Dna replication

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Dna replication

  1. 1. DNA REPLICATION<br />Universidad Pontificia Bolivariana<br />María Paulina Henao Zuluaga<br />Medicine Student<br />3rd Semester<br />
  2. 2.
  3. 3.
  4. 4. INTRODUCTION<br />An essential property of the genetic material is its ability to make exact copies of itself.<br />DIRECTION<br />5’---- 3’<br />ENZYMES <br /><ul><li>DNA Polymerases,
  5. 5. DNA Ligase
  6. 6. Primase
  7. 7. SSDPB (Single Strand DNA BindingProtein)
  8. 8. Topoisomerases,
  9. 9. RNAse- H</li></li></ul><li>HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE<br />BIOLOGY & NATURE<br />(July 19, 2011) <br /> <br />
  10. 10. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE<br />
  11. 11. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE<br />The cell increase proliferation  process<br />CANCER<br />“FRAGILE SITES “ are created in the early cancer stages<br /> Later cells enters in stress on DNA replication<br />Discover bases of DNA breakage<br />
  12. 12. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE<br />
  13. 13. OBSERVATION<br />
  14. 14. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS<br /> BIOLOGY & NATURE<br />(July 7, 2011) <br /> <br />
  15. 15. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS<br />In normal conditions<br />
  16. 16. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS<br />Uncontrolled and excessiveproliferation<br />
  17. 17. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS<br />Cks 1 and Cks 2 proteins <br />Avoid the checkpoint in the STAGE ”S” <br />Cells  continuous playback with the damaged genome<br />
  18. 18. OBSERVATION<br />
  19. 19. MEDICAL UTILITY<br />
  20. 20. MEDICAL UTILITY<br />With the discovery of protein function Cks1 and Cks2 may be finding new ways of treatment and prevention against cancer by preventing the large increase of these in the early stages of disease development, improving the quality of life for thousands of people.<br />
  21. 21. MEDICAL UTILITY<br />With the discovery of the molecular basis of DNA breakage, are disclosed new features of the structure of DNA that promote the development of cancer, identifying the initial cancer processes such as fragile sites. This can be used to prevent cancer development through genetic modification.<br />
  22. 22. MEDICAL UTILITY<br />All these studies that realize about the operation, structure and application of DNA, serve as the basis for many other studies and provide valuable information in front of a cure for some diseases that affect millions of people such as cancer. Those discovers help  to preserve the quality of life and the people.<br />
  23. 23. BIBLIOGRAFHY<br />Scientistsfind “brake-override” proteinsthatenabledevelopment of somecancers.URL:http://esciencenews.com/articles/2011/07/07/scientists.find.brake.override.proteins.enable.development.some.cancers .(Biology& Nature).<br /> <br />MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p.<br />HebrewU. scientistsidentify molecular basisfor DNA breakage. URL: http://esciencenews.com/articles/2011/07/19/hebrew.u.scientists.identify.molecular.basis.dna.breakage. (Biology & Nature) .<br /> <br />
  24. 24. THANKS<br />

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