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Dna replication

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  • 1. DNA REPLICATION
    Universidad Pontificia Bolivariana
    María Paulina Henao Zuluaga
    Medicine Student
    3rd Semester
  • 2.
  • 3.
  • 4. INTRODUCTION
    An essential property of the genetic material is its ability to make exact copies of itself.
    DIRECTION
    5’---- 3’
    ENZYMES
    • DNA Polymerases,
    • 5. DNA Ligase
    • 6. Primase
    • 7. SSDPB (Single Strand DNA BindingProtein)
    • 8. Topoisomerases,
    • 9. RNAse- H
  • HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE
    BIOLOGY & NATURE
    (July 19, 2011)
     
  • 10. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE
  • 11. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE
    The cell increase proliferation  process
    CANCER
    “FRAGILE SITES “ are created in the early cancer stages
     Later cells enters in stress on DNA replication
    Discover bases of DNA breakage
  • 12. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE
  • 13. OBSERVATION
  • 14. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS
     BIOLOGY & NATURE
    (July 7, 2011)
     
  • 15. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS
    In normal conditions
  • 16. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS
    Uncontrolled and excessiveproliferation
  • 17. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS
    Cks 1 and Cks 2 proteins
    Avoid the checkpoint in the STAGE ”S”
    Cells  continuous playback with the damaged genome
  • 18. OBSERVATION
  • 19. MEDICAL UTILITY
  • 20. MEDICAL UTILITY
    With the discovery of protein function Cks1 and Cks2 may be finding new ways of treatment and prevention against cancer by preventing the large increase of these in the early stages of disease development, improving the quality of life for thousands of people.
  • 21. MEDICAL UTILITY
    With the discovery of the molecular basis of DNA breakage, are disclosed new features of the structure of DNA that promote the development of cancer, identifying the initial cancer processes such as fragile sites. This can be used to prevent cancer development through genetic modification.
  • 22. MEDICAL UTILITY
    All these studies that realize about the operation, structure and application of DNA, serve as the basis for many other studies and provide valuable information in front of a cure for some diseases that affect millions of people such as cancer. Those discovers help  to preserve the quality of life and the people.
  • 23. BIBLIOGRAFHY
    Scientistsfind “brake-override” proteinsthatenabledevelopment of somecancers.URL:http://esciencenews.com/articles/2011/07/07/scientists.find.brake.override.proteins.enable.development.some.cancers .(Biology& Nature).
     
    MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p.
    HebrewU. scientistsidentify molecular basisfor DNA breakage. URL: http://esciencenews.com/articles/2011/07/19/hebrew.u.scientists.identify.molecular.basis.dna.breakage. (Biology & Nature) .
     
  • 24. THANKS