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Central dogma
 

Central dogma

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    Central dogma Central dogma Presentation Transcript

    • PROTEIN Transcription Translation DNA RNA
      • Transcription of DNA to RNA to protein : This dogma forms the backbone of molecular biology and is represented by THREE major stages.
      • 1. Replication.
      • 2. Transcription .
      • 3. Translation .
      • Unwinding of DNA to produce a copy during a cell division.
      • The enzymes involved were helicase,polymerase,
      • RNA primase,ligase.
      • The leading strand operate in a continous fashion
      • Whereas the lagging strand is not in a continous fashion (okazaki fragments)
      • Copying of part of DNA strand (base pair of a gene)
      • by complementary base pairs.
      • Only one strand of DNA (the template strand) is transcribed.
      • RNA polymerase opens the part of the DNA to be transcribed.
    •  
    • codon=3 base pairs= responsible for amino acid building blocks of amino acid=protein
      • The ribosome binds to the mRNA at the start codon (AUG)
      • During this stage, complexes, composed of an amino acid linked to tRNA, sequentially bind to the appropriate codon in mRNA by forming complementary base pairs with the tRNA anticodon .
      • 2 subunits (large and small) form a 3D groove
      • 2 major sites:
      • P site---holds the growing polypeptide
      • A site---new amino acids enter here
      • The ribosome moves from codon to codon along the mRNA. Amino acids are added one by one, translated into polypeptidic sequences dictated by DNA and represented by mRNA.
      • At the end, a release factor binds to the stop codon, terminating translation and releasing the complete polypeptide from the ribosome.
    •