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Clinical features of thyroid malignancy
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Clinical features of thyroid malignancy

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  • 1. THYROID MALIGNANCY CLINICAL FEATURES NEETHI.T.P ROLL NO: 29
  • 2. PAPILLARY CARCINOMA OF THYROID CLINICAL FEATUTES • Thyroid swelling – soft or firm or hard solid or cystic solitary or multinodular • Compression features are uncommon • Often descrete lymphnodes in the neck (40%) are palpable • This may present with secondaries in neck lymphnodes with occult primary
  • 3. FOLLICULAR CARCINOMA CLINICAL FEATURES • Swelling in the neck- firm or hard and nodular • Tracheal compression/ infiltration & stridor • Dyspnoea, haemoptysis, chest pain when there are lung secondaries
  • 4. • Hoarseness of voice if recurrent laryngeal nerve involvement occurs • Absence of carotid pulsation, if lesion infiltrate into carotid sheath (positive berry’s sign) • Pulsatile secondaries in skull and longbones
  • 5. CLINICAL SCORING SYSTEMS • AMES clinical scoring system Based on Age distant Metastasis Extent of primary tumour Size of primary tumour
  • 6. • AGES clinical scoring system Based on Age pathologic Grade of the tumour Extent of the tumour Size of the tumour
  • 7. Prgnostic risk classification for patients based on AMES or AGES Risk parameter LOW HIGH age <40 >40 gender female male extent No local extension, intrathyroidal, no capsular invasion Capsular invasion, extrathyroidal extension metastasis none Regional or distant size <2 cm >4 cm grade Well differentiated Poorly differentiated
  • 8. ANAPLASTIC CARCINOMA CLINICAL FEATURES • Swelling in thyroid region- rapidly progressive hard with involvement of isthmus and lateral lobes • Stridor and hoarseness of voice due to tracheal obstruction • Dysphagia • Fixity to the skin • Positive berry’s sign
  • 9. MEDULLARY CARCINOMA CLINICAL FEATURES • Thyroid swelling often with enlargement of neck nodes • Diarrhoea, flushing (30 %) • Hypertension, pheochromocytoma, and mucosal neuromas when associated with MEN II syndrome
  • 10. • Sporadic and familial types occur in adulthood • Cases associated with MEN II syndrome occur in younger age group • Paraneoplastic syndrome like cushing’s, carcinoids may be present.
  • 11. THANK YOU

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