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Cancer, alzheimers, diabetes – what do all have in common?
 

Cancer, alzheimers, diabetes – what do all have in common?

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Cancer, Alzheimers, diabetes are diseases of lifestyle. Learn how the begin in the body and what you can do to protect yourself.

Cancer, Alzheimers, diabetes are diseases of lifestyle. Learn how the begin in the body and what you can do to protect yourself.

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    Cancer, alzheimers, diabetes – what do all have in common? Cancer, alzheimers, diabetes – what do all have in common? Presentation Transcript

    • © 1
    • WHO AM I? I am a Medical Herbalist, trained in the UK, in integrated medicine in clinics, hospitals and university environments I treat cancer, pre cancerous and chronic auto immune conditions such as Diabetes, Alzheimer's, thyroid and women’s problems in a (w) holistic protocol, on a science evidenced basis with plant drugs Disclosure - No commercial ties © 2
    • WHAT DO I DO? I ASSESS THE CONDITION ( DIAGNOSE ) , EXAMINE THE PATIENT, TAKE A CASE HISTORY, COMPOUND ( PRESCRIBE ); IDENTIFY THE CAUSE OF THE PROBLEM WITH THE OBJECTIVE OF RESOLVING IT WITH PLANT DRUGS ON AN EVIDENCED BASED BASIS. © 3
    • WHY ARE WE TALKING ABOUT CANCER, DIABETES TYPE II AND ALZHEIMERS IN ONE SENTENCE? BECAUSE: © 4
    • OVER VIEW - CANCER, ALZHEIMER'S, DIABETES • CANCER IS A CHRONIC ENDOCRINE METABOLIC DISEASE IT IS A DISEASE OF ABERRANT CELL SIGNALLING AND PROLIFERATION • DIABETES IS A CHRONIC ENDOCRINE METABOLIC DISEASE IT IS A DISEASE OF ABERRANT CELL SIGNALLING AND CELL DEATH • ALZHEIMERS IS A CHRONIC ENDORCINE METABOLIC DISEASE IS A DISEASE OF ABERRANT CELL SIGNALLING AND PROLIFERATION © 5
    • THEY ARE ALL CHRONIC DISEASES Chronic diseases are those medical issues people ‘live with’ in the defined medical model and do not cause immediate death The current medical model is not designed for chronic diseases Nearly all chronic disease are diseases of excess/lifestyle only around 5% are genetic Life expectancy has grown in 20 yrs. from 72 to 84 in 20 years this means that the consequences of excess will become more and more apparent © 6
    • ALL ARE METABOLIC ENDOCRINE DISEASES WHAT IS THIS? It means that this triad of disease arise from an impaired functioning of all the physical and chemical changes that take place in the body to enable bodily growth & function which is determined in large part by the endocrine glands This means all have a slow onset which is reversible at many stages • Glucose disturbance appears years before a diabetes diagnosis. European Association for the Study of Diabetes (EASD) 47th Annual Meeting: Abstract 335.September 13, 2011. THIS MEANS YOU ARE WHAT YOU EAT! This means all involve the brain © 7
    • THE MICROBIOME Dietary Deficiencies + Viruses} Bacteria} combine to create most chronic auto immune diseases cancer, Alzheimer's, Parkinson's, MS, arthritis, diabetes © 8
    • MICROBIOME The Microbiome is the most exciting development in the last 50 yrs. in medicine What you eat is totally under your control and preventable medicine There will never be a drug for bacteria & viruses in the gut as they mutate Most plants have anti bacterial and anti viral properties! The microbiome and cancer.Schwabe RF, Jobin C.Nat Rev Cancer. 2013 Nov;13(11):800-12 Assessing the human gut microbiota in metabolic diseases. Karlsson F, et al Diabetes. 2013 Oct;62(10):3341-9 Extragastric diseases and Helicobacter pylori. Roubaud Baudron C, et al Helicobacter. 2013 Sep;18 Suppl 1:44-51. Alzheimer's disease and the microbiome. Bhattacharjee S, Lukiw WJ. Front Cell Neurosci. 2013 Sep 17;7:153. doi: 10.3389/fncel.2013.00153. © 9
    • ALL INVOLVE DYSREGULATION OF THE THYROID – HPA/AXIS The Thyroid plays the music written by the Hypothalamus in the brain The signalling hormone TSH from the brain gets converted to T4 and T3 in the gland. These hormones act on cells in all bodily tissues and can alter gene products Subclinical hypothyroidism is endemic in Ontario (Cancer in Ontario Overview : A statistical report 2011) The hormones regulate protein, carbohydrate and fat metabolism – in other words all functions and diseases within the body normally described as endocrine metabolism. Another way is to say it regulates all fuel ( glucose ), Cells ( fats ) and DNA (protein) © 10
    • COMMON PATHOLOGIES Cancer, Alzheimer’s and Diabetes all start via a common pathway of nutritional deficiencies or excess leading to a process called inflammation. More women than men; 40-60yrs; western world; obesity UBIQUITIN Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? . Jara JH, et al. Davee Department of Neurology and Clinical Neurological Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Mitochondrial sirtuins as therapeutic targets for age-related disorders.Shih J, Donmez G.Genes Cancer. 2013 Mar;4(3-4):91-6. doi: 10.1177/1947601912474931. Common pathologies for neurodegenerative disorders Brain Nerve. 2012 Jun;64(6):675-9. Are neurodegenerative diseases "protein cancers"?. Hasegawa M.Depart of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Japan. Autophagy Dysfunction & its Link to Alzheimer's Disease & Diabetes Mellitus. Wilson CM, et al CNS Neurol Disord Drug Targets. 2013 Sep 18 [Diabetes type 2 and Alzheimer disease - one or two diseases? Mechanisms of association]. Marszałek M. et al 2013 Jul 23;67:653-71 © 11
    • MORTALITY Top causes of death Cancer, diabetes and Alzheimer's is projected by 2050 to be the third In older people > 65 yrs. 2 of these diseases may be present at one time The relative risks imparted by diabetes are greatest (about twofold or higher) for cancers of the liver, pancreas, and endometrium, and lesser (about 1.2–1.5 fold) for cancers of the colon and rectum, breast, and bladder. Other cancers (e.g., lung) do not appear to be associated with an increased risk in diabetes, and the evidence for others (e.g., kidney, non-Hodgkin ) is inconclusive Diabetes Care 2010 July (33) 7 1674-1685 © 12
    • ALL INVOLVE NEUROLOGICAL PATHWAYS The invasion of the neurological pathways start in the gut – the results are expressed differently in each disease Brain Fog β-amyloid is transmitted via neuronal connections along axonal membranes. Song HL, Shim S, Kim DH, Won SH, Joo S, Kim S, Jeon NL, Yoon SY. Ann Neurol. 2013 Oct 2. doi: 10.1002/ana.24029. Amyloid is also found deposited in the islet cells of the Pancreas It is also found in cancer – eg brain and lymphomas, prostate cancers etc. © 13
    • SURGERY & DRUGS ALL 3 CONDITIONS ARE OVER TREATED with poor outcomes Diabetes and Alzheimer’s are untreatable by surgery except when side effects become extreme - gangrene Cancer is upregulated by surgery – Peeters et al 2008 ELI JONES 1895 Avoid PET, CT scans in cancer Do Not perform PSA testing for prostate cancer with men no symptoms of disease who are expected to live < 10yrs. J Clin Oncol Oct 29 2013 © 14
    • DRUGS • Alzheimers – Aricept claims to reduce progression only. CMAJ. 2013 Sep 23. Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis. Tricco AC et al • Diabetes – Metformin commonly but failure to address B12 deficiency other commonly used drugs actually have been shown to make the collapse of the pancreas worse Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Moore EM, et al.Diabetes Care. 2013 Oct;36(10):2981-7. • Cancer – those commonly used all have life threatening consequences Avastin – recent publicity – failed to discuss the pharmacological issues and consequences. © 15
    • STATINS – DON’T! Statins can cross the blood brain barrier and are responsible for fog brain commonly described by patients. Potential underlying mechanisms for statin side effects. Brain and Behaviour 15 My 2013 March 2012 the FDA announced that it was revising the labels of all statins to warn that they can raise blood glucose and hemoglobin A1c levels. updating the label of lovastatin to warn that a number of interacting drugs can increase statin exposure up to 20-fold and trigger rhabdomyolysis. revised label for lovastatin will include new contraindications and dose limitations. The Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial showed a 27% increase in diabetes mellitus in patients taking rosuvastatin compared to placebo. Note - Ubiquitin © 16
    • ALL 3 ARE REVERSIBLE AND PREVENTABLE All progress as a long process of inflammation in the body All take years of physiological change before they can be diagnosed under the current conventional model All involve high homocysteine levels ignored by current models despite easy prevention Plasma homocysteine, Alzheimer and cerebrovascular pathology: Hooshmand B, et al Brain. 2013 Sep;136(Pt 9):2707-16. © 17
    • CAUSES FOR ALL 3 – DIET DIET DIET Copper Bacteria Lack of B vitamins Lack of fresh vegetables and fruit Excess of sugar and processed foods Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates.Kavanagh K et al JM.Am J Clin Nutr. 2013 Aug;98(2):349-57. Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases. Magrone T, et al. Can J Physiol Pharmacol. 2013 Jun;91(6):387-96. doi: 10.1139/cjpp-2012-0307 © 18
    • MED DIET Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and MetaAnalysis. PROSPERO 2013 Singh B, Parsaik et alDepartment of Neurology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Clinical Neuroscience, University of North Dakota School of Medicine Background/Objective: To conduct a systematic review of all studies to determine whether there is an association between the Mediterranean diet (MeDi) and cognitive impairment. screened, five studies met eligibility criteria. Higher adherence to the MeDi was associated with reduced risk of had 33% less risk MCI and AD. The subjects in the highest MeDi tertile (adjusted HR = 0.67; 95% CI, 0.55-0.81; p < 0.0001) of cognitive impairment (MCI or AD) as compared to the lowest MeDi score tertileprogressing from MCI to AD. © 19
    • SUGAR IS WHITE SWEET AND DEADLY!* The presence of sugar in processed foods has grown exponentially since 1900 – so has the diagnosis of Cancer – Diabetes - Alzheimers Globally, sugar consumption has tripled in the past 50 years. But, it turns out, the greatest threat to human health is one type of sugar in particular: fructose. In the US, per-capita consumption of fructose, a common food additive there – mainly in the form of high-fructose corn syrup – has increased more than 100-fold since 1970. Processed foods lack key nutrients. 1tsp = fruits J.Physiol 2012 590:2485-2499 Gomez-Pinella see also Lustig / Yudkin* © 20
    • DIET - SUGAR Warburg in 1925 deduced quite correctly that: “Cancer has only one prime cause. It is the replacement of normal oxygen respiration of the body’s cells by anaerobic oxygen deficient cell respiration” Confirmed again in 2008 by another Nobel prize winner! Ist calorie restriction to treat cancer randomised clinical trial approved by Duke University Feb 2013 Use of Metformin endemic but this is not the answer! – Increases cognitive impairment – Moore Diabetes Care 2013 Sept 5 – B12 issues not present if gallega officinalis is used! © 21
    • SUGAR Grains translate to sugars in the body: Sugar is inflammatory to the body ( inflammation being the key pathological process in cancer, diabetes and Alzheimer's ) Sugar provides a better less hostile environment in the gut for bacteria and viruses to grow and live ( bacteria and viruses part of the pathological processes of cancer ) High circulating sugar levels impede the function of the brain, liver, kidneys, pancreas and thyroid. The receptors leading to further biochemical processes in the body are altered. Obesity and other concomitant diseases © 22
    • SUGAR & MORTALITY THE INCREASE IN MORTALITY IN CANCER – DIABETES - ALZHEIMERS HAS MIRRORED THE USE OF PROCESSED FOODS AND INCREASED CONSUMPTION OF SUGAR IN 1900 CANCER/DIABETES WAS NOT EVEN IN THE TOP 10 CAUSES OF DEATH TODAY IN NORTH AMERICA IT IS THE NUMBER ONE & TWO CAUSE OF DEATH Mortality by diet and physical activity (PA) in Women’s Healthy Eating and living Study comparison group Pierce J et al J Oncol 25:2345 2007 CDC.ORG © 23
    • BE ALIVE AVOID PROCESSED FOODS LOVE YOUR VEGGIES INNOVATE AND EAT A WIDE RANGE OF FOOD STUFFS Value moderation ELIMINATE SUGAR FROM YOUR DIET © 24
    • STRESS Minimize Stress stimulates the fear flight mechanisms and upregulates physiological functions – like driving a car at 90mph all the time, in turn that ‘exhausts’ the adrenal glands and inhibits proper metabolism Hans Seyle – Canadian GAS syndrome © 25
    • EXERCISE At least an hour a day is mandatory - our lifestyle has become very sedentary but our bodies are not designed to be sedentary Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice. Liu HL, et al. Behav Brain Res. 2013 Aug 19;256C:261-272. In cancer and diabetes exercise has shown consistently a long term beneficial effect resulting in good prognosis © 26
    • WHAT CAN I DO ABOUT? LOTS!! There are many very effective herbal medicine protocols which inhibit the development of cancer, diabetes, Alzheimer's These plants have huge amounts of science about them. Curcuma Longa – Turmeric is probably the best known 98 metabolic pathways affected – efficacy shown against 19 cancers, diabetes and Alzheimer's “Most efficacious cancer drug is a plant” Prof. BB Aggarwal MD Anderson Cancer centre & University of Texas © 27
    • PLANTS & CANCER Angiogenic and proliferative effect of the cytokine VEGF in Ehrlich ascites tumour cells in inhibited by Glycyrrhiza glabra. Sheela ML et al Int Immunopharmacol 2006 Mar 6(3)494-8 Anti tumour properties of Boswellic acid against Ehrlick ascites cells bearing mouse Agrawal SS et al Food Chem Toxicol 2011 Sept 49(9) Cancer has 27 principal pathways for growth – I have plants which block all those pathways Garlic, Cat’s claw, Red Clover, Black Cohorsh, Yew, Poke, Chaga, Magnolia Etc. etc. etc. etc. etc. © 28
    • PLANTS AND DIABETES Do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 Indian medicinal plants. Kalekar SA, et al. BMC Complement Altern Med. 2013 Oct 5;13(1):257. Improved glycemic control and lipid profile in hyperlipidemic type diabetic patients consuming Salvia officinalis L. leaf extract: a randomize placebo. Controlled clinical trial. Kianbakht S, Dabaghian FH. Complement Ther Med. 2013 Oct;21(5):441-6. Evidence based herbal drug standardization approach in coping with challenges of holistic management of diabetes: a dreadful lifestyle disorder of 21st century. Et al .J Diabetes Metab Disord. 2013 Jul 4;12(1):35.. © 29
    • PLANTS & ALZHEIMERS Effect of plant extracts on Alzheimer’s disease: An insight into therapeutic avenues Obulescu M, et al J Neurosci Rural Pract 2011 Jan 2(1) 56-61 Berberine a potential multipotent natural product to combat Alzheimer’s disease Ji HF,et al Molecules 2011 Aug 9 16 (8) 6732-40 Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: 16 week trial Akhondzaheh S et al.J Clin Pharm Ther 2010 Oct 35 (5) 581-8 Orally administrated cinnamon extract reduces beta amyloid oligomerization and corrects cognitive impairment in Alzheimer’s Frydom-Marom A et al, Plos One 2011 Jan 28 6 (1) e 16564 Ginseng & Rosemary & Lemon Balm & CitrusPsychogeriatrics. 2009 Dec;9(4):173-9. doi: 10.1111/j.1479-8301.2009.00299.x.Effect of aromatherapy on patients with Alzheimer's disease.Jimbo D, et al School of Health Science, Faculty of Medicine, Tottori University, Japan. J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):863-6.Melissa officinalis extract double blind, randomised, placebo controlled trial. Akhondzadeh S, et alRoozbeh Psychiatric Hospital, Tehran University , Tehran, I © 30
    • OTC - CAVEATS Illegal to sell a medically efficacious dose Most are not pharmaceutical grade No evidence base / extrapolation claims Contents /label/marketing claim Unnecessary with a proper diet No consideration of individual needs Failure to address polysupplementation © 31
    • EXAMPLE OF OTC ISSUES DO NOT USE PROTEIN POWDER WHERE THERE ARE SUGARS – AGAVE, STEVIA, SYNTHETIC SWEETNERS, Just because its ‘natural’ does not mean its good for you Circulating insulin like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis. Growth Hormone & IGF research Vol 17 Issue 6 Dec 2007 Hosback et al Vitamin A © 32
    • BE SENSIBLE PLEASE DO NOT SELF TREAT THE PLANT DRUGS I USE ARE NOT AVAILABLE OVER THE COUNTER IN SOME DISEASE USE OF OVER THE COUNTER SUPPLEMENTATION IS HARMFUL. PLEASE NOTE IT IS ADVISED, THAT ANY PLANTS MENTIONED IN THIS TALK, ARE ONLY USED UNDER PROFESSIONAL GUIDANCE. .A professional: will recognise all the issues within the body Select herbs that will impact positively on these issues without causing problems in order to co exist with orthodox drugs, © 33
    • REFERENCES Some of the references used have been shown in the text but if you want a full list please email me at mrsmg@sympatico.ca All references are available on Pubmed © 34
    • FOUNDATION I AM IN THE PROCESS OF ESTABLISHING A FOUNDATION TO GIVE CANADIANS THE OPPORTUNITY TO HAVE THE EDUCATION I RECEIVED TO BE ABLE TO TREAT PEOPLE WITH PLANT MEDICINE WHICH IS DESIGNATED BY THE UN AS A ‘ HUMAN RIGHT ’ THERE IS CURRENTLY NO DEGREE COURSE AVAILABLE IN CANADA NOR EDUCATION AT THE LEVEL I RECEIVED. THE CONCEPT OF THE FOUNDATION IS TO PROVIDE THE FUNDS TO ESTABLISH A DEGREE COURSE WITHIN AN EXISTING UNIVERSITY ASSOCIATED WITH A HOSPITAL IN CANADA THE FOUNDATION IS ALSO TO DEVELOP A RECPRICOCITY FOR TRAINING WITH ST HILDA’S COLLEGE OXFORD FOR THOSE WISHING TO DO HIGHER DEGREES SUCH AS AN MSC. ELINOR RHODE LIVES ON! © 35
    • THANK YOU Morwenna Given MEDICAL HERBALIST BA MA (Oxon) BSc m.OHA BHG AHG RH www.medicusherbis.com © 36