The document discusses the history of genome sequencing, from the 15 year, $3 billion effort to sequence the first human genome to current efforts to sequence over 1000 personal genomes. It describes how genome sequencing has progressed from using Perl scripts and modules to analyze early genomes to now employing flexible data structures to capture and analyze sequencing data from many species and individuals. The goal is to better understand common diseases and conditions by comparing genomes within and across species.