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Aging is a self-destruct program that kicks in at age 25 in humans
Aging is natural degeneration!
Weight gain, high blood pressure, high cholesterol, cancers, heart attacks, autoimmune diseases, etc. occur years after hormone deficiencies begin and occur more often in people with lower hormone levels!
Studies of balanced hormone restoration show the expected benefits and no proof of harm !!
Progesterone synthesized in 1942. Poorly absorbed orally
Chemically altered to make “ progestins ”—among the first drugs to be patented.
“ HRT” came to mean the use of alien molecules that had hormone-like effects
Drug co.s became dependent on HRT profits
Drug co.s push doctors to use hormone substitutes and to ignore or fear natural hormones!!
Dirty Secret: Conventional “HRT” is really H S T!
Progesterone substitutes :
medroxyprogesterone acetate ( MPA-Provera ) and 30+ other “ progestins ”
Estradiol substitutes : conjugated equine estrogens ( CEE-Premarin ) and ethinyl estradiol (birth control pills)
Testosterone substitute : oral methyltestosterone
Patented drugs —not hormones !
Most docs don’t know the difference!
Premarin Conjugated Equine Estrogens (CEE) Estradiol-17 β Dihydroequilin-17β CEE contains at least 10 estrogens, only 3 are human . CEE contains 3x more Dihydroequilin than Estradiol . DHE has 10% higher binding affinity for est. receptors. DHE binds far less to SHBG and has a slower metabolic clearance The most abundant estrogen in CEE is Equilin sulfate . Kuhl H, Climacteric 2005;8(Suppl 1):3–63 Human Horse
Estradiol Ethinyl estradiol EE cannot be inactivated by normal oxidation! EE does not interact with estrogen receptor ! EE is 12,000-60,000 times more potent by weight! EE is much more thrombogenic than estradiol EE in Birth Control Pills Acetylene
Progesterone vs. Progestins Progesterone MPA (Provera ) Megestrol Every progestin has a different spectrum of androgenic, estrogenic, glucocorticoid , and progestational effects!
Testosterone Substitution Testosterone Methyltestosterone Methyltestosterone ( in Estratest ) aromatizes to an alien estrogen and increases risk of breast cancer , also causes liver damage and breast enlargement in bodybuilders Headlines: “Testosterone therapies increase risk of breast cancer.”
“ In both peripheral and cerebral vasculature (of live animals), synthetic progestins caused endothelial disruption, accumulation of monocytes in the vessel wall, platelet activation and clot formation, which are early events in atherosclerosis, inflammation and thrombosis. Natural progesterone or estrogens did not show such toxicity .”
Premenopausal women with low P levels had 5.4 times greater risk of early breast cancer , 10x greater risk for all cancers
Am J Epidem 1981;114:209-17.
Breast cancer victims have signs of progesterone resistance
Br J Obstet Gynaecol. 1998 Mar;105(3):345-51.
P downregulates BRCA1 and induces apoptosis in breast cancer cell lines.
Anticancer Res. 2005 Jan-Feb;25(1A):243-8.
Progesterone and Breast Cancer —the Evidence cont.
Estrogen cream applied to the breast induces proliferation , adding progesterone cream reduces proliferation to baseline
Fertil Steril 1995; 63:785-91
Estrogen is carcinogenic in breast cell cultures unless progesterone is present
J Steroid Biochem Mol Biol. 2003 Oct;87(1):1-25.
Estrogen upregulates cancer-promoting gene bcl-2, progesterone downregulates it.
Ann Clin Lab Sci. 1998 Nov-Dec;28(6):360-9.
E3N-EPIC Study Bioidentical estradiol plus progesterone decreased the risk of breast cancer ! Int J Cancer. 2005 Apr 10;114(3):448-54. Cohort study 54,000 women 5.8 years f/u c/w WHI-- 16,000, 6 yr. f/u No Evidence that BHRT is safer?
ORDET Study Int. J. Cancer 112 (2004) (2), pp. 312–318. Higher progesterone= lower risk of breast cancer 6,000 women 5 yr. F/U