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Alzheimers, Parkinsons’ ALS,MS, Fibromyalgia &Neurodegenerative Disease –Common Pathologies &Prevention                By:...
2         WHO AM I?Iam a medical herbalist, trained in University, Hospital and clinics in the UK Witha practise in down...
3   WHAT DO I DO? A person   who treats medical disease  ‘wholistically’ on an evidence based basis  with whole plant ext...
4   WHAT IS: NEURODEGENERATIVE DISEASE? Theseare diseases with the more familiar  names such as MS & Alzheimers They hav...
5The search for causesdetermined by drug patentability Genetic         in Origin?   Front Biosci (Elite Ed). 2013 Jan 1;...
6  Common causes All  these disorders have much in common.  Aetiology is surprising uniform Brain Nerve. 2012  Jun;64(6):...
7           Viral and Bacterial               Implications   Commensal microbiota and myelin autoantigen    cooperate to...
8                                                            MORE COMMON FACTORS   More women than men   Am J Public He...
9         Even More Common              Factors   Affects an older population   Previously confined to the Western World...
10                RECAP In the past @ 75yrs we have changed: No exercise – the car Diet – proliferation of processed fo...
11        THE MICROBIOME           PROJECT The microbiome is the most exciting  development in science in the last 50 yrs...
12                  MICROBIOME   Auto immunity diseases arise from the gutKirsten Berer & Krishnamorthy Max Planck Instit...
13Bacterial Actions   The inappropriate bacteria in the gut release   Lipases and other chemicals which in turn   Relea...
14       PREVENTION Itstarts at birth with: Exercise Appropriate diet. You are what you eat. Stress avoidance Mental ...
15         EXERCISE   "It is clear from this study and others that physical    performance in late life plays an incredib...
16MORE……research has shown that exercise programs among patients withneurologic disorders "increase the patients sense of ...
17           STRESS:Mitochondrial defects andoxidative stress in Alzheimerdisease and Parkinson disease.Free Radic Biol Me...
18                         DIET Gluten  intolerance may be a factor Hybridised grains and overconsumption Poor nutritio...
19More…..   Human nutrition, the gut microbiome and the    immune system.   Kau AL, et al;Nature. 2011 Jun 15;474(7351):...
20More…. Overprocessed    foods and foods not fit for  human consumption Two thirds of all raw shop bought chicken in  t...
21               SUGAR   Like all diseases of excess sugar plays a key role in    destabilising the body’s normal mechani...
22More….The Role of Glucose Transporters in Brain Disease: Diabetes andAlzheimers Disease.Shah K, Desilva S, Abbruscato T....
23            KEY:     MISSING INGREDIENTS   Our locally grown vegetables do not have    sufficient zinc, selenium   Mos...
24MORE….. Ameliorationof Alzheimers disease by neuroprotective effect of sulforaphane in animal model. Kim HV, et al Amyl...
25                 VITAMIN D   Ontario is well known for its lack of vitamin D in    the population – it is recognised to...
26                  Drugs   Basically the drugs used for most    neurodegenerative diseases do not prevent    progression...
27           PLANTSProtective effect of paeonol on neurotoxicityinduced by Abeta1-42 and underlyingmechanisms. Zhong SZ, e...
28More…… Turmeric Curcuminoids          in neurodegenerative diseases. Kim DS, et al Recent Pat CNS Drug Discov. 2012 De...
29               THEY WORK!   Reversible worsening of symptoms after taking Cat’s    claw ( Clin.Neuropharmacol 2008)   ...
30                 CAUTIONS   PLEASE NOTE: IT IS ADVISED, THAT ANY PLANTS    MENTIONED IN THIS TALK, ARE ONLY USED    UND...
31 REFERENCES www.   Pubmed, Science directIhave a full list of references for those who are interested – if you would l...
32THANK YOU     MORWENNA GIVENWWW.MEDICUSHERBIS.COM ©2013
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  1. 1. Alzheimers, Parkinsons’ ALS,MS, Fibromyalgia &Neurodegenerative Disease –Common Pathologies &Prevention By: Morwenna Given Medical Herbalist BA MA (Oxon) BSC BHG 1 m.OHA AHG RH 24th January 2012
  2. 2. 2 WHO AM I?Iam a medical herbalist, trained in University, Hospital and clinics in the UK Witha practise in downtown Toronto focussing on: Chronicauto immune diseases including MS, Cancer, Alzheimers, diabetes, thyroid and Womens’ issues ©
  3. 3. 3 WHAT DO I DO? A person who treats medical disease ‘wholistically’ on an evidence based basis with whole plant extracts A person who treats the cause of the problem not just the symptom We are specialists in the use of medicinal plants and their ability to resolve disease ©
  4. 4. 4 WHAT IS: NEURODEGENERATIVE DISEASE? Theseare diseases with the more familiar names such as MS & Alzheimers They have been placed in this category of medical disease as they are diagnosed and measured by change in the brain and nerves. Each specific disease has its own characteristics for diagnosis such as amyloid plaques in Alzheimers ©
  5. 5. 5The search for causesdetermined by drug patentability Genetic in Origin? Front Biosci (Elite Ed). 2013 Jan 1;5:167-77.Genetics of familial and sporadic Alzheimers disease.Piaceri I, Nacmias B, Sorbi S. Failure of current treatments Biochem Pharmacol. 2012 Nov 22. pii: S0006-2952(12)00755-1. doi: 10.1016/j.bcp.2012.11.014. Alzheimers Therapeutics: Continued clinical failures question the validity of the amyloid hypothesis - but what lies beyond? Mullane K, Williams M. Amyloid hypthesis
  6. 6. 6 Common causes All these disorders have much in common. Aetiology is surprising uniform Brain Nerve. 2012 Jun;64(6):675-9. Are neurodegenerative diseases "protein cancers"?.Hasegawa M.Dept. of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. Zhang H et alJ Neurosci. 2012 Oct 31;32(44):15565-76. doi: 10.1523/JNEUROSCI.3668-12.2012
  7. 7. 7  Viral and Bacterial Implications Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Berer K, et al Nature. 2011 Oct 26;479(7374):538-41. doi: 10.1038/nature10554. PMID: 22031325 Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Derfuss T, et al. Brain. 2001 Jul;124(Pt 7):1325-35. PMID: 11408328 Intracerebral propagation of Alzheimers disease: Strengthening evidence of a herpes simplex virus etiology.Ball MJ,et al.Alzheimers Dement. 2012 Nov 14. doi:pii: S1552- 5260(12)02420-X. 10.1016/j.jalz.2012.07.005. PMID: 23159044
  8. 8. 8  MORE COMMON FACTORS More women than men Am J Public Health. 2013 Jan 17. Trends in Mortality Risk by Education Level and Cause of Death Among US White Women From 1986 to 2006. Montez JK, Zajacova A. Depression Neurochem Int. 2013 Jan 7. pii: S0197-0186(12)00412-3. doi: 10.1016/j.neuint.2012.12.014.Effect of diet on serotonergic neurotransmission in depression. Shabbir F,et al. Poor diet Toxicol Lett. 2013 Jan 4. pii: S0378-4274(12)01461-0. doi: 10.1016/j.toxlet.2012.12.023. Acrolein induces Alzheimers disease-like pathologies in vitro and in vivo.Huang et al. LIFESTYLE Infection, inflammation, and chronic diseases: consequences of a modern lifestyle. Ehlers S, 99(th) Dahlem Conference. Trends Immunol. 2010 May;31(5):184-90. ©
  9. 9. 9 Even More Common Factors Affects an older population Previously confined to the Western World Now increasing at rapid rates in the BRICK Countries Involves dysregulation of the HPA axis Involves prolonged inflammation Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimers disease.Lassmann H. J Neural Transm. 2011 May;118(5):747-52. doi:10.1007/s00702-011-0607-8. Epub 2011 Mar 5. Review. PMID: 21373761 ©
  10. 10. 10 RECAP In the past @ 75yrs we have changed: No exercise – the car Diet – proliferation of processed foods high in sugars and bacteria DT on line bacteria in chicken 23/01/13 Heavy use of antibiotics High stress and culture of not being ill But our bodies have not changed but we now live @ 25yrs more than 50 yrs ago ©
  11. 11. 11 THE MICROBIOME PROJECT The microbiome is the most exciting development in science in the last 50 yrs. What you eat is totally under your control and preventable medicine There will never be a drug for bacteria as they mutate like viruses Most plants have anti bacterial and anti viral properties! ©
  12. 12. 12 MICROBIOME Auto immunity diseases arise from the gutKirsten Berer & Krishnamorthy Max Planck Institute Freiburg Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ochoa-Repáraz J,et al Ann Neurol. 2011 Feb;69(2):240-7. doi: 10.1002/ana.22344. Review. Gut bacterias trigger the reaction that causes the body’s immune system to misbehave – which is why amyloid deposits in the brain are a late stage feature…….Parkinsons develops years before signs and symptoms lead to a diagnosis ©
  13. 13. 13Bacterial Actions The inappropriate bacteria in the gut release Lipases and other chemicals which in turn Release proinflammatory and cytotoxic compounds which then attack the bodies’ own cells creating anti bodies which invade the immune system. These chemicals then get circulated via neural and plasma networks to the brain where the damage can be visible eg protein clumps of amyloid.
  14. 14. 14 PREVENTION Itstarts at birth with: Exercise Appropriate diet. You are what you eat. Stress avoidance Mental exercise Laughter and happiness ©
  15. 15. 15 EXERCISE "It is clear from this study and others that physical performance in late life plays an incredibly important role in our cognitive health," said Dr. Erickson. "Although more research is needed into the causal mechanisms and pathways by which this works, it is clear that physical performance in late life is critical for retaining a healthy brain." Arch Neurol. Published online October 22, 2012. Exercise May Beat Mental Activity in Preserving Cognition. Medscape. Oct 24, 2012. ©
  16. 16. 16MORE……research has shown that exercise programs among patients withneurologic disorders "increase the patients sense of self-efficacy, theirsense of involvement in their care and overall belief in their abilities toperform certain activities."“… patient involvement leads to higher satisfaction with care, andgreater likelihood of following provider recommendations,". "Inessence, exercise puts the patient — not a pill — at the center of care,which is exactly where patients want and ought to be."Arch. Neurologist Nov 5th 2012 ©
  17. 17. 17 STRESS:Mitochondrial defects andoxidative stress in Alzheimerdisease and Parkinson disease.Free Radic Biol Med. 2012 Nov 29. pii: S0891-5849(12)01823-0. doi:10.1016/j.freeradbiomed.2012.11.014.Yan MH, Wang X, Zhu X.Personal observation: MS starts with a combinedviral infection and emotional distress involving 5http receptors ©
  18. 18. 18 DIET Gluten intolerance may be a factor Hybridised grains and overconsumption Poor nutrition – lack of key vitamins, minerals in immunocompromised patients directly relates to poor function Inflammation mediated memory dysfunction and effects of a ketogenic diet High glucose levels affect the HPA Kim do et al Plos One 2012 7(5) 35476 ©
  19. 19. 19More….. Human nutrition, the gut microbiome and the immune system. Kau AL, et al;Nature. 2011 Jun 15;474(7351):327-36. doi: 10.1038/nature10213. Review. PMID: 21677749 Traditional Chinese medicine: balancing the gut ecosystem. Li H,et al Phytother Res. 2009 Sep;23(9):1332-5. doi: 10.1002/ptr.2590.PMID: 19253310 Homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin. PLoS One. 2012;7(11):e48247. Doi. 10.1371/journal.pone.0048247. Wang et al
  20. 20. 20More…. Overprocessed foods and foods not fit for human consumption Two thirds of all raw shop bought chicken in the UK is contaminated by campylobacter www.telegraph.co.uk/foodand drink/foodanddrinknews/9820838/FSA Gloopy type margarine has diacetyl which has been shown to promote beta amyloid which is the hallmark of Alzheimers. More SS et ak The butter flavorant Diacetyl exacerbates Beta-Amyloid cytotoxicity Chem Res. In Toxicology 25th June 2012
  21. 21. 21 SUGAR Like all diseases of excess sugar plays a key role in destabilising the body’s normal mechanisms including brain function Excess sugar is derived from an inappropriate diet i.e. one high in grains Insulin resistance a hall mark of co morbidities e.g. PCOS High circulating levels of glucose affect the brain J.Physiol 2012 590:2485-2499 Gomez-Pinella ©
  22. 22. 22More….The Role of Glucose Transporters in Brain Disease: Diabetes andAlzheimers Disease.Shah K, Desilva S, Abbruscato T. Int J Mol Sci. 2012 Oct3;13(10):12629-55. doi: 10.3390/ijms131012629Reccomended readingJ Yudkin: Pure White and Deadly Penguin 2012reprint
  23. 23. 23 KEY: MISSING INGREDIENTS Our locally grown vegetables do not have sufficient zinc, selenium Most people do not eat enough fish- iodine Most people eat too much processed flour based food – inhibiting - bromine. All of which is interesting considering that is now recognised neurological diseases starts in the gut.
  24. 24. 24MORE….. Ameliorationof Alzheimers disease by neuroprotective effect of sulforaphane in animal model. Kim HV, et al Amyloid. 2012 Dec 19. Eat your sprouts!!
  25. 25. 25 VITAMIN D Ontario is well known for its lack of vitamin D in the population – it is recognised to be endemic Reduced vitamin D is associated with the geographic incidence of neuromuscular disorders Loss/Lack of vitamin D affects bones, muscles, thyroid, liver etc. ©
  26. 26. 26 Drugs Basically the drugs used for most neurodegenerative diseases do not prevent progression – merely delay at best Extensive side effects Affect the quality of life VERY POOR EVIDENCE TO JUSTIFY USE I RECOMMEND YOU READ BAD PHARMA by Ben Goldacre 4th Estate ©
  27. 27. 27 PLANTSProtective effect of paeonol on neurotoxicityinduced by Abeta1-42 and underlyingmechanisms. Zhong SZ, et al. (Paeony)St John’s Wort – HypericumCentella asiatica – Gota ColaMacuna Puriens Uncaria/ Cats ClawBrahmi –Panax ginseng - Kudzu Pueria LobataPlants with anti bacterial & anti viral properties ©
  28. 28. 28More…… Turmeric Curcuminoids in neurodegenerative diseases. Kim DS, et al Recent Pat CNS Drug Discov. 2012 Dec;7(3):184-204. PMID: 22742420 © Gingko Astragalas Andrographis And more and more but only when used at a therapeutic dose and as compounds ©
  29. 29. 29 THEY WORK! Reversible worsening of symptoms after taking Cat’s claw ( Clin.Neuropharmacol 2008) A diversity of compounds isolated from herbal materials were reported to be effective on neurotoxic models of PD by modulating multiple key events or signaling pathways implicated in the pathogenesis of PD j.Ethnopharmacol 2012 feb 15 We use a combination of plants in a tincture to synergise and maximise effectiveness which is not possible in a conventional drug ©
  30. 30. 30 CAUTIONS PLEASE NOTE: IT IS ADVISED, THAT ANY PLANTS MENTIONED IN THIS TALK, ARE ONLY USED UNDER PROFESSIONAL GUIDANCE. BOTANICAL MEDICINE AS COMPOUNDED BY A PROFESSIONAL IS NOT AVAILABLE OVER THE RETAIL COUNTER. It is not advisable to self treat A professional: will recognise all the issues within the body; Select herbs that will impact positively on these issues without causing problems in order to co exist with other medications ©
  31. 31. 31 REFERENCES www. Pubmed, Science directIhave a full list of references for those who are interested – if you would like either to email me or put your name down tonight I will send them to you. It is several pages long! ©
  32. 32. 32THANK YOU MORWENNA GIVENWWW.MEDICUSHERBIS.COM ©2013
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