5The search for causesdetermined by drug patentability Genetic in Origin? Front Biosci (Elite Ed). 2013 Jan 1;5:167-77.Genetics of familial and sporadic Alzheimers disease.Piaceri I, Nacmias B, Sorbi S. Failure of current treatments Biochem Pharmacol. 2012 Nov 22. pii: S0006-2952(12)00755-1. doi: 10.1016/j.bcp.2012.11.014. Alzheimers Therapeutics: Continued clinical failures question the validity of the amyloid hypothesis - but what lies beyond? Mullane K, Williams M. Amyloid hypthesis
6 Common causes All these disorders have much in common. Aetiology is surprising uniform Brain Nerve. 2012 Jun;64(6):675-9. Are neurodegenerative diseases "protein cancers"?.Hasegawa M.Dept. of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. Zhang H et alJ Neurosci. 2012 Oct 31;32(44):15565-76. doi: 10.1523/JNEUROSCI.3668-12.2012
7 Viral and Bacterial Implications Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Berer K, et al Nature. 2011 Oct 26;479(7374):538-41. doi: 10.1038/nature10554. PMID: 22031325 Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Derfuss T, et al. Brain. 2001 Jul;124(Pt 7):1325-35. PMID: 11408328 Intracerebral propagation of Alzheimers disease: Strengthening evidence of a herpes simplex virus etiology.Ball MJ,et al.Alzheimers Dement. 2012 Nov 14. doi:pii: S1552- 5260(12)02420-X. 10.1016/j.jalz.2012.07.005. PMID: 23159044
13Bacterial Actions The inappropriate bacteria in the gut release Lipases and other chemicals which in turn Release proinflammatory and cytotoxic compounds which then attack the bodies’ own cells creating anti bodies which invade the immune system. These chemicals then get circulated via neural and plasma networks to the brain where the damage can be visible eg protein clumps of amyloid.
19More….. Human nutrition, the gut microbiome and the immune system. Kau AL, et al;Nature. 2011 Jun 15;474(7351):327-36. doi: 10.1038/nature10213. Review. PMID: 21677749 Traditional Chinese medicine: balancing the gut ecosystem. Li H,et al Phytother Res. 2009 Sep;23(9):1332-5. doi: 10.1002/ptr.2590.PMID: 19253310 Homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin. PLoS One. 2012;7(11):e48247. Doi. 10.1371/journal.pone.0048247. Wang et al
20More…. Overprocessed foods and foods not fit for human consumption Two thirds of all raw shop bought chicken in the UK is contaminated by campylobacter www.telegraph.co.uk/foodand drink/foodanddrinknews/9820838/FSA Gloopy type margarine has diacetyl which has been shown to promote beta amyloid which is the hallmark of Alzheimers. More SS et ak The butter flavorant Diacetyl exacerbates Beta-Amyloid cytotoxicity Chem Res. In Toxicology 25th June 2012
22More….The Role of Glucose Transporters in Brain Disease: Diabetes andAlzheimers Disease.Shah K, Desilva S, Abbruscato T. Int J Mol Sci. 2012 Oct3;13(10):12629-55. doi: 10.3390/ijms131012629Reccomended readingJ Yudkin: Pure White and Deadly Penguin 2012reprint
23 KEY: MISSING INGREDIENTS Our locally grown vegetables do not have sufficient zinc, selenium Most people do not eat enough fish- iodine Most people eat too much processed flour based food – inhibiting - bromine. All of which is interesting considering that is now recognised neurological diseases starts in the gut.
24MORE….. Ameliorationof Alzheimers disease by neuroprotective effect of sulforaphane in animal model. Kim HV, et al Amyloid. 2012 Dec 19. Eat your sprouts!!