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Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
Tang 03d macromolecules-nucleic acids-2010 update
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Tang 03d macromolecules-nucleic acids-2010 update

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  • 1. Nucleic acids pp 80 - 84
  • 2. Nucleic Acids Nucleic acids are used for:  maintaining genetic continuity  delivering information for protein synthesis  energy molecule (ATP – adenosine triphosphate) Two major nucleic acid polymers: 1. DNA – deoxyribonucleic acid 2. RNA – ribonucleic acid
  • 3. Nucleic Acids DNA RNA  located in the nucleus  double-stranded, double helix structure  stable molecule  mainly found in cytoplasm  single-stranded structure  less stable molecule
  • 4. Nucleotides The basic subunit of nucleic acids is a nucleotide. Three components: 1. phosphate 2. pentose sugar 3. nitrogenous base
  • 5. Pentose Sugar 1’ 2’3’ 4’ 5’ 1’ 2’3’ 4’ 5’
  • 6. Nitrogenous Bases purines pyrimidines DNA/RNA DNA/RNA DNA/RNA RNA DNA
  • 7. Nucleic Acid Phosphodiester bond formed between 1. pentose sugar OH group of one nucleotide 2. phosphate group of another nucleotide NOTE: 3’-carbon and 5’- carbon atoms are linked by a phosphate group
  • 8. Nucleic Acid Linking nucleotides together produces a single-strand of DNA The phosphate and deoxyribose form the DNA’s “backbone” backbone nitrogenous bases
  • 9. Complimentary Base Pairing Nitrogenous bases can “stick” to one another via hydrogen bonding. Complimentary base pairs: Adenine  Thymine (AT) - 2 hydrogen bonds Guanine  Cytosine (GC) - 3 hydrogen bonds
  • 10. Nucleic Acid Complimentary base pairing results in double-stranded DNA. Both DNA strands run antiparallel to each other (oriented in opposite directions). One strand is from 5’3’, while the other strand is from 3’5’. antiparallelstrand 5’ 3’ 3’ 5’
  • 11. Complimentary Base Pairing The two antiparallel strands coil together to form a double helix.
  • 12. Double Helix
  • 13. Overview

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