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Global hr forum2007-ewert_bengtsson-the biotech industry in the uppsala region-result of academic research and private entrepreneurship

Global hr forum2007-ewert_bengtsson-the biotech industry in the uppsala region-result of academic research and private entrepreneurship






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    Global hr forum2007-ewert_bengtsson-the biotech industry in the uppsala region-result of academic research and private entrepreneurship Global hr forum2007-ewert_bengtsson-the biotech industry in the uppsala region-result of academic research and private entrepreneurship Presentation Transcript

    • The biotech industry in the Uppsala region – result of academic research and private entrepreneurship Ewert Bengtsson Centre for Image Analysis Uppsala University Sweden
    • brief personal introduction: Ewert Bengtsson ofessor of computerized image analysis ead of the Centre for Image Analysis in Uppsala – Working mainly with biomedical applications enior advisor to the vice chancellor on information technology hair of the virtual IT-faculty – Working to promote technology transfer from Uppsala University
    • Innovation Performances Sweden – a small countr in northern Sweden Europe with million inhabitants Source: 2006 European Region Innovation Scoreb Jan 2007
    • Uppsala is the fourth largest city Sweden with 180 000 inhabitants. Uppsala BIO Uppsala has about one quarter o Sweden’s biotech sector in the shap of universities, industry and nationa agencies. Stockholm, the capital of Sweden which is also strong in biotechnolog only 45 minutes away by car or train The Uppsala - Stockholm region more than half of Sweden’s biotech industry and is quite competitive als on the international level.
    • European biotech industry 2003 European companies per country Source: Ernst & Young
    • • Universities with high quality Lets examine education the factors • Long history of top level research that led to • Successful cooperation between academia and this strong private entrepreneurs leadin to new companies position • Effective public organisation establishing triple helix growth support
    • Uppsala University The oldest university in northern Europe, founded 1497 A complete university with nine faculties 39000 students 2500 graduate students 6000 employees including 4000 teachers/researchers The best ranking Swedish university in international comparisons
    • Education at Uppsala University 39,000 undergraduate students More than 40 programs of study 1,800 single-subject courses 2,500 graduate students Student exchange programs with 400 universities in 40 countries Many courses and programs in subjects essential for biotechnology e.g.: Bioengineering, Genomics, Information technology, Mathematics, Materials science, Image Analysis, Biodiversity and Evolutionary biology.
    • Education in Molecular Biotechnology A educational program of particular interest to biotechnology is the Engineering program Molecular Biotechnology which combines a solid foundation in mathematics and classical engineering topics with biology, producing engineers that can take on challenging research and development tasks
    • Education in Pharmacology • Sweden’s only faculty of pharmacy is found at Uppsala University. • The faculty has a national responsibility for research and higher education in the fields of pharmaceutical chemistry, pharmaceutical bioscience, and pharmacy. • Research is divided into drug discovery, delivery and usage. • The Faculty of Pharmacy offers Master Programs in Pharmacy and Dispensing Pharmacy, plus a Bachelor Program in Pharmacy and Engineering that specializes in chemical technology for pharmaceuticals and materials.
    • Education in Entrepreneurship • An optional final year of the engineering programs focusing on entrepreneurship • The Uppsala Executive MBA program
    • Unbroken tradition of scientific achievement Century Scientist Achievement Nobel prize 18th O. Rudbeck The lymphatic system 18th C. Linnæus Systema Naturæ classification 18th A. Celcius Thermometric scale (°C) C. Linnæus 18th J.J. Berzelius Chemical elements (Se, Th, Si, Ti, Z) 19th A. J. Ångström Modern spectroscopy (Å unit) 19-20th A. Gullstrand Dioptrics of the eye 1911 19-20th R. Barany Functioning of the ear 1914 T. Svedberg 19-20th M. Siegbahn X-ray spectroscopy 1924 19-20th T. Svedberg Ultracentrifuge 1926 20th A. Tiselius Electrophoresis 1948 20th K. Siegbahn Electron spectroscopy 1981 A. Tiselius 20th J.Porath, P. Flodin Gel filtration 20th G. Johansson, Immunoglobulin E H. Bennich, L. Wide
    • Today research is carried out in several campus areas • Biomedical Centre – chemistry, pharmacology, surface biotechnology, bioinformatics • Linnæus Center for Bioinformatics • Ångström Laboratory – – material sciences, physics • Center for Mathematics and IT • Centre for Image Analysis • Ludwig Institute for Cancer Research • Uppsala Clinical Research Center • University Hospital – clinical research, clinical trials • Rudbeck Laboratory – molecular genetics and medicine
    • he Swedish University of Agricultural Sciences, SLU, also has its main campus ocated in Uppsala LU has about 3500 students and 2900 employees our faculties: – Faculty of Forest Sciences – Faculty of Natural Resources and Agricultural Sciences – Faculty of Veterinary Medicine and Animal Science – Faculty of Landscape Planning and Horticultural Sciences Research campuses and centers – Veterinary Medicine Center – Uppsala Genetics Center – plant biology and forest genetics – Biomedical Centre (together with UU) – Linnæus Center for Bioinformatics (together with UU) – Centre for Image Analysis (together with UU)
    • Center for Ångström Rudbeck Mathematics and Laboratory Laboratory Information Technology material sciences, molecular genetics physics, energy, and medicine MEMS SVA Veterinary versity Uppsala National Medicine Veterinary spital Science Park Institute Center al research, al trials MPA Medical Products Agency Uppsala Clinical Research Center Dag Hammarskjölds väg Biomedical Centre chemistry, pharmacology, surface biotechnology, bioinformatics Linnæus Center for Bioinformatics Uppsala Microbiomi Cent Linnæus Center for RNA biology Ludwig Institute for Cancer Research ost of the research centers and campuses are located along bout 3 km stretch of road making it easy to cooperate
    • Some key Uppsala research results in biotech • Spectroscopy • The Ultracentrifuge • Electrophoresis • Gel filtration • Immunoglobulin E • Function of Hyauluronic acid • Dextran • Heparin
    • Current biotech research in Uppsala Drug development • Drug development, especially drug delivery. – Identify disturbances in the genetic factors behind public health diseases such as rheumatism, diabetes, dementia, cancer and obesity. • Understanding the mechanisms behind dementia – New technologies, above all PET and MRI, have opened up exciting possibilities for studying brain activity. – Uppsala PET Centre/Imanet AB has a leading position in this research. – Trying to develop drugs for Alzheimer’s disease. • Interdisciplinary approaches – Pharmaceutical chemists and structural biologists work together with colleagues from medical fields to create new and effective drugs.
    • Current biotech research in Uppsala Using biobanks for clinical research • High-quality biobanks form, together with the public healthcare system’s well-established register of reliable medical records, a very valuable resource for clinical research and clinical trials. • One major goal is to use the biobanks to improve medical care and support clinical research and quality development. • Uppsala Clinical Research Center, UCR – has established a large- scale Internet-based quality register for cardiac and cancer care. – UCR is organized within Uppsala University and Uppsala County Council.
    • Current biotech research in Uppsala Mapping genes and proteins • Research in proteins and genetics. – Analyzing genetic risk factors for cervical cancer – the second most common cancer worldwide among women. • Human Proteome Resource - all human proteins are mapped. – Carried out together with colleagues in Stockholm – High-throughput analytical technologies are used in collaboration with groups at Stanford University, USA, and within Europe. • A high-throughput DNA sequencing platforms has been developed and commercialized.
    • Current biotech research in Uppsala Evolutionary biology and materials reserach • Trying to solve energy issues by utilizing bacteria that extract energy from sunlight. • Uppsala University is also the first to use genomic technology on wild animals. • Uppsala University has Sweden’s largest concentrated environment for material research at the Ångström laboratory. – Its clean-room facility is an appointed national resource for biotechnology and nanotechnology projects.
    • Transforming research into business • The first successful major pharmaceutical company that grew out of Uppsala University research was Pharmacia. – Started in the early 19th century – Moved to Uppsala in 1950 in order to facilitate the collaboration with the Physical Chemistry Institute at UU. • Pharmacia grew rapidly and extended its activity. – The first subsidiary was formed in the USA in 1952. – A few decades later it had 56 subsidiaries in 22 countries, and the total number of employees was 20,000, of whom 500 were in Uppsala. •Then through a series of mergers it eventually became part of Pfizer in 2003 – Pfizer closed down most operations in Uppsala but significant parts of the expertise among its researchers led to formation of new successful companies
    • Commercial success based on Uppsala research results
    • Some of the current actors in he Uppsala Biotech sector
    • Olink A couple of examples of succesful Q-Med companies
    • Olink – a new biotech start-up Olink, a venture between university researchers and local entrepreneurs, has developed a new method of analyzing proteins. In one format, the technology uses high-precision micro- structures made via polymer replication.
    • Olink – success factors • Interdisciplinary research co-operation within Uppsala University, biology, biotechnology, image analysis, microstructures research • Outstanding research facilities (Rudbeck and Ångström labs) • Close proximity to other local companies with key technologies • Support from the local innovation system • International co-operation with leading research groups, partly funded by the European Union • Followed a well-proven pathway (innovation, patent, proof-of-principle, market need, business plan, initial financing)
    • Q-Med – world-leader in facial esthetics. Growing force in medical implants. RESTYLANE™ products dominate the world market for filling out lips, wrinkles and folds. DEFLUX™ and ZUIDEX™ enjoy increasing success in treating uro- gynecological disorders. Bengt Ågerup, founder and CEO, Q-Med
    • Q-Med – success factors • One corporate HQ centre in Uppsala for business strategy, R&D, clinical research, product manufacture, marketing and sales • Skilled personnel available in the region – ‘from people who understand production to those who know how to sell’ • In-house ‘business school’ promotes individual development • International location, close to international airport
    • The triple helix approac Activities to Researchers promote the Public support organisations formation of new companies and Private entrepreneurs secure long term sustainable growth within the biotech sector
    • Complete innovation concept Finance Know-how Growth companies Venture and Incubator industrial programs capital Start-up companies Business plan Entrepreneur Seed financing skills and training Business idea Patent Advice and Pre-seeding scouting Innovation Research and education
    • STUNS • STUNS – the Foundation for cooperation between the universities in Uppsala, the business sector and the community, was founded in 1985 by – the Uppsala County Administrative Board, – Uppsala University, – SLU – the Swedish University of Agricultural Sciences, – the Municipality of Uppsala, the County Council of Uppsala – the Chamber of Commerce for Uppsala County. • Key current projects are –The Innovation System –Uppsala Innovation Centre –Uppsala BIO
    • The Innovation System • There are several organizations supporting the transfer of research results into commercial products in Uppsala. • During 2004, several of these organizations relocated to a common, central location in order to facilitate working more closely together. • The objective of the activities is to establish an efficient support structure through which research results and high-quality innovations can generate companies, job opportunities and strong economic growth in the region.
    • Uppsala Innovation Centre, UIC • UIC is Uppsala’s business incubator, a tool used during the initial building phase of new enterprises focused on commercialization, financing and future viability. • UIC supports new business ideas originating from the universities and the public sector, as well as private business. • The key objective is to improve entrepreneurs’ and newly started enterprises’ chances of becoming successful. • UIC offers training and business idea development, support and guidance via business coaching, etc. • UIC aims to create healthy companies able to leave the incubator after two or three years and then continue independently.
    • Uppsala Bio • The goal of Uppsala Bio is to secure long term sustainable growth within the biotech sector, • To do so Uppsala Bio is – Providing innovation support through the BioX program – Developing skills and training programs – Developing communication activites • Support to market need orientated
    • Market Need Oriented Research – Uppsala BIO-X A cross-disciplinary research effort focused on Life Science Cutting-edge science New opportunities for industry Scientific Advisory Board – industry & academia Bringing an industrial mindset into an academic setting Bridging over the first gap of commercialization of research
    • Uppsala BIO-X Bridging the gap Academia Basic research Publication Explorative Product research development Uppsala BIO-X Industry • Funding • Project management • Networks • Market perspective
    • Skills and training programs Coaching programs for life science management Encourage frequent contacts between academia and industry - Matchmaking competencies Attract young people to science Communication activites Tell the world what happens in Uppsala www.uppsalabio.com Arenas for meetings, networking and partnering Create a local understanding of and support for biotechnology
    • Uppsala BIO - Partners • Uppsala University AMO •ATEA • Swedish University of Alpha Helix •Klövern Agricultural Sciences AroCell Biotage •Proffice • Uppsala Academic Hospital Doxa • City of Uppsala GE Healthcare • Region of Uppsala Mikrokemi • County of Uppsala Olink Orexo • Innovationsbron Phadia • Uppsala University Holding AB Q-Med • Connect Uppsala Solvay • Chamber of Commerce Svanova • ALMI Uppsala Åmic
    • Uppsala Science Park • Most of the actors in the Uppsala Innovation System are located within Uppsala Science Park, which also is host to about 150 small companies most of which are in the biotech sector,
    • vest in Uppsala stablishing a business in a new region requires information about everything om taxes and salary levels to premises, partners and environmental gulations. Invest in Uppsala is the official investment agency for the City of ppsala – set up to promote Uppsala to potential corporate investors and to ssist companies establish a business or search for partners. ree-of-charge services include: London 2.5 h Stockholm 40 m •Help with all aspects of physical planning •Contact with authorities and organizations Beijing 8 h •Locating office and industrial premises •Partners and match-making Arlanda 30 min •Staff recruitment Boston 12 h •Housing and accommodation •Personalized study visits
    • • Sweden ranked 2nd out of Living and 175 countries in the UN 2004 Human Development Index working • Uppsala excels in lifestyle n Uppsala and living standards • Two universities of great breadth and diversity • Small town prosperity, cosmopolitan atmosphere • Countryside, forests and breathtaking coastal region • International location Source: Invest in Uppsala
    • Some general Swedish factors promoting succesful business development Wages among the lowest in Europe, especially for scientists Corporate tax (28%) is the continent’s next lowest, dividends from foreign subsidiaries not subject to Swedish taxation Deregulated society and infrastructure People work across company and organizational borders Academic researchers retain commercial rights to their discoveries Centralized public health system with unique medical and genetic records
    • Challenges for the future • Many small biotech companies – how to secure venture capital, make them profitable, and get them to stay in the region following mergers or when they grow big • Competence – how to awaken young persons’ interest in science and secure management skills • Fill the pipeline – stay in the scientific frontline and establish new research fields plus make sure that technology transfer works • Infrastructure – secure transition from small university town to a modern international city maintaining an attractive environment
    • Our vision: Uppsala – Stockholm one of world’s top five biotech regio
    • Our vision: Uppsala – Stockholm one of world’s top five biotech regio Thank you for your attentio