of significant genes                               4 patients   3 patients4 patients        3 patients    43       ...
Interpretingthe tell-talesigns
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Squamous Cell Carcinoma: Looking for tale-tell signs

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Squamous Cell Carcinoma: Looking for tale-tell signs

  1. 1. SquamousCell LungCarcinomaLooking fortell-tale Nachosigns Caballero
  2. 2. P2-N
  3. 3. P1 P2P4 P3
  4. 4. Normal P2Intermediate Tumor
  5. 5. P2-N
  6. 6. Human height followsa normal distribution
  7. 7. Distribution of the number of reads that align to each gene # reads
  8. 8. RNA Seq data can be modeled using anegative binomial distribution # reads
  9. 9. Significance High Low - 0 + Log Fold Change
  10. 10. Genes with significant count differences betweennormal and intermediate samples Normal Intermediate Tumor Patient 1 Patient 2 Patient 3 Patient 4 100K counts 10K counts 1K counts 100 counts 10 counts 1 counts
  11. 11. CDON counts are significantly smaller in intermediate than in normal Patient 1 Patient 2 Patient 3 Patient 4
  12. 12. Number of significant genes 71 1267Intermediate Tumor vs vs Normal Normal
  13. 13. Number of significant genes 4 patients 3 patients4 patients 3 patients 43 28 15 226 1041 217 Intermediate Tumor vs vs Normal Normal
  14. 14. Interpretingthe tell-talesigns
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