Food “Allergy” Testing for Adverse Food Reactions


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Learn how to differentiate classes of adverse reactions to food, understand the mechanism of sensitivity reactions, and interpret reports of IgG4 food antibodies.

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  • Hello I am Christie Egeston.....
  • Food “Allergy” Testing for Adverse Food Reactions

    1. 1. IgG4 and IgE
    2. 2. Objectives <ul><li>Learn how to differentiate classes of adverse reactions to food </li></ul><ul><li>Understand mechanism of sensitivity reactions </li></ul><ul><li>Interpret reports of IgG4 food antibodies </li></ul>
    3. 3. Types of Adverse Reactions to Food <ul><li>Immunological </li></ul><ul><ul><li>Atopy or Allergy - IgE </li></ul></ul><ul><ul><li>(Hyper) Sensitivity - IgG </li></ul></ul><ul><li>Physiological </li></ul><ul><ul><li>Lactose Intolerance </li></ul></ul><ul><li>Biochemical </li></ul><ul><ul><li>MSG Intolerance </li></ul></ul>
    4. 4. Definition of Common Terms
    5. 5. Characteristics of IgE and IgG-Mediated Reactions to Food
    6. 6. IgE <ul><li>Mediates Classical Allergic Symptoms </li></ul><ul><ul><li>Sneezing, nose runs, eyes water </li></ul></ul><ul><li>Works by attaching to mast cells in mucosa linings </li></ul><ul><ul><li>Loaded with histamines </li></ul></ul><ul><ul><li>Able to produce cytokines (chemicals that can influence the behavior of other cells) </li></ul></ul>
    7. 7. IgE <ul><li>Extremely Sensitive System </li></ul><ul><ul><li>Individual reacts from someone sitting at the next table eating crab </li></ul></ul><ul><li>Extreme Reaction  Anaphylaxis and Death </li></ul><ul><li>Normal Function is Gating for IgA System </li></ul><ul><ul><li>Antigen detected by IgE in gut cells changes permeability, allowing IgA to stream out and intercept and destroy parasites </li></ul></ul>
    8. 8. IgG <ul><li>Protects tissues </li></ul><ul><li>Initially called Gamma Globulin </li></ul><ul><ul><li>Early used intravenously, not knowing why it did good things </li></ul></ul><ul><ul><li>Later found to produce “serum sickness” </li></ul></ul><ul><li>Highly inflammatory </li></ul>
    9. 9. IgG <ul><li>IgG Molecules are Trans-Placental </li></ul><ul><ul><li>Only source of specific protection for newborn </li></ul></ul><ul><ul><li>Transfers immunological memory from the mother </li></ul></ul>
    10. 10. IgG4 and IgE Food Antibody Testing <ul><li>Requires serum specimen </li></ul><ul><li>Finger stick analysis measures 30 food reactions </li></ul><ul><li>Patient motivational tool </li></ul><ul><li>Straightforward interpretation of lab results </li></ul><ul><li>Rotation diet provides easy implementation </li></ul><ul><li>Significant improvements of many symptoms </li></ul>
    11. 11. Treatment of Delayed Food Allergy Based on Specific IgG RAST Testing <ul><li>114 patients with chronic, disabling symptoms </li></ul><ul><li>Elimination of foods was sole treatment </li></ul><ul><li>70% of group obtained 75% improvement </li></ul><ul><li>20% of group obtained 100% improvement </li></ul>Dixon HS. Otolaryngol Head Neck Surg 2000 Jul: 123(1 part1):48-54
    12. 12. Incidence of Food Allergies
    13. 13. Food Sensitivities <ul><li>They can occur at any age, triggering many different symptoms and contributing to a variety of disorders, including: </li></ul><ul><li>Inflammatory Bowel Disease </li></ul><ul><li>Fatigue </li></ul><ul><li>ADD/ADHD </li></ul><ul><li>Migraine </li></ul><ul><li>Skin Problems </li></ul><ul><li>Rheumatoid Arthritis </li></ul><ul><li>Sinusitis </li></ul><ul><li>Recurrent Ear Infections </li></ul>
    14. 14. Commonly Reported Symptoms in Patients with Delayed Food Sensitivities
    15. 15. Assessment of IgG Reactions <ul><li>20 or Greater IgG4 Reactions: If more than twenty foods have an IgG reaction this is an indication of an intestinal permeability problem or &quot;leaky gut.” </li></ul><ul><li>5 to 19 IgG4 Reactions: Intestinal permeability may be a problem, and steps should be taken as indicated above. </li></ul><ul><li>Few IgG4 Reactions: If there are one to five reactions to foods, these should again be eliminated from the diet to test for involvement in patient symptoms. </li></ul>
    16. 16. No IgG Reactions <ul><li>The absence of reactions in this test may be due to several possibilities: </li></ul>
    17. 17. <ul><li>Allergix Profile </li></ul><ul><li>52-year-old male </li></ul>
    18. 18. <ul><li>52-year-old male, generally in good health </li></ul><ul><li>Interested in losing weight </li></ul><ul><li>Heartburn </li></ul><ul><li>History of antibiotic use due to chronic diarrhea </li></ul><ul><li>Regular, loose stools </li></ul><ul><li>Oral thrush </li></ul><ul><li>GIfx revealed dysbiosis and several opportunistic bacteria </li></ul>Presenting Symptoms
    19. 20. GIfx Immunology markers
    20. 21. <ul><li>Gluten-free diet </li></ul><ul><li>Focused on healing the gut: </li></ul><ul><ul><li>Paleofiber 2 tbs/d </li></ul></ul><ul><ul><li>Factor IV — Bifidobacter sp. only probiotic </li></ul></ul><ul><ul><li>Biotagen prebiotic </li></ul></ul><ul><ul><li>Digestive Enzymes </li></ul></ul><ul><ul><li>Plant enzymes </li></ul></ul><ul><ul><li>GI Revive </li></ul></ul><ul><ul><li>Betaine HCl </li></ul></ul>Treatment
    21. 22. <ul><li>Treatment </li></ul><ul><ul><li>Continued with previous protocol for gut healing and elimination diet </li></ul></ul><ul><ul><li>Increased Betaine HCl </li></ul></ul><ul><li>Losing weight </li></ul>Follow-up (3 months)
    22. 23. <ul><li>Anti-gliadin antibody has improved with elimination of gluten. </li></ul>Immunology
    23. 24. <ul><li>Patient’s diet is much improved </li></ul><ul><li>Still gluten-free </li></ul><ul><li>Weight loss of 65 lbs. </li></ul><ul><li>Patient wasn’t mentally prepared to accept such dramatic improvements </li></ul>Follow-up (6 months)
    24. 26. Immunology
    25. 27. Conclusion <ul><li>IgG Reactions: </li></ul><ul><ul><li>High incidence </li></ul></ul><ul><ul><li>Cause a variety of chronic symptoms </li></ul></ul><ul><ul><li>Usually unsuspected as an offending food </li></ul></ul><ul><ul><li>Offending foods removed and/or rotated from diet </li></ul></ul><ul><li>IgE Reactions: </li></ul><ul><ul><li>Low incidence </li></ul></ul><ul><ul><li>Cause short term symptoms </li></ul></ul><ul><ul><li>Usually known as offending food </li></ul></ul><ul><ul><li>Offending foods permanently removed from diet </li></ul></ul>