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  • 1. Bio Material
  • 2. Mina Akrami Supervisor: Dr. M.H. Rasoulifard Bio Material M o n d a y k h o r d a d 6t h Zanjan university Faculty of science Environmental department
  • 3. 3 Index: Introduction Definition _Bio Material Science _ Bio Materials History Different groups & generations of Bio Materials Bio Material charectrization Applications Bio Material „s Future Refrences Bio Material
  • 4. M.Akrami * May 27th 2013 introduction definition history generation characterization application refrences 4Bio Material Engineering Science Basic Scien ce Medica l Scienc e
  • 5. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences Bio Material science :“ Bio Material science” is the physical and biological study of materials and their interactions with the biological environment. Bio Material 5
  • 6. M.Akrami * May 27th 2013 introduction definition history generation characterization application refrences A biomaterial can be defined as any material used to make devices to replace a part or a function of the body in a safe, reliable, economic, and physiologically acceptable manner. Bio Material 6 http://www.biomaterials.org/index.cfm
  • 7. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 7Bio Material 1860 • Lister develops aseptic surgical technique early 1900' s • Bone plates used to fix fractures 1930 's • Introduction of stainless steel, cobalt chromium alloys 1938 • first total hip prosthesis 1940 's • Polymers in medicine: PMMA bone repair; cellulose for dialysis; nylon sutures 1952 • Mechanical heart valve HISTORY:
  • 8. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 8Bio Material 195 3 • Dacron (polymer fiber) vascular grafts 195 8 • Cemented (PMMA) joint replacement 196 0 • first commercial heart valves 197 0's • PEO (polyethyleneoxide) protein resistant thin film coating 197 6 • FDA ammendment governing testing & production of biomaterials /devices • Artificial heart 197 5 • Society for Biomaterials formed HISTORY:
  • 9. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 9 Evolution of Biomaterial Science & Technology: 1st generation (since 1950s) Goal: Bioinertness 2nd generation (since 1980s) Goal: Bioactivity 3rd generation (since 2000s) Goal: Regenerate functional tissue Bio Material
  • 10. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences Biocompatibility: The ability of a material to perform with an appropriate host response in a specific application. 10 B=f(X1,X2......Xn) Where X : material, design, application etc. Bio Material B.D.Ratener,A.S.Hoffman,F.J.Scheon, J.E.Lemon,Biomaterials science, firth edittion,2002,p 86-102
  • 11. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 11Bio Material B.D.Ratener,A.S.Hoffman,F.J.Scheon, J.E.Lemon,Biomaterials science,firth edittion,2002,p 86-102
  • 12. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 12Bio Material Acceptance of the plate to the tissue surface, i.e., biocompatibility Pharmacological acceptability (nontoxic, nonallergenic , nonimmunogenic, noncarcinogenic, etc.) Chemically inert and stable (no time-dependent degradation) Adequate mechanical strength Adequate fatigue life Sound engineering design Proper weight and density Relatively inexpensive, reproducible, and easy to fabricate and process for large-scale production
  • 13. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 13Bio Material http://embo.blogfa.com./coam6
  • 14. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 14Bio Material Metals • stainless steel • cobalt alloys • titanium alloys Ceramics Polymers • Silicones • Poly ethylene • Poly vinyl chloride • Polyureth anes • polylactid es Composite • Collagen • Gelatin • Elastin • Silk • polysacc harides Classes of Biomaterials: •Aluminum oxide •Zirconia •Calcium phosphate http://www.biomaterials.org/index.cfm
  • 15. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 15Bio Material Orthopedic screws fixation Dental Implants Drug Delivery Devices Skin cartilage Ocular implants Bone replacemen ts Heart valves Dental Implants Biosensors Implantable Microelectr es Metals Polymers Ceramics Composites
  • 16. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 16Bio Material Bioceramics: The class of ceramics used for repair and replacement of diseased and damaged parts of the musculoskeletal system are referred to as bioceramics.
  • 17. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 17Bio Material Bioceramics Nearly inert bioceramics LTI Carbon Ultra LTI carb on AL2O 3 ZrO2 Vitreous carbon Bioactive ceramics HA Bio activ e glass Resorseable bioceramics TC P Calci um phosp hate TSA Tissue attachment (Replacement) Tissue attachment (Inteftacial bonding) Tissue attachment (Mechanical) http://www.brg.blogfa.com
  • 18. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 18 Bioceramic Coatings: Coatings of hydroxyapatite are often applied to metallic implants (most commonly titanium/titanium alloys and stainless steels) to alter the surface properties. Bone Fillers: Hydroxyapatite may be employed in forms such as powders, porous blocks or beads to fill bone defects or voids. Two forms for biomedical applications: either dense or porous http://biomaterials.materials.ox.ac.uk
  • 19. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 19Bio Material A10(BO4)6X2 The ability to integrate in bone structures and support bone ingrowth, without breaking down or dissolving (i.e it is bioactive). Hydroxyapatite is a thermally unstable compound, decomposing at temperature from about 800-1200 Oc depending on its stoichiometry. Generally speaking dense hydroxyapatite does not have the mechanical strength to enable it to succeed in long term load bearing applications http://www.biomaterials.org/index.cfm
  • 20. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 20 Applications of Porous Bioceramics: Bio Material
  • 21. 21 Applications of Porous Bioceramics in Cervical Vertebra: Bio Material M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences
  • 22. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 22 Applications of Bioceramics in vertebral column Bio Material
  • 23. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 23 Applications of Porous Bioceramics : Bio Material
  • 24. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 24 Applications of Porous Bioceramics in Ophthalmology: Bio Material
  • 25. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 25 Bioceramics for Femur Fracture Treatment: Bio Material
  • 26. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 26 Bioceramics for Bone Fillers: Bio Material
  • 27. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 27Bio Material Advantages and disadvantages of bioceramics: Biocompatible Wear resistant light weight Low tensible strength Difficult to fabricate Low toughness Not resilient
  • 28. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 28Bio Material Advantages of polymeric biomaterials: are ease of manufacturability to produce various shapes (latex, film, sheet, fibers, etc.), ease of secondary proccessability, reasonable cost, and availability with desired mechanical and physical properties. B.D.Ratener,A.S.Hoffman,F.J.Scheon, J.E.Lemon,Biomaterials science,firth edittion,2002,p 124-187
  • 29. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 29Bio Material
  • 30. M.Akrami * May 27th 2013 introduction definition history generation characterization applications refrences 30 Vascular grafts: Basic Material: Polyurethane , Teflon & Dacron. Challenge: Maintenance of mechanical integrity Long term blood compability ( avoidance blood clotting) Bio Material http://www.biomat.net/index.php?id=6
  • 31. M.Akrami * May 27th 2013 introduction definition history generation characterization application refrences An appropriate combination of engineers, clinicians and basic science researches will pave the way for the development of better bio materials and hence (medical) devices that will help improve the quality of life of humans. 31Bio Material
  • 32. M.Akrami * May 27th 2013 introduction definition history generation characterization application refrences 32Bio Material
  • 33. M.Akrami * May 27th 2013 introduction definition history generation characterization application refrences 33 Bio Material Reference s:[1]. B.D.Ratner, A.S.Hoffman, F.J.Schoen, J.E.Lemon, biomaterial scoence,academic press, firth edittion, 2002. [2]. M. Wiens, X. H. Wang, U. Schloßmacher, I. Lieberwirth, G. Glasser, H. Ushijima, H. C. Schröder and W. E. G. Müller, Osteogenic potential of bio- silica on human osteoblast-like (SaOS-2) cells, Calcif. Tissue Int., 2010, 87, 513– 524. [3]. U. Schlossmacher, M. Wiens, H. C. Schröder, X. H. Wang, K. P. Jochum and W. E. G. Müller, Silintaphin-1: interaction with silicatein during structure guiding biosilica formation, FEBS J., 2011, 278, 1145–1155.[4]. M. T. Drake, B. Srinivasan, U. I. Mödder, J. M. Peterson, L. K. McCready, B. L. Riggs, D. Dwyer, M. Stolina, P. Kostenuik and S. Khosla, Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women, J. Clin. Endocrinol. Metab., 2010, 95, 5056–5062. [5]. W. Zhai, C. He, L. Wu, Y. Zhou, H. Chen, J. Chang and H. Zhang, J. Biomed. Mater. Res., Part B, 2012, 100, 1397– 1403. [6]. H. Wu, G. Liu, S. Zhang, J. Shi, L. Zhang, Y. Chen, F. Chena and H. Chena, J. Mater. Chem., 2011, 21, 3037–3045.