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124937 52-6


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  • 1. Click for suppliers of this productTolterodine tartrate (cas 124937-52-6) MSDS1.1.1IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKINGProduct identifiersProduct nameProduct NumberBrandCAS-No.::::Tolterodine L-tartratePZ0009124937-52-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses : Laboratory chemicals, Manufacture of substances2.2.12.2HAZARDS IDENTIFICATIONClassification of the substance or mixtureClassification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]Acute toxicity, Oral (Category 3)Reproductive toxicity (Category 2)Classification according to EU Directives 67/548/EEC or 1999/45/ECPossible risk of harm to the unborn child. Toxic to aquatic organisms, may cause long-term adverse effects inthe aquatic environment.Label elementsLabelling according Regulation (EC) No 1272/2008 [CLP]PictogramSignal wordHazard statement(s)H301H361Precautionary statement(s)P281P301 + P310Supplemental HazardDangerToxic if swallowed.Suspected of damaging fertility or the unborn child.Use personal protective equipment as required.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.noneStatementsAccording to European Directive 67/548/EEC as amended.Hazard symbol(s)R-phrase(s)R63R51/53Possible risk of harm to the unborn child.Toxic to aquatic organisms, may cause long-term adverse effects in theaquatic environment.S-phrase(s)S22S36/37S57Do not breathe dust.Wear suitable protective clothing and gloves.Use appropriate container to avoid environmental contamination. hazards - noneCOMPOSITION/INFORMATION ON INGREDIENTSSubstancesSynonyms : DetrolTolterodine tartratePNU-200583E2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenoltartrateDetrusitol
  • 2. FormulaMolecular WeightComponentTolterodine L-tartrate::C22H31NO·C4H6O6475,57 g/molConcentrationCAS-No. 124937-52-6 - AID MEASURESDescription of first aid measuresGeneral adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.In case of skin contactWash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.In case of eye contactFlush eyes with water as a precaution.If swallowedNever give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.Most important symptoms and effects, both acute and delayedTo the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughlyinvestigated.Indication of any immediate medical attention and special treatment neededno data available5. MEASURESExtinguishing mediaSuitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Special hazards arising from the substance or mixtureCarbon oxides, nitrogen oxides (NOx)Advice for firefightersWear self contained breathing apparatus for fire fighting if necessary.Further informationno data availableACCIDENTAL RELEASE MEASURESPersonal precautions, protective equipment and emergency proceduresWear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequateventilation. Evacuate personnel to safe areas. Avoid breathing dust.Environmental precautionsPrevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into theenvironment must be avoided.Methods and materials for containment and cleaning upPick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closedcontainers for disposal.Reference to other sectionsFor disposal see section 13.HANDLING AND STORAGEPrecautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols.Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fireprotection.Conditions for safe storage, including any incompatibilitiesStore in cool place. Keep container tightly closed in a dry and well-ventilated place.Specific end usesno data available
  • 3. CONTROLS/PERSONAL PROTECTIONControl parametersComponents with workplace control parametersExposure controlsAppropriate engineering controlsAvoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling theproduct.Personal protective equipmentEye/face protectionFace shield and safety glasses Use equipment for eye protection tested and approved underappropriate government standards such as NIOSH (US) or EN 166(EU).Skin protectionHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching gloves outer surface) to avoid skin contact with this product. Dispose ofcontaminated gloves after use in accordance with applicable laws and good laboratory practices.Wash and dry hands.The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and thestandard EN 374 derived from it.Body ProtectionComplete suit protecting against chemicals, The type of protective equipment must be selectedaccording to the concentration and amount of the dangerous substance at the specific workplace.Respiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face particlerespirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineeringcontrols. If the respirator is the sole means of protection, use a full-face supplied air respirator. Userespirators and components tested and approved under appropriate government standards such asNIOSH (US) or CEN (EU).9.9.1PHYSICAL AND CHEMICAL PROPERTIESInformation on basic physical and chemical propertiesa)b)c)d)e)f)g)h)AppearanceOdourOdour ThresholdpHMelting point/freezingpointInitial boiling point andboiling rangeFlash pointEvaporation rateForm: solidno data availableno data availableno data available206 - 212 °Cno data availableno data availableno data availablei) Flammability (solid, gas) no data availablej)k)l)Upper/lowerflammability orexplosive limitsVapour pressureVapour densityno data availableno data availableno data availablem) Relative density no data availablen)o)p)q)r)s)t)Water solubilityPartition coefficient: n-octanol/waterAutoignitiontemperatureDecompositiontemperatureViscosityExplosive propertiesOxidizing properties0,012 g/lPOW: 5,24no data availableno data availableno data availableno data availableno data available9.2 Other safety informationno data available
  • 4. no data available10. REACTIVITYReactivityno data availableChemical stabilityno data availablePossibility of hazardous reactionsno data availableConditions to avoidno data availableIncompatible materialsStrong oxidizing agentsHazardous decomposition productsOther decomposition products - no data availableTOXICOLOGICAL INFORMATIONInformation on toxicological effectsAcute toxicityLD50 Oral - mouse - > 200 mg/kgSkin corrosion/irritationSkin - rabbit - No skin irritationSerious eye damage/eye irritationno data availableRespiratory or skin sensitizationguinea pig - Did not cause sensitization on laboratory animals. - Did not cause sensitization on laboratoryanimals.Germ cell mutagenicityDid not show mutagenic effects in animal experiments.CarcinogenicityDid not show carcinogenic effects in animal experiments.IARC: No component of this product present at levels greater than or equal to 0.1% is identified asprobable, possible or confirmed human carcinogen by IARC.Reproductive toxicityDid not show teratogenic effects in animal experiments.Suspected human reproductive toxicantAnimal testing did not show any effects on fertility.Specific target organ toxicity - single exposureno data availableSpecific target organ toxicity - repeated exposureno data availableAspiration hazardno data availablePotential health effectsInhalationIngestionSkinMay be harmful if inhaled. May cause respiratory tract irritation.Toxic if swallowed.May be harmful if absorbed through skin. May cause skin irritation.Eyes May cause eye irritation.Signs and Symptoms of ExposureTo the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughlyinvestigated.Additional InformationRTECS: Not available12.12.1ECOLOGICAL INFORMATIONToxicity
  • 5. no data availableToxicity to daphnia andother aquaticinvertebrates.Toxicity to algaeLC50 - Daphnia magna (Water flea) - 1,7 mg/l - 48 hRemarks: no data available12.212.312.412.512.613. and degradabilityno data availableBioaccumulative potentialno data availableMobility in soilno data availableResults of PBT and vPvB assessmentno data availableOther adverse effectsToxic to aquatic data availableDISPOSAL CONSIDERATIONSWaste treatment methodsProductOffer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professionalwaste disposal service to dispose of this material. Dissolve or mix the material with a combustible solventand burn in a chemical incinerator equipped with an afterburner and scrubber.Contaminated packagingDispose of as unused product.TRANSPORT INFORMATIONUN numberADR/RID: -14.2 UN proper shipping nameADR/RID: Not dangerous goodsIMDG: Not dangerous goodsIATA: Not dangerous goods14.3 Transport hazard class(es)ADR/RID: -14.4 Packaging groupADR/RID: -14.5 Environmental hazardsADR/RID: no14.6 Special precautions for userno data availableIMDG: -IMDG: -IMDG: -IMDG Marine pollutant: noIATA: -IATA: -IATA: -IATA: no15.15.115.216.REGULATORYINFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.Safety, health and environmental regulations/legislation specific for the substance or mixtureno data availableChemical Safety Assessmentno data availableOTHER INFORMATIONFurther informationThe above information is believed to be correct but does not purport to be all inclusive andshall be used only as a guide. The information this document is based on the resent stateof our knowledge and is applicable to the product with regard to appropriate safety precautions.It does not represent any guarantee of the properties of the product. guidechem shall not beheld liable for any damage resulting from handling or from contact with the above product.See reverse side of invoice or packing slip for additional terms and conditions of sale.