The Thyroid and Cancer
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The Thyroid and Cancer

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The Thyroid and Cancer The Thyroid and Cancer Presentation Transcript

  • © 1
  • Today, we are going to be talking about the role of the thyroid , its diseases, Causes of dysfunction and its relationship to all forms of cancer © 2
  • WHO AM I ? I am a Medical Herbalist, trained in the UK, in integrated medicine in clinics, hospitals and university environments I treat cancer, pre cancerous and chronic auto immune conditions such as MS, Alzheimer's, thyroid and women’s problems in a (w) holistic protocol, on a science evidenced basis with plant drugs Disclosure - No commercial ties © 3
  • WHAT DO I DO I ASSESS THE CONDITION ( DIAGNOSE ) , EXAMINE THE PATIENT, TAKE A CASE HISTORY, COMPOUND ( PRESCRIBE ); IDENTIFY THE CAUSE OF THE PROBLEM WITH THE OBJECTIVE OF RESOLVING IT WITH PLANT DRUGS ON AN EVIDENCED BASED BASIS. © 4
  • WHY ARE WE TALKING ABOUT THE THYROID? © 5
  • BECAUSE IT’S THE CONDUCTOR! The Thyroid plays the music written in the Hypothalamus in the brain The signalling hormone TSH from the brain gets converted to T4 and T3 in the gland. These hormones act on cells in all bodily tissues and can alter gene products The hormones regulate protein, carbohydrate and fat metabolism – in other words all functions and diseases within the body normally described as endocrine metabolism. Another way is to say it regulates all fuel ( glucose ), Cells ( fats ) and DNA ( protein In addition the cells of the parathyroid embedded in the gland regulate serum calcium levels © 6
  • BECAUSE It is endemic in Ontario and thyroid cancer is the fastest growing type Cancer in Ontario Overview : Astatistical report 2011 And Most OHIP practitioners have never been educated or recognise the vital role this gland plays in human health “ Most doctors would not consider a thyroid examination on most healthy women of a normal age in a physical exam” Cathy Maclean Head of Dept Family Medicine University of Calgary quoted in Globe & Mail 2011 Oct 24. ‘ © 7
  • © © 8
  • PINEAL PARATHYROID PITUITARY GLANDS These glands all closely interrelate to the thyroid Pineal – responsible for circadian rhythms Parathyroid- cells of the parathyroid embedded in the gland regulate serum calcium levels in conjunction with calcitonin and Vitamin D Pituitary – anterior and posterior Releases prolactin ( female hormone for lactation/birth processes ) FSH/LH , ACTH, TSH, GH Oxytocin, ADH © 9
  • PROBLEMS OF THE THYROID HASHIMOTOS GRAVES IDIOPATHIC EUTHYROID SICK SYNDROME SUB CLINICAL FUNCTION HYPER/HYPO NODULES CANCER © 10
  • THE THYROID GLAND This is a butterfly shaped gland which is wrapped around the throat, so when it swells it has an impact on Your throat Your neck Your voice cords Your neck muscles Your swallowing/ eating Most common and obvious sign is goitre – turkey neck! ( very visible even in a cursory examination of a woman! ) © 11
  • OTHER SIGNS & SYMPTOMS Obesity Carpel tunnel Hypertension Constipation Palpitations Hair loss And lots more! © 12
  • WHAT DOES THE THYROID DO FOR YOU!? Lets look at some of the functions of the body where the thyroid is crucial • FERTILITY / LACTATION • SUGAR REGULATION / DIABETES • OBESITY/Liver function • FEMALE HORMONE DISORDERS EG PCOS • CARDIAC REGULATION / PALPITATIONS • TEMPERATURE REGULATION/SWEATS • BONE HEALTH • OXYGENATION ( IE METABOLIC RATE ) • Anything involving steroid hormones/fat soluble vitamins.ADEK © 13
  • ENDOCRINE FUNCTIONS Involve the hypothalamus in the brain The pituitary gland in the brain The thyroid and other endocrine glands Hormones and their receptors All in a complex pattern of vertical horizontal and diagonal axes. © 14
  • MAJOR THYROID BLOOD MARKERS Thyroid stimulating hormone Free T 4 Free T 3 Thyroid peroxidase Thyroid anti globulin Reverse T3 Each of these monitors the major stages of the hormonal signalling process © 15
  • NEURO ENDOCRINE SIGNALLING The body works on a complex neuro endocrine signalling mechanism i.e. cells signal when they want to receive something and signal when the delivery has been completed The body is composed of major 401 type traffic highways and minor rural roads all with parking bays, traffic lights, policemen, traffic wardens! In the thyroid TSH converts T4 which converts to T3 which eventually converts T3 to T2 and T1. 20% of the conversion occurs in the thyroid gland itself and 80% over the rest of the body. When there is sufficient of say T3 then less TSH is produced on a negative feed back loop. © 16
  • ROAD WORKS Within the feedback loop there are various intermediate stages; blocking any of these stages can cause dysregulation of the gland egTSH converting to T4 can be blocked by bromine and other things. Bromine is commonly found in imported US processed foods such as pizza bases. It is legal in the US but not in Canada to put bromine in processed flours. Once a product has been created it is not a legal requirement to disclose its presence but in a country where there is endemic sub clinical hypothyroidism in my view this is a major loop hole Health Canada should be addressing © 17
  • CAUSES OF DYSREGULATION DIET: EXCESS CONSUMPTION OF GRAINS – BROMINE LACK OF IODINE – FISH EXCESSIVE CONSUMPTION OF BRASSICAS LACK OF BASIC NUTRIENTS – ZINC/SELENIUM GENETIC – TRANSFERENCE OF ANTIBODIES TO THE FETUS VIRUSES © 18
  • DYSREGULATION LEADS TO DISEASE Cancer, diabetes, infertility etc. OHIP approach is to ignore the issue until it becomes acute i.e. the gland is beyond saving…….lasting damage will already have been done at this point. No prevention or long term considerations Surgery/ ablation of the gland and prescribe thyroxine – the only drug available – for life Side effects of thyroxine particularly in women increase with age. Low risk thyroid cancer Overdiagnosed Overtreated Aug 28 2013 Brito JP et al BMJ © 19
  • BE AWARE Other factors which cause dysregulation of the thyroid: Drugs e.g. lithium, Tamoxifen Iodide Beta blockers, steroids, androgens, phenytoin, Salicylates, anti depressants Statins Environmental agents including chemicals e.g. benzenes © 20
  • RADIATION American Thyroid Association released policy statement for minimising radiation exposure whenever possible June 18 2012 @ incr 3.2% annually 1996-2010 from medical imaging An exponential growth in incidence of Thyroid Cancer: Trends and the impact of CT imaging Hoang JK et al AJNR 2013 oct 10 PMID 24113469 © 21
  • WHAT YOU CAN DO ABOUT IT? CHANGE YOUR DIETARY LIFESTYLE CUT THE CARBS EAT FISH ELIMINATE SUGAR BE ALIVE © 22
  • WHAT I CAN DO ABOUT IT? LOTS! THROUGH THE USE OF MY PLANTS I CAN MAKE THE THYROID NORMAL I CAN RAISE /LOWER TSH, Free T4 and T3 and remove some of the anti thyroglobulin antibodies to reduce TPO anti bodies. WITHANIA, BLADDERWRACK, COLEUS, NETTLE, MYRRH, BACOPA AND OTHERS ALL OF WHICH HAVE BEEN EVIDENCED FOR THEIR EFFECT WHEN ADMINISTERED BY A QUALIFIED MEDICAL HERBALIST. In a truly personalised format for each person. © 23
  • TAKE CHARGE OF YOUR HEALTH Good thyroid health helps to ensure good health through out the body For further information on more detailed workings of the thyroid for example: The Thyroid and Fertility please see my website www.medicusherbis.com © 24
  • WHAT IS CANCER IS AN METABOLIC ENDOCRINE DISEASE WHEREVER IT OCCURS IN THE BODY DRIVEN BY INFLAMMATION IT IS A DISEASE OF PROLIFERATION I.E GROWTH IT IS A DISEASE OF ABERRANT CELL SIGNALLING Cancer is only divided up into different types as this suits the surgical approach and patenting conventional medicine. IT IS ALWAYS A DISEASE OF PROLIFERATION AND ALWAYS DRIVEN BY HORMONES WHERE EVER IT IS LOCATED IN THE BODY © 25
  • PRINCIPAL CAUSES OF ALL TYPES OF CANCER Diet Alcohol Lack of exercise ) ) 70% ) Bacteria & Viruses 20% Iatrogenic 5% Genetic - Brac 1& 11 mutations especially 5% © 26
  • CONVENTIONAL APPROACH Surgery Jones in 1895 and Peeters in 2005 Journal of Surgery both observed: Surgical removal of the primary tumour activates cancer All associated with long term side effects , complications, reoccurrence and poor results including diabetes Chemotherapy Radiation Complications of radio iodine treatment of thyroid carcinoma Lee S, J Natl Canc Netw 2010:8(11):12771287 © 27
  • EVIDENCE LACKING FOR CURRENT PROTOCOLS Increasing it is being recognised that radiation is not of benefit as it is both an inflammatory process and destabilises DNA BUT many hospitals have invested huge sums in radiology which have to be justified OHIP produces such poor pathology reports including omitting key diagnostic markers e.g. Ki67 that any chemotherapy protocol has no evidence of validity for the patient Gepar Trio Trial Annals of Oncology Aug 2013 It has been known since 1895 that surgical intervention stimulates cancer in the body. Take charge of your own health! © 28
  • ROLE OF THYROID IGNORED UNLESS IT IS THYROID CANCER OR MESTATISIS Statistically 80% of women with breast cancer have at least sub clinical thyroid disorder with outcomes worse if it is hyperthyroidism. In my practise it is 100% for all cancers A large cohort study of hypothyroidism and hyperthyroidism in relation gynecologic cancers Kang JH et al Obstet Gynecol Int 2013 ;2013:743721 doi 10.1155/2013/743721 © 29
  • THYROID LINKS TO CANCER Breast – hormone and lipid metabolism Prostate - hormone metabolism Colon – dietary metabolism Thyroid fastest growing cancer in US and Canada Lung – hormone metabolism Pancreatic – carbohydrate metabolism Liver – metabolism all types and breakdown of hormones Bone – oestrogen, vitamin D and calcium Leukaemia's & Lymphomas – kidneys, immunity © 30
  • THYROID CANCER 4 Main types Papillary, Follicular, Medullary, Anaplastic Surgery may work for papillary but no longer considered a ‘true’ cancer No effective Chemotherapy drug for any - Soforenib Radiation leads to: DNA destabilisation Increased NFKB ( inflammation ) Further tissue damage © 31
  • BREAST AND GYNAECOLOGICAL CANCERS This type of cancer is driven by oestrogen and progesterone – steroid hormones derived from cholesterol The ACTH hormone influences FSH/LH which stimulates thyroid hormones which in turn stimulates growth hormone, thyroid, thus influences the ovaries and the testes and further down the line oestrogen, progesterone and testosterone Hall LC, et al. Effects of thyroid hormones on human breast cancer cell proliferation. J Steroid Biochem Mol Biol. 2008;109:57–66. Orai 3 is an estrogen receptor alpha regulated Ca2+ channel promotes tumorigenesis Motiani RK Faseb J 2012 Sep 19 PMID 22993197 Cancer: Thyroid circadian clock-altered in cancer? Wilson C Nat Rev Endocrinol 2013 Sept 13 © 32
  • LIVER & PANCREATIC CANCERS TSH signals the thyroid which then signals and influences the Pancreas and in turn the liver through the production of insulin/glucagon If the metabolism is impaired the liver is impaired as it is the site of both the creation of cholesterol and the detoxification of hormones for excretion J Thyroid Res. 2011;2011:152850. doi: 10.4061/2011/152850.. Why can insulin resistance be a natural consequence of thyroid dysfunction ? Brenta G.Department of Endocrinology, glucose metabolism and analyze the mechanisms whereby alterations of thyroid hormones lead to insulin resistance.PMID: 21941681 PMCID: PMC3175696 © 33
  • COLON AND LUNG The microbiome project has shown that many cancers start in the gut. β-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells. Dentice M, et al. Gastroenterology. 2012 Oct;143(4):1037-47. Metastasis squared: colon cancer spread to the pre-existing skeletal metastasis of thyroid carcinoma. Majumder S, et al. Am J Gastroenterol. 2012 Jun;107(6):956-7. Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers. Kiyamova R, Biomarkers. 2012 Jun;17(4):362-71. doi: 10.3109/1354750X.2012.677476. © 34
  • KIDNEY Indian J Endocrinol Metab. 2012 Mar-Apr; 16(2): 204–213. doi: 10.4103/2230-8210.937Interactions between thyroid disorders and kidney diseaseGopal Basu et al There are several interactions between thyroid and kidney functions in each other organ's disease states. Thyroid hormones affect renal development and physiology. Thyroid hormones have pre-renal and intrinsic renal effects by which they increase the renal blood flow and the glomerular filtration rate (GFR). Hypothyroidism is associated with reduced GFR and hyperthyroidism results in increased GFR as well as increased renin – angiotensin – aldosterone activation. Chronic kidney disease (CKD) is characterized by a low T3 syndrome which is now considered a part of an atypical nonthyroidal illness. CKD patients also have increased incidence of primary hypothyroidism and subclinical hypothyroidism. © 35
  • WHAT CAN YOU DO ABOUT IT? DIET EXERCISE Dr. Lakoski 2013 American Society of Clinical Oncology Being Fit can protect against developing, dying of cancer Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological studyBMJ 2013; 347 doi: http://dx.doi.org/10.1136/bmj.f5577 DE STRESS The GAS syndrome – Hans Selye – Canadian Stress is known to deplete immunity and increase the rate of Cancer it releases pro inflammatory cytokines which act as stimulants © 36
  • SUGAR Warburg in 1925 deduced quite correctly that: “Cancer has only one prime cause. |It is the replacement of normal oxygen respiration of the body’s cells by anaerobic oxygen deficient cell respiration” Confirmed again in 2008 by another Nobel prize winner! Ist calorie restriction to treat cancer randomised clinical trial approved by Duke University Feb 2013 Use of Metformin in USA but this is not the answer! © 37
  • SUGAR Grains translate to sugars in the body: Sugar is inflammatory to the body ( inflammation being the key pathological process in cancer ) Sugar provides a better less hostile environment in the gut for bacteria and viruses to grow and live ( bacteria and viruses part of the pathological processes of cancer ) High circulating sugar levels impede the function of the brain, liver, kidneys, pancreas and thyroid. The receptors leading to further biochemical processes in the body are altered. Obesity and other concomitant diseases © 38
  • MORTALITY AND SUGAR THE INCREASE IN MORTALITY IN CANCER HAS MIRRORED THE USE OF PROCESSED FOODS AND INCREASED CONSUMPTION OF SUGAR IN 1900 CANCER WAS NOT EVEN IN THE TOP 10 CAUSES OF DEATH TODAY IN NORTH AMERICA IT IS THE NUMBER ONE CAUSE OF DEATH Mortality by diet and physical activity (PA) in Women’s Healthy Eating and living Study comparison group Pierce J et al J Oncol 25:2345 2007 © 39
  • SUGAR IS WHITE SWEET AND DEADLY!* The presence of sugar in processed foods has grown exponentially since 1900 – so has the diagnosis of Cancer Globally, sugar consumption has tripled in the past 50 years. But, it turns out, the greatest threat to human health is one type of sugar in particular: fructose. In the US, per-capita consumption of fructose, a common food additive there – mainly in the form of high-fructose corn syrup – has increased more than 100-fold since 1970. Processed foods lack key nutrients. 1tsp = fruits J.Physiol 2012 590:2485-2499 Gomez-Pinella see also Lustig / Yudkin © 40
  • BE ALIVE AVOID PROCESSED FOODS LOVE YOUR VEGGIES INNOVATE AND EAT A WIDE RANGE OF FOOD STUFFS Value moderation ELIMINATE SUGAR FROM YOUR DIET © 41
  • WHAT CAN I DO ABOUT IT? LOTS! There are many very effective herbal medicine protocols which inhibit the development of cancer These plants have huge amounts of science about them. Curcuma Longa – Turmeric is probably the best known 98 metabolic pathways affected – efficacy shown against 19 cancers “Most efficacious cancer drug is a plant “ Prof. BB Aggarwal MD Anderson Cancer centre & University of Texas © 42
  • PLANTS Angiogenic and proliferative effect of the cytokine VEGF in Ehrlich ascites tumour cells in inhibited by Glycyrrhiza glabra. Sheela ML et al Int Immunopharmacol 2006 Mar 6(3)494-8 Anti tumour properties of Boswellic acid against Ehrlick ascites cells bearing mouse Agrawal SS et al Food Chem Toxicol 2011 Sept 49(9) Cancer has 27 principal pathways for growth – I have plants which block all those pathways © 43
  • OTC CAVEATS illegal to sell a medically efficacious dose most are not pharmaceutical grade no evidence base / extrapolation claims Contents /label/marketing claim Unnecessary with a proper diet No consideration of individual needs Failure to address polysupplementation © 44
  • EXAMPLES OF OTC ISSUES DO NOT USE PROTEIN POWDER WHERE THERE ARE SUGARS – AGAVE, STEVIA, SYNTHETIC SWEETNERS, Just because its ‘natural’ does not mean its good for you Circulating insulin like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis. Growth Hormone & IGF research Vol 17 Issue 6 Dec 2007 Hosback et al POTASSIUM IODIDE © 45
  • REFERENCES Some of the references used have been shown in the text but if you want a full list please email me at mrsmg@sympatico.ca All references are available on Pubmed © 46
  • BE SENSIBLE PLEASE DO NOT SELF TREAT THE PLANT DRUGS I USE ARE NOT AVAILABLE OVER THE COUNTER IN SOME DISEASE USE OF OVER THE COUNTER SUPPLEMENTATION IS HARMFUL. PLEASE NOTE IT IS ADVISED, THAT ANY PLANTS MENTIONED IN THIS TALK, ARE ONLY USED UNDER PROFESSIONAL GUIDANCE. .A professional: will recognise all the issues within the body Select herbs that will impact positively on these issues without causing problems in order to co exist with orthodox drugs, © 47
  • THANK YOU Morwenna Given MEDICAL HERBALIST BA MA (Oxon) BSc m.OHA BHG AHG RH www.medicusherbis.com © 48