Rapid technological advances, regulatory reform, and the new science of personalized medicine are the three primary factors driving unprecedented levels of innovation in the healthcare industry. These factors are forcing convergence among all members of the healthcare ecosystem in ways that enable all members to create greater value through extensive coordination, collaboration, and competition. Increasingly, providers, payers, products, and patients are leveraging mobile information technology to participate in M2M (mobile-to-mobile) digital healthcare delivery. Some of the key questions facing healthcare organizations, and particularly their CIOs, are: Where in the healthcare innovation ecosystem should we focus? What types of innovations create the most value for our organization? How do we enable greater levels of innovations from a strategic, process, and infrastructure perspectives? What are the barriers to developing and adopting innovation in the healthcare industry, and within healthcare organizations, and how do we overcome these barriers?