Examples of Phase Diagrams
Interpretation Experimental data  visualization
Visualization Reconstructed 3-D Vector Rescale the vector to RGB color system Each vector will define a color block in the...
Phase diagram created using high-resolution second derivative UV spectroscopy data.
Phase diagram generated using ANS fluorescence and intrinsic Trp fluorescence intensity data and CD molar ellipticity data...
Phase diagram rPA based on intrinsic, ANS binding fluorescence and CD 2 Stable phase Structrally altered and aggregated st...
Empirical phase diagram (EPD) of RSV over the pH range 3-8 Data included in the generation of the EPD are all negative sec...
Adenovirus Type 2
Non-Viral Gene Delivery Vehicle DOTAP
Non-Viral Gene Delivery Vehicle DOTAP (Charge ratio =4.0)
Non-Viral Gene Delivery Vehicle DOTAP/DOPE
Non-Viral Gene Delivery Vehicle DOTAP/DOPE (Charge ratio = 4.0)
Non-Viral Gene Delivery Vehicle PLL (Charge ratio =4.0)
Ty21a bacteria
HSPPC96
HSPPC96 Visual Interpretation
HSC70
HSC70 Visual Interpretation
FGF1
FGF1, heparin excipient
FGF1, sucrose excipient
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Phase diagram

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Phase diagram

  1. 1. Examples of Phase Diagrams
  2. 2. Interpretation Experimental data visualization
  3. 3. Visualization Reconstructed 3-D Vector Rescale the vector to RGB color system Each vector will define a color block in the phase diagram at its corresponding coordinates (pH, T)
  4. 4. Phase diagram created using high-resolution second derivative UV spectroscopy data.
  5. 5. Phase diagram generated using ANS fluorescence and intrinsic Trp fluorescence intensity data and CD molar ellipticity data of recombinant ricin toxin A-chain.
  6. 6. Phase diagram rPA based on intrinsic, ANS binding fluorescence and CD 2 Stable phase Structrally altered and aggregated state Molten globule state Severely structurally altered phase
  7. 7. Empirical phase diagram (EPD) of RSV over the pH range 3-8 Data included in the generation of the EPD are all negative second-derivative UV peaks, CD signal at 222 nm, optical density at 350 nm, intrinsic fluorescence peak position, intrinsic fluorescence intensity at 330 nm, and ANS fluorescence intensity at 485 nm Ausar, et al , Mol. Pharm., 2 (6), 491 -499, 2005.
  8. 8. Adenovirus Type 2
  9. 9. Non-Viral Gene Delivery Vehicle DOTAP
  10. 10. Non-Viral Gene Delivery Vehicle DOTAP (Charge ratio =4.0)
  11. 11. Non-Viral Gene Delivery Vehicle DOTAP/DOPE
  12. 12. Non-Viral Gene Delivery Vehicle DOTAP/DOPE (Charge ratio = 4.0)
  13. 13. Non-Viral Gene Delivery Vehicle PLL (Charge ratio =4.0)
  14. 14. Ty21a bacteria
  15. 15. HSPPC96
  16. 16. HSPPC96 Visual Interpretation
  17. 17. HSC70
  18. 18. HSC70 Visual Interpretation
  19. 19. FGF1
  20. 20. FGF1, heparin excipient
  21. 21. FGF1, sucrose excipient

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