Chapter 22 Microbial Diseases of the Nervous System
Structure and function of the nervous system <ul><li>Central nervous system </li></ul><ul><li>Peripheral nervous system </...
 
Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul>
 
Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><ul><li>Haemophilus influenza </li></ul></ul><ul...
 
Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><li>Listeriosis </li></ul><ul><li>Tetanus </li><...
 
Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><li>Listeriosis </li></ul><ul><li>Tetanus </li><...
 
 
Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><li>Listeriosis </li></ul><ul><li>Tetanus </li><...
 
Viral diseases of the nervous system <ul><li>Polio </li></ul><ul><ul><li>Higher incidence in summer </li></ul></ul><ul><ul...
 
 
Viral diseases of the nervous system <ul><li>Polio </li></ul><ul><li>Rabies </li></ul><ul><ul><li>Virus multiplies in PNS ...
 
 
Viral diseases of the nervous system <ul><li>Polio </li></ul><ul><li>Rabies </li></ul><ul><li>Arboviral encephalitis </li>...
 
 
 
Prion diseases of the nervous system <ul><li>Sheep scrapie </li></ul><ul><li>Creutzfeldt-Jacob disease </li></ul><ul><li>B...
 
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Chapter 22

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Chapter 22

  1. 1. Chapter 22 Microbial Diseases of the Nervous System
  2. 2. Structure and function of the nervous system <ul><li>Central nervous system </li></ul><ul><li>Peripheral nervous system </li></ul><ul><li>Blood-brain barrier </li></ul>
  3. 4. Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul>
  4. 6. Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><ul><li>Haemophilus influenza </li></ul></ul><ul><ul><li>Neisseria sp. </li></ul></ul><ul><ul><li>Streptococcus pneumoniae </li></ul></ul>
  5. 8. Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><li>Listeriosis </li></ul><ul><li>Tetanus </li></ul><ul><ul><li>Clostridium tetani </li></ul></ul><ul><ul><li>Neurotoxin blocks relaxation signal to muscle </li></ul></ul><ul><ul><li>Prevent with tetanus toxoid </li></ul></ul><ul><ul><li>Treat symptoms with antitoxin </li></ul></ul>
  6. 10. Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><li>Listeriosis </li></ul><ul><li>Tetanus </li></ul><ul><li>Botulism </li></ul><ul><ul><li>Clostridium botulinum </li></ul></ul><ul><ul><li>Neurotoxin blocks release of acetylcholine </li></ul></ul><ul><ul><li>Infant botulism </li></ul></ul><ul><ul><li>Wound botulism </li></ul></ul>
  7. 13. Bacterial diseases of the nervous system <ul><li>Meningitis </li></ul><ul><li>Listeriosis </li></ul><ul><li>Tetanus </li></ul><ul><li>Botulism </li></ul><ul><li>Leprosy </li></ul><ul><ul><li>Mycobacterium leprae </li></ul></ul>
  8. 15. Viral diseases of the nervous system <ul><li>Polio </li></ul><ul><ul><li>Higher incidence in summer </li></ul></ul><ul><ul><li>Virus has high affinity for motor nerves </li></ul></ul><ul><ul><li>Salk vaccine in 1954 </li></ul></ul><ul><ul><li>Sabin vaccine in 1963 </li></ul></ul>
  9. 18. Viral diseases of the nervous system <ul><li>Polio </li></ul><ul><li>Rabies </li></ul><ul><ul><li>Virus multiplies in PNS and migrates to CNS </li></ul></ul><ul><ul><li>Long incubation period </li></ul></ul><ul><ul><li>Furious rabies </li></ul></ul><ul><ul><li>Paralytic rabies </li></ul></ul><ul><ul><li>Prevention </li></ul></ul><ul><ul><ul><li>Vaccination </li></ul></ul></ul>
  10. 21. Viral diseases of the nervous system <ul><li>Polio </li></ul><ul><li>Rabies </li></ul><ul><li>Arboviral encephalitis </li></ul><ul><ul><li>Transmitted by mosquitoes </li></ul></ul><ul><ul><li>Disease can result in permanent neurological damage </li></ul></ul><ul><ul><li>Prevent by controlling vectors </li></ul></ul>
  11. 25. Prion diseases of the nervous system <ul><li>Sheep scrapie </li></ul><ul><li>Creutzfeldt-Jacob disease </li></ul><ul><li>Bovine spongioform encephalopathy </li></ul>

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