Serofuloderma

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Serofuloderma

  1. 1. <ul><li>Causative organism : </li></ul><ul><li>Mycobacterium tuberculosis </li></ul><ul><li>Classification : </li></ul><ul><li>Primary tuberculosis of the skin </li></ul><ul><li>Miliary tuberculosis of the skin </li></ul><ul><li>Lupus vulgaris </li></ul><ul><li>Scrofuloderma </li></ul><ul><li>Tuberculosis verrucosa cutis </li></ul><ul><li>Tuberculosis cutis orificialis </li></ul><ul><li>Tuberculide : </li></ul>Tuberculosis of skin
  2. 2. <ul><li>Vary rare condition </li></ul><ul><li>It consist of : </li></ul><ul><li>1. Tuberculous chancre </li></ul><ul><li>2. regional lymph node </li></ul><ul><li>Tuberculous chancre is asymptomatic ulcerated nodule covered by crust </li></ul><ul><li>The ulcer has the characteristic of tuberculous ulcer . </li></ul>Primary tuberculosis of the skin
  3. 3. Primary inoculation tuberculosis A large, ulcerated nodule at the site of M.tuberculosis inoculation on the right thigh associated with inguinal lymphadenopathy. The erythematous papules on the left forearm occurred at the site of tuberculin testing.
  4. 4. <ul><li>It is rare haematogenous dissemnated of tuberculosis . </li></ul><ul><li>The very rare skin eruption consist of generalized erythematous papules and pustule in an immuno-suppressed person </li></ul>Miliary tuberculosis of the skin
  5. 5. <ul><li>Occur as an exogenous inculation of bacilli in a person with high degree of immunity . </li></ul><ul><li>Age : usually children and also in adult </li></ul><ul><li>Site : </li></ul><ul><li>Site of trauma </li></ul><ul><li>Extremities and buttocks </li></ul><ul><li>Morphology: </li></ul><ul><li>A verrucous indurated plaque with fissure and active inflammatory border . </li></ul>Tuberculosis verrucosa cutis
  6. 6. Tuberculosis verrucosa cutis Crusted and hyperkeratotic plaque arising at the site of inoculation in an individual previously infected with M. tuberculosis . There is no associated lymphadenopathy
  7. 7. <ul><li>The most common form of skin tuberculosis </li></ul><ul><li>Site : head and neck especially around the nose . </li></ul><ul><li>Morphology : </li></ul><ul><li>- patches : </li></ul><ul><li>reddish brown </li></ul><ul><li>well demarcated </li></ul><ul><li>contained deep seated nodules </li></ul><ul><li>positive diascopy </li></ul><ul><li>Scarring is evident and could be mutilating </li></ul><ul><li>Course : chronic with healing of center by scarring and extension of the lesion at the periphery . </li></ul>Lupus vulgaris
  8. 8. Lupus vulgaris Reddish-brown plaque, which on diascopy exhibits the diagnostic yellow-brown apple-jelly color
  9. 9. <ul><li>Types of lupus vulgaris : </li></ul><ul><li>Hypertrophic or verrucus type. </li></ul><ul><li>Atrophic type . </li></ul><ul><li>Ulcerative type . </li></ul><ul><li>Tumor like type . </li></ul><ul><li>Complication : </li></ul><ul><li>Development of squamous cell carcinoma </li></ul><ul><li>Deforming scars </li></ul><ul><li>Destruction of the nose </li></ul>
  10. 10. Lupus vulgaris
  11. 11. Scrofuloderma Scrofuloderma represent a direct extension from underlying focus (bone or LN) to the skin. Site : _ Neck _Chest Morphology : -An asymptomatic reddish swelling which breaks down to form sinuses, fistulate or tuberculuos ulcers. -Characteristic caseous materil discharges from lesions.
  12. 12. Tuberculosis Cutis Orificialis <ul><li>Tuberculoisis cutis orificialis occurs on or around orifices of patients with low immunity and internal tuberculosis. </li></ul><ul><li>Site: </li></ul><ul><li>-On and around orifices (mouth,anus,…) </li></ul><ul><li>Morphology: </li></ul><ul><li>-Tuberculous ulcer with a granulating base. </li></ul>
  13. 13. Papulonecrotic Tuberculide <ul><li>Site: widely distributed. </li></ul><ul><li>Morphology: papules with central necrosis. </li></ul><ul><li>Response to anti-tuberculous therapy: good. </li></ul>
  14. 14. Lichen Scrofulosorum <ul><li>Site: TRUNK </li></ul><ul><li>Morphology: </li></ul><ul><li>Lichenoid papules. </li></ul><ul><li>Follicular. </li></ul><ul><li>Skin-colored. </li></ul><ul><li>Response to anti- tuberculosis therapy: good. </li></ul>
  15. 15. Erythema Induratum ofBazin <ul><li>Age&sex: young adult woman </li></ul><ul><li>Site: lower leg( posterior aspect). </li></ul><ul><li>Morphology: </li></ul><ul><li>-Deep-seated subcutaneous nodule. </li></ul><ul><li>-Usually ulcerates. </li></ul><ul><li>-Heals with atrophic scar. </li></ul>
  16. 16. Histopathology of Cutaneous Tuberculosis <ul><li>-Dermal tuberculous tubercles formed of central caseation ( may be absent) and surrounded by epithelioid cells , giant cells, monocytes and lymphocytes . </li></ul>
  17. 17. Treatment of Tuberculosis <ul><li>General: </li></ul><ul><li>Good nutrition . </li></ul><ul><li>Search for underlying focus </li></ul><ul><li>Medical Treatment: </li></ul><ul><li>Combination of more than one anti-tuberculous drug </li></ul><ul><li>e.g: </li></ul><ul><li>1. Rifampicin : 20 mg /kg/day(adult dose:600 mg/day). </li></ul><ul><li>Isoniazid (INH) : 6 mg /kg/ day (adult dose:300 mg/day). </li></ul><ul><li>Ethambutol: 15mg/kg/day. </li></ul><ul><li>Pyrazinamide: 1.5-2.5 gm/day. </li></ul><ul><li>III. Surgical excision of small lesions. </li></ul>

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