Although is also a conjunction, and can come either
at the beginning of a sentence, or between the two clauses that you wish to contrast:
Though can be used in exactly the same way,
and is more common in informal speech :
They went on a picnic although it was raining. Although it was raining, they went on a picnic. Though /Although it was raining, they went on a picnic. They went on a picnic though/ although it was raining.
Though can also be used as an adverb, to mean however (see below).
This use is very similar to ‘però’ in Catalan
"Strange place, isn't it?" "Yes. Very interesting, though ." Frogs, though , are amphibians and not reptiles.
However and nevertheless emphasize the fact that the second thing that you are saying contrasts with the first. Nevertheless is more formal . However and Nevertheless are always followed by a COMMA The government vowed to reduce inflation. Nevertheless , one year later, the rate has increased by 3 percent. The children had a lovely day. However , they arrived home very sunburnt.
In spite of + noun is very similar to although + clause In spite of and despite can be followed by an -ing form. We can also use despite + noun in the same way as in spite of in more formal English: He went to the gym in spite of his broken leg (= although he had a broken leg ) He looks very fit in spite of his age (= although he's very old ) In spite of not being able to swim, she survived for almost an hour in the sea. We went to the party despite being tired . We went to the party despite the rain .