Mesothelioma Emerging Treatments


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A look at emerging therapies in the treatment of mesothelioma

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  • Mesothelioma Emerging Treatments

    1. 1. New Mesothelioma Treatments A look at emerging therapies for the treatment of mesothelioma. Additional information about the therapies mentioned in this presentation can be found here: http://
    2. 2. Emerging Mesothelioma Treatments <ul><li>Traditional treatment for mesothelioma patients has been surgery, chemotherapy or radiation. </li></ul><ul><li>In some cases, depending on a patient’s status, a combination of these therapies (multi-modality) will be used </li></ul><ul><li>However, even with combination therapy, patient response is generally low </li></ul>
    3. 3. New Approaches <ul><li>In an effort to find new and effective ways to treat mesothelioma, physicians have begun testing some of the following therapies in both clinical trials and laboratory settings. </li></ul><ul><li>For current clinical trials that may include some of these new therapies, visit our page on mesothelioma clinical trials </li></ul>
    4. 4. Anti-Angiogenesis Treatment <ul><li>Angiogenesis refers to the growth/development of blood vessels </li></ul><ul><li>Cancerous tumors require their own blood vessels to grow. </li></ul><ul><li>One possible method of treatment involves anti-angiogenesis drugs that inhibit tumor growth by preventing vascular endothelial growth factor, a protein secreted by some cancerous cells, from reaching receptors that help build blood vessels </li></ul>
    5. 5. Immunotherapy/Biological Therapy <ul><li>Immunotherapy is using the body’s own immune system to target cancerous cells </li></ul><ul><li>Researchers have discovered that the immune system can be capable of recognizing healthy cells vs. cancerous cells and can target cancerous cells for removal. </li></ul><ul><li>Substances used to promote immunotherapy are called biological response modifiers (BRM)s </li></ul><ul><li>BRMs may be used to: </li></ul><ul><ul><li>Enhance the immune system </li></ul></ul><ul><ul><li>Eliminate, regulate, or suppress body responses that permit cancer growth. </li></ul></ul><ul><ul><li>Make cancer cells more susceptible to destruction by the immune system. </li></ul></ul><ul><ul><li>Alter cancerous cell growth patterns to those of normal cells. </li></ul></ul><ul><ul><li>Block or reverse the transformation of a normal cell into a cancer cell. </li></ul></ul><ul><ul><li>Prevent a cancer cell from spreading (metastasis) </li></ul></ul>
    6. 6. Photodynamic Therapy PDT <ul><li>Based on the premise that cells treated with photosensitive drugs will die when exposed to light at particular frequencies </li></ul><ul><li>Drug is administered intravenously and accumulates in diseased cells and is removed from healthy cells </li></ul><ul><li>Laser light is administered to cancerous sites and the light activates an active form of oxygen that destroys surrounding cancer cells </li></ul><ul><li>Timing is crucial because the therapy needs to occur when the drug has been removed from healthy cells but is still present in cancerous cells </li></ul>
    7. 7. Gene Therapy <ul><li>Treatment modifies expression of individual genes towards a therapeutic approach </li></ul><ul><li>Two forms </li></ul><ul><ul><li>Replacement gene therapy replaces a mutated or missing gene with an original in an attempt to control cell division </li></ul></ul><ul><ul><li>Knockout gene therapy targets the products of oncogenes in an attempt to render them inactive and ultimately recude cell growth </li></ul></ul>
    8. 8. Alternative Medicine <ul><li>Alternative medicine covers healing and treatment approaches not accepted or offered by conventional medicine </li></ul><ul><li>Some forms of alternative medicine can be useful in managing side effects </li></ul><ul><li>It is recommended you discuss any alternative therapies with your doctor. For instance some nutritional supplements can interfere with anti-cancer drugs and lessen their potency </li></ul>
    9. 9. Virotherapy <ul><li>Virotherapy attempts to attack a tumor by using a virus that is created to attack certain cells </li></ul><ul><li>This form of treatment is in the laboratory stages but virotherapy has produced some promising results </li></ul>
    10. 10. Unconventional Therapies <ul><li>Patients and their families may come across “unconventional therapies” while researching cancer treatments </li></ul><ul><li>These treatments are often described as curing terminal illnesses but aren’t used by mainstream medicine because of coverups, corporations, etc… </li></ul><ul><li>These do not work and waste valuable treatment time. Please consult with your physician if you have any questions. </li></ul>
    11. 11. More Information <ul><li>There are ongoing clinical trials involving some of the therapies mentioned. </li></ul><ul><li>If you would like more information on current clinical trials for mesothelioma visit: http:// </li></ul>