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ARTERIOSCLEROSIS  –  ATHEROSCLEROSIS  –  A general hardening of the arteries A a specific type of arteriosclerosis, refers to the accumulation of lipid in the walls of the arteries, gradually leading to an arteriosclerotic condition or a reduced blood flow
ATHerosclerosis  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LEADING CAUSES OF DEATH
 
Mycardial Infarction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disease Onset Different in Different populations and Related to Combination of Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PRIMARY ARTERIES & END ORGANS Heart Coronary Arteries Kidney Renal Arteries Brain Cerebral Arteries Legs Femoral & Abdominal Arteries
NATURAL HISTORY OF ATHEROSCLEROSIS Clean Artery Fatty Steaks Fibrous Plaque Clinical Lesion
Anatomy of Artery  www.lef.org/magazine/mag2005
ARTERIAL HEALTH
SUPPLY & DEMAND Supply of Blood  To do the Work
Triad of Signs/Symptoms ,[object Object],[object Object],[object Object],[object Object],MI Signs/Symptoms 1) Severe, prolonged chest pain/pressure—radiate to the arms, back, neck, associated w/ sweating, nausea, or vomiting. 2) increased serum levels of cardiac enzymes:CK; CPK toponin 3) ECG changes in the leads overlying the area of infarction
DIFFERENCE BETWEEN ANGINA AND INFARCT ANGINA INFARCT Similar Symptoms < 15 min > 15 min Relieved by Nitro Not relieved by Nitro  Relieved by Rest Not relieved by Rest
SUPPLY & DEMAND ,[object Object],[object Object],[object Object],[object Object]
2 Types of infarctions  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Exercise Impact ,[object Object],[object Object],[object Object],[object Object],[object Object]
Benefits of Exercise ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
EXERCISE EFFECTIVENESS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Assessment Flow-Mediated Dilation Pre
Fasting Four Hours after a High-Fat Meal 8-10% 4-5% Pre Pre Pre
Impact of Exercise Flow-Mediated Dilation = 8% Pre Pre Post 4.1 mm 4.7 mm
Faulx, et al,  American Heart Journal  145:943-951, 2003 Iiyama, et al.  American Heart Journal  132:779-782, 1996 Hashimoto, et al.  International Journal of Obesity: Relar Metab D isord 22:477-484, 1998.  Caballero, A.E.,  Obesity Research  11:1278-1289, 2003. Celermajer,et al. J Am Coll Cardiol 24:471-476, 1994.
Tsai, et al.  Clinical Science  106:315-319, 2004 Anderson, et al,  Atherosclerosis  154:475-483, 2001 Ceriello, et al, Circulation 106:1211-1218, 2002
Hamby et al,  Diabetes Care  26:2119-2125, 2003 Watts, et al,  Journal Pediatrics  144:620-625, 2004 Walsh, et al,  JAP  95:20-25, 2003 EXERCISE IMPROVES ENDOTHELIAL FUNCTION
Overweight Men Lee et al,  Am J Clin Nutr  69:373-380, 1999
-May take one or more meds after acute MI -Beta Blockers greatly reduced HR - No change in exercise response - Vasodilators - Diuretics  -Ca Cblockers  may increase exercise tolerance (improve heart function) Medications
Intensity   40-80% of Vo2 max  RPE: 11-15 Frequency: 3 x wk Duration: 20-40min  Mode: Depends on individual, encourage PA in daily living Exercise Programming

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Mi cad

  • 1. ARTERIOSCLEROSIS – ATHEROSCLEROSIS – A general hardening of the arteries A a specific type of arteriosclerosis, refers to the accumulation of lipid in the walls of the arteries, gradually leading to an arteriosclerotic condition or a reduced blood flow
  • 2.
  • 4.  
  • 5.
  • 6.
  • 7. PRIMARY ARTERIES & END ORGANS Heart Coronary Arteries Kidney Renal Arteries Brain Cerebral Arteries Legs Femoral & Abdominal Arteries
  • 8. NATURAL HISTORY OF ATHEROSCLEROSIS Clean Artery Fatty Steaks Fibrous Plaque Clinical Lesion
  • 9. Anatomy of Artery www.lef.org/magazine/mag2005
  • 11. SUPPLY & DEMAND Supply of Blood To do the Work
  • 12.
  • 13. DIFFERENCE BETWEEN ANGINA AND INFARCT ANGINA INFARCT Similar Symptoms < 15 min > 15 min Relieved by Nitro Not relieved by Nitro Relieved by Rest Not relieved by Rest
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 20. Fasting Four Hours after a High-Fat Meal 8-10% 4-5% Pre Pre Pre
  • 21. Impact of Exercise Flow-Mediated Dilation = 8% Pre Pre Post 4.1 mm 4.7 mm
  • 22. Faulx, et al, American Heart Journal 145:943-951, 2003 Iiyama, et al. American Heart Journal 132:779-782, 1996 Hashimoto, et al. International Journal of Obesity: Relar Metab D isord 22:477-484, 1998. Caballero, A.E., Obesity Research 11:1278-1289, 2003. Celermajer,et al. J Am Coll Cardiol 24:471-476, 1994.
  • 23. Tsai, et al. Clinical Science 106:315-319, 2004 Anderson, et al, Atherosclerosis 154:475-483, 2001 Ceriello, et al, Circulation 106:1211-1218, 2002
  • 24. Hamby et al, Diabetes Care 26:2119-2125, 2003 Watts, et al, Journal Pediatrics 144:620-625, 2004 Walsh, et al, JAP 95:20-25, 2003 EXERCISE IMPROVES ENDOTHELIAL FUNCTION
  • 25. Overweight Men Lee et al, Am J Clin Nutr 69:373-380, 1999
  • 26. -May take one or more meds after acute MI -Beta Blockers greatly reduced HR - No change in exercise response - Vasodilators - Diuretics -Ca Cblockers  may increase exercise tolerance (improve heart function) Medications
  • 27. Intensity 40-80% of Vo2 max RPE: 11-15 Frequency: 3 x wk Duration: 20-40min Mode: Depends on individual, encourage PA in daily living Exercise Programming

Editor's Notes

  1. No Improvement in Cardiac Performance Ejection Fraction Cardiac Output