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EU2020 calls for transformation. The gap between latest research knowledge and the real life practice is huge. We need societal innovations and pioneering regions, as pathfinders and rapid prototypers. The presentation will focus on modernizing the Triple Helix to be based on the new regional innovation ecosystem concepts integrated with the Aalto University and its strategic partners and local industries. One of the main drivers of change is a new mindset which can be characterized as the Venture Garage Mindset.