Your SlideShare is downloading. ×
0
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Hemostatika
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Hemostatika

694

Published on

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
694
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
16
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. HEMOSTATIKA
  • 2. • HEMOSTASIS: Mekanisme perlindungan tbh dr kehilangan drh Aktivitas pembuluh darah Fungsi trombosit pembekuan darahPEMBEKUAN DRH Proses kimia dimana protein plasma berinteraksi utk mengubah fibrinogen fibrin
  • 3. Kegagalan hemostasisPERDARAHANKegagalan mempertahankanfluiditas darah TROMBOSISISTILAH ~ HEMOSTASIS Trombosit Trombus Emboli Tromboemboli
  • 4. PROSES PEMBEKUAN DARAH• AKTIVASI TROMBOPLASTIN• PEMBENTUKAN TROMBIN DR PROTROMBIN• FIBRIN DR FIBRINOGEN
  • 5. HAMBATAN PEMBEKUAN FACT KOAG LARUT FACT KOAG BENT AKTIF DIMETAB FEED BACK TROMBIN MK KOAG ALAMI (AT III, PROT C+S)
  • 6. SISTEM FIBRINOLITIK• PLASMINOGEN• AKTIVATOR PLASMINOGEN• £2 ANTIPLASMIN + INH PLASMINOGEN AKTIVATOR
  • 7. ANTIKOAGULANMENCEGAH PEMBEKUAN DRHIND: INH TROMBUS & EMBOLI INH DRH BEKU IN VITROPEMBAGIAN:1. HEPARIN2. AK ORAL : - DERIVAT 4 HIDROKSIKUMARIN - DERIVAT INDAN 1,3 DION3. AK IKAT ION Ca
  • 8. HEPARIN• ENDOGEN: MUKOPOLISAKRIDA MENGANDUNG SULFAT, DISINTESIS SEL MAST (TU: PARU)• F. DINAMIK: IKAT AT III• PENGARUH THD HSL PEMERIKS: - UBAH BENT ERY + LEUKO - KADAR OB LIPOFILIK (PROPANOLOL, FENITOIN, DIGOKSIN)
  • 9. EFEK LAIN : TEKAN KEC EFEK SEKRESI ALDOSTERON KDR TIROKSIN PLASMA INH AKTIVATOR FIBRINOLITIK INH PENYEMBUHAN LUKA TEKAN IMUNITAS SELLULAR MEMPERCEPAT PENYEMBUHAN LUKA BAKAR F.KINETIK- ORAL : TDK DIABS- PEMBERIAN : SC/IV- METAB :HATI- EKSRESI : URINE- TDK MLL PLASENTA & ASI
  • 10. • ES/INTOKSIKASI - PERDARAHAN GIT - HEMATURIA - HEMATOM - HIPERSENSITIVE• KI - HEMOFILIA, HIPERTENSI BERAT, SYOK - PEMBERIAN BERSAMAAN ETANOL & ALKOHOLINDIKASI - EMBOLI PARU - TROMBOSIS VENA - OKLUSI ARTERI - INFARK MIOCARD AKUTINTOKSIKASI PROTAMIN SULFAT
  • 11. ANTIKOAGULAN ORALKELOMPOK: DRVT 4 HIDROKSI KUMARIN DRVT INDAN 1,3 DION F.DINAMIK MK : ANTAGONIS VIT K AKTIVITAS DIPENGARUHI: - ASUPAN VIT K - JUML LEMAK MKNAN - INTERAKSI OB
  • 12. INTERAKSI• RESPON - INH ABS: GRISEOVULFIN - INDUKSI ENZ MIKROSOMA HATI ( BARBITURAT) - RANGS FAKTOR PEMBEKUAN DRH• RESPON - GESER IK ( FENILBUTAZON) - INH ENZ HATI (CHLORAMFENICOL) - INH AVAIBIL VIT K (A.BIOTIK, STEROID) - INH FACT COAG (SALISILAT)
  • 13. F.KINETIK PO (WARFARIN: IM,IV) ABS (WARFARIN > SEMPURNA DR DIKUMAROL) PENYIMPANAN : PARU2, HATI, LIMPA, GINJAL EKSRESI: - URIN (BENT METABOLIT) - TINJA (TDK ABS) - URIN JINGGA(ANISINDION) KUMARIN LWT SAWAR URIN SEKRESI LEWAT ASI
  • 14. • PERDARAHAN : VIT K( FITOKUINON)• KI: - CENDERUNG PERDARAHAN - PENY HATI, GINJ BERAT - LONG TIME(ALKOLISME, INTENSIVE SALISILAT)• INDIKASI ~ HEPARIN
  • 15. ++ A.COAG IKAT ION Ca• Na SITRAT (TRANFUSI, TDK TOKSIK)• As/ SENY OKSALAT ( TOKSIK IN VIVO)• Na EDETAT
  • 16. ANTITROMBOSIT• INH AGREGASI TROMBOSIT• EX : ASPIRIN DIPIRIDAMOL SULFINPIRAZON DEKSTRAN
  • 17.  ASPIRIN - INH SINTESIS TAX2(INH COX) - ES: MUAL(ANTASID) DIPIRIDAMOL - INH AMBILAN & METAB ADENOSIN O/ SEL ERY & ENDOTEL PD - ADENOSIN INH FS TROMBOSIT STIMULASI ADENILATE SIKLASE  VASODILATOR SULFIPIRAZON -INH SINT PROSTAGLANDIN DEKSTRAN -INH AGREGASI TROMBOSIT
  • 18. TROMBOLITIK• INDIKASI : - INFARK MIOPCARK AKUT - TROMBOSIS VENA DALAM - EMBOLI PARU - TROMBOEMBOLI• EX: - STREPTOKINASE - UROKINASE (ANTIDOT: AS AMINOKAPROAT) - RT-PA
  • 19. HEMOSTATIK LOKAL - HEMOSTATI SERAP ( SPON GEALTIN, OKSISEL, BUSA FIBRIN INSANI) - ASTRIGEN ( FERI KLORIDA, AS TANAT, NITRAS ARGENTI) - KOAGULAN ( TROMBIN, AKTIVATOR PROTROMBIN) - VASOKONSTRITOR( EPI, NE) SISTEMIK -DESMOPRESIN - VIT K - AS AMINOKAPROAT - AS TRANEKSAMAT - FIBRINOGEN INSANI

×