More of Mendel
What we know…1. Inheritance of biological characteristics   is determined by genes2. Principle of Dominance  –   When ther...
Does the segregation of 1 pair of alleles affect thesegregation of another pair         of alleles?
• Let’s look at Pea shape and pea color  – Round (R) vs. wrinkled (r)  – Yellow (Y) vs. green (y)• Remember, there are 4 p...
Make a test cross of: •True breeding Round Yellow Peas          •Genotype (RRYY)•True breeding Wrinkled Green peas        ...
• What is the phenotype of the F1  offspring?• What is the genotype of the F1  offspring?
What this first cross        told us…• All F1 offspring were heterozygous for  seed shape (round) and seed color (yellow) ...
Now cross these hybrid(RrYy) plants on a new 4X4     Punnett Square
What does the F2 cross        tell us?• Are there combinations of alleles that we  did not see in either of the parents?• ...
Principle of Independent       Assortment• Genes for different traits can  segregate independently during the  formation o...
Mendel’s 4 Principle’s1. Inheritance of biological   characteristics is determined by   genes2. Principle of Dominance3. L...
Exceptions to Mendel• Genetics more complicated• Some alleles are neither dominant  nor recessive• Many traits are control...
Incomplete Dominance• When red flowered (CRCR) plants were  crossed with white flowered (CWCW) plants  they made…pink flow...
Codominance• Both alleles contribute to the phenotype• Chickens   – Allele for black feathers is codominant with allele fo...
Multiple Alleles• When a gene has more than two alleles• NOT more than 2 alleles for a person but MORE than 2 alleles for ...
Polygenic Traits•   ―Poly‖ many•   ―-genic‖ genes•   Traits controlled by two or more genes•   Several genes interact to p...
Epistasis• When the expression of one gene effects the expression of  another gene• Ex. Fur color in mice…controlled by 2 ...
Homework• Complete a Dihybrid cross for 2 mice  that are heterozygous for both  Brown fur (Bb) and Pigment  deposition (Pp...
Genes and the          Environment• Genes provide the plan for development• How the plan unfolds depends on the  environme...
Genes
Applying Mendel’s   Principles…• Apply Mendel’s Principles to many  organisms, including humans• Thomas Hunt Morgan (1900’...
• Would genes on the same chromosome be inherited together?• Thomas noticed that almost every  single time he crossed two ...
Gene Linkage• Thomas Hunt Morgan gave us the answer  – 1910 PRINCIPLE of LINKAGE  – 50 Drosophilia genes  – Seemed to cont...
• Linkage groups are made up of genes  that seem to be inherited together• Linkage groups assort independently  but all ge...
Conclusions1. Each chromosome is actually a group of linked   genes2. Mendel’s Principle of Independent Assortment   holds...
How Mendel missed it…• What 7 genes did he study?• 6 of the 7 genes were on different  chromosomes• Two genes were on the ...
• If two genes are on the  same chromosome, does  that mean they are linked  for ever?  – No, chromosomes cross    over du...
Lucky Student•   Alfred Sturtevant 1911•   Columbia University•   Worked in Morgan’s Lab•   Hypothesis    – If two genes a...
Gene Linkage and           Crossing Over• The farther apart 2 genes are on a  chromosome….  – The more likely they are to ...
1.                 Steps for Dihybrid cross          Make a Key     1.         Trait 1: height           1.       Dominant...
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
Genetics part 2
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Genetics part 2

  1. 1. More of Mendel
  2. 2. What we know…1. Inheritance of biological characteristics is determined by genes2. Principle of Dominance – When there are two or more alleles for a gene, some are dominant while others are recessive3. Law of Segregation – In sexually reproducing organisms, adult cells have two copies of each gene—one from each parent; these genes segregate when GAMETES are formed
  3. 3. Does the segregation of 1 pair of alleles affect thesegregation of another pair of alleles?
  4. 4. • Let’s look at Pea shape and pea color – Round (R) vs. wrinkled (r) – Yellow (Y) vs. green (y)• Remember, there are 4 possible gametes• If a parent is homozygous dominant (true- breeding dominant) for both shape and color, what will all possible gametes be?• If a parent is homozygous recessive (true- breeding recessive) for both shape and color, what will all possible gametes be?
  5. 5. Make a test cross of: •True breeding Round Yellow Peas •Genotype (RRYY)•True breeding Wrinkled Green peas •Genotype (rryy) ry ry ry ry RY RY RY RY
  6. 6. • What is the phenotype of the F1 offspring?• What is the genotype of the F1 offspring?
  7. 7. What this first cross told us…• All F1 offspring were heterozygous for seed shape (round) and seed color (yellow) RrYy• The F1 plant was made from fusing a gamete carrying RY and a gamete carrying ry• Will the dominant alleles stay together or separate when making the F2 offspring?
  8. 8. Now cross these hybrid(RrYy) plants on a new 4X4 Punnett Square
  9. 9. What does the F2 cross tell us?• Are there combinations of alleles that we did not see in either of the parents?• This means that the alleles for seed color separated independently than the alleles for seed shape• Genes that segregate separately do NOT influence each other’s inheritance
  10. 10. Principle of Independent Assortment• Genes for different traits can segregate independently during the formation of gametes. This principle helps account for many genetic variations in plants, animals and other organisms.
  11. 11. Mendel’s 4 Principle’s1. Inheritance of biological characteristics is determined by genes2. Principle of Dominance3. Law of Segregation4. Principle of Independent Assortment
  12. 12. Exceptions to Mendel• Genetics more complicated• Some alleles are neither dominant nor recessive• Many traits are controlled by multiple alleles or multiple genes
  13. 13. Incomplete Dominance• When red flowered (CRCR) plants were crossed with white flowered (CWCW) plants they made…pink flowers (CRCW)• Which allele is dominant? – neither• Incomplete dominance: – Case in which one allele is not dominant over another – The heterozygous phenotype is somewhere between the two homozygous phenotypes
  14. 14. Codominance• Both alleles contribute to the phenotype• Chickens – Allele for black feathers is codominant with allele for white feathers – Chicken looks speckled with black and white feathers – Not like the blending of dominant phenotypes… – BOTH dominant phenotypes show up• In humans – Gene for protein that controls cholesterol levels in the blood – People with heterozygous form make both types of protien
  15. 15. Multiple Alleles• When a gene has more than two alleles• NOT more than 2 alleles for a person but MORE than 2 alleles for the trait exist• Coat color in rabbits – A single gene for coat color – At least 4 different alleles – Simple dominance and make 4 possible coat colors• Genes for human blood type – 3 different alleles: IA, IB, I • You can get different genotypes: – IAIA – IAi – IAIB – IBIB – I bi – ii • You can get different Phenotypes: – Type A (dom) – Type B (dom) – Type AB (dom) – Type O (recessive)
  16. 16. Polygenic Traits• ―Poly‖ many• ―-genic‖ genes• Traits controlled by two or more genes• Several genes interact to produce a trait• Wide range of phenotypes• Skin color – Four different genes• Fruit Fly eye color – Three genes make the reddish brown pigment
  17. 17. Epistasis• When the expression of one gene effects the expression of another gene• Ex. Fur color in mice…controlled by 2 separate genes – Gene 1 • Brown fur pigment (BB or Bb) is dominant over gray fur pigment (bb) – Gene 2 • Coat Pigment depositing gene • Dominant gene (CC or Cc) means fur will get pigment and this is determined by gene one • Recessive gene (cc) means that no pigment will be deposited on fur…whether the they have the gene for black or brown fur • The gene for Pigment Deposition is the EPISTATIC gene because it alters the Phenotypic ration• Sd
  18. 18. Homework• Complete a Dihybrid cross for 2 mice that are heterozygous for both Brown fur (Bb) and Pigment deposition (Pp)• Predict your phenotypic ratio…• What are you final phenotypic ratios?• Write a paragraph explaining your results.
  19. 19. Genes and the Environment• Genes provide the plan for development• How the plan unfolds depends on the environment• Example: – Sunflower has genes for height and color of flowers – But these traits are also influenced by climate, soil conditions and water availability
  20. 20. Genes
  21. 21. Applying Mendel’s Principles…• Apply Mendel’s Principles to many organisms, including humans• Thomas Hunt Morgan (1900’s) – American geneticist – Common fruit fly • Drosophilia melanogaster • Produced offspring very quickly • Single pair of flies=100 offspring• Mendel’s principle’s were tested with Drosophilia and many other organisms and they applied to all of them as well
  22. 22. • Would genes on the same chromosome be inherited together?• Thomas noticed that almost every single time he crossed two flies that each had red eyes and mini wings, the offspring almost always inherited BOTH red eyes and mini wings – This went against Mendel’s Principle of Independent Assortment…(review!)
  23. 23. Gene Linkage• Thomas Hunt Morgan gave us the answer – 1910 PRINCIPLE of LINKAGE – 50 Drosophilia genes – Seemed to contradict Principle of Independent Assortment b/c certain genes were always inherited together – He grouped the fly’s genes into linkage groups
  24. 24. • Linkage groups are made up of genes that seem to be inherited together• Linkage groups assort independently but all genes in one group are inherited together• Drosophilia – 4 linkage groups – 4 chromosomes• What can be concluded?
  25. 25. Conclusions1. Each chromosome is actually a group of linked genes2. Mendel’s Principle of Independent Assortment holds true but an adjustment needs to be made… IT IS THE CHROMOSOMES THAT ASSORT INDEPENDENTLY, NOT THE INDIVIDUAL GENES
  26. 26. How Mendel missed it…• What 7 genes did he study?• 6 of the 7 genes were on different chromosomes• Two genes were on the same chromosome but they were so far apart on the same chromosome that they assorted independently
  27. 27. • If two genes are on the same chromosome, does that mean they are linked for ever? – No, chromosomes cross over during meiosis so they can separate – Crossing over produces new combinations of alleles – Important for genetic diversity
  28. 28. Lucky Student• Alfred Sturtevant 1911• Columbia University• Worked in Morgan’s Lab• Hypothesis – If two genes are farther apart on a chromosome, the they are more likely to be separated during meiosis• Experiment – Measured the rate at which linked genes were separated and recombined to make a ―map‖ of distances between genes• Conclusion – Recombination rates could be used to make gene maps – Gene maps showed the location of a gene on a chromosome
  29. 29. Gene Linkage and Crossing Over• The farther apart 2 genes are on a chromosome…. – The more likely they are to ―cross-over‖• The closer two genes are on the same chromosome… – The less likely they are to be separated
  30. 30. 1. Steps for Dihybrid cross Make a Key 1. Trait 1: height 1. Dominant phenotype: Tall TT or Tt (ways to get it) 2. Recessive phenotype: Short tt 2. Trait2: color 1. 2. Dominant phenotype: Purple Recessive phenotype: White pp PP or Pp • Dominant- capital letter D 3. Write out genotypes for each parent • Recessive- lower case d 3. ____x____2. Write Out Gametes for each Parent (use • Homozygous- arrows) – 2 of the same size letter 1. 4 gametes for each parent (_ _) – If its two little letters3. Make Punnett Square (16) boxes recessive dd 1. Label parent one and write gametes along top 2. Label Parent 2 and write their gametes on side – If its 2 big letters it is 3. Fill in each box (should have 4 letters) dominant DD4. Tally genotypes • Heterozygous-5. Write out 4 possible phenotypic combinations 1. Dominant trait 1 and dominant for trait – 2 different size letters 2:______ (capital and lowercase) Dd 2. Dominant trait 1 and recessive trait 2:_______ – ALWAYS dominant 3. Recessive trait 1 and Dominant trait 2:_______ 4. Recessive trait 1 and recessive trait 2:________6. Tally Phenotypes (should =16)7. Write phenotypic ratio 1. __dd__:__dr__:__rd__:__rr__
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