PRESENTED
BY :MALVIKA
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PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
ExPASy
SWISS-PROT
PIR
PDB
1. PROTEIN STRUCTURE
2.NCBI
1.PROTEIN STRUCTURE
2. NCBI
1. PROTEIN STRUCTURE
2. NCBI
3. DATABASES
Protein Database

is a
collection of sequences
from several sources,
including translations from
annotated coding regions ...
1.
2.
3.
4.
5.
6.
7.
8.

PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
EXPASY
SWISS-PROT
PIR
PDB
 Finds

regions of local similarity
between sequences .
 Compares nucleotide or
protein sequences to sequence
databases....
Can be used to infer
functional and evolutionary
relationships between
sequences.
 It can also help in
identifying membe...
1.
2.
3.
4.
5.
6.
7.
8.

PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
ExPASy
SWISS-PROT
PIR
PDB
Ex pert P rotein A nalysis
Sy stemis a bioinformatics
ExPASy

resource portal operated by the
Swiss Institute of Bioinform...
Ex pert P rotein A nalysis
Sy stem
It provides access to scientific
databases and software tools
(i.e., resources) in diff...
1.
2.
3.
4.
5.
6.
7.
8.
9.

PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
EXPASY
PUB-MED
SWISS-PROT
PIR
PDB
•SWISS-PROT also called UniProt is;
a comprehensive, high-quality and
freely accessible database of protein
sequence and f...
SWISS-PROT
• Contains a large amount of information
about the biological function of proteins
derived from the research li...
1.
2.
3.
4.
5.
6.
7.
8.
9.

PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
EXPASY
PUB-MED
SWISS-PROT
PIR
PDB
 PIR was established in 1984 by the National
Biomedical Research Foundation (NBRF) as a
resource to assist researchers in...
1.
2.
3.
4.
5.
6.
7.
8.
9.

PROTEIN STRUCTURE
NCBI
DATABASES
SWISS-PROT
PUB-MED
EXPASY
BLAST
PIR
PDB
 Protein Data Bank (PDB) is a repository for the 3D structural data of large biological molecules, such
as proteins and n...
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
PROTEIN STRUCTURE DATABANK
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PROTEIN STRUCTURE DATABANK

  1. 1. PRESENTED BY :MALVIKA
  2. 2. 1. 2. 3. 4. 5. 6. 7. 8. PROTEIN STRUCTURE NCBI DATABASES BLAST ExPASy SWISS-PROT PIR PDB
  3. 3. 1. PROTEIN STRUCTURE 2.NCBI
  4. 4. 1.PROTEIN STRUCTURE 2. NCBI
  5. 5. 1. PROTEIN STRUCTURE 2. NCBI 3. DATABASES
  6. 6. Protein Database is a collection of sequences from several sources, including translations from annotated coding regions in Gen Bank, Ref Seq as well as records from SWISSPROT, PIR & PDB.
  7. 7. 1. 2. 3. 4. 5. 6. 7. 8. PROTEIN STRUCTURE NCBI DATABASES BLAST EXPASY SWISS-PROT PIR PDB
  8. 8.  Finds regions of local similarity between sequences .  Compares nucleotide or protein sequences to sequence databases.  Calculates statistical significance from matches.
  9. 9. Can be used to infer functional and evolutionary relationships between sequences.  It can also help in identifying members of the gene family .
  10. 10. 1. 2. 3. 4. 5. 6. 7. 8. PROTEIN STRUCTURE NCBI DATABASES BLAST ExPASy SWISS-PROT PIR PDB
  11. 11. Ex pert P rotein A nalysis Sy stemis a bioinformatics ExPASy resource portal operated by the Swiss Institute of Bioinformatics (SIB). The portal is aimed for both expert users and for people that are not familiar with a specific domain in life sciences.
  12. 12. Ex pert P rotein A nalysis Sy stem It provides access to scientific databases and software tools (i.e., resources) in different areas of life sciences including proteomics, genomics, phylogeny, systems biology, population genetics, transcriptomics etc. etc
  13. 13. 1. 2. 3. 4. 5. 6. 7. 8. 9. PROTEIN STRUCTURE NCBI DATABASES BLAST EXPASY PUB-MED SWISS-PROT PIR PDB
  14. 14. •SWISS-PROT also called UniProt is; a comprehensive, high-quality and freely accessible database of protein sequence and functional information. •Many entries are derived from genome sequencing projects.
  15. 15. SWISS-PROT • Contains a large amount of information about the biological function of proteins derived from the research literature. • The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.
  16. 16. 1. 2. 3. 4. 5. 6. 7. 8. 9. PROTEIN STRUCTURE NCBI DATABASES BLAST EXPASY PUB-MED SWISS-PROT PIR PDB
  17. 17.  PIR was established in 1984 by the National Biomedical Research Foundation (NBRF) as a resource to assist researchers in the identification and interpretation of protein sequence information.  PIR has provided many protein databases and analysis tools freely accessible to the scientific community, including the Protein Sequence Database (PSD).
  18. 18. 1. 2. 3. 4. 5. 6. 7. 8. 9. PROTEIN STRUCTURE NCBI DATABASES SWISS-PROT PUB-MED EXPASY BLAST PIR PDB
  19. 19.  Protein Data Bank (PDB) is a repository for the 3D structural data of large biological molecules, such as proteins and nucleic acids.  PDB is overseen by an organization called the Worldwide Protein Data Bank, wwPDB.  PDB is a key resource in areas of structural biology, such as structural genomics.
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