• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
Review on microneedles
 

Review on microneedles

on

  • 3,222 views

 

Statistics

Views

Total Views
3,222
Views on SlideShare
3,222
Embed Views
0

Actions

Likes
0
Downloads
95
Comments
0

0 Embeds 0

No embeds

Accessibility

Categories

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Review on microneedles Review on microneedles Presentation Transcript

    • A SEMINAR ONA REVIEW ON MICRONEEDLES DEPARTMENT OF PHARMACEUTICSGuided by. Presented by.DR. BANERGEE S. K. Mr. ghanvat mitesh d.m. Pharm, Ph. d M.PHARM FIRST YEAR VISHAL JUNNAR SEVA MANDAL,SVISHAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH, ALE, PUNE
    • CONTENTS INTRODUCTION MICRONEEDLES TYPES OF MICRONEEDLES FABRICATION TECHNIQUE OF MICRONEEDLES COATING OF MICRONEEDLES PENITRATION OF MICRONEEDLES EVALUATION OF MICRONEEDLES ADVANTAGES OF MICRONEEDLES DISADVANTAGES OF MICRONEEDLES CONCLUSION REFERENCES
    • I. INTRODUCTIONPatch-based transdermal drug delivery offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections relating to patient acceptability and injection safety.• Types - Routes Of Administration• New Drug Delivery System• Transdermal Drug Delivery System
    • MICRONEEDLES INTRODUCTION Figure 1: Microneedle with blue color (electron micrograph).
    • TYPES OF MICRONEEDLESI. Solid microneedles 1. Silicon microprobes 2. Silicon microneedles 3. Metal microneedlesII. Hollow microneedles 1. Silicon hollow microneedles 2. Metal hollow microneedles 3. Glass hollow microneedles
    • I. Solid microneedles1. Silicon microprobes Figure 2: A single silicon microprobe fabricated by anisotropic silicon etching and used to deliver genes to plant and mammalian cells.
    • 2. Silicon microneedlesFigure 3: Arrays of solid silicon microneedles used in transdermal drug delivery study and demonstrated enhancement of dermal permeability.
    • 3. Metal microneedlesFigure 4: Solid stainless steel microneedle arrays Figure 5: Images of coated solid metalused in an insulin delivery test using diabetic rats microneedles.in vivo.
    • II. Hollow microneedles 1. Silicon hollow microneedlesFigure 6: Arrays of symmetric silicon hollow Figure 7: Arrays of hollow silicon microneedles microneedles used in fluid injection used for transdermal liquid transport. experiments.
    • 2. Metal hollow microneedles Figure 8: An array of hollow, metallic microneedles used for skin insertion test.
    • 3. Glass hollow microneedles Figure 9: A single, beveled-tip, hollow glass microneedle used in micro-infusion within human cadaver skin.
    • Other type of microneedlesFigure 10: Solid biodegradable polymer microneedles with calcium encapsulated at the needle tips used for in vitro transdermal insertion test.
    • FABRICATION OF MICRONEEDLES1. Fabrication of solid microneedles2. Fabrication of hollow microneedles Figure 12: A schematic representation of fabrication process used in making the hollow microneedle array.
    • COATING OF MICRONEEDLESCoating solution: • 1% (w/v) carboxymethyalcellulose sodium salt • 0.5% lutrol F-68 NF • drug model/ biopharmaceutical.Drug model:• 0.01% suforhodamine• 0.01% calcium• 3% vitamin B• 1% bovine serum albumin• 0.5% plasmid DNA
    • PENETRATION OF MICRONEEDLES Figure 13: Penetration of microneedles into the skin.
    • EVALUATION OF MICRONEEDLES In vitro evaluation In vitro evaluation is carried out to determine optimization of microneedles, penetration force, strength of microneedles, delivery efficacy etc. In vivo evaluation The in vivo preclinical evaluation of microneedles was performed on animals like mice and guinea pig in order to determine the delivery efficacy, penetration force, bending force and to evaluate the skin toxicity testes using vaccine delivery.
    • ADVANTAGES OF MICRONEEDLES• Pain-free administration.• Easy to use.• Discreetness.• Continuous release.• Controlled release.• Safer handling.
    • DISADVANTAGES OF MICRONEEDLES• Local inflammation• Skin irritation• Expensive
    • CONCLUSION require a very low insertion force . penetrate human skin. fabricated with high process yield.
    • REFERENCES Roxhed N; A fully integrated microneedle-based transdermal drug delivery system; 2007; Royal institute of technology. getDocument_urn_nbn_se_kth_diva-4484-2__fulltext.pdf Lad J; Clinical evaluation of a novel microneedle patch, 2006-2007; Cranfield University; search_hl=en&q=drug+used+for+preparation+microneedles(pdf)&sta rt20&sa=N.pdf Satoskar RS, Bhandarkar SD and Ainapure SS. Text book of pharmacology and pharmacotherapeutics. 2003, 18th Ed. 5-9. Roxhed N; A fully integrated microneedle-based transdermal drug delivery system; 2007; Royal institute of technology. getDocument_urn_nbn_se_kth_diva-4484-2__fulltext.pdf