Online Bioscience Course for IT Professionals Spring 2010
Class Mechanics… <ul><li>View online video lecture every Monday (1-2 hour) </li></ul><ul><li>Comment on video lecture usin...
Lecture 1: Biosciences Overview
Take Homes: <ul><li>What is Life? </li></ul><ul><li>The Cell is the Basic Unit of Life on Earth </li></ul><ul><li>All Life...
http:// www.youtube.com/watch?v =zKNZjP9BdCw The “Big Picture”-an Overview
http:// www.youtube.com/watch?v =zKNZjP9BdCw
What is Life?: Dictionary.com  Unabridged (v 1.1)  -  Cite This Source  -  Share This   life            laɪf/  Pronunciati...
Problems?: <ul><ul><ul><li>viruses?  </li></ul></ul></ul><ul><ul><ul><li>Mimivirus ( http:// en.wikipedia.org/wiki/Mimivir...
Alien Life… “ The Andromeda Strain”  http:// www.youtube.com/watch?v =aqGztEExN4Y
http:// www.youtube.com/watch?v =aqGztEExN4Y The Andromeda Strain: It’s a Crystal!
<ul><ul><ul><li>CHONPS+”minor contaminants” based… </li></ul></ul></ul><ul><ul><ul><li>H 2 O solvent </li></ul></ul></ul><...
Take Home I <ul><ul><ul><li>What is Life? </li></ul></ul></ul>Terrestrial living systems are all based on carbon compounds...
The Basic Unit of Life on Earth is the Cell-and there are Two Types: Prokaryote Eukaryote plant animal
Prokaryotic Cell Structure Prokaryote=no nucleus
Eukaryotic Animal Cell Structure Eukaryote=has a nucleus
Eukaryotic Plant Cell Structure
http:// www.youtube.com/watch?v =MMrvmZ2i1sE The “Inner Life” of a Eukaryotic Cell
http:// www.youtube.com/watch?v =MMrvmZ2i1sE The “Inner Life” of a Eukaryotic Cell
Size-Eukaryotes are Generally Bigger than Prokaryotes
Prokaryotes & Eukaryotes have  Different Genetic Structures as  Well…
Take Home II <ul><ul><ul><li>The Cell is the Basic Unit of Life on Earth </li></ul></ul></ul>There are two types of cells,...
from  Doolittle, W. Ford (1997) Proc. Natl. Acad. Sci. USA 94, 12751-12753 The Tree of Life:
<ul><li>Most of modern cell and molecular biology has been  </li></ul><ul><li>derived from the study of about 8 “model” or...
Take Home III <ul><ul><ul><li>All Life on Earth is Related  via  a Common Ancestor </li></ul></ul></ul>All organisms on ea...
The “Central Dogma”  of Molecular Biology: DNA RNA PROTEIN START STOP TRANSCRIPTION TRANSLATION REPLICATION GENE CODONS AM...
The “Central Dogma” in Action: http:// www.youtube.com/watch?v = NJxobgkPEAo
The “Central Dogma” in Action: http:// www.youtube.com/watch?v = NJxobgkPEAo
Molecular Biology's Central Dogma- The Movie! (everything to scale)! http:// www.youtube.com/watch?v =GkdRdik73kU
Molecular Biology's Central Dogma- The Movie! (everything to scale)! http:// www.youtube.com/watch?v =GkdRdik73kU
Take Home IV <ul><ul><ul><li>The “Central Dogma” of Molecular Biology </li></ul></ul></ul>All known Earth organisms use DN...
Proteins act as Enzymes: http:// www.youtube.com/watch?v = cbZsXjgPDLQ
Proteins act as Enzymes: http:// www.youtube.com/watch?v = cbZsXjgPDLQ
Proteins act as Machines: http:// www.youtube.com/watch?v =InIha7bCTjM&feature=related
Proteins act as Machines: http:// www.youtube.com/watch?v =InIha7bCTjM&feature=related
Take Home V <ul><ul><ul><li>All Life can be Understood in Chemical Terms </li></ul></ul></ul>All known Earth organisms use...
Next Week: Biomolecules, Viruses and Cells More details on the chemicals and molecules that make up cells and viruses…what...
Instructor Mark E Minie PhD [email_address]
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Lecture 1 bioscience overview 592010 post

  1. 1. Online Bioscience Course for IT Professionals Spring 2010
  2. 2. Class Mechanics… <ul><li>View online video lecture every Monday (1-2 hour) </li></ul><ul><li>Comment on video lecture using website discussion </li></ul><ul><li>board </li></ul><ul><li>Attend the online Office Hour on Wednesday at 12 NOON </li></ul><ul><li>online using tokbox.com and webcam </li></ul><ul><li>Online Final Exam given 7/7/2010 </li></ul>
  3. 3. Lecture 1: Biosciences Overview
  4. 4. Take Homes: <ul><li>What is Life? </li></ul><ul><li>The Cell is the Basic Unit of Life on Earth </li></ul><ul><li>All Life on Earth is Related via a Common Ancestor </li></ul><ul><li>The “Central Dogma” of Molecular Biology </li></ul><ul><li>All Life can be Understood in Chemical Terms </li></ul>
  5. 5. http:// www.youtube.com/watch?v =zKNZjP9BdCw The “Big Picture”-an Overview
  6. 6. http:// www.youtube.com/watch?v =zKNZjP9BdCw
  7. 7. What is Life?: Dictionary.com Unabridged (v 1.1) - Cite This Source - Share This life       laɪf/ Pronunciation Key - Show Spelled Pronunciation [lahyf] Pronunciation Key - Show IPA Pronunciation noun, plural lives       laɪvz/ Pronunciation Key - Show Spelled Pronunciation [lahyvz] Pronunciation Key - Show IPA Pronunciation , adjective – noun 1.the condition that distinguishes organisms from inorganic objects and dead organisms, being manifested by growth through metabolism, reproduction, and the power of adaptation to environment through changes originating internally. 2.the sum of the distinguishing phenomena of organisms, esp. metabolism, growth, reproduction, and adaptation to environment.
  8. 8. Problems?: <ul><ul><ul><li>viruses? </li></ul></ul></ul><ul><ul><ul><li>Mimivirus ( http:// en.wikipedia.org/wiki/Mimivirus ) </li></ul></ul></ul><ul><ul><ul><li>prions? </li></ul></ul></ul><ul><ul><ul><li>self replicating proteins ( http:// en.wikipedia.org/wiki/Prions ) </li></ul></ul></ul><ul><ul><ul><li>non-replicating organisms? </li></ul></ul></ul><ul><ul><ul><li>Neurons…don’t replicate… </li></ul></ul></ul><ul><ul><ul><li>computer programs? </li></ul></ul></ul><ul><ul><ul><ul><li>Computer viruses </li></ul></ul></ul></ul><ul><ul><ul><ul><li>SPORE ( http://en.wikipedia.org/wiki/Spore_(2008_video_game ) </li></ul></ul></ul></ul><ul><ul><ul><li>many other examples? </li></ul></ul></ul><ul><ul><ul><li>Crystals </li></ul></ul></ul><ul><ul><ul><li>DNA nanomachines (PMID: 18654284 ) </li></ul></ul></ul>
  9. 9. Alien Life… “ The Andromeda Strain” http:// www.youtube.com/watch?v =aqGztEExN4Y
  10. 10. http:// www.youtube.com/watch?v =aqGztEExN4Y The Andromeda Strain: It’s a Crystal!
  11. 11. <ul><ul><ul><li>CHONPS+”minor contaminants” based… </li></ul></ul></ul><ul><ul><ul><li>H 2 O solvent </li></ul></ul></ul><ul><ul><ul><li>self-contained (Cells) </li></ul></ul></ul><ul><ul><ul><li>self-replicating </li></ul></ul></ul><ul><ul><ul><li>DNA/RNA/PROTEIN/LIPID/CARBOHYDRATE </li></ul></ul></ul><ul><ul><ul><li>components (“PARTS”) </li></ul></ul></ul><ul><ul><ul><li>Adaptive short-term (interacts with environment </li></ul></ul></ul><ul><ul><ul><li>in “real-time”) </li></ul></ul></ul><ul><ul><ul><li>Adaptive long-term (interacts with environment in </li></ul></ul></ul><ul><ul><ul><li>“ deep-time”) </li></ul></ul></ul>For our Purposes:
  12. 12. Take Home I <ul><ul><ul><li>What is Life? </li></ul></ul></ul>Terrestrial living systems are all based on carbon compounds and use liquid water. They are self-contained, use macromolecules such as nucleic acids and proteins to function, and react to and adapt to their environment over the short-term (movement) and also over the long-term (evolution).
  13. 13. The Basic Unit of Life on Earth is the Cell-and there are Two Types: Prokaryote Eukaryote plant animal
  14. 14. Prokaryotic Cell Structure Prokaryote=no nucleus
  15. 15. Eukaryotic Animal Cell Structure Eukaryote=has a nucleus
  16. 16. Eukaryotic Plant Cell Structure
  17. 17. http:// www.youtube.com/watch?v =MMrvmZ2i1sE The “Inner Life” of a Eukaryotic Cell
  18. 18. http:// www.youtube.com/watch?v =MMrvmZ2i1sE The “Inner Life” of a Eukaryotic Cell
  19. 19. Size-Eukaryotes are Generally Bigger than Prokaryotes
  20. 20. Prokaryotes & Eukaryotes have Different Genetic Structures as Well…
  21. 21. Take Home II <ul><ul><ul><li>The Cell is the Basic Unit of Life on Earth </li></ul></ul></ul>There are two types of cells, prokaryotes and eukaryotes, each of which have very different structures, genetic mechanisms and behaviors yet are composed of mostly the same kinds of biomolecules and have very similar genetic codes…
  22. 22. from Doolittle, W. Ford (1997) Proc. Natl. Acad. Sci. USA 94, 12751-12753 The Tree of Life:
  23. 23. <ul><li>Most of modern cell and molecular biology has been </li></ul><ul><li>derived from the study of about 8 “model” organisms: </li></ul><ul><ul><li>E. coli </li></ul></ul><ul><ul><li>Yeast </li></ul></ul><ul><ul><li>C. elegans (nematode) </li></ul></ul><ul><ul><li>Drosophila (Fruit Fly) </li></ul></ul><ul><ul><li>Arabidopsis (plant) </li></ul></ul><ul><ul><li>Mouse </li></ul></ul><ul><ul><li>Rat </li></ul></ul><ul><ul><li>Human </li></ul></ul><ul><li>Based on the principle of conservation through evolution, </li></ul><ul><li>the lessons learned from these “models” are assumed to </li></ul><ul><li>be applicable to all terrestrial cells and organisms…there </li></ul><ul><li>are exceptions however…more on this later…much later… </li></ul>Model Organisms:
  24. 24. Take Home III <ul><ul><ul><li>All Life on Earth is Related via a Common Ancestor </li></ul></ul></ul>All organisms on earth are related by evolution from a common ancestor which existed on Earth about 4-3.5 billion years ago…this fact allows us to use studies of a few “Model” organisms to form the basis for our understanding of all Life…
  25. 25. The “Central Dogma” of Molecular Biology: DNA RNA PROTEIN START STOP TRANSCRIPTION TRANSLATION REPLICATION GENE CODONS AMINO ACIDS
  26. 26. The “Central Dogma” in Action: http:// www.youtube.com/watch?v = NJxobgkPEAo
  27. 27. The “Central Dogma” in Action: http:// www.youtube.com/watch?v = NJxobgkPEAo
  28. 28. Molecular Biology's Central Dogma- The Movie! (everything to scale)! http:// www.youtube.com/watch?v =GkdRdik73kU
  29. 29. Molecular Biology's Central Dogma- The Movie! (everything to scale)! http:// www.youtube.com/watch?v =GkdRdik73kU
  30. 30. Take Home IV <ul><ul><ul><li>The “Central Dogma” of Molecular Biology </li></ul></ul></ul>All known Earth organisms use DNA, RNA and Proteins. These “parts” function according to the so called “Central Dogma” of Molecular Biology… DNA>RNA>PROTEIN
  31. 31. Proteins act as Enzymes: http:// www.youtube.com/watch?v = cbZsXjgPDLQ
  32. 32. Proteins act as Enzymes: http:// www.youtube.com/watch?v = cbZsXjgPDLQ
  33. 33. Proteins act as Machines: http:// www.youtube.com/watch?v =InIha7bCTjM&feature=related
  34. 34. Proteins act as Machines: http:// www.youtube.com/watch?v =InIha7bCTjM&feature=related
  35. 35. Take Home V <ul><ul><ul><li>All Life can be Understood in Chemical Terms </li></ul></ul></ul>All known Earth organisms use proteins to accomplish such basic functions as metabolism and movement, and as such all biological activity can be understood in chemical terms
  36. 36. Next Week: Biomolecules, Viruses and Cells More details on the chemicals and molecules that make up cells and viruses…what they look like and how they work…
  37. 37. Instructor Mark E Minie PhD [email_address]

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