What is wrong with this karyotype?
- Occurs in 1 of every 800 births
- Slanting eyes with folds of skin at the inner corners
- Short neck, small head, small oral cavity (mouth)
- Smaller, poor muscle tone, hyperflexibility of joints
- Some degree of mental retardation
- XO female (no “Y” means - not a guy)
- Short stature, lack of ovarian development (infertile), and folds of skin on the neck are common.
- Arms that turn out at the elbow and a low hairline along the back of the neck are also seen.
- Are males because they are XX Y
- 1 out of every 500-1000 births
- Often tall, but not always “in proportion”
- Fail to develop normal secondary sex characteristics
- Often have learning disabilities
- Nondisjunction of sex chromosomes
- - trisomy (XXY, XXX, XYY)
- Nondisjunction of autosomal chromosomes
- - only trisomy 21 is usually not fatal
- - trisomy 13 and trisomy 18 may
- survive up to a year after birth