Tissue engineering

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  • PDF – info on nanohttp://web.mit.edu/lms/www/PDFpapers/Zhang,%20et%20al%20SCB.pdfhttp://www.technologyreview.com/news/409877/nanofibers-heal-spinal-cords/ - Nanofibres heal spinal chords
  • http://iopscience.iop.org/1758-5090/4/1/015005 - computer guided cad
  • http://iopscience.iop.org/1758-5090/4/1/015005 - computer guided cad
  • Tissue engineering

    1. 1. By Mike Orser & Ryan McGee
    2. 2. "an interdisciplinary field that applies theprinciples of engineering and lifesciences toward the development ofbiological substitutes that restore,maintain, or improve tissue function or awhole organ"
    3. 3. 1. What are Scaffolds?2. Some different scaffold design techniques A ) Nanofibre Self-Assembly B ) Gas Foaming C ) CAD/CAM technologies D ) Electro spinning3. Multimedia - Organ Printing Demonstrations4. Future of this technology5. Drawbacks6. Conclusion
    4. 4. What are Scaffolds? Scaffolds are structures that are manufactured for the sole purpose of allowing cells to grow. Key Elements of Scaffolds and cell development- • Structures that are able to support 3-D cell structures • Allow for cell attachment, migration and growth • Enable diffusion of cell nutrients • Allow the manipulation of cells to form as correctly shaped tissue Scaffold
    5. 5. Nanofibre Self-Assembly Below is a nanofibre structure in Or molecular self- assembly is one of which cells will be introduced to the few methods of creating grow as a complete organ or biomaterials. bone structure. This method requires hydro gel scaffolds that cells use to assemble and grow them self as 3-D tissue structures Can be used in the healing process as these nanofibres promote the growth and attachment of nerve fibers  Nano fibers break down into nutrients after 2- 3 weeks but their purpose of making cell growth possible allow for complete cell structures at this time.
    6. 6. Gas FoamingThis technique allowsfor a medium to becreated in which cellscan be introduced togrow.Although not as porousas the Nano fibrestructure it is cheaper tocreate and does assistin growing strong cellstructures.
    7. 7. CAD/CAM technologies Cad/cam technologies can be used to create a more complex scaffold structure. Scaffold design and printing with a computer allow cells to grow and match that of the real organ or bones’ internal structure. • More realistic organ properties • Smaller more precise porous structure • Larger cell attachment surface area
    8. 8. ElectroSpinning This technique of making scaffolds allows for a more precise finely woven structure. High voltage is used to create such a densely woven structure for cells to attach… • Allows for more consistent cell growth • Faster reproduction • More complex cell structures with nerves
    9. 9.  In the future, this technology will continue to advance. More and more complex organs will be able to be created. Eventually whole body parts and perhaps whole bodies me be possible to create with this technology.
    10. 10.  With this technology always advancing, ethical issues may created in the future. One example is if a whole body can be created for transplant, can it not be considered a person? Also cost is a factor. This technology is very new and expensive therefore cost must decrease to allow this technology to be viable in a widespread invirnment.
    11. 11. With the further research and engineering, the manufacturing of body parts is becoming more and more a possibility. From this the possibility of increasing life longevity will become more apparent as we engineer new ways to replace organs that are failing.
    12. 12. Image Sources:  HIA. (Artist). (2010). Tissue engineering. [Web Photo]. Retrieved from http://en.wikipedia.org/wiki/File:Tissue_engineering_english.jpg   HIA. (Photographer). (2010). Gefäßprothese. [Web Photo]. Retrieved from http://en.wikipedia.org/wiki/File:Gef%C3%A4%C3%9Fprothese.JPG  Nilsen , K. (Photographer). (2012). Scanning electron microscope picture of nanofibrous electrospun membrane using pvc and peo polymers 2. [Web Photo]. Retrieved from http://en.wikipedia.org/wiki/File:Scanning_Electron_Microscope_Picture_of_Nanofibrous_Electr ospun_Membrane_Using_PVC_and_PEO_Polymers_2.png HIA. ( Animater) (2010). Tissue Engineering. [Web Photo ]. Retrieved from http://en.wikipedia.org/wiki/Tissue_engineeringResearched Content Sources: BBC. (2012) Printing a human kidney. [Web Article]. Retrieved from http://www.bbc.com/future/story/20120621-printing-a-human-kidney Drury J. L.; Mooney D. J. Biomaterials 2003, 24, 4 ed. Retrieved from http://www.sciencedirect.com/science/article/pii/S0142961203003405 Ma, P . (May 2004). "Scaffolds for tissue fabrication". Materials Today: 30–40. Mikos AG, Temenoff JS (2000). "Formation of highly porous biodegradable scaffolds for tissue engineering" (PDF). Electronic Journal of Biotechnology 3: 114–9. Retrieved from http://www.scielo.cl/pdf/ejb/v3n2/art03.pdf.

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