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Mibbi strenda
Mibbi strenda
Mibbi strenda
Mibbi strenda
Mibbi strenda
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Mibbi strenda

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  • STRENDA stands for Standards for Reporting Enzymology Data and the Commission has been founded in 2004 under the auspices of the Beilstein-Institut and is supported since then.
    The Commission work is accompanied by the biannually held ESCEC Symposia. The next symposium will be in September 2011.
     
    At the first Symposium on ESCEC there was a common agreement that standardized descriptions of materials, methods and results for enzymology experiments are desired and useful.

    With this idea of the establishment of standards for reporting minimum information, the STRENDA Commission took over to address the following issues.
    to propose standardized assay conditions

    This issue has just been tackled when standard assay conditions for the functional characterization of the yeast glycolysis enzymes were developed and tested.

    to define minimal information for reporting enzyme functional data
    to define the requirements for the deposition of such data in a form that will be available to any relevant database.
  • For a high degree of comparability, enzymology in basic research relies in a first step data which include minimum experimental information.
    about the experimental set up which includes also description of the methodology,
    about the materials and methods used such as enzyme information, preparation, assay condition etc.,
    and about the data obtained which means information about measured kinetic parameters and mechanisms, inhibition and activation parameters and so on.
     
    Capturing Uniform Enzyme Data
     
    The third goal is the development of a comprehensive data acquisition and storage system in compliance with the STRENDA guidelines.
    This system is proposed to act as a portal for the submission of enzyme data prior or during publication to a freely accessible, public database. The prototype is accessible here for a community-wide evaluation. We have already received numerous comments and suggestions for this project which will be considered at the following development steps.

    We hope that both the guidelines and data acquisition system will lead to the publication and storage of materials, methods and results in a comprehensive way.
  • Due to the efforts of the members of STRENDA the network of co-operations, collaborations and contacts is continuously growing:
     
    in 2005 JCBN approved the guidelines at the annual NC-IUBMB meeting (International Union of Biochemistry and Molecular Biology),
    close contacts to YSBN and the NIH Chemical Genomics Center as well as to department of Biotechnology and Enzyme Catalysis and Regulation at the National Institute of
    General Medical Sciences
    STRENDA is registered at the MIBBI project since 2007.
    More or less incidentally the European Section of Applied Biocatalysis, a subsection of the European Federation of Biotechnolgy, became aware of the STRENDA guidelines and
    the members of this working group decided to adopt the STRENDA guidelines for their purposes.
    So, who will be next? Any input, cooperation and contribution are highly appreciated
    The major database producers in the enzyme field are also closely connected with STRENDA. SABIO-RK implements the recommendations of the STRENDA commission.
    The STRENDees appreciated that a number of journals have already adopted the guidelines for their instructions for authors, amongst them are FEBS J., Biochemistry, JBC,
    ABB, BBRC and all nine sections of BBA, Nature Chemical Biology entered recently and FEBS Letters will follow soon.
    Up to date, 15 biochemical journals have already adopted the STRENDA Guidelines for their instructions for authors.
    BMC, PLoS and OMICS recommend the authors to the MIBBI portal for prescriptive checklists for reporting their research data.
    So we hope that further journals will follow.
  • Transcript

    • 1. STRENDA MIBBI Workshop 2010 = Standards for Reporting Enzymology Data The Commission: R. Armstrong, A. Bairoch, A. Cornish-Bowden, P. Halling, J. Rohwer, T. Leyh, K. Tipton, D. Schomburg, C. Steinbeck and C. Kettner (co-ordination) Missions: 1. Standardized experimental conditions*; 2. Definition of minimum information for reporting enzyme functional data (“STRENDA Guidelines”); 3. Definition of requirements for the submission of uniform functional data (“STRENDA e-form”). Founded and supported by the Beilstein-Institut since 2004 www.strenda.org Accompanied by Int‘l Symposia on ESCEC (next Sept. 2011) * Van Eunen et al. (2010) FEBS J. 277(3):749-760
    • 2. Minimum Information… …about experimental set up. …about materials and methods used. …about data obtained. e.g., identity and source of enzyme, description of reaction… e.g. use of kinetic param. units, determination of params., inhibition and activation, statistics… MIBBI Workshop 2010* http://www.beilstein-institut.de/STRENDA/eform/eform.html …for the STRENDA „e-form“ * e.g., preparation of enzyme, experimental conditions, methodology of assay,… … for capturing uniform enzyme data. Publication of materials, methods and results comprehensively.
    • 3. The STRENDA Network STRENDA JCBN/ IUBMB MIBBI YSBN NIHEFB- ESAB ? SABIO- RK BRENDA Biochemistry JBC BBA (all 9 sections) ABB BBRC ? MIBBI Workshop 2010 FEBS Lett. FEBS J. PLoS BMC OMICS Nat.Chem. Biol.
    • 4. http://www.beilstein-institut.de/en/projects/strenda/ The Commission: Richard Armstrong, Vanderbilt Univ., Nashville, TN, USA Amos Bairoch, SBI, Geneva, Switzerland Athel Cornish-Bowden, CNRS-BIP, Marseille, France Peter Halling, Univ. of Strathclyde, Glasgow, UK Johann Rohwer, Univ. of Stellenbosch, South Africa Tom Leyh, The Albert Einstein College, New York, USA Keith Tipton, Trinity College, Dublin, Ireland Dietmar Schomburg, Technical University of Braunschweig Christoph Steinbeck, EBI, Cambridge, UK Carsten Kettner, Beilstein-Institut, Frankfurt STRENDA There was a young lady called BRENDA And I tried to find data to send her But she says "It's no good, And I think that you should Send me stuff that's consistent with STRENDA (Athel Cornish-Bowden, Feb. 2004)
    • 5. There was a young lady called BRENDA And I tried to find data to send her But she says "It's no good, And I think that you should Send me stuff that's consistent with STRENDA (Athel Cornish-Bowden, Feb. 2004)

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