Food “Allergy” Testing for Adverse Food Reactions

4,761 views
4,519 views

Published on

Learn how to differentiate classes of adverse reactions to food, understand the mechanism of sensitivity reactions, and interpret reports of IgG4 food antibodies.

0 Comments
4 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
4,761
On SlideShare
0
From Embeds
0
Number of Embeds
2
Actions
Shares
0
Downloads
0
Comments
0
Likes
4
Embeds 0
No embeds

No notes for slide
  • Hello I am Christie Egeston.....
  • Food “Allergy” Testing for Adverse Food Reactions

    1. 1. IgG4 and IgE
    2. 2. Objectives <ul><li>Learn how to differentiate classes of adverse reactions to food </li></ul><ul><li>Understand mechanism of sensitivity reactions </li></ul><ul><li>Interpret reports of IgG4 food antibodies </li></ul>
    3. 3. Types of Adverse Reactions to Food <ul><li>Immunological </li></ul><ul><ul><li>Atopy or Allergy - IgE </li></ul></ul><ul><ul><li>(Hyper) Sensitivity - IgG </li></ul></ul><ul><li>Physiological </li></ul><ul><ul><li>Lactose Intolerance </li></ul></ul><ul><li>Biochemical </li></ul><ul><ul><li>MSG Intolerance </li></ul></ul>
    4. 4. Definition of Common Terms
    5. 5. Characteristics of IgE and IgG-Mediated Reactions to Food
    6. 6. IgE <ul><li>Mediates Classical Allergic Symptoms </li></ul><ul><ul><li>Sneezing, nose runs, eyes water </li></ul></ul><ul><li>Works by attaching to mast cells in mucosa linings </li></ul><ul><ul><li>Loaded with histamines </li></ul></ul><ul><ul><li>Able to produce cytokines (chemicals that can influence the behavior of other cells) </li></ul></ul>
    7. 7. IgE <ul><li>Extremely Sensitive System </li></ul><ul><ul><li>Individual reacts from someone sitting at the next table eating crab </li></ul></ul><ul><li>Extreme Reaction  Anaphylaxis and Death </li></ul><ul><li>Normal Function is Gating for IgA System </li></ul><ul><ul><li>Antigen detected by IgE in gut cells changes permeability, allowing IgA to stream out and intercept and destroy parasites </li></ul></ul>
    8. 8. IgG <ul><li>Protects tissues </li></ul><ul><li>Initially called Gamma Globulin </li></ul><ul><ul><li>Early used intravenously, not knowing why it did good things </li></ul></ul><ul><ul><li>Later found to produce “serum sickness” </li></ul></ul><ul><li>Highly inflammatory </li></ul>
    9. 9. IgG <ul><li>IgG Molecules are Trans-Placental </li></ul><ul><ul><li>Only source of specific protection for newborn </li></ul></ul><ul><ul><li>Transfers immunological memory from the mother </li></ul></ul>
    10. 10. IgG4 and IgE Food Antibody Testing <ul><li>Requires serum specimen </li></ul><ul><li>Finger stick analysis measures 30 food reactions </li></ul><ul><li>Patient motivational tool </li></ul><ul><li>Straightforward interpretation of lab results </li></ul><ul><li>Rotation diet provides easy implementation </li></ul><ul><li>Significant improvements of many symptoms </li></ul>
    11. 11. Treatment of Delayed Food Allergy Based on Specific IgG RAST Testing <ul><li>114 patients with chronic, disabling symptoms </li></ul><ul><li>Elimination of foods was sole treatment </li></ul><ul><li>70% of group obtained 75% improvement </li></ul><ul><li>20% of group obtained 100% improvement </li></ul>Dixon HS. Otolaryngol Head Neck Surg 2000 Jul: 123(1 part1):48-54
    12. 12. Incidence of Food Allergies
    13. 13. Food Sensitivities <ul><li>They can occur at any age, triggering many different symptoms and contributing to a variety of disorders, including: </li></ul><ul><li>Inflammatory Bowel Disease </li></ul><ul><li>Fatigue </li></ul><ul><li>ADD/ADHD </li></ul><ul><li>Migraine </li></ul><ul><li>Skin Problems </li></ul><ul><li>Rheumatoid Arthritis </li></ul><ul><li>Sinusitis </li></ul><ul><li>Recurrent Ear Infections </li></ul>
    14. 14. Commonly Reported Symptoms in Patients with Delayed Food Sensitivities
    15. 15. Assessment of IgG Reactions <ul><li>20 or Greater IgG4 Reactions: If more than twenty foods have an IgG reaction this is an indication of an intestinal permeability problem or &quot;leaky gut.” </li></ul><ul><li>5 to 19 IgG4 Reactions: Intestinal permeability may be a problem, and steps should be taken as indicated above. </li></ul><ul><li>Few IgG4 Reactions: If there are one to five reactions to foods, these should again be eliminated from the diet to test for involvement in patient symptoms. </li></ul>
    16. 16. No IgG Reactions <ul><li>The absence of reactions in this test may be due to several possibilities: </li></ul>
    17. 17. <ul><li>Allergix Profile </li></ul><ul><li>52-year-old male </li></ul>
    18. 18. <ul><li>52-year-old male, generally in good health </li></ul><ul><li>Interested in losing weight </li></ul><ul><li>Heartburn </li></ul><ul><li>History of antibiotic use due to chronic diarrhea </li></ul><ul><li>Regular, loose stools </li></ul><ul><li>Oral thrush </li></ul><ul><li>GIfx revealed dysbiosis and several opportunistic bacteria </li></ul>Presenting Symptoms
    19. 20. GIfx Immunology markers
    20. 21. <ul><li>Gluten-free diet </li></ul><ul><li>Focused on healing the gut: </li></ul><ul><ul><li>Paleofiber 2 tbs/d </li></ul></ul><ul><ul><li>Factor IV — Bifidobacter sp. only probiotic </li></ul></ul><ul><ul><li>Biotagen prebiotic </li></ul></ul><ul><ul><li>Digestive Enzymes </li></ul></ul><ul><ul><li>Plant enzymes </li></ul></ul><ul><ul><li>GI Revive </li></ul></ul><ul><ul><li>Betaine HCl </li></ul></ul>Treatment
    21. 22. <ul><li>Treatment </li></ul><ul><ul><li>Continued with previous protocol for gut healing and elimination diet </li></ul></ul><ul><ul><li>Increased Betaine HCl </li></ul></ul><ul><li>Losing weight </li></ul>Follow-up (3 months)
    22. 23. <ul><li>Anti-gliadin antibody has improved with elimination of gluten. </li></ul>Immunology
    23. 24. <ul><li>Patient’s diet is much improved </li></ul><ul><li>Still gluten-free </li></ul><ul><li>Weight loss of 65 lbs. </li></ul><ul><li>Patient wasn’t mentally prepared to accept such dramatic improvements </li></ul>Follow-up (6 months)
    24. 26. Immunology
    25. 27. Conclusion <ul><li>IgG Reactions: </li></ul><ul><ul><li>High incidence </li></ul></ul><ul><ul><li>Cause a variety of chronic symptoms </li></ul></ul><ul><ul><li>Usually unsuspected as an offending food </li></ul></ul><ul><ul><li>Offending foods removed and/or rotated from diet </li></ul></ul><ul><li>IgE Reactions: </li></ul><ul><ul><li>Low incidence </li></ul></ul><ul><ul><li>Cause short term symptoms </li></ul></ul><ul><ul><li>Usually known as offending food </li></ul></ul><ul><ul><li>Offending foods permanently removed from diet </li></ul></ul>

    ×