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Cause of Nausea & Vomiting
Radiotherapy & Chemotherapy
During Pregnancy (Hyperemesis Gravidarum)
Surgery
During Journey
Se...
Existing Product Information
 Brand Name : PERISET
 Composition : Ondansetron Hydrochloride USP
8 mg tablet and 4 ml inj...
NEW Product Information
 Brand Name : PERISET
 Composition : Ondansetron Hydrochloride USP
 Therapeutic group : Anti-em...
Indications
 The management of nausea and vomiting
◙ induced by cytotoxic chemotherapy,
◙ for the prevention and treatmen...
Serotonin release from Small intestine
Vomiting center(medulla)
Serotonin binds with central 5-HT3 receptor in
Chemorecept...
Mechanism of Action
Ondansetron is a selective Serotonin 5-HT3 receptor antagonist.
Its effects are thought to be on both ...
Dosage And Administration
Age Category Oral Solution
Adults/ Geriatric / Child
of 12 years or over
Highly emetogenic cancer chemotherapy: 30 ml (24 ...
Age Category Oral Solution
Adults/ Geriatric / Child
of 12 years or over
The recommended oral dosage is 10 ml (8 mg)
Peris...
Age Category Oral Solution
Adults/ Geriatric /
Child of 12 years or
over
20 ml (16 mg) Periset Oral Solution 1
hour
before...
Pregnancy category B.
Use In Children
This drug Ondansetron IM/IV injection is recommended
for child (from 1 month).
Target Doctors
 Oncology
 Surgery practitioners
 Hospital practitioners
 General practitioners
 Gyane practitioners
...
Market Information (Generic)
The market size of Ondansetron is 22.38 crore (app.) with Growth 33.08%.
Ref: 2nd
Q, 2012
Bra...
Market Information (Oral Solution)
The market size of Ondansetron is 4.34 crore (app.).
Ref: 2nd
Q, 2012
Brand Company Sal...
Highlighting Points
PERISET…
◙ Relives nausea and vomiting effectively & safely in
adults and children
◙ Ensures effective...
NVP Don-A Periset
Nausea and
vomiting during
pregnancy
Prevention and relief of
acute nausea & vomiting,
nausea associated...
PERISET
(Ondansetron Hydrochloride USP)
Presented by
Mohammed Moshiur Rahaman
Brand Executive
Brand Management Department
...
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
Periset oral solution (Ondansetron) ppt.
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Periset oral solution (Ondansetron) ppt.

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Transcript of "Periset oral solution (Ondansetron) ppt."

  1. 1. Cause of Nausea & Vomiting Radiotherapy & Chemotherapy During Pregnancy (Hyperemesis Gravidarum) Surgery During Journey Severe Diarrhea (Acute Gastroenteritis) After Accident
  2. 2. Existing Product Information  Brand Name : PERISET  Composition : Ondansetron Hydrochloride USP 8 mg tablet and 4 ml injection (2 mg/ml)  Therapeutic group : Anti-emetic  Product group : B & G  Pack Size : 3 X 10’s tablets (8 mg tablet) 1 X 5’s ampoules (4 ml injection)  Unit Price (proposed) : 10.00 tk (8 mg tablet) 30.00 tk (4 ml injection)
  3. 3. NEW Product Information  Brand Name : PERISET  Composition : Ondansetron Hydrochloride USP  Therapeutic group : Anti-emetic  Product group : B & G  Pack Size : 1 X 1’s Phial 50 ml Oral Solution (4 mg/ 5 ml) in PET bottle  Unit Price (proposed) : 40.00 tk (50 ml Oral Solution )
  4. 4. Indications  The management of nausea and vomiting ◙ induced by cytotoxic chemotherapy, ◙ for the prevention and treatment of post-operative nausea and vomiting (PONV) ◙ for the prevention of nausea and vomiting associated with radiotherapy, either total body irradiation or single high dose fraction to the abdomen.
  5. 5. Serotonin release from Small intestine Vomiting center(medulla) Serotonin binds with central 5-HT3 receptor in Chemoreceptor Trigger zone Radio & Chemotherapy Serotonin binds withSerotonin binds with peripheral 5-HT3 receptorperipheral 5-HT3 receptor in GI Tractin GI Tract VOM reflex VOM reflex P E R I S E T X X
  6. 6. Mechanism of Action Ondansetron is a selective Serotonin 5-HT3 receptor antagonist. Its effects are thought to be on both peripherial and central Vagus nerves. Peripherharal ► reduce the activity of the peripheral vagus nerve, which activates the vomiting center in the medulla oblongata. Central ► The other is a blockage of serotonin receptors in the chemoreceptor tigger zone.
  7. 7. Dosage And Administration
  8. 8. Age Category Oral Solution Adults/ Geriatric / Child of 12 years or over Highly emetogenic cancer chemotherapy: 30 ml (24 mg) Periset Oral Solution administered 30 minutes before start of emetogenic chemotherapy. Moderate emetogenic cancer chemotherapy: 10 ml (8 mg) Periset Oral Solution administered 30 minutes before start of emetogenic chemotherapy. A further 10 ml (8 mg) dose should be administered after 8 hours of the first dose. One 10 ml (8 mg) dose should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy. Pediatric (4-11 years) 5 ml (4 mg) Periset Oral Solution should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. Then 5 ml (4 mg) oral solution should be administered 3 times a day (every 8 hours) for 1-2 days after completion of chemotherapy. Chemotherapy Induced Nausea and Vomiting
  9. 9. Age Category Oral Solution Adults/ Geriatric / Child of 12 years or over The recommended oral dosage is 10 ml (8 mg) Periset Oral Solution 3 times daily. For total body irradiation, 10 ml (8 mg) Periset Oral Solution should be administered 1-2 hours before each fraction of radiotherapy administered each day. For single high-dose fraction radiotherapy to the abdomen, one 10 ml (8 mg) Periset Oral Solution should be administered 1-2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1-2 days after completion of radiotherapy. For daily fractionated radiotherapy to the abdomen, 10 ml (8 mg) Periset Oral Solution should be administered 1-2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy Radiotherapy induced nausea and Vomiting
  10. 10. Age Category Oral Solution Adults/ Geriatric / Child of 12 years or over 20 ml (16 mg) Periset Oral Solution 1 hour before induction of anesthesia. Postoperative Nausea and Vomiting
  11. 11. Pregnancy category B.
  12. 12. Use In Children This drug Ondansetron IM/IV injection is recommended for child (from 1 month).
  13. 13. Target Doctors  Oncology  Surgery practitioners  Hospital practitioners  General practitioners  Gyane practitioners  PC doctors  Child specialist
  14. 14. Market Information (Generic) The market size of Ondansetron is 22.38 crore (app.) with Growth 33.08%. Ref: 2nd Q, 2012 Brand Company Sales value(crore) yearly Emistat Healthcare 9.90 Zofra SK+F 3.31 Anset Opsonin 3.24 Onaseron Incepta 2.29
  15. 15. Market Information (Oral Solution) The market size of Ondansetron is 4.34 crore (app.). Ref: 2nd Q, 2012 Brand Company Sales value(crore) yearly Zofra SK+F 1.70 Anset Opsonin 1.08 Onaseron Incepta 0.52
  16. 16. Highlighting Points PERISET… ◙ Relives nausea and vomiting effectively & safely in adults and children ◙ Ensures effective control of vomiting in acute gastroenteritis ◙ Is an effective first-line antiemetic for patients undergoing chemotherapy, radiotherapy and surgery ◙ Safe & effective in hyperemesis gravidarum
  17. 17. NVP Don-A Periset Nausea and vomiting during pregnancy Prevention and relief of acute nausea & vomiting, nausea associated with migraine Control nausea & vomiting in various condition (Radiotherapy, Chemotherapy, PONV, Acute gateroenterititis, Hyperemesis gravidarum) Stomach mortility Safe for child (IM/IV from 1 month and Tablet, Oral solution from 4 years)
  18. 18. PERISET (Ondansetron Hydrochloride USP) Presented by Mohammed Moshiur Rahaman Brand Executive Brand Management Department The ACME Laboratories Ltd.
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