HANTA VIRUSHANTA VIRUS
InfectionsInfections
Dr.T.V.Rao MDDr.T.V.Rao MD
Hanta VirusesHanta Viruses
Hanta virus belong toHanta virus belong to
family - Bunyaviridaefamily - Bunyaviridae
Found Glo...
Hanta Virus diseasesHanta Virus diseases
Hantavirus infections are caused by aHantavirus infections are caused by a
group ...
Hanta virusHanta virus
Source of Hanta Virus InfectionsSource of Hanta Virus Infections
There are several distinctThere are several distinct
Hant...
Spread of Hanta VirusSpread of Hanta Virus
InfectionsInfections
Breeding of RodentsBreeding of Rodents
have relation to spreadhave relation to spread
of Infectionof Infection
Diseases produced byDiseases produced by
Hanta virus InfectionsHanta virus Infections
1 Hemorrhagic fever with Renal Syndr...
Hemorrhagic Fever with RenalHemorrhagic Fever with Renal
SyndromeSyndrome
The virus were first isolated inThe virus were f...
Hemorrhagic Fever – RenalHemorrhagic Fever – Renal
syndromesyndrome
Acute Hanta viral infection causes aAcute Hanta viral ...
MangementMangement
Hemorrhagic fever, andHemorrhagic fever, and
renal failure are managedrenal failure are managed
with su...
Hanta virus – PulmonaryHanta virus – Pulmonary
syndromesyndrome
Caused by novel Hanta virusCaused by novel Hanta virus
( S...
Other viruses causing HPSOther viruses causing HPS
New York virusNew York virus
Black Creek canalBlack Creek canal
virusvi...
Clinical ManifestationsClinical Manifestations
Infections and subclinical infections are not common.Infections and subclin...
PathogenesisPathogenesis
Hanta viral antigens are found inHanta viral antigens are found in
endothelial cells.endothelial ...
Laboratory DiagnosisLaboratory Diagnosis
Detection of antigens by immunoDetection of antigens by immuno
histochemistry,his...
ManagementManagement
Maintenance of adequateMaintenance of adequate
OO22
Supporting homodynamicSupporting homodynamic
func...
Control and PreventionControl and Prevention
Rodent controlRodent control
Avoiding control ofAvoiding control of
Rodents a...
Created for benefit of HealthCreated for benefit of Health
Care WorkersCare Workers
Dr.T.V.Rao MDDr.T.V.Rao MD
EmailEmail
...
Hanta virus-1217124829483391-9
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Hanta virus-1217124829483391-9

  1. 1. HANTA VIRUSHANTA VIRUS InfectionsInfections Dr.T.V.Rao MDDr.T.V.Rao MD
  2. 2. Hanta VirusesHanta Viruses Hanta virus belong toHanta virus belong to family - Bunyaviridaefamily - Bunyaviridae Found GloballyFound Globally Causes serious diseases,Causes serious diseases, can be fatalcan be fatal It is estimated there areIt is estimated there are 100,000 to 200,000100,000 to 200,000 infections occurinfections occur worldwide.worldwide. Dr.T.V.Rao MDDr.T.V.Rao MD
  3. 3. Hanta Virus diseasesHanta Virus diseases Hantavirus infections are caused by aHantavirus infections are caused by a group of viruses known as hantaviruses.group of viruses known as hantaviruses. These viruses cause two serious illnessesThese viruses cause two serious illnesses in humans. They are hemorrhagicin humans. They are hemorrhagic (pronounced heh-meh-RA-jik) fever with(pronounced heh-meh-RA-jik) fever with renal syndrome (HFRS) and hantavirusrenal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS).pulmonary syndrome (HPS). Dr.T.V.Rao MDDr.T.V.Rao MD
  4. 4. Hanta virusHanta virus
  5. 5. Source of Hanta Virus InfectionsSource of Hanta Virus Infections There are several distinctThere are several distinct Hanta viruses, eachHanta viruses, each associated with specificassociated with specific Rodent HostRodent Host The Infection in RodentsThe Infection in Rodents are life long withoutare life long without deleterious effects.deleterious effects. Humans get infected byHumans get infected by inhaling aerosols ofinhaling aerosols of Rodent excreta.Rodent excreta. ( Urine, Feces, Saliva )( Urine, Feces, Saliva )
  6. 6. Spread of Hanta VirusSpread of Hanta Virus InfectionsInfections
  7. 7. Breeding of RodentsBreeding of Rodents have relation to spreadhave relation to spread of Infectionof Infection
  8. 8. Diseases produced byDiseases produced by Hanta virus InfectionsHanta virus Infections 1 Hemorrhagic fever with Renal Syndrome1 Hemorrhagic fever with Renal Syndrome ( HFR )( HFR ) 2 Hanta virus pulmonary Syndrome ( HPS )2 Hanta virus pulmonary Syndrome ( HPS ) Infection with Hanta virus is associatedInfection with Hanta virus is associated with Geographic distribution of Rodentswith Geographic distribution of Rodents and nature of the Virus.and nature of the Virus.
  9. 9. Hemorrhagic Fever with RenalHemorrhagic Fever with Renal SyndromeSyndrome The virus were first isolated inThe virus were first isolated in 1976 in Korea from a Rodent1976 in Korea from a Rodent Apodemus AgrarisApodemus Agraris Urban Rats are to beUrban Rats are to be persistently infected withpersistently infected with Hanta virusHanta virus Rats migrate on trading shipsRats migrate on trading ships and disperse the virus worldand disperse the virus world widewide Hanta virus infection hasHanta virus infection has occurred in persons whoseoccurred in persons whose occupations place them inoccupations place them in contact with Ratscontact with Rats
  10. 10. Hemorrhagic Fever – RenalHemorrhagic Fever – Renal syndromesyndrome Acute Hanta viral infection causes aAcute Hanta viral infection causes a Interstitial nephritisInterstitial nephritis Lead to acute renal insufficiency and renalLead to acute renal insufficiency and renal failure in severe formfailure in severe form Generalized hemorrhage and shock mayGeneralized hemorrhage and shock may occur with case fatalities upto 5 – 15 %occur with case fatalities upto 5 – 15 % Dr.T.V.Rao MDDr.T.V.Rao MD
  11. 11. MangementMangement Hemorrhagic fever, andHemorrhagic fever, and renal failure are managedrenal failure are managed with supportive treatment.with supportive treatment. Rodent controlRodent control Protection from exposureProtection from exposure to rodent droppings andto rodent droppings and contaminated material.contaminated material.
  12. 12. Hanta virus – PulmonaryHanta virus – Pulmonary syndromesyndrome Caused by novel Hanta virusCaused by novel Hanta virus ( Sin Nombre virus )( Sin Nombre virus ) First case was reported from NorthFirst case was reported from North AmericaAmerica Primarily anPrimarily an adult respiratoryadult respiratory disease syndromedisease syndrome The deer mouse ( PeromyscusThe deer mouse ( Peromyscus maniculats) is the primary rodentmaniculats) is the primary rodent for Sin Nombre virusfor Sin Nombre virus 10 % of the deer mouse are infected.10 % of the deer mouse are infected. Other viruses resembling novelOther viruses resembling novel Hantavirus can cause Hanta viralHantavirus can cause Hanta viral pulmonary syndromepulmonary syndrome Dr.T.V.RaoDr.T.V.Rao
  13. 13. Other viruses causing HPSOther viruses causing HPS New York virusNew York virus Black Creek canalBlack Creek canal virusvirus Bayou virusBayou virus and each type of virusand each type of virus has a different Rodenthas a different Rodent hosthost
  14. 14. Clinical ManifestationsClinical Manifestations Infections and subclinical infections are not common.Infections and subclinical infections are not common. Hantavirus pulmonary syndrome is generally severe withHantavirus pulmonary syndrome is generally severe with reported mortality rate of > 30 % or greater.reported mortality rate of > 30 % or greater. Present withPresent with Fever, Headache,MyalgiaFever, Headache,Myalgia Prolonged pulmonary edemaProlonged pulmonary edema Leading to respiratory compromiseLeading to respiratory compromise No signs of hemorrhageNo signs of hemorrhage Dr.T.V.Rao MDDr.T.V.Rao MD
  15. 15. PathogenesisPathogenesis Hanta viral antigens are found inHanta viral antigens are found in endothelial cells.endothelial cells. In macrophages in lung, heart,In macrophages in lung, heart, Spleen,LymphnodesSpleen,Lymphnodes Leads to functional impairment of vascularLeads to functional impairment of vascular endotheliumendothelium Person to person transmission is rarePerson to person transmission is rare
  16. 16. Laboratory DiagnosisLaboratory Diagnosis Detection of antigens by immunoDetection of antigens by immuno histochemistry,histochemistry, RT – PCR for viral antigen detectionRT – PCR for viral antigen detection Specific antibodies by recombinantSpecific antibodies by recombinant proteinsproteins A four fold rise of IgM antibody titerA four fold rise of IgM antibody titer between acute and convalescent serum isbetween acute and convalescent serum is diagnosticdiagnostic Dr.T.V.Rao MDDr.T.V.Rao MD
  17. 17. ManagementManagement Maintenance of adequateMaintenance of adequate OO22 Supporting homodynamicSupporting homodynamic functioningfunctioning Antiviral drug Ribavirin isAntiviral drug Ribavirin is some benefitsome benefit Dr.T.V.Rao MDDr.T.V.Rao MD
  18. 18. Control and PreventionControl and Prevention Rodent controlRodent control Avoiding control ofAvoiding control of Rodents and RodentRodents and Rodent droppingsdroppings Care must be taken toCare must be taken to avoid inhaling aerolizedavoid inhaling aerolized dried excreta whendried excreta when cleaning Rodent infectedcleaning Rodent infected structures.structures. Dr.T.V.Rao MDDr.T.V.Rao MD
  19. 19. Created for benefit of HealthCreated for benefit of Health Care WorkersCare Workers Dr.T.V.Rao MDDr.T.V.Rao MD EmailEmail doctortvrao@gmail.comdoctortvrao@gmail.com

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