Chapter 20

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Chapter 20

  1. 1. Chapter 20 Antimicrobial Drugs
  2. 2. Chemotherapy <ul><li>Antibiotic </li></ul><ul><li>Synthetic </li></ul><ul><li>Semisynthetic </li></ul><ul><li>Bactericidal </li></ul><ul><li>Bacteriostatic </li></ul>
  3. 3. Spectrum of activity <ul><li>Broad spectrum </li></ul><ul><li>Narrow spectrum </li></ul><ul><li>Selective toxicity </li></ul>
  4. 4. Action of antimicrobial drugs <ul><li>Inhibition of cell wall synthesis </li></ul>
  5. 6. Action of antimicrobial drugs <ul><li>Inhibition of cell wall synthesis </li></ul><ul><li>Inhibition of protein synthesis </li></ul>
  6. 8. Action of antimicrobial drugs <ul><li>Inhibition of cell wall synthesis </li></ul><ul><li>Inhibition of protein synthesis </li></ul><ul><li>Injury to plasma membrane </li></ul>
  7. 10. Action of antimicrobial drugs <ul><li>Inhibition of cell wall synthesis </li></ul><ul><li>Inhibition of protein synthesis </li></ul><ul><li>Injury to plasma membrane </li></ul><ul><li>Inhibition of nucleic acid synthesis </li></ul><ul><li>Inhibition of synthesis of essential metabolites </li></ul>
  8. 12. Other antimicrobials <ul><li>Antifungal drugs </li></ul><ul><li>Antiviral drugs </li></ul><ul><li>Antiprotozoan drugs </li></ul><ul><li>Antihelminthic drugs </li></ul>
  9. 13. Evaluation of antimicrobials <ul><li>Disk-diffusion method </li></ul>
  10. 16. Evaluation of antimicrobials <ul><li>Disk-diffusion method </li></ul><ul><li>Broth dilution tests </li></ul>
  11. 18. Effectiveness of antimicrobial agents <ul><li>Drug resistance </li></ul><ul><li>Antibiotic safety </li></ul><ul><li>Combination of drugs </li></ul>

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