09 CeoMeeting- Session2- Mascoma
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09 CeoMeeting- Session2- Mascoma

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Session 2: Industrial Biotechnology

Session 2: Industrial Biotechnology

Title: Replacing Fossil Fuels – How Do We Scale Up Without Compromising On Food And Environment?

Dr Jim Flatt, Mascoma

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    09 CeoMeeting- Session2- Mascoma 09 CeoMeeting- Session2- Mascoma Presentation Transcript

    • Development and Commercialization of Consolidated BioProcessing for Cellulosic Biofuels Production MLSCF CEO Life Sciences Conference, 6 October 2009 Jim Flatt, Ph.D. Mascoma Corporation CONFIDENTIAL
    • Mascoma Background Team • Founded502 by Charlieyman & LeeLyndfrom DartmouthCollege, W world renownedleadersin cellulosicbiofuels research • Experienced industryleadershipteam • 70 + persontechnologyteam principallybasedin NH Consolidated Bioprocessing (CBP) Technology • Gamechanging “widely consideredto be the ultimate lowrcostconfigurationfor cellulose hydrolysisandfermentation” – DOE/SA JointResearch U Agenda • Enableslowrcostbiologicalconversionof cellulosicbiomassto a broadrangeof products • Lowcostandabundantfeedstock(currentlytargetinghardwoods) Facilities • CorporateOffice& Lab • Pilot & DemoPlant (Rome,NY) • Commercial acilityPlanned(inross, Michigan) F K • $49.5M in stateandfederal grants
    • Track Record of Securing Significant Private and Government Funding • Raised 0 $1 Million of equity • Strategicinvestmentsby industryrleadingpartners • Financial investmentsfrom toprtier venturecapital funds • Awardedover $60 million in FederalandState Confidential governmentfunding
    • Why Consolidated Bioprocessing? lower costs through enzyme reduction and process simplification Conventional Approach Mascoma Approach Feedstock Supply Steam & Power Generation Waste Treatment Mascoma Conditioning focus Enzyme Hydrolysis Supply Conditioning Fermentation Key Developing Distillation Technology & Storage
    • CBP Organism Development Strategy Goal Cellulose Utilization Ethanol Producer greenfield retrofit application application •C. thermocellum •T. saccharolyticum Yeast Substrate Strategy Metabolism Strategy Cellulose Utilization Commonalities X Cellulose Utilization X Ethanol Producer Ethanol Producer
    • Mascoma Recombinant Cellulolytic Yeast March,2007 to December, 2008: >3,000rfold improvement in expression levels
    • Enzyme Reductionon Hardwood Equivalent performance with 2.5 rfold less added enzyme Further reduction anticipated
    • Proof of Concept: CBP Yeast Ferments Paper Sludge to Ethanol with no added cellulase Positive Control 50 85% Appearance at 120 hrs. Yield 40 Ethanol Yield (g/L) CBP 30 20 10 CBP strain non-CBP Negative Control strain M1179 0 0 20 40 60 80 100 120 140 Fermentation Time (hours) 18% solids, 1 mg/gTS β
    • CBP Scalerup – Rome Demonstration Facility 60 50 Milestones Concentration (g/ l) 40 first E85 produced 11/08 30 CBP scale-up Q1.09 20 process engr. 2009 - 10 10 0 0 20 40 60 80 100 Age (h) 120 140 160 180 November 2008 Confidential
    • Promising Initial Results on Palm Residues Screening Test on Palm Residue Types • aqueous-based pretreatment • stem has highest yield • low lignin (17 – 18%) Palm Residue Carbohydrate Yield Max Ethanol Yield (% theoretical) (gal/mt) Empty Fruit Bunch 73 62 Stem 80 76 Frond 71 62
    • Mascoma Business Model • Diversify Feedstock – form funded collaborations to tailor Mascoma technology to other feedstocks e.g. paper sludge, palm residue and bagasse – equity participation for both parties • Diversify End products – form funded collaborations to adapt Mascoma technology to produce non-ethanol products • Commercial Rollout with Regional Partners – form JV with local partners – value capture for JV partner and Mascoma via equity – multiple plant focus – non-ethanol products
    • Conclusions – success hardwoodcanbe leveragedto other on cellulosicfeedstocks, includingpalmresidues