03 pedigree charts

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03 pedigree charts

  1. 1. Pedigree charts
  2. 2. Pedigree charts <ul><li>Why do we use them? </li></ul><ul><li>Because experimental crosses with humans are not possible. </li></ul><ul><li>Then what information do we use to determine inheritance of traits? </li></ul><ul><li>Medical history </li></ul><ul><li>Historical data </li></ul><ul><li>Family records </li></ul>
  3. 3. Pedigree charts Some symbols to remember: Normal female Normal male Normal (sex is unknown) Female with phenotype of interest Male with phenotype of interest Person with phenotype of interest (unknown sex) Female heterozygous for recessive allele Male heterozygous for recessive allele
  4. 4. Pedigree charts Some symbols to remember: I II First born Last born Roman numerals represent generation siblings
  5. 5. Pedigree charts Some symbols to remember: I II One-egg Monozygotic Identical twins Two-egg dizygotic fraternal twins
  6. 6. Pedigree charts How do we use a pedigree chart? When people have children… I II III If this child had a genetic disease, we can trace who it came from by completing the pedigree from family and medical records Mother’s family Father’s family
  7. 7. Pedigree charts Hemophilia in the royal family I II III IV0
  8. 8. Pedigree charts Hemophilia
  9. 9. Pedigree charts Hemophilia in the royal family
  10. 10. Pedigree charts Royal Family Historical Record
  11. 11. Pedigree charts Albino
  12. 12. Pedigree charts Pedigree showing albinism
  13. 13. Pedigree charts Tay Sachs
  14. 14. Pedigree charts Pedigree showing Tay Sachs
  15. 15. Pedigree charts Autosomal recessive: Involves a recessive allele on a non-sex chromosome Autosomal dominant: Involves a dominant allele on a non-sex chromosome X-linked recessive: Involves a recessive allele on the X-chromosome X-linked dominant: Involves a dominant allele on the X-chromosome Y-linked: Involves an allele on the Y-chromosome

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