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IS THERE A LINK BETWEEN THE DIET OF PREGNANT WOMEN AND THE RISK OF DEVELOPING PREECLAMPSIA?
AIMS <ul><li>No specific aetiology has been discovered for preeclampsia.  </li></ul><ul><li>This study aims to identify wh...
WHAT IS PREECLAMPSIA? <ul><li>Affects between 3% and 10% of pregnant women </li></ul><ul><li>hypertension (≥ 140/90 mmHg) ...
WHAT ARE THE DANGERS? <ul><li>Perinatal Mortality </li></ul><ul><li>Intrauterine growth restriction of the fetus  </li></u...
RISKS OF PREECLAMPSIA <ul><li>There are defined independent risks for preeclampsia  </li></ul><ul><ul><li>hypertension </l...
METHODOLOGY <ul><li>This will be a descriptive quantitative study to identify whether there is a link between the diet and...
METHODS <ul><li>Sample  –  1,000 women   from a variety of maternity settings </li></ul><ul><li>Inclusion criteria  –  wom...
EXAMPLES OF QUESTIONS
DATA ANALYSIS <ul><li>Questionnaire to be coded to enable data analysis </li></ul><ul><li>Interpretation – to include freq...
EXPECTED OUTCOMES <ul><li>This study may bring to light food groups that are risk factors for preeclampsia </li></ul><ul><...
References <ul><li>Bodnar, L.M., Tang, G., Ness, R.B., Harger, G., & Roberts, J.M. (2006, June). Periconceptional multivit...
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Transcript of "Preeclampsia research presentation"

  1. 1. IS THERE A LINK BETWEEN THE DIET OF PREGNANT WOMEN AND THE RISK OF DEVELOPING PREECLAMPSIA?
  2. 2. AIMS <ul><li>No specific aetiology has been discovered for preeclampsia. </li></ul><ul><li>This study aims to identify whether there is a link between overall diet and the risk of developing preeclampsia </li></ul>
  3. 3. WHAT IS PREECLAMPSIA? <ul><li>Affects between 3% and 10% of pregnant women </li></ul><ul><li>hypertension (≥ 140/90 mmHg) with proteinuria (≥ 1+ on urine dipstick) after 20 weeks of gestation </li></ul>
  4. 4. WHAT ARE THE DANGERS? <ul><li>Perinatal Mortality </li></ul><ul><li>Intrauterine growth restriction of the fetus </li></ul><ul><li>Preterm labour </li></ul><ul><li>In the developed world there is a fivefold increase of </li></ul><ul><li>perinatal mortality of infants born to preeclamptic </li></ul><ul><li>mothers </li></ul><ul><li>Maternal Death </li></ul><ul><li>One of the leading causes </li></ul><ul><li>Responsible for 10-15% of maternal deaths in </li></ul><ul><li>the developed world </li></ul><ul><li>Responsible for 20-80% of maternal deaths in </li></ul><ul><li>the developing world </li></ul>
  5. 5. RISKS OF PREECLAMPSIA <ul><li>There are defined independent risks for preeclampsia </li></ul><ul><ul><li>hypertension </li></ul></ul><ul><ul><li>obesity </li></ul></ul><ul><ul><li>diabetes </li></ul></ul><ul><ul><li>DIET? </li></ul></ul>
  6. 6. METHODOLOGY <ul><li>This will be a descriptive quantitative study to identify whether there is a link between the diet and nutritional supplements of pregnant women (prior to and throughout their pregnancy) and the occurrence of preeclampsia. </li></ul>
  7. 7. METHODS <ul><li>Sample – 1,000 women from a variety of maternity settings </li></ul><ul><li>Inclusion criteria – women that fit the definition of pre-eclampsia </li></ul><ul><li>Exclusion criteria – women who have pre-determined risk factors to pre-eclampsia </li></ul><ul><li>Instrument – food frequency questionnaire </li></ul><ul><li>Data collection – education by research assistants 4 weeks after birth </li></ul>
  8. 8. EXAMPLES OF QUESTIONS
  9. 9. DATA ANALYSIS <ul><li>Questionnaire to be coded to enable data analysis </li></ul><ul><li>Interpretation – to include frequency distribution </li></ul><ul><li>Multivariate pattern analysis </li></ul><ul><li>Cluster analysis </li></ul>
  10. 10. EXPECTED OUTCOMES <ul><li>This study may bring to light food groups that are risk factors for preeclampsia </li></ul><ul><li>Subsequent risk could be reduced by implementing valid and researched nutritional advice based on this research </li></ul><ul><li>This in turn could reduce neonatal and maternal mortality rates </li></ul>
  11. 11. References <ul><li>Bodnar, L.M., Tang, G., Ness, R.B., Harger, G., & Roberts, J.M. (2006, June). Periconceptional multivitamin use reduces the risk of preeclampsia. Epidemiology, 164 (5), 470-477. Retrieved March 23 2010 from Midirs database. </li></ul><ul><li>Fred Hutchinson Cancer Research Centre. (2010). Food frequency questionnaires . Retrieved from http://www.fhcrc.org/science/shared_resources/nutrition/ffq/gsel.pdf </li></ul><ul><li>Haugen, M., Brantsœter, A.L., Trogstad, L., Alexander, J., Roth, C., Magnus, P., & Meltzer, H.M. (2009, September). Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology, 20 (5), 720-726. Retrieved March 23 2010 from Midirs database. </li></ul><ul><li>Hu, F.B (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Current Opinion in Lipidology 13 (1) 3-9 </li></ul><ul><li>Israel, G.D. (2009) Determining sample size. Retrieved from http://edis.ifas.ufl.edu/pd006 </li></ul><ul><li>Kourlaba, G., Panagiotakos, D.B., & Stavrinos, V. (2008). The diagnostic accuracy of composite indices is associated with the number of partitions of their components: a simulation study. Advances and Applications in Statistics 8 : 89–99. </li></ul><ul><li>Meads, C.A., Cnossen, J.S., Meher, S., Juarez-Garcia, A., ter Riet, G., Duley, L, Roberts, T.E., Mol, B.W., Van der Post, J.A., Leeflang, M.M, Barton, P.M., Hyder, C.J., Gupta, J.K, & Khan, K.S. (2008). Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modeling. Health technology assessment 12 (6) 1-286. Retrieved from http://www.hta.ac.uk </li></ul><ul><li>Peterson, H. (2010). Genetic studies of preeclampsia. Stockholm: Karolinksa Institutet, Department of Biosciences and Nutrition. </li></ul><ul><li>Roberts, J.M., Balk, J.L., Bodnar, L.M., Belizán, J.M., Bergel, E., & Martinez, A. (2003, May). Nutrient involvement in preeclampsia. The Journal of Nutrition, 133, 1684S-1692S. Retrieved March 23 2010 from Midirs database. </li></ul><ul><li>Zhang, C., Williams, M., King, I.B., Dashow, E.E., Sorensen, T.K., Frederick, I.O., & Luthy, D. (2002, January). Vitamin C and the risk of preeclampsia – results from dietary questionnaire and plasma assay. Epidemiology, 13 (4), 409-416. Retrieved March 22 2010 from Midirs database. </li></ul>
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