Mesothelioma Emerging Treatments
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Mesothelioma Emerging Treatments

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A look at emerging therapies in the treatment of mesothelioma

A look at emerging therapies in the treatment of mesothelioma

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  • Prepared by Mesotheliomaweb.org

Mesothelioma Emerging Treatments Mesothelioma Emerging Treatments Presentation Transcript

  • New Mesothelioma Treatments A look at emerging therapies for the treatment of mesothelioma. Additional information about the therapies mentioned in this presentation can be found here: http:// www.mesotheliomaweb.org/newapproaches.htm
  • Emerging Mesothelioma Treatments
    • Traditional treatment for mesothelioma patients has been surgery, chemotherapy or radiation.
    • In some cases, depending on a patient’s status, a combination of these therapies (multi-modality) will be used
    • However, even with combination therapy, patient response is generally low
  • New Approaches
    • In an effort to find new and effective ways to treat mesothelioma, physicians have begun testing some of the following therapies in both clinical trials and laboratory settings.
    • For current clinical trials that may include some of these new therapies, visit our page on mesothelioma clinical trials
  • Anti-Angiogenesis Treatment
    • Angiogenesis refers to the growth/development of blood vessels
    • Cancerous tumors require their own blood vessels to grow.
    • One possible method of treatment involves anti-angiogenesis drugs that inhibit tumor growth by preventing vascular endothelial growth factor, a protein secreted by some cancerous cells, from reaching receptors that help build blood vessels
  • Immunotherapy/Biological Therapy
    • Immunotherapy is using the body’s own immune system to target cancerous cells
    • Researchers have discovered that the immune system can be capable of recognizing healthy cells vs. cancerous cells and can target cancerous cells for removal.
    • Substances used to promote immunotherapy are called biological response modifiers (BRM)s
    • BRMs may be used to:
      • Enhance the immune system
      • Eliminate, regulate, or suppress body responses that permit cancer growth.
      • Make cancer cells more susceptible to destruction by the immune system.
      • Alter cancerous cell growth patterns to those of normal cells.
      • Block or reverse the transformation of a normal cell into a cancer cell.
      • Prevent a cancer cell from spreading (metastasis)
  • Photodynamic Therapy PDT
    • Based on the premise that cells treated with photosensitive drugs will die when exposed to light at particular frequencies
    • Drug is administered intravenously and accumulates in diseased cells and is removed from healthy cells
    • Laser light is administered to cancerous sites and the light activates an active form of oxygen that destroys surrounding cancer cells
    • Timing is crucial because the therapy needs to occur when the drug has been removed from healthy cells but is still present in cancerous cells
  • Gene Therapy
    • Treatment modifies expression of individual genes towards a therapeutic approach
    • Two forms
      • Replacement gene therapy replaces a mutated or missing gene with an original in an attempt to control cell division
      • Knockout gene therapy targets the products of oncogenes in an attempt to render them inactive and ultimately recude cell growth
  • Alternative Medicine
    • Alternative medicine covers healing and treatment approaches not accepted or offered by conventional medicine
    • Some forms of alternative medicine can be useful in managing side effects
    • It is recommended you discuss any alternative therapies with your doctor. For instance some nutritional supplements can interfere with anti-cancer drugs and lessen their potency
  • Virotherapy
    • Virotherapy attempts to attack a tumor by using a virus that is created to attack certain cells
    • This form of treatment is in the laboratory stages but virotherapy has produced some promising results
  • Unconventional Therapies
    • Patients and their families may come across “unconventional therapies” while researching cancer treatments
    • These treatments are often described as curing terminal illnesses but aren’t used by mainstream medicine because of coverups, corporations, etc…
    • These do not work and waste valuable treatment time. Please consult with your physician if you have any questions.
  • More Information
    • There are ongoing clinical trials involving some of the therapies mentioned.
    • If you would like more information on current clinical trials for mesothelioma visit: http:// www.mesotheliomaweb.org/newapproaches.htm