09 CeoMeeting- Session 3- Chromatin

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Session 3: Agriculture & Nutrition

Title : Doubling Crop Productivity And Ensuring Nutritional Security

Dr Daphne Preuss, Chromatin

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09 CeoMeeting- Session 3- Chromatin

  1. 1. Chromatin, Inc. Redesigning crops for agriculture and bioenergy CEO’s Life Science Conference – Kuala Lumpur October 6, 2009 Daphne Preuss Chromatin, Inc.
  2. 2. Chromatin overview !! Developed a leading innovation for modifying crops !!Allows addition of multiple genes to a plant in a single step !! Market access via the world’s premier agricultural companies !!Corn, soybean, canola, cotton and sugarcane !! Financing raised in Q4 2008 to improve energy crops Chromatin, Inc.
  3. 3. Market for gene stacks Biotech crop sales Stacked Traits 8.0 40 % Stacked Traits Sales ($Billion) 6.0 30 4.0 20 3 genes 2.0 10 1-2 genes 0.0 0.0 00 01 02 03 04 05 06 07 08 00 01 02 03 04 05 06 07 08 By 2010, Monsanto & Dow will use breeding to stack 8 different pest and herbicide resistance genes in corn (Smartstax™) 1 x 2 x 3 x 4 X 5 x 6 x 7 x 8 Chromatin, Inc.
  4. 4. Chromatin’s Gene Stacking Technology Gene Stack Assembled Mini-chromosome Improved Crop Higher yield More nutritious A B C D E F G H I J K L + More biomass Higher value products Benefits Validation •! Accelerates product •! Peer-review publications: development pipelines PLoS Genetics, (2007) Carlson et al. •! Any crop Chromosoma, (2009) •! Faster development, Ananiev et al. lower costs Mini-chromosomes •! 15 issued patents; Single-step gene >35 applications pending •! Streamlined regulatory stack delivery into process plants 4 Chromatin, Inc.
  5. 5. Chromatin’s licenses to industry leaders •! Non-exclusive: corn, soybean, cotton, canola •! Exclusive: sugarcane (+ others under discussion) •! Chromatin retains rights to improvements •! Payments: -! Fees -! Milestones - Royalties Chromatin, Inc.
  6. 6. Crop-specific market strategy Mini- Crops & + Genes + + End User Chromosomes Feedstocks Non-exclusive Partnerships in traditional agriculture traditional crop Chromatin (corn, soy, cotton, canola) licenses Exclusive co- Owned / licensed development Chromatin by Chromatin Partner Partner relationships and / or partners Proprietary Owned / Owned / licensed product Chromatin by Chromatin licensed by Partner development Chromatin Chromatin, Inc.
  7. 7. Energy crops !! Most significant cost of biofuel production !! ~70% of biorefinery costs !! Most have not been optimized through breeding !! Agronomic yields are suboptimal !! Crop cultivation (planting, harvesting, seed / pest treatment) is undeveloped !! Most have not been bred for “energy” traits !! Inconsistent quality reduces yield Chromatin, Inc.
  8. 8. Optimizing energy crops requires many genetic changes Genes on the market today: Energy traits: •! Insect resistance •! Herbicide resistance •! Improved feedstock conversion -! Biomass yield Genes in industry pipelines: -! Cellulose recalcitrance •! Better insect / herbicide resistance •! Increased seed yield -! Enzymes •! Reduced nitrogen use •! Optimized product selectivity •! Drought tolerance •! Healthy oils -! Minimized by-product (CO2) •! Amylase •! Optimized processing efficiencies Other agronomic traits: •! Feedstock + yeast + enzymes •! Viral / bacterial resistance •! Lower energy / chemicals use •! Cold / heat / salt tolerance •! Water and nutrient use •! Faster fermentation cycles Chromatin, Inc.
  9. 9. Chromatin’s Energy Crop Improvement Platform Feedstock Molecular Transgenic Value-added Traits Breeding Breeding Hybrids Feedstock Products Production Proprietary Technology partners Ethanol Butanol Hydrocarbons Monomers Polymers 9 Chromatin, Inc.
  10. 10. Management Team Over 100 years expertise spanning agriculture, biotech & energy Daphne Preuss •! Co-Founder & CEO Jeff Scheib •! VP Biofuels (Previously BP and Cilion) Ken Davenport •! VP Strategic Development (Previously Bayer and ArborGen) Ken Moonie •! Business Development 10 Chromatin, Inc.
  11. 11. Investors and operations Raised $24M total Chicago Champaign-Urbana + Field sites Chromatin, Inc.
  12. 12. Chromatin, Inc. Redesigning crops for agriculture and bioenergy •! Disruptive technology platform •! Strategic alliances to bring technology to existing markets •! Expanding platform to improve energy crops Chromatin, Inc.

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