INDUSTRIAL CHEMICAL PROCESS MATERIAL & ENERGY BALANCE ASSIGNMENT2 Question 10
MUHAMAD NORULAKMAL B. AB MALIK.
MASURI KAMA BT KAMARUDDIN SHAH.
CHARMINE CHEALSEA JHONNY.
The bark from the willow tree—Salix Alba—contains high levels of salicin, the glycoside of salicylic acid.
1853, French chemist Charles F. Gerhardt synthesized a primitive form of aspirin, a derivative of salicylic acid.
1897 Felix Hoffmann, a German chemist working at the Bayer division of I.G. Farber, discovered a better method for synthesizing the drug.
WHAT IS ASPIRIN?
Aspirin is the general name for acetylsalicylic acid (ASA).
The synthetic drug was developed as an analgesic (painkiller).
It was the first NSAID (nonsteroidal anti-inflammatory drug), and probably still the most effective.
it is also the trademark of the drug produced by Bayer in Germany.
in other places the term aspirin refers to ASA by itself or as an ingredient in other drugs.
SYNTHESIZING ACETYL SALICYLIC ACID
To synthesize aspirin,
salicylic acid will be combined with acetic anhydride.
small amount of phosphoric acid added as catalyst.
Synthesis from petroleum
INDUSTRIAL SCALE SYNTHESIS
CURRENT USES OF ASPIRIN
Over-the-counter pain relief, especially for headaches.
Reduction of swelling and inflammation in arthritis and injuries.
Anti-coagulant given to sufferers of heart attack.
Can reduce severity of heart attack if taken at first symptoms.
Recovery after cardiovascular surgery.
Treatment of rheumatoid arthritis, osteoarthritis and other rheumatoid diseases.
Using data from the literature, design a small pilot-plant-size process for producing 5 kg of aspirin per hour, by the reaction of salicyclic acid with acetic anhydride.(note: Your design should include a flow diagram, plus a complete material and energy balance).
FLOW SHEET DIAGRAM
Basis 5kg/hr of Aspirin production
Summary of calculation:
ENERGY BALANCE ON REACTOR
DATA FOR CALCULATION
ENERGY BALANCE ON COOLER TANK
ENERGY BALANCE ON FILTER
TOTAL ENERGY BALANCE
Q total= Q reactor + Q cooling tank + Q filter tank