SLAS 2014 - Society for Laboratory Automation and Screening

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SLAS 2014 - Society for Laboratory Automation and Screening

  1. 1. Preliminary Program Short Courses: January 18-19 Conference: January 20-22 Exhibition: January 19-21 SLAS2014.org Premier Sponsor:
  2. 2. What Makes Slas2014 Unique? World-class educational content: Peer-selected podium presentations, posters and short courses tailor-made for life sciences research and development professionals looking to leverage technology and automation to further research and improve scientific outcomes. Expansive, interactive products and services exhibition: See the latest laboratory technologies, talk one-on-one with product experts, seek insight from experienced users, and leave SLAS2014 prepared to develop a roadmap for new products to drive objectives at your organization. Visit SLAS2014.org for the latest event details and to register. Questions? Visit SLAS2014.org or contact SLAS Global Headquarters by phone at +1.877.990.SLAS (7527) or by e-mail at slas@slas.org. Join a community you can count on year-round: With more than 5,500 professionals from across the globe expected to attend, plentiful networking opportunities allow you to connect with thousands of practicing scientists, researchers, engineers, academics and technology experts who attend SLAS2014. These relationships yield productive benefits and expedite problem-solving cycles for months, if not years, after the final conference session.
  3. 3. Contents 4 5 8 14 22 29 31 32 33 35 37 What’s New Short Courses Keynotes Schedule SIGs Exhibition Hotel & Travel Career Path Board & Committees Sponsors Registration SLAS2014.org 3
  4. 4. What’s New at SLAS2014 The SLAS annual conference has earned the well-deserved reputation of being a pre-eminent industry event due to its unique combination of peer-reviewed education, new product information and intelligent networking opportunities. To enhance the attendee experience at SLAS2014, the following elements have been added to this year’s program. See detailed descriptions later in this program and on SLAS2014.org. Satellite Symposiums Sunday, January 19 Pioneering Stem Cell Research for Regenerative Medicine A satellite symposium held in conjunction with the Sanford Consortium at their facility in La Jolla, CA Monday, January 20 Innovative Technologies for the Discoveries of New Medicines A satellite symposium held in conjunction with the Genomics Institute for the Novartis Research Foundation (GNF) at their facility in San Diego, CA Short Course Introduction to the Derivation and Maintenance of Human-Induced Pluripotent Stem Cells Special Updates SLAS affairs in Europe and Asia Enhanced Career Counseling Individual mentoring by American Chemical Society (ACS) San Diego members, and expert-led workshops on interviewing and professional networking Special Sessions • Disruptive Technologies (Live Streaming) • Phenotypic vs. Target Based Drug Discovery SLAS2014 Conference App Use your smartphone or tablet to stay on top of the latest SLAS2014 news, plan your itinerary, review session abstracts, take notes, visit the e-poster gallery, view a virtual exhibition floor map and exhibitor listing, and more with the new SLAS2014 conference app for iOS and Android devices, available as a free download in early 2014. Watch SLAS2014.org for information. Sponsored by
  5. 5. Short Courses Seventeen unique short courses allow you to explore a specific scientific technology topic on an in-depth basis. From introductory through advanced level curricula, SLAS2014 Short Courses are oneor two-day offerings led by expert instructors that deliver in-depth education and training in a convenient, concentrated format. Short course attendance is limited and requires an additional registration fee. For additional information on the Short Course program, visit SLAS2014.org/shortcourses. Saturday, January 18, 8:30 am - 4:30 pm SLAS2014 Short Courses are popular ways to explore key scientific topics Establishing Cell-Based Assays for Screening This course describes developing standard procedures for handling cultured cells to set up cell-based assays, techniques for measuring cell health and the pathways leading to cytotoxicity, developing siRNA screening assays, and an overview of various GPCR screening methods. Terry Riss Promega Lisa Minor In Vitro Strategies LLC Geoffrey Bartholomeusz UT M.D. Anderson Cancer Center Liquid Handling Boot Camp—A Beginner’s Hands-On Introduction to Lab Automation Learn about lab automation in a hands-on environment. One third of the class time is lecture and two thirds is hands-on work with the robots. Douglas Gurevitch University of California, San Diego Petar Stojadinović National University NEW Introduction to the Derivation and Maintenance of Human-Induced Pluripotent Stem Cells This course provides an overview on the basic biology and laboratory techniques required to derive and maintain human induced pluripotent stem cell (iPS) lines from skin fibroblasts. Additional topics include characterization assays for iPS and Embryonic Stem cells (ES) with an emphasis on the use of fluorescence activated cell sorting (FACS) and flow cytometry (FCM) and protocols for the derivation of neural lineage cell lines. David J. Kahler The New York Stem Cell Foundation Justin Ichida Justin Provchy Amgen Sunday, January 19, 8:30 am - 4:30 pm 3D Cell-Based Assays for Drug De-Risking The continually rising numbers of compound failures and increasing costs of drug and substance development are fostering the use of biologically more complex cell models. Physiological relevance is a key parameter of improving the predictive power of cell-based assays. This course covers advanced 3D cell culture technologies and their use in substance testing. University of Southern California Ursula Graf-Hausner Kelvin Lam University of Applied Sciences Zürich Simplex Pharma Advisors Jens M. Kelm InSphero AG, Zürich SLAS2014.org 5
  6. 6. Applied Information Technology for the Laboratory This course provides decision makers and practitioners from bio-pharma, healthcare, and academia with a comprehensive overview of IT topics and trends in laboratory automation, data management, and systems integration. Burkhard Schaefer BSSN Software Automating Scientific Data Analysis and Visualization with Excel and VBA (Laptop Required) This course explores advanced features of Excel 2007 and Excel 2010 that are useful to scientists and engineers. Topics covered include importing and processing experimental data, handling of data arrays, creation of custom user interfaces, curve fitting, and automatic generation of charts. Mark F. Russo Bryn Mawr College Stephen Carafello Green Iguana Productions LLC Automation for In Vitro Diagnostics In vitro diagnostics (IVD) entails the diagnosis, screening and monitoring of human diseases based on identification and quantification of small molecules, proteins, nucleic acids, or cells obtained from patient specimens. Automation has fundamentally changed the IVD industry and continues to play an important role in the move towards disseminated testing and personalized medicine. Angelika Niemz Keck Graduate Institute High-Content Screening: Instrumentation, Assay Development, Screening, Image and Data Analysis High-content screening is a powerful technology platform for implementing functional cell-based assays that allow truly multiparametric analysis in the physiological context of intact cells. This course provides a state-of-the-art overview of the components of HCS (instrumentation, reagents, HC assay development, automated image analysis and multi-parametric data analysis, and data standards) together with some showcases of small molecule and RNAi high-content screens in industry and academia. Eberhard Krausz ChemBioCon Vance Lemmon University of Miami James G. Evans Vala Sciences 6 SLAS2014 Preliminary Program Introduction to Laboratory Automation This course presents a broad introduction to laboratory automation in the R&D laboratory environment (i.e. non-clinical). A general understanding of a laboratory environment is helpful. Steven D. Hamilton SLAS Director of Education James M. Gill II Label-Free/Biophysics Methods for Screening Gain an overview of the most relevant biochemical biophysics/ label-free technologies for screening and lead finding. Learn just how this novel technologies toolbox helps drug discovery projects. This short course also focuses on biophysics assay applications and the detection, quantification and qualification of ligand/protein binding events. Christine Genick Novartis Delphine Collin Boehringer Ingelheim LIMS in the Organization This short course provides an overview of the system development lifecycle of a LIMS and the identification of the common issues and problems associated with the project. Robert D. McDowall McDowall Consulting Next Generation Sequencing Technology Fundamentals and Applications Next generation sequencing (NGS) technologies allow laboratories to do genome-wide research that was previously only possible at large genome centers. This course teaches the key concepts and applications of major sequencing technologies (Illumina, 454, SOLiD, Ion Torrent & PacBio) including their technology basics, sample preps, data analysis and associated IT supports. Dawei Lin National Institute of Health Ryan Kim University of California, Davis Genome Center
  7. 7. Sample Management: Best Practice, Trends and Challenges Presented in Partnership with the International Society for Biological and Environmental Repositories (ISBER) This course provides current status and considered best practice in the discipline of sample management. It focuses on the traditional aspects of compound management (including how to maintain and measure quality of compounds) but covers the synergies and differences in managing biologics. Consideration is given to key challenges and future directions. Because of the growth and interest in biological sample management, the course has been expanded to cover this discipline. Sue Holland Crimmin GlaxoSmithKline Katheryn Shea Two-Day Short Courses Saturday, January 18 Sunday, January 19 8:30 am - 4:30 pm Getting Started with Excel & VBA (Laptop Required) Excel is widely used in scientific laboratories to automate tedious data manipulation and presentation tasks. This course reviews many of the tools built into Excel for handling problems commonly encountered in the laboratory. It also introduces the use of Visual Basic for Applications scripting language as a way to customize Excel and expand upon its functionality. Precision for Medicine William Neil Martin Echols Technical Project Management Microfluidics I/II Course objectives include mapping the phases of a project introducing specific project management tools and discussing and demonstrating the application of these tools in the development and implementation of new technologies and processes for diagnostics, manufacturing and drug discovery. Simon English Invetech Brian Hanrahan Invetech This course is an introduction to microfluidics and the application of this technology in the life sciences. It is designed to give a compact overview of the most important aspects of working with liquids in confined spaces as well as the handling of minute amounts of chemicals, highlighting the essential differences between microfluidic-based approaches and more traditional biochemical analysis systems. Attendees receive a broad “first glimpse” impression of all the different bits and pieces (technological, physical and chemical) that are required to implement at functional lab-on-a-chip devices. Jörg P. Kutter University of Copenhagen Johan Nilsson Lund University Sabeth Verpoorte University of Groningen Pharmacokinetics and Pharmacodynamics in Drug Discovery This course is designed to equip biologists and chemists with an understanding of the principles of pharmacology as applied to the drug discovery process. Specifically, the two days focus on Pharmacokinetics (day 1) and Pharmacodynamics (day 2). This can be seen as being loosely based on the dose-response relationship as knowledge of both of these variables are needed in the assessment of therapeutic value. Terry Kenakin University of North Carolina SLAS2014.org 7
  8. 8. Keynote Speakers Sponsored by Eric J. Topol, M.D. Live streaming session – watch SLAS2014.org for details. Director, Scripps Translational Science Institute Monday, January 20, 9 - 10 am The Convergence of the Digital Era and Medicine We have the newfound capability to digitize human beings. This includes not only virtually all physiologic metrics (such as blood pressure, heart rhythm, etc.) that can be remotely monitored in real time, but also converting smartphones to laboratory instruments for assays of chemistries, genotypes, and a large range of critical biometrics. Furthermore, whole genome sequencing and related “omic” applications such as cancer tumor sequencing, RNA sequence, the microbiome, and epigenome – are providing unprecedented biological assessment of each individual. Collectively, these new tools provide the ability to render health care “unplugged” and enable the direct transmission of key data and information to the patient, which is transformative and likely represents the biggest shakeup in the history of the medicine. Jad Abumrad and Robert Krulwich Co-Hosts, Radiolab Wednesday, January 22, 3:45 - 4:45 pm Story vs. Sound vs. Science A discussion of their ups, downs, successes and failures in communicating — or trying to communicate—science. Abumrad and Krulwich talk about some of the techniques and tricks they’ve learned along the way and share some “tales from the front” including their complicated feelings about the Krebs Cycle, perfect pitch, musical language, brain body loops and mantis shrimp by way of deconstructed audio and video. Read the SLAS Electronic Laboratory Neighborhood (ELN) feature on Dr. Eric J. Topol. 8 SLAS2014 Preliminary Program View Here >
  9. 9. Allied Organizations at SLAS2014: An Exceptional Array of Access SLAS2014 features sessions, news, networking, innovation and unique access made possible by partnerships with other organizations whose missions are complementary to SLAS’s charter of serving the scientific community: Analytical, Life Science and Diagnostics Association (ALDA) Tuesday, January 21 at 7 - 9 am An invite-only session for senior executives featuring presentations on global trends in laboratory automation techniques, as well as their applications and their strategic implications. Association for Molecular Pathology (AMP) Tuesday, January 21 at 4:30 pm and Wednesday, January 22 at 9:30 am AMP representatives delivers presentations on special diagnostics and biomarkers. International Society for Biological and Environmental Repositories (ISBER) Sunday, January 19, 8:30 am – 4:30 pm New this year, SLAS partners with ISBER to present the Short Course, Sample Management: Best Practice, Trends and Challenges (additional fee required). Laboratory Products Association (LPA) Monday, January 20, 7 - 8 am LPA and SLAS host a special session to announce the preliminary results of the 2014 North American Laboratory Equipment Purchasing Trends Survey. SLAS2014 also features representatives and program contributions from an exceptional array of industry-leading, allied strategic partner organizations: Late Night with LRIG – Rapid Fire Innovation Session Monday, January 20, 6:30 – 8:30 pm Sponsored by the Laboratory Robotics Interest Group (LRIG), the San Diego LRIG Chapter, Bay Area LRIG Chapter, and the European Laboratory Robotics Interest Group (ELRIG) A traditional highlight of the conference, this session features an interactive forum including an overview, discussion and open Q&A about new technologies from 15 peer-selected companies. American Chemical Society (ACS) Society of Biomolecular Imaging and Informatics (SBI2) HCS/HCA Data and Informatics SIG Monday and Tuesday, January 20-21 Tuesday, January 21, 8 – 9:15 am Members of the American Chemical Society (ACS) San Diego chapter provides individual mentoring and career advice to SLAS2014 attendees. The HCS/HCA Data and Informatics SIG is presented in partnership with the Society of Biomolecular Imaging and Informatics (SBI2). The group will actively address issues in the area of information technology and foster discussions, information sharing and meetings among group members and SIG participants at SLAS2014. For details on these sessions and other strategic alliances at SLAS2014, visit SLAS2014.org/alliances SLAS2014.org 9
  10. 10. Pioneering Stem Cell Research for Regenerative Medicine researchers affiliated with the Sanford Consortium, along with a facility tour and networking reception. The latest program details are available at SLAS2014.org. Participation in this event is free to registered SLAS2014 attendees, though space is limited and advance registration is required. Complimentary round-trip bus transportation from the San Diego Convention Center is provided. Sanford Consortium for Regenerative Medicine in La Jolla, CA SLAS thanks the Sanford Consortium and event sponsors Cellular Dynamics International, DiscoveRx and High Res Biosolutions for their generous support in producing this symposium. Sunday, January 19, 12:30 – 4:30 pm SLAS is pleased to partner with the Sanford Consortium for Regenerative Medicine and event sponsors Cellular Dynamics International, DiscoveRx and HighRes Biosolutions to present Pioneering Stem Cell Research for Regenerative Medicine, a satellite symposium for SLAS2014 attendees. This symposium imparts the latest scientific developments in stem cell research aimed at diagnosing, treating and eventually curing degenerative disease through regenerative treatments. The program includes multiple scientific presentations by leading Satellite Symposia at SLAS2014 Innovative Technologies for the Discovery of New Medicines Genomics Institute of the Novartis Research Foundation in San Diego, CA Monday, January 20, 6:30 – 10 pm SLAS is pleased to collaborate with the Genomics Institute of the Novartis Research Foundation—and event sponsors Cisbio, Molecular Devices and Tecan—to present Innovative Technologies for the Discovery of New Medicines, a satellite symposium taking place in conjunction with SLAS2014. This symposium highlights technology and research at the Genomics Institute of the Novartis Research Foundation, a part of the Novartis Institutes for BioMedical Research. The program 10 SLAS2014 Preliminary Program includes scientific presentations by leading researchers and technologists affiliated with GNF, plus a tour of the GNF facility. The latest program details are available at SLAS2014.org. Participation in this event is free to registered SLAS2014 attendees, though space is limited and advance registration is required. Complimentary round-trip bus transportation from the San Diego Convention Center is provided. SLAS thanks the Genomics Institute of the Novartis Research Foundation and event sponsors Cisbio, Molecular Devices and Tecan for their generous support in producing this symposium.
  11. 11. Conference-at-a-Glance (Schedule Subject to Change) Saturday, January 18, 2014 7:30 am - 5 pm Registration Open (Short Course participants only.) Short Courses: Establishing Cell-Based Assays for Screening; Introduction to the Derivation and Maintenance of Human-Induced Pluripotent Stem Cells; Liquid Handling Boot Camp (Hands-on) 8:30 am - 4:30 pm Two-Day Courses: Drug Discovery Getting Started with Excel & VBA (Laptop Required); Microfluidics I/II; Pharmacokinetics and Pharmacodynamics in Sunday, January 19, 2014 (Short Course only registration is available.) 7:30 am - 7 pm 8:30 am - 4:30 pm Registration Open Short Courses: 3D Cell-Based Assays for Drug De-Risking; Applied Information Technology for the Laboratory; Automating Scientific Data Analysis and Visualization With Excel and VBA (Laptop Required); Automation for In Vitro Diagnostics; High Content Screening: Instrumentation, Assay Development, Screening, Image and Data Analysis; Introduction to Laboratory Automation; Label-Free/Biophysics Methods for Screening; LIMS in the Organization; Next Generation Sequencing Technology Fundamentals and Applications; Sample Management: Best Practice, Trends and Challenges; Technical Project Management Two-Day Courses: Getting Started with Excel & VBA (Laptop Required); Microfluidics I/II; Pharmacokinetics and Pharmacodynamics in Drug Discovery 12:30 - 4:30 pm Satellite Symposium: Pioneering Stem Cell Research for Regenerative Medicine 4:30 - 7 pm Exhibition Open 5:30 - 6:30 pm SLAS Student and Early Career Professionals Mixer 5:30 - 7 pm Welcome Reception in the Exhibit Hall Monday, January 20, 2014 7 - 8 am Laboratory Products Association (LPA) Special Session 7 - 8 am SLAS Career Connections: Joanne Kamens Session 7:30 am - 6 pm Registration Open 8 - 8:30 am Morning Beverage Break 8:30 - 9 am Keynote Session: Welcome and Opening Remarks 9 - 10 am Keynote Speaker: Eric J. Topol, Director, Scripps Translational Science Institute; The Convergence of the Digital Era and Medicine; Live Streaming Sponsored by Thermo Scientific 10 - 10:30 am Beverage Break in the Exhibit Hall 10 - 10:45 am Eric Topol Book Signing in SLAS Member Center 10 am - 6:30 pm SLAS Career Connections: Job Boards, One-on-One Career Coaching and ACS San Diego Chapter Mentoring Sessions 10 am - 6:30 pm Exhibition Open 10 am - 6:30 pm Poster Viewing in Exhibit Hall Assay Development and Screening Automation & High-Throughput Technologies Drug Target Biology Informatics Micro/Nano Technologies Special Session The Dynamic Lab: Informatics for Laboratory Operations Management Nanotechnology for Molecular Assays Disruptive Technologies (Live Streaming) Session 1 10:30 am - 12:30 pm Cell-Based Assay Development Advances in Integrated Chemical Synthesis Case Studies in Modern Phenotypic Drug Discovery 12:30 - 1:15 pm Exhibitor Tutorials: Agilent Technologies, Artel, PerkinElmer, TAP Biosystems, TTP Labtech 12:30 - 1:30 pm Lunch in the Exhibit Hall, Sponsored by Laboratory Products Association (LPA) 12:30 - 1:30 pm SLAS Career Connections: Joanne Kamens Session 12:30 - 1:45 pm Exhibitor Tutorials: Beckman Coulter, BioTek Instruments, BMG Labtech, Brooks Automation, Labcyte, Thermo Scientific, Wyatt Technology 12:45 - 1:45 pm Special Update: SLAS in Asia 12:45 - 1:45 pm Special Update: SLAS in Europe 1 - 1:30 pm SLAS Author Meet & Greet in Member Center: Pak Kin Wong, University of Arizona, Tucson 1 - 3 pm Poster Presentations (Even Numbered Posters) 1:30 - 2 pm SLAS Author Meet & Greet in Member Center: Yi-Chien Wu, University of California, Los Angeles 2 - 2:30 pm SLAS Author Meet & Greet in Member Center: Edward Chow, National University of Singapore SLAS2014.org 11
  12. 12. Conference-at-a-Glance (Continued) 2 - 2:45 pm Exhibitor Tutorials: Genedata, Hamamatsu, HighRes BioSolutions, Promega, Tecan 2:30 - 3 pm Beverage Break in the Exhibit Hall Assay Development and Screening Automation & High-Throughput Technologies Drug Target Biology Informatics Micro/Nano Technologies Special Session Data Mining in Chemical and Biological Spaces: If We Only Knew What We Knew? Scaling Up Microfluidic Diagnostics Phenotypic vs. Target-Based Drug Discovery Session 2 3 - 5 pm Biochemical Technologies and Screening Biophysical Techniques for Ligand Screening Case Studies and Approaches to Rare Diseases 5:30 - 6:30 pm Reception in Exhibit Hall Celebrating 2014 SLAS Journal Achievement Award Honorees 6:30 - 8:30 pm Late Night with LRIG - Rapid-Fire Innovation Session Sponsored by the Laboratory Robotics Interest Group (LRIG), the San Diego LRIG Chapter, Bay Area LRIG Chapter, and the European Laboratory Robotics Interest Group (ELRIG) 6:30 - 10 pm Satellite Symposium: Innovative Technologies for the Discovery of New Medicines Tuesday, January 21, 2014 7 - 8:15 am SLAS Career Connections: Mock Interviews: Preparation and Practice for Getting the Jobs You Want; Dan Eustace, University of Connecticut 7 - 9 am Analytical, Life Science and Diagnostic Association Special Session (Invitation Only) 7:30 - 8 am Morning Beverage Break 7:30 - 5:30 pm Registration Open 8 - 9:15 am Special Interest Groups: Academic Drug Discovery; ADMET; HCS/HCA Data and Informatics; Informatics; Labware Leachables 9:15 - 10 am Exhibitor Tutorials: Nanion Technologies 10 - 10:30 am Beverage Break in the Exhibit Hall 10 am - 6 pm SLAS Career Connections: Job Board, One-on-One Career Coaching and ACS San Diego Chapter Mentoring Sessions 10 am - 6 pm Exhibition Open 10 am - 6 pm Poster Viewing in the Exhibit Hall Assay Development and Screening Automation & High-Throughput Technologies Drug Target Biology Diagnostics & Biomarkers Informatics Micro/Nano Technologies Extracting Meaning from Complex Data Droplet and Digital Microfluidics Session 3 10:30 am - 12:30 pm Chemical Probes for Target Validation and Pathway Analysis 12:30 - 1:15 pm Exhibitor Tutorials: Agilent Technologies, Beckman Coulter, MaxCyte, PerkinElmer, TTP Labtech 12:30 - 1:30 pm Lunch Break in the Exhibit Hall; Sponsored by American Chemical Society San Diego 12:30 - 1:45 pm Exhibitor Tutorial: BMG Labtech, Brooks Automation, IntelliCyt, Labcyte, PerkinElmer, Qiagen 1 - 1:30 pm SLAS Author Meet & Greet in the Member Center: Thom Hughes, Montana Molecular 1 - 3 pm Poster Presentations (Odd Numbered Posters) 1:30 - 2 pm SLAS Author Meet & Greet in the Member Center: Peter Simpson, AstraZeneca 2 - 2:15 pm New Product Award Announcement 2 - 2:30 pm SLAS Author Meet & Greet in the Member Center: Joshua Kangas, Carnegie Mellon University and University of Pittsburgh 2 - 2:45 pm Exhibitor Tutorials: Genedata, m2p-labs, Promega, Tecan 12 SLAS2014 Preliminary Program Advances in HighThroughput Analytics and Automation Pathogen Detection & Identification Case Studies Using Stem Cells
  13. 13. Conference-at-a-Glance 2:30 - 3 pm (Continued) Beverage Break in the Exhibit Hall Automation & High-Throughput Technologies Assay Development and Screening Bioanalytical Techniques Diagnostics & Biomarkers Informatics Micro/Nano Technologies Oncology Converting Data to Knowledge Paper-Based Diagnostics Session 4 High Content Screening 3 - 5 pm Illumination of the Druggable Genome Through HighThroughput Technologies Bioanalytical Techniques for Stem Cells 5 - 6 pm Exhibition Closing Reception, featuring Passport to Prizes drawing 6:30 - 8:30 pm SLAStronomy: Networking Event (see page 27) Sponsored by Agilent Technologies Wednesday, January 22, 2014 7:30 - 8 am Morning Beverage Break 8 - 9:15 am Special Interest Groups: Automation Quality Control; Phenotypic Drug Discovery; Technology Transfer and CRO/CMO Project Management; Women Professionals in Science and Technology 8:30 am - 1:30 pm Registration Open 9 - 9:30 am Morning Beverage Break Assay Development and Screening Automation & High-Throughput Technologies Bioanalytical Techniques Diagnostics & Biomarkers Informatics Micro/Nano Technologies Novel Platforms for Personalized Medicine Pre-Competitive and Collaborative Solutions to Common Problems Single-Cell Analysis and Cell-Based Assays Session 5 9:30 - 11:30 am Expanding the Druggable Genome Innovations in Label Free, Multiplex and High Content Technologies Applications for NextGeneration Sequencing 11:30 am - 12 pm Lunch for Conference Participants 11:45 am - 1:15 pm JALA & JBS Author Workshop: How to Get Your Work Published 12 - 1:15 pm Special Interest Groups: Drug Repurposing; Sample Management; Screen Design and Assay Technology; Standards Initiatives; Stem Cells and 3D Microtissues Assay Development and Screening Automation & High-Throughput Technologies Bioanalytical Techniques Informatics Micro/Nano Technologies Emerging Trends for Labs of the Future Next Generation Cell-Based and Small Animal Assays Session 6 1:30 - 3:30 pm 3:45 - 5 pm How Chemistry Influences the Screening Strategy Applications of Automated Technologies in Quantitative Biology High-Throughput Target Identification Closing Keynote Speaker: Jad Abumrad and Robert Krulwich, Co-hosts, NPR’s Radiolab; Topic: Story vs. Sound vs. Science Sponsored by Thermo Scientific Announcement of the SLAS Innovation Award Winner Look Who’s Back! See his journey to SLAS2014 at SLAS2014.org SLAS2014.org 13
  14. 14. Conference Schedule (Schedule Subject to Change) Short Course Program is held on Saturday, January 18 and Sunday, January 19. For complete listing see pages 5-7. Sunday, January 19, 2014 7:30 am - 7 pm Registration Open 8:30 am - 4:30 pm Short Courses 12:30 - 4:30 pm Satellite Symposium: Pioneering Stem Cell Research for Regenerative Medicine 4:30 - 7 pm Exhibition Open 5:30 - 6:30 pm SLAS Student and Early Career Professionals Mixer 5:30 - 7 pm Welcome Reception in the Exhibit Hall Monday, January 20, 2014 7 - 8 am Laboratory Products Association (LPA) Special Session Sponsored by: 7 - 8 am SLAS Career Connections: Joanne Kamens Session 7:30 am - 6 pm Registration Open 8 - 8:30 am Morning Beverage Break 8:30 - 9 am Keynote Session: Welcome and Opening Remarks 9 - 10 am Keynote Speaker: Eric J. Topol, Director, Scripps Translational Science Institute; Topic: The Convergence of the Digital Era and Medicine Live Streaming 10 - 10:30 am Beverage Break in the Exhibit Hall 10 - 10:45 am Eric Topol Book Signing in SLAS Member Center 10 am - 6:30 pm SLAS Career Connections: Job Boards, One-on-One Career Coaching and ACS San Diego Chapter Mentoring Sessions 10 am - 6:30 pm Exhibition Open 10 am - 6:30 pm Poster Viewing in Exhibit Hall 10:30 am - 12:30 pm Assay Development and Screening Sponsored by: Cell Based Assay Development; Session Chair: Sabrina Corazza, Axxam 10:30 am Detection of Ca++ Transients in iPS-Derived Cardiomyocytes as a Measure of Cardiomyocyte Function: Establishment of an HTS-Ready Assay; Silke Schwengberg, Cells at Work Consulting & Services 11 am Characterization of the Cancer-Associated Fibroblast Phenotype of Human Mesenchymal Stem Cells and Fibroblast Using High Content Image Based Analysis; Yu-Chih Hsu, Eli Lilly and Company 11:30 am High-Throughput siRNA and Small Molecule Screens to Elucidate Cellular Pathways Involved in Human Papillomavirus Oncogenesis; Jennifer Smith, Harvard Medical School 12 pm A Bright Future: Where-Optogenetics Meets with Voltage Gated Ion Channels; Sabrina Corazza, Axxam 10:30 am - 12:30 pm Automation & High-Throughput Technologies 10:30 am Synthesis-to-Assay Automation: A Novel Approach to Speed up Hit to Lead Programs; Alberto Bresciani, IRBM Science Park SpA 11 am The Integration of Chemical Synthesis with Biological Screening – Rapid Generation of Structure Activity Relationship Data for Drug Discovery; David Parry, Cyclofluidic 11:30 am High-Throughput/High-Output Automated Workflow Solutions in Drug Development; Eva Lu Ping Wu, Chemspeed Technologies 12 pm Programmable Synthesis and Integrated Chemical Discovery Enabled by 3D-Printed Reactionware; Leroy Cronin, The University of Glasgow Advances in Integrated Chemical Synthesis; Session Chair: David Parry, Cyclofluidic #SLAS2014 14 SLAS2014 Preliminary Program Join the SLAS Social Media Communities Our online communities are growing every day. Stay up-to-date and join in the discussions. Sign-up now!
  15. 15. Conference Schedule 10:30 am - 12:30 pm (Schedule Subject to Change) Monday, January 20, 2014 (Continued) Drug Target Biology Case Studies in Modern Phenotypic Drug Discovery; Session Chair: Vance Lemmon, University of Miami 10:30 am Turning the Hearing Problem Inside Out: In Vivo Phenotypic Screening for Small Molecules to Prevent Hearing Loss; Edwin Rubel, University of Washington 11 am Where's the Target? The Use of Phenotypic Screening to Discover Innovative Drug Candidates; Rebecca Pruss, TROPHOS 11:30 am High-Content Phenotypic Profiling of Three-Dimensional Tissue by Biodynamic Imaging; David Nolte, Animated Dynamics 12 pm Heterogeneity in the Response of Cancer Cells to Cytokine Stimulation and STAT3 Inhibitors: Determining a Heterogeneity Index; D. Lansing Taylor, University of Pittsburgh 10:30 am - 12:30 pm Informatics 10:30 am Cheminformatics Workflows Using Mobile Apps for Drug Discovery; Sean Ekins, Collaborative Drug Discovery 11 am A Novel Approach for Managing Process Tracking in a Highly Diverse Workflow Environment; Melinda Sosa, Southern Research Institute 11:30 am ELNs & Evernote: How the Switch to Electronic Documentation Can Help Today’s Researchers; Emily Walsh, New York University School of Medicine 12 pm Managing Demand Fluctuations in the Dynamic Laboratory; Harold Weller, Bristol-Myers Squibb 10:30 am - 12:30 pm Micro/Nano Technologies 10:30 am Nanofluidic Technology for Innovative Protein and Peptide Kinetic Studies; Sumita Pennathur, University of California, Santa Barbara 11 am Synthetic Protein Nanocages: Controlled Assembly, Payload Encapsulation and Site-Specific Surface Conjugation for Therapeutic, Diagnostic and Screening Applications; Miguel de los Rios, Fabrus 11:30 am Diamond-Enhanced Nanomedicine; Dean Ho, Division or Oral Biology and Medicine; The Jane and Jerry Weintraub Center for Reconstructive Biotechnology; Department of Bioengineering; California NanoSystems Institute; Jonsson Comprehensive Cancer Center 12 pm Antibody Discovery with Droplet Microfluidics; Colin Brenan, HiFiBiO SAS 10:30 am - 12:30 pm Special Session 10:30 am Open Source Hardware in Regenerative Medicine; Jordan Miller, Rice University 11 am Quantitative Assessment of Target Engagement in Living Cells Using Bioluminescence Resonance Energy Transfer; Keith Wood, Promega 11:30 am Personalized Mass Spectrometers: A Dream Poised to Become Reality; Christopher Brown, 908 Devices 12 pm How do we Feel? Mechanisms of Thermo- and Mechano-Transduction; Michael Bandell, Genomics Institute of the Novartis Research Foundation 12:30 - 1:15 pm Exhibitor Tutorials: Agilent Technologies, Artel, PerkinElmer, TAP Biosystems, TTP Labtech 12:30 - 1:30 pm Lunch in the Exhibit Hall 12:30 - 1:30 pm SLAS Career Connections: Joanne Kamens Session 12:30 - 1:45 pm Exhibitor Tutorials: Beckman Coulter, BioTek Instruments, BMG Labtech, Brooks Automation, Labcyte, Thermo Scientific, Wyatt Technology 12:45 - 1:45 pm Special Update: SLAS in Asia 12:45 - 1:45 pm Special Update: SLAS in Europe 1 - 1:30 pm SLAS Author Meet & Greet in Member Center: Pak Kin Wong, University of Arizona The Dynamic Lab: Informatics for Laboratory Operations Management; Session Chair: Mark Russo, Bristol-Myers Squibb Nanotechnology for Molecular Assays; Session Chair: Sumita Pennathur, University of California, Santa Barbara Disruptive Technologies (Live Streaming); Session Chair: Dan Sipes, Genomics Institute for the Novartis Research Foundation 1 - 3 pm Poster Presentations (Even Numbered Posters) 1:30 - 2 pm SLAS Author Meet & Greet in Member Center: Yi-Chien Wu, University of California, Los Angeles 2 - 2:30 pm SLAS Author Meet & Greet in Member Center: Edward Chow, National University of Singapore 2 - 2:45 pm Exhibitor Tutorials: Genedata, Hamamatsu, HighRes BioSolutions, Promega, Tecan 2:30 - 3 pm Beverage Break in the Exhibit Hall 3 - 5 pm Sponsored by: Assay Development and Screening Biochemical Technologies and Screening; Session Chair: Yuhong Du, Emory Chemical Biology Discovery Center, Emory University 3 pm Multiplexed Protein-Protein and Protein-DNA Interaction Assay for Myc Inhibitor Discovery; Yuhong Du, Emory Chemical Biology Discovery Center, Emory University 3:30 pm Ligand Discovery for Glaucoma-Associated Myocilin Using a Generic Biochemical Binding Assay; Raquel Lieberman, Georgia Institute of Technology 4 pm Integrating Mechanism Into High-Throughput Screening: Kinase Screening Strategies That Maximize Hit Value; Maureen Beresini, Genentech 4:30 pm Understanding E3 Ligases and Their Role in Drug Discovery – An Overview of Assay Development and Screening for a RING E3 Ligase; Helen Boyd, AstraZeneca SLAS2014.org 15
  16. 16. Conference Schedule 3 - 5 pm (Schedule Subject to Change) Monday, January 20, 2014 (Continued) Automation & High-Throughput Technologies Biophysical Techniques for Ligand Screening; Session Chair: Michael Hennig, Roche 3 pm Advances in Biosensors Beyond Hit identification: Use of SPR for Binding Site Localization, Mechanism of Action, and Adaptive Hit Expansion During Fragment Screening; Anthony Giannetti, Genentech 3:30 pm HTS by NMR of Combinatorial Libraries: A New Approach to Target Protein-Protein Interactions; Maurizio Pellecchia, Sanford Burnham Medical Research Institute 4 pm Label-Free, Free-Solution Assays in the Study of Orthosteric and Allosteric GPCR Ligand Binding Using Back-Scattering Interferometry; Scot Weinberger, Molecular Sensing 4:30 pm A Flexible and Robust Strategy for Evaluating Potential Drug Targets Utilizing High-Throughput Mass Spectrometry; Karen Maegley, Pfizer Oncology 3 - 5 pm Drug Target Biology Case Studies and Approaches to Rare Diseases; Session Chair: Wei Zheng, National Center for Advancing Translational Sciences, National Institute of Health (NIH) 3 pm Phenotypic Screening for Lead Identification and Drug Development to Treat lysosomal Storage Diseases; Wei Zheng, National Center for Advancing Translational Sciences (NCATS), National Institute of Health (NIH) 3:30 pm Identification of Novel Small Molecular Chaperones for the Treatment of Gaucher Disease with Implications for Parkinsonism; Wendy Westbroek, National Human Genome Research Institute 4 pm Discovery and Development of the Potent and Selective EZH2 Inhibitor EPZ-6438 for Genetically Defined Non-Hodgkin Lymphoma; Alejandra Raimondi, Epizyme 4:30 pm Lessons Learned From a High-Throughput Phenotypic Screen: Gamma-Globin Induction Using Primary Human Bone Marrow Day 7 Erythroid Progenitor Cells; Hu Li, GlaxoSmithKline 3 - 5 pm Informatics Data Mining in Chemical and Biological Spaces: If We Only Knew What We Knew?; Session Chair: Andreas Bender, University of Cambridge 3 pm Integrating Chemical and Biological Data for Mode-of-Action Analysis, Anticipating Compound Toxicities and Compound Design; Andreas Bender, University of Cambridge 3:30 pm Efficient Sampling of Bioactive Chemical Space Through the Combination of Chemical and Biological Descriptors; Anne Wassermann, Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research 4 pm Quantitative High-Throughput Profiling of the Tox21 10K Compound Library for Environmental Hazards: Applications in Chemical Prioritization, Predictive Modeling and Mechanism of Toxicity Characterization; Ruili Huang, National Institute of Health (NIH)/National Center for Advancing Translational Sciences (NCATS) 4:30 pm Exploring Compound Combinations in High-Throughput Settings: Going Beyond 1D Metrics; Rajarshi Guha, National Center for Advancing Translational Sciences (NCATS) 3 - 5 pm Micro/Nano Technologies Scaling up Microfluidic Diagnostics; Session Chair: Catherine Klapperich, Boston University 3 pm Collagen Engineering for Simple, Consistent Production of Complex Model Tissues for Drug Discovery - “Stem Cell Niche in a Dish”; Rosemary Drake, TAP Biosystems 3:30 pm Design for Low Cost Manufacturing of Point of Care Microfluidic Devices; Alexis Sauer-Budge, Fraunhofer USA - CMI 4 pm Paper-Based Sensors for Low-Cost Diagnostics; Jason Rolland, Diagnostics For All 4:30 pm Nanoscale Spotting: Picoliter Droplet Dispensing to Enable High-Throughput Experimentation; Claude Dufresne, Scienion US 3 - 5 pm Special Session 3 pm The Value of Phenotypic Assays to Drug Discovery; David Swinney, Institute for Rare and Neglected Diseases Drug Discovery 3:30 pm Target – Based or Phenotypic Drug Discovery – Which is Better or is That the Wrong Question?; Frank Sams-Dodd, Willingsford Ltd. 4 pm Phenotypic Versus Target-Based Assays: Yin and Yang; Melvin Reichman, LIMR Chemical Genomics Center (LCGC) 4:30 pm A New Perspective on Phenotypic vs. Target-Based Screening; Bernard Munos, InnoThink Center for Research in Biomedical Innovation 5:30 - 6:30 pm Reception in Exhibit Hall Celebrating 2014 SLAS Journal Achievement Award Honorees 6:30 - 8:30 pm Late Night with LRIG - Rapid-Fire Innovation Session Sponsored by the Laboratory Robotics Interest Group (LRIG), the San Diego LRIG Chapter, Bay Area LRIG Chapter, and the European Laboratory Robotics Interest Group (ELRIG) 6:30 - 10 pm Satellite Symposium: Innovative Technologies for the Discovery of New Medicines Phenotypic vs. Target-Based Drug Discovery; Session Chair: Lorenz Mayr, AstraZeneca Tuesday, January 21, 2014 7 - 8:15 am 7 - 9 am SLAS Career Connections: Mock Interviews: Preparation and Practice for Getting the Jobs You Want; Dan Eustace, University of Connecticut Analytical, Life Science and Diagnostic Association Special Session (Invitation Only) 7:30 - 8 am Morning Beverage Break 7:30 am - 5:30 pm Registration Open 16 SLAS2014 Preliminary Program
  17. 17. Conference Schedule (Schedule Subject to Change) Tuesday, January 21, 2014 (Continued) 8 - 9:15 am Special Interest Groups: Academic Drug Discovery; ADMET; HCS/HCA Data and Informatics; Informatics; Labware Leachables 9:15 - 10 am Exhibitor Tutorials: Nanion Technologies 10 - 10:30 am Beverage Break in the Exhibit Hall 10 am - 6 pm SLAS Career Connections: Job Board, One-on-One Career Coaching and ACS San Diego Chapter Mentoring Sessions 10 am - 6 pm Exhibition Open 10 am - 6 pm Poster Viewing in the Exhibit Hall 10:30 am - 12:30 pm Assay Development and Screening 10:30 am I Only Have Eye for Ewe: Small-Molecule Modulators of the Hedgehog Pathway; James Chen, Stanford University 11 am A Gametocytocidal Screen for Identification of New Antimalarial Agents and Drug Targets; Wei Sun, National Center for Advancing Translational Sciences 11:30 am Novel High-Throughput Assays for Cytotoxic T lymphocyte Function Based on Flow Cytometry; Adam Zweifach, Department of Molecular and Cell Biology, University of Connecticut 12 pm High-Content Screen Reveals Novel Small Molecule Inducers of Promyelocytic Leukemia Nuclear Body (PML-NB) Formation; Christian Hassig, Sanford-Burnham Medical Research Institute 10:30 am - 12:30 pm Chemical Probes for Target Validation and Pathway Analysis; Session Chair: Christian Hassig, Sanford-Burnham Medical Research Institute Automation & High-Throughput Technologies Advances in High-Throughput Analytics and Automation; Session Chair: Harold Weller, Bristol-Myers Squibb 10:30 am Integrating Cutting-Edge Technologies that Enable High-Throughput Automation for Compound Library QC Management; Louis Scampavia, Scripps Research Institute 11 am Quest for a Mass Spectrometry-Based Plate Reader: Using Front-End Automation Technologies to Increase MS Throughput for Screening Support; Andrew Wagner, Bristol-Myers Squibb 11:30 am Optimizing High-Throughput LC/MS/MS Bioanalysis in Drug Discovery; Hui Zhang, Pfizer 12 pm High Throughput Screening for Modulators of Sirtuin 1 Using Mass Spectrometry Plate Reader; Shuwen Sun, University of Michigan 10:30 am - 12:30 pm Diagnostics & Biomarkers 10:30 am Fully Automated, Sample-to-Answer, High-Throughput Platforms for Molecular Diagnostic Assays; Daniel Kolk, Hologic|Gen-Probe 11 am Flexible and Fully-Automated Sample to Result PCR System ‘geneLEAD’ XII plus and geneLEAD I plus’; Tetsuya Ueda, Research and Development Division, Precision System Science 11:30 am Microfluidic Acoustic Trapping for Sepsis Diagnosis Using MALDI-MS; Simon Ekström, Lund University, LTH 12 pm An Improved Point of Care Solution for Nucleic Acid Analysis with Detection in 15 Minutes or Less; Cassie Keppel, MS 10:30 am - 12:30 pm Drug Target Biology Pathogen Detection & Identification; Session Chair: Daniel Kolk, Hologic|Gen-Probe Case Studies Using Stem Cells; Session Chair: Steve Rees 10:30 am Phenotypic Screening in Human iPSC-Derived Cardiomyocytes: Ischemia-Reperfusion Model; Siobhan Malany, Sanford Burnham Medical Research Institute 11 am Rapid and Efficient Conversion of Human Fibroblasts and Embryonic Stem Cells to Sensory Neurons; Joel Blanchard, Scripps Research Institute 11:30 am Use of Stem Cell Derived Cardiomyocytes for the Detection of Cardiotoxicity; Amy Pointon, AstraZeneca 12 pm Regenerating the Heart of a Non-Human Primate; Xiulan Yang, University of Washington 10:30 am - 12:30 pm Informatics Extracting Meaning From Complex Data; Chair: Ellen Berg, BioSeek, a Division of DiscoveRx 10:30 am Predictive Models for Mechanism of Action Classification from Phenotypic Assay Data – Application to Phenotypic Drug Discovery; Ellen Berg, BioSeek, a Division of DiscoveRx 11 am Finding Patterns in a Complex In Vitro Data Set: Insights From the ToxCast Project, a Screen of 1000 Environmental Chemicals x 780 In Vitro Assays; Judson Richard, U.S. EPA 11:30 am Probing the Interconnection of Pathways and Feedback Mechanisms Using a Combination Screening Approach; Timothy Smith, Genomics Institute of the Novartis Research Foundation 12 pm Data-Driven Prediction of Therapeutic Efficacy and Optimization of De Novo Drug Combinations on a Proteomic Scale; Hann Wang, University of California, Los Angeles SLAS2014.org 17
  18. 18. Conference Schedule 10:30 am - 12:30 pm (Schedule Subject to Change) Tuesday, January 21, 2014 (Continued) Micro/Nano Technologies Droplet and Digital Microfluidics; Session Chair: Amar Basu, Wayne State University 10:30 am Fluid Handling Operations in Droplet Microreactors: Optical Tweezing, Sorting, Particle Segregation, and Label Free Sensing in Picoliter Volumes; Amar Basu, Wayne State University 11 am Microfluidic Droplet Generation for Digital PCR; Luc Bousse, Bio-Rad 11:30 am Automated Hanging Drop Cell Spheroid Culture Using Digital Microfluidics; Andrew Aijian, University of California, Los Angeles, Department of Bioengineering 12 pm Proteins at the Water/Oil Interface In Droplet Microfluidics; Brett Litten, Global High-Throughput Screening Centre, Alderley Park 12:30 - 1:15 pm Exhibitor Tutorials: Agilent Technologies, Beckman Coulter, MaxCyte, PerkinElmer, TTP Labtech 12:30 - 1:30 pm Lunch Break in the Exhibit Hall 12:30 - 1:45 pm Exhibitor Tutorial: BMG Labtech, Brooks Automation, IntelliCyt, Labcyte, PerkinElmer, Qiagen 1 - 1:30 pm Sponsored by: SLAS Author Meet & Greet in the Member Center: Thom Hughes, Montana Molecular, Bozeman 1 - 3 pm Poster Presentations (Odd Numbered Posters) 1:30 - 2 pm SLAS Author Meet & Greet in the Member Center: Peter Simpson, AstraZeneca 2 - 2:15 pm New Product Award Announcement 2 - 2:30 pm SLAS Author Meet & Greet in the Member Center: Joshua Kangas, Carnegie Mellon University and University of Pittsburgh 2 - 2:45 pm Exhibitor Tutorials: Genedata, m2p-labs, Promega, Tecan 2:30 - 3 pm Beverage Break in the Exhibit Hall 3 - 5 pm Assay Development and Screening 3 pm Multi Parametric High Content Screening of Human Stem Cell-Derived Cardiomyocytes; Alex Savtchenko, SBMRI 3:30 pm High Content Analysis and 3D Microtissues – Friend or Foe?; Matthias Fassler, PerkinElmer 4 pm Development of a Fully Automated Ultra-High-Throughput Flow Cytometry Screening System to Enable Novel Drug Discovery; John Joslin, Genomics Institute of the Novartis Research Foundation (GNF) 4:30 pm Novel Technologies for Efficient and Specific RNAi in Mammalian Cells; Marc Bickle, MPI-CBG 3 – 5 pm Automation & High-Throughput Technologies High Content Screening; Session Chair: Edward Ainscow, Genomics Institute of the Novartis Research Foundation (GNF) Illumination of the Druggable Genome Through High-Throughput Technologies; Session Chair: Hugh Rosen, Scripps Research Institute 3 pm Functional, Chemoproteomic Interrogation of Kinome and Nucleotide Binding Space for Drug Discovery and Development; John Kozarich, ActivX Biosciences 3:30 pm Activity-Based Proteomics – Applications for Enzyme and Inhibitor Discovery; Benjamin Cravatt, Scripps Research Institute 4 pm Studying Gene Function in 3D Microtissue Models; Jens Kelm, InSphero AG 4:30 pm Illuminating the Druggable Genome: Scaffold Hopping in GPCRs; Hugh Rosen, Scripps Research Institute 3 - 5 pm Bioanalytical Techniques 3 pm Reprogramming of Somatic Cells to iPS Cells (iPSCs) Using Non-Integrative Methods; Kelvin Lam, Simplex Pharma Advisors 3:30 pm Genomic Architecture of Neurons From Stem Cells and Lineage Reprogramming; Justin Ichida, University of Southern California 4 pm Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting; David Kahler, The New York Stem Cell Foundation 4:30 pm Discovering the Optimal Microenvironments for Stem Cell Differentiation Using a High Content Array Method; Marie Zhang, MicroStem 3 - 5 pm Diagnostics & Biomarkers Bioanalytical Techniques for Stem Cells; Session Chair: Kelvin Lam, Simplex Pharma Advisors Oncology; Session Chair: Maureen Cronin, Celgene 3 pm A Multiplexed Label-Free Photonic Method for Rapidly Screening Soluble Human Leukocyte Antigen Peptide Complexes in Cancer Biomarker Discovery; Jon Weidanz, Texas Tech University Health Sciences Center 3:30 pm Prediction of Efficacious Drug Treatments for Leukemic Patients Using an Acoustic Dispensing-Driven Multiplexed Ex Vivo Drug Sensitivity Testing Platform; Krister Wennerberg, Institute for Molecular Medicine Finland FIMM, University of Helsinki 4 pm Validation and Clinical Application of a Cancer Genomic Profiling Test Using Next-Generation Sequencing; Garrett Frampton, Foundation Medicine 4:30 pm How Circulating Tumor Cells Can Help Identify Targets for New Cancer Drugs; Martin Fleisher, Memorial Sloan-Kettering Cancer Center 18 SLAS2014 Preliminary Program Sponsored by:
  19. 19. Conference Schedule (Schedule Subject to Change) Tuesday, January 21, 2014 (Continued) 3 - 5 pm Informatics 3 pm Clinical Diagnostics and Data Integration; Patrick Warren, The Children's Hospital of Philadelphia 3:30 pm A Semantic Computing Platform to Enable Translational and Clinical Omics; Jonathan Hirsch, Syapse 4 pm Informatics: Converting Data to Knowledge. First...What Is It That I Want To Know?; Paul Banfer, EISC Lab Data Automation 4:30 pm Using Open Source Tools and Public Data to Build Machine Learning Models in Support of Neglected Diseases Drug Discovery; Paul Kowalczyk, SCYNEXIS Converting Data to Knowledge; Session Chair: Art Morales, NIBR 3 - 5 pm Micro/Nano Technologies 3 pm The Role of Lateral Flow Devices in the Modern Food System; Frank Klein, Neogen 3:30 pm Aqueous Two-Phase Complex Fluid Systems for Improving the Detection Limit of the Lateral-Flow Immunoassay; Daniel Kamei, University of California, Los Angeles 4 pm Automated Recombinant Antibody Discovery Platform: Taking Phage Display to the Next Level; Marcin Paduch, Recombinant Antibody Network The University of Chicago 4:30 pm Kinase Strips for Routine Creations of Inhibitor Selectivity Profiles: A Novel approach to Targeted and Flexible Kinase Profiling; Hicham Zegzouti, Promega 5 - 6 pm Exhibition Closing Reception, featuring Passport to Prizes drawing 6:30 - 8:30 pm Paper-Based Diagnostics; Session Chair: Daniel Kamei, University of California, Los Angeles SLAStronomy: Networking Event (see page 27) Sponsored by: Wednesday, January 22, 2014 7:30 - 8 am Morning Beverage Break 8 - 9:15 am Special Interest Groups: Automation Quality Control Special Interest Group; Phenotypic Drug Discovery; Technology Transfer and CRO/CMO Project Management; Women Professionals in Science and Technology 8:30 am - 1:30 pm Registration Open 9 - 9:30 am Morning Beverage Break 9:30 - 11:30 am Assay Development and Screening Expanding the Druggable Genome; Session Chair: Anton Simeonov, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) 9:30 am Expanding the Druggable Space for Pulmonary Disease Through Proteostasis; William Balch, Scripps Research Institute 10 am Whole-Organism Screening for Parasitic Diseases; Michelle Arkin, Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco 10:30 am Developing a Successful Hit Identification Cascade for Glyoxalase 1; Andrew Clifton, AstraZeneca 11 am Discovery of NEDD8 System Inhibitors with Novel Mechanism of Action; Eduard Sergienko, Sanford-Burnham Medical Research Institute 9:30 - 11:30 am Automation & High-Throughput Technologies 9:30 am Duplexed Multiplexed Kinase Assays: In Search of Selective Mechanisms of Inhibition; Sanjay Saldanha, Bristol-Myers Squibb 10 am Implementation of an Automated MALDI High-Throughput Screening System for Drug Discovery; Scott Busby, Novartis Institutes for Biomedical Research 10:30 am SensiQ Pioneer: A Data-Rich SPR Platform for Rapid Biophysical Characterization of Protein-Small Molecule Interactions; Kartik Narayan, Merck 11 am Development of a Hollow Fiber Membrane Based High-Throughput Liquid-Liquid Micro-Extraction Method for the Analysis of Protein Binding; Youxin Li, Tianjin University 9:30 - 11:30 am Innovations in Label Free, Multiplex and High Content Technologies; Session Chair: Jonathan O’Connell, Bristol-Myers Squibb Bioanalytical Techniques Applications for Next-Generation Sequencing; Session Chair: Ken Patel, Sandia National Laboratories 9:30 am Multiplexed Detection of Pathogen Sequences by Heterologous Extension Ligation Sequencing Reaction (HELSR); David Hirschberg, Columbia University 10 am High-Throughput Artificial Membrane Platform for DNA Nanopore Sequencing; Jason Poulos, Librede 10:30 am High-Throughput Characterization and Spatial Analysis of Microbial Species Found in Environmental Samples: A Novel Whole Genome Metagenomic Sequencing Approach; Stanley Langevin, Sandia National Laboratories 11 am Using Bulk Lateral Ultrasonic (BLU) Energy for Increasing Hybridization Kinetics; Vibhu Vivek, Microsonic Systems Inc. SLAS2014.org 19
  20. 20. Conference Schedule 9:30 - 11:30 am 9:30 am (Schedule Subject to Change) Wednesday, January 22, 2014 (Continued) Diagnostics & Biomarkers Novel Platforms for Personalized Medicine; Session Chair: William Wachsman, University of California, San Diego and VASDHS Parallel Multi-Platform Region Specific Next Generation and Big Dye DNA Sequencing; Bert Gold, National Cancer Institute Sponsored by: 10 am Distributed Health Sensing at the Point of Care; Eliah Aronoff-Spencer, University of California, San Diego 10:30 am Micofluidic Platform for the Multiplexed Detection of miRNA, mRNA, and Proteins at Single-Cell Resolution; Meiye Wu, Sandia National Laboratory 11 am Portable Bioanalysis System for Cancer Stem Cell Quantification; Anjan Panneer Selvam, University of Texas at Dallas 9:30 - 11:30 am Informatics 9:30 am Improving the Drug Development Feedback Loop; Alpheus Bingham, InnoCentive 10 am Allotrope Foundation: Building an Open Framework for Laboratory Data; Janet Cheetham, Amgen 10:30 am HELM: Yet Another Open Standard or an Effective Tool for Handling Large Biologics?; Roland Knispel, ChemAxon 11 am Building the BioAssay Research Database – A Next-Generation Platform for Annotating and Understanding Chemical Biology Datasets.; Joshua Bittker, Broad Institute Pre-Competitive and Collaborative Solutions to Common Problems; Session Chair: Dana Vanderwall, Bristol-Myers Squibb 9:30 - 11:30 am Micro/Nano Technologies 9:30 am Rapid Detection of Bacteria in Blood Using Microencapsulated DNAzyme Sensors; Weian Zhao, University of California, Irvine 10 am High Speed Multi-Spectral Imaging and Analysis of Cells; William Ortyn, EMD Millipore 10:30 am Single-Cell, High-Plex Protein Secretion Profiling to Delineate Functional Cellular Heterogeneity; Rong Fan, Yale University 11 am Electrokinetic Sample Preparation and Volume Reduction for Single-Cell Antimicrobial Susceptibility Testing and Pathogen Detection; Yi Lu, University of Arizona 11:45 am - 1:15 pm JALA & JBS Author Workshop: How to Get Your Work Published 12 - 1:15 pm Special Interest Groups: Drug Repurposing; Sample Management; Screen Design and Assay Technology; Standards Initiatives; Stem Cells and 3D Microtissues Single-Cell Analysis and Cell-Based Assays; Session Chair: Tony Huang, PSU 1:30 - 3:30 pm Assay Development and Screening 1:30 pm Expanding Your HTS Library: Similarity, Diversity, Quality; Jonathan Baell, Monash Institute of Pharmaceutical Sciences 2 pm Protein-Protein-Interactions: The “Grand Challenge” of Modern Drug Discovery; Lorenz Mayr, AstraZeneca 2:30 pm The Efficient Interplay of Biophysical Sceening Methods in Fragment-Based Lead Generation; Dirk Ullmann, Evotec 3 pm Chemocentric HTS Triage and Hit Follow-Up; Michael Walters, Department of Medicinal Chemistry How Chemistry Influences the Screening Strategy; Session Chair: Gunda Georg, UMN 20 SLAS2014 Preliminary Program
  21. 21. Conference Schedule 1:30 - 3:30 pm (Schedule Subject to Change) Wednesday, January 22, 2014 (Continued) Automation & High-Throughput Technologies Applications of Automated Technologies in Quantitative Biology; Session Chair: Craig Schulz, Amgen 1:30 pm Automated Hybridoma Screening, Expansion, Archiving and Antibody Purification; Paul Anderson, Genomics Institute of the Novartis Research Foundation (GNF) 2 pm A Microfluidic DNA Library Preparation Platform for Next-Generation Sequencing; Mais Jebrail, Sandia National Labs/Department of Biotechnology & Engineering 2:30 pm FISHLiPS: A Case Study in Automating a Third-Party Analytical Device; Mike Berke, Amgen Automation 3 pm Qube - Bringing Direct Ion Channel Recordings to HTS; Richard Kondo, Sophion Bioscience 1:30 - 3:30 pm Bioanalytical Techniques High-Throughput Target Identification; Session Chair: Brian Paegel, Scripps Research Institute 1:30 pm Cross Competition as a Mechanistic Probe to Determining the Site of Action of Drug Candidates; Gaochao Tian, Biological Reagents and Assay Development, GlaxoSmithKline 2 pm High-Throughput Direct Measurement of Small Molecule Binding to Intracellular Targets; Jonathan P. Orme, AstraZeneca 2:30 pm Expanding the Proteomic Target ID Toolbox: Post-Translational Modification-Dependent Proteases; Brian Paegel, Scripps Research Institute 3 pm Using HTS to Define a Basis Set of RNA Motif-Small Molecules Interactions to enable the Design of Chemical Probes Targeting RNA; Matthew Disney, Scripps Research Institute 1:30 - 3:30 pm Informatics 1:30 pm Medical Device as an Object of Desire; Vadik Marmeladov, Lapka 2 pm TBD 2:30 pm Cross-Platform Operating System for Laboratory Automation; Gregory Linshiz, Lawrence Berkeley National Laboratory - Joint BioEnergy Institute (JBEI) 3 pm Intro to 3D Printing for the Lab; Eric Jones, National Center for Advancing Translational Sciences, National Institute of Health (NIH) 1:30 - 3:30 pm Micro/Nano Technologies 1:30 pm In Vivo Cellular-Resolution High-Throughput Whole-Animal Phenotyping; Mehmet Yanik, Massachusetts Institute of Technology 2 pm High-Throughput/High Content Technology for Automated Small Model Organism Manipulation and Analysis Developed for C.elegans, Drosophila and Zebrafish; Rock Pulak, Union Biometrica 2:30 pm On-Demand Optical Immobilization of C.elegans for Long-Term High-Resolution Imaging; Hyundoo Hwang, Georgia Institute of Technology 3 pm Microfluidic Devices for Cell Culture and Handling in Organ-on-a-Chip Applications; Claudia Gärtner, microfluidic ChipShop GmbH 3:45 - 5 pm Emerging Trends for Lab of the Future; Session Chair: Robin Smith, Artus Labs Next Generation Cell-Based and Small Animal Assays; Session Chair: Nikos Chronis, University of Michigan Closing Keynote Speaker: Jad Abumrad and Robert Krulwich, Co-hosts, NPR’s Radiolab; Topic: Story vs. Sound vs. Science; Announcement of the SLAS Innovation Award Winner Sponsored by: SLAS Point-to-Point E-News Brief This mobile-friendly weekly e-mail news brief keeps you up to date with SLAS news announcements, deadline reminders and selected industry headlines. Visit SLAS.org to sign up for a free subscription and browse the archives. SLAS2014.org 21
  22. 22. Special Interest Groups (SIGs) One of the key benefits of attending SLAS2014 is the ability to meet face-to-face with others in your area of interest and expertise. Over the course of the conference you enjoy the esteemed company and expertise of thousands of scientific peers with similar interests, professional roles and relevant experience— the opportunities to collaborate at the conference and beyond are unlimited. SLAS2014 features the following organized Special Interest Groups: Tuesday, January 21, 8 - 9:15 am Academic Drug Discovery Andrew Napper, Chair The Academic Drug Discovery SIG is a forum to discuss the challenges of chemical probe and lead discovery in universities and not-for-profit research centers. Active participation is welcome from vendors and pharmaceutical and biotech companies to maximize the impact of collaborative efforts to advance target validation and chemical probe and lead discovery projects originating in academic labs. In recent years greater understanding of disease biology and advances in assay technologies have led to high-throughput screens for numerous new targets. Overall, despite notable exceptions, these advances have not been matched by successful academic discovery chemistry leading to small molecule modulators of the new targets. Therefore, the question posed at the SLAS2014 Conference will be: “Academic drug discovery: What kinds of chemical libraries do we need to give us novel, high-value hits, and how do we access them?” Several experts provides short presentations and participate in a panel discussion with the audience to address this question. ADMET Time-Dependent Inhibition of Cytochrome P450: A Deep Dive Into Methods for Abbreviated Testing David M. Stresser, Chair Evaluation of time dependent inhibition (TDI) properties in drug candidates is generally required for any compound entering development. Methods to evaluate TDI, particularly in abbreviated formats, differ widely among laboratories and there appears to be misunderstandings and/or lack of consensus on how to address shortcomings in these assays. In this presentation, the experimental and theoretical considerations in the conduct of abbreviated TDI testing are covered in depth. Methods considered are the single Kobs, the progress curve, the measurement of partition ratios and the IC50 shift assay. The merits of multiple experimental variations in the IC50 shift assay, including in depth discussion on the use of a dilution step are explored. 22 SLAS2014 Preliminary Program HCS/HCA Data and Informatics Chip Allee and Paul Johnston, Chairs The Society for Biomolecular Imaging and Informatics (SBI2), is working with SLAS to reactivate the HCS/HCA Data and Informatics SIG for SLAS2014. The discussion topics include: • Developing algorithms for 3D+ image analysis and data mining such as clustering and phenotypic identification, and statistical methods used for this analysis – Discussion leader: Joy Prisco • HCS and HTS data analysis in the single cell world of flow cytometry – Discussion leader: J. Paul Robinson • HCS/HCA in vitro model systems for hepatotoxicity – Discussion leader: Joe Trask • Is there a need for standards in HCS/HCA? – Discussion leader: Paul Johnston Informatics Viral Vyas and Dawei Lin, Chairs The SLAS Informatics SIG is being developed in order to provide software developers an opportunity to better understand and influence the state of informatics in the laboratory. The focus of this SIG is on systems architecture from the board to the user interface and thus includes topics such as hardware/ software interfaces, data management, metadata management, asynchronous coding and operating systems, networking and “big data issues.” The Informatics SIG hopes to involve developers from academics, industry and the vendor community, and looks forward to partnering with other SIGs both inside and outside SLAS. Labware Leachables Lynn Rasmussen, Chair Plastics are ubiquitous in the modern world which includes the biology research laboratory. If we think about plastics at all we often assume that they are inert and have no effect on the things they contact. This ranges from your lunch to your current laboratory experiment. In reality plastics are not inert. They can absorb components from the liquids they come into contact with or leach components from the plastic manufacturing and molding process into those liquids. What the compositions of these leachates are and how to identify them is not clear. How they impact the experimental results is even less well understood. The Labware Leachables SIG was started to investigate the scope and impact of leachates on experimental data. Join us to learn more, share your experiences and discuss what actions should be taken to identify and quantify the chemicals that can leach from plastic ware.
  23. 23. Wednesday, January 22, 8 - 9:15 am Automation Quality Control Craig Schulz, Chair The implementation of laboratory automation has become an industry standard to alleviate tedious manual operations, improve data quality and increase throughput. However, relying on these devices should not be done in blind faith, as this equipment can and does fail. This SIG session focuses on quality metrics associated with the successful use and maintenance of laboratory automation. Topics of discussion include; instrument validation, techniques for QC, in-line process assessment, and instrument robustness. In addition, instrument lifecycle management highlighted with topics ranging from acquisition, qualification of automated versus manual techniques, equipment support models (vendor or internal), and strategies for equipment replacement. The intent of this discussion group is to share experiences on how to optimize and utilize laboratory automation to ensure it functions at its fullest potential. Phenotypic Drug Discovery An Open Discussion on Phenotypic Drug Discovery (PDD) Jonathan Lee, Chair The majority of modern drug discovery efforts incorporate reductionist views of biology where identification and validation of specific molecular targets form the foundation of the research strategy. In contrast, recent analysis indicates that the majority of first in class NMEs were discovered by target agnostic approaches relying on phenotypic strategies. Significantly, the disconnect between the prevalent use of TDD and the historical productivity of PDD comes at a time when the pharmaceutical industry is experiencing issues with research innovation and productivity. Pharmaceutical researchers need to reevaluate the “Molecular Mindset” that has dominated our collective drug hunting culture. To this end, the PDD SIG will serve as a discussion forum for the global research community to share discuss and debate topics related to PDD research. Participants share their experiences, perceptions, and thoughts on the advantages and disadvantages of PDD and how PDD complements TDD. Topics related to PDD such as target identification and validation, chemical diversity, chemical genomics, chemo-informatics, poly-pharmacology, translational pharmacology, biological model systems, patient tailoring etc–are also in scope. Women Professionals in Science and Technology Robyn Rourick, Chair Come join a ‘Lean In’ Circle where a panelist of women amongst fellow SLAS peers will discuss their personal stories in relation to Sheryl Sandberg’s ‘Lean In’ concept. The book, released earlier in 2013, has catalyzed significant controversial debate. The book has hit home with many women across industries from technology to biotech. This is an opportunity for you to take note of the ‘Lean In’ movement and possibly identify and apply aspects to your own careers and lives. A quote from Sheryl’s nonprofit states, “We often achieve more in groups than we do as individuals.” “Lean In” Circles put this idea into practice.” Through SLAS’ Women Professionals in Science and Technology, we want to champion and empower women of all levels to achieve their goals and dreams. ‘Lean In’ has inspired many to continue career journeys through mentorship, active volunteering and networking. If you are driven to achieve then please plan on joining us. Wednesday, January 22, Noon - 1:15 pm Drug Repurposing Roger Bosse and Mathieu Arcand, Chairs This year’s Special Interest Group meeting will aim to discuss how industrial, governmental and academic groups can work together to synergize their efforts in order to develop new treatments and cures for disease by finding new indications for existing compounds using creative solutions. Discussions will focus on: • Latest technological advances available to research groups to execute biochemical, cellular and phenotypic assays. • Industrial and governmental programs to facilitate drug repositioning: During the last years, pharmaceutical companies made some of their high-quality compounds available for repositioning. Different government bodies from United States and Europe are now providing funding support to stimulate the development of therapies for diseases still lacking effective treatments. • Examples of successful drug repositioning collaborative efforts. Technology Transfer and CRO/CMO Project Management Liming Shi and Raymond Price, Chairs The outsourcing model is attractive for virtual companies as a way to maintain their flexibility in the face of capital-intensive R&D spending, as well as larger pharma that seeks to move R&D resources away from ‘commodity’ activities towards higher value-added efforts. The model still faces a number of challenges, however. After the success of last year’s format, a roundtable discussion follows to explore novel models, challenges, and solutions for those seeking to optimize their outsourcing experience. Potential questions to be discussed include: In the past few years, how has your organization changed how it addresses outsourcing? What best practices would you recommend for managers interested in outsourcing research? What kinds of research, if any, is particularly challenging to outsource (i.e., what do you keep in house, no matter what)? SLAS2014.org 23
  24. 24. Sample Management Richard Kuo and Timothy Dawes, Chairs The Sample Management SIG provides a forum for discussing sample library management issues in the modern drug discovery high-throughput screening laboratory. Sample libraries include discrete compounds, defined compound mixtures, natural product extracts, and biologics (tissues, cells, DNA, RNA, and antibodies). Topics of critical importance include issues involved in: • Sample Collection: Sample acquisition, structural diversity, physical storage, physical manipulation, sample purity and stability. • Materials Management: Logistics, information technology, customer support, quality control and systems integration. • Instrumentation and Laboratory Automation: Sample preparation, sample retrieval, screening set creation, non-scale technologies, and analytical methodologies. Screen Design and Assay Technology Design of Experiment – Uncapping the Bottleneck Kenda Evans and Jim Beasley, Chairs Assay development and optimization has the potential to become the bottleneck in many HTS and/or lead optimization campaigns. Most assay development plans follow a standard brute force method of testing one variable at a time to optimize a statistical variable such as S/N, S/B, and/or Z’. However, Design of Experiment (DOE) is a technique that enables scientists to use a systematic method to simultaneously evaluate multiple parameters that can reveal complex interactions of these variables. DOE has the potential to speed up the assay development process while also allowing for a more thorough evaluation of assay variables. Examples of where DOE has been applied in assay development to quickly optimize assays as well as software improvements that could facilitate DOE being utilized more frequently are discussed. Standards Initiatives Burkhard Schaefer and Dana Vanderwall, Chairs The Standards Initiatives SIG promotes standardization and interoperability of instruments and data systems in the laboratory. This SIG is a unique forum that brings together two general groups of stakeholders: standard builders and standard consumers. Its purpose is to raise awareness of community-driven standardization efforts that are underway. It also provides a forum to foster collaboration between standards initiatives to ensure greater impact and better utilization of community resources. 24 SLAS2014 Preliminary Program This session kicks off with a showcase of a number of current standards efforts that are in varying stages of development. Each group presents a quick summary of their activities, current status, and an application example. Afterwards, the presenters are available in a panel discussion format. The SIG has three major goals: creating awareness, facilitating collaboration and providing a community. #1 Awareness The first goal of the SIG is to raise awareness of standards. It gives standards initiatives a venue to get their message out and get people interested in their efforts. End users are given the opportunity to learn about the available standards out there. Perhaps one of these standards will help solve a current problem in their lab. #2 Collaboration We are now seeing a number of standardization initiatives in the laboratory and lab informatics space. This is great news. Since building a standard is a major multi-year effort, this SIG tries to foster communication and collaboration between the different groups. Most standards initiatives suffer from constrained resources. By working together we leverage synergies, deliver results more quickly, and make a larger impact on the scientific community. #3 Community The final goal of the SIG is to create a community of like-minded people interested in standards. Joining the SIG can help you grow your personal network and connect to the stakeholders in the standards space. Stem Cells and 3D Microtissues Three-Dimensional (3D) Culture of Stem Cells for Compound Screening Marcie Glicksman and G. Sitta Sittampalam, Chairs Developing multi-cell type three-dimensional (3D) micro-tissues from stem cells is becoming a critical tool for drug discovery. These models generated in micro-wells (96- and 384-well) have been found to improve differentiation and function and are therefore more physiologically relevant. Developing these new models is critical for future success of preclinical discovery and translation to the clinic. With 3D assay development and imaging technologies, it is inevitable that bottlenecks in reagent development, new and novel bio-analytical and informatics tools will have to be developed. Successful creation of these models using human cells can also be future substitutes for poor animal models that are currently in use. This SIG includes presentations and discussion around this topic.
  25. 25. OLYMPIC GOLD BASILE eln.slas.org POPA-BURKE PATEL KOLB Welcome to the Neighborhood! The SLAS Electronic Laboratory Neighborhood ... ... is a place for laboratory science and technology professionals to learn more about like-minded colleagues and their personal and professional achievements. It brings the SLAS scientific community to life with real stories by and about real people. From Singapore to Seattle to Stockholm, eager postdocs, seasoned Nobel Laureates, and those who work diligently at benchtops and in classrooms share their ideas, hopes and fears in this friendly and informative international neighborhood. Meet Your Neighbors: • Giancarlo Basile: Adjusting to Change in Laboratory Automation and Life • Chad Mirkin: Spherical Nucleic Acids • Al Kolb: Unity Yields Progress • Encouraging Young Scientists: It’s Olympic Gold at GSK! • Think About It: Nobel Prize Winner Sir Harold Kroto Throws Down the Gauntlet • Dean Ho: Nanodiamonds Battling Cancer • Ali Khademhosseini: Sets a Pace for Tissue Engineering • Women in Chemistry: Progress Made, but Obstacles Remain Sharing experience and perspective on science-related topics, this open access membership e-zine is an official publication of the Society for Laboratory Automation and Screening (SLAS). Visit eln.slas.org. If you have story suggestions, please e-mail eln@slas.org. SLAS2014.org 25
  26. 26. Celebrate Innovation–A Commitment to Excellence The Society’s highest honors recognize significant contributions to the field of laboratory science and technology by SLAS members, students, conference participants and companies. $10,000 SLAS Innovation Award This $10,000 cash prize award recognizes the work behind one conference podium presentation that proves to be exceedingly innovative and contributes to the exploration of technologies in the laboratory. Last year’s winner was Andrea Weston, Bristol-Myers Squibb, for her exceptional presentation on Making a Quantum Leap in Mass Spectrometry Throughput: Applying the NextVal MassInsight Technology to Monitor Cytochrome P450 Enzyme Inhibition in Human Liver Microsomes. The Innovation Award winner is named during the closing session of SLAS2014 on Wednesday afternoon. Read the SLAS ELN features on previous SLAS Innovation Award winners. View Here > Student Poster Competition This cash award of $500 is awarded to the top three student poster winners at SLAS2014. The winning posters are showcased in the SLAS Member Center and on SLAS2014.org. Additionally, the winners are interviewed by The Lab Man for his blog and podcast. The poster award ceremony takes place Monday, January 20 at 4 pm. Jörg Kutter with 2013 Innovation Award Winner Andrea Weston and SLAS President Jeff Paslay Tony B. Academic Travel Awards These awards recognize approximately 45 up-and-coming researchers who demonstrate outstanding achievement in laboratory science and technology. The Tony B. Academic Travel Awards include roundtrip coach airfare, conference registration and hotel accommodations. Each scholarship recipient actively participates in the conference by presenting a podium presentation or a poster. SLAS Young Scientist Award SLAS partners with the Institute of Food Technologists (IFT), ELRIG and MipTec to recognize and award the top poster presenters at their annual conferences. Winners of this prestigious award receive a $500 cash prize, as well as complimentary registration and roundtrip travel and lodging at SLAS2014, where they present their posters. The 2013 SLAS Young Scientist Award delegates are: Read the SLAS ELN feature where SLAS2013 Student Poster Award Winners share their stories. View Here > Institute of Food Technologists (IFT) Shintaro Pang, University of Massachusetts Amherst Detection and Discrimination of Multi-Pesticides Using Single Aptamer-Based Surface Enhanced Raman Spectroscopy ELRIG Kris Wilson, University of Edinburgh A Novel High-Throughput Drug Screening Technique Targeting Human Kynurenine 3-Monooxygenase MipTec Eyram Adjogatse, University College London Multiple Drug Design Strategies for the Discovery of New Treatments for Human African Trypanosomiasis 26 SLAS2014 Preliminary Program
  27. 27. Access to an Exceptional Array of People Previous attendees can attest that SLAS is an authentic, dedicated community that shines brightest at this annual conference. SLAS members are refreshingly friendly and accessible; they always look to share insights, pose questions and expand their personal networks with old friends and new acquaintances. Attendee interaction between sessions, at meals and breaks, in the exhibit hall, at SIGs and during evening social events is when some of the most inspired exchanges take place. A sure highlight of SLAS2014 is an evening of food, fun and games on Tuesday, January 21, highlighted by offerings prepared by two of Southern California’s premier chefs. Don’t miss this unique opportunity that can only happen in-person at SLAS2014. Community Insights Friendships Inspiring SLAStronomy Tuesday, January 21, 6:30 - 8:30 pm Hilton San Diego Bayfront While gastronomy is the study of food and culture, SLAStronomy is a celebration of the unique culture and community that is SLAS. (Of course, food and fun are key ingredients of SLAStronomy.) On Tuesday evening, SLAS2014 attendees enjoy a special dining “contest” featuring two of Southern California’s premier chefs, Carissa Giacalone and Patrick Dahms, preparing their personal Sponsored by: take on a delicious entrée item. Attendees release their inner foodie by voting for their preferred dish, and also have the opportunity to interact with our guest chefs while celebrating the SLAS2014 experience with an impressive and extensive array of food and drinks. SLAStronomy also features live music and the provenpopular game room with complimentary foosball, ping pong and air hockey to provide for friendly competition among attendees. Don’t miss this evening of fun, food and networking. SLAStronomy Chefs Chef Carissa Seward Giacalone Carissa Giacolone graduated from the prestigious Le Cordon Bleu culinary institute in Paris, honing her culinary skills under the tutelage of some of Paris’s premier chefs and patissieres, including Jean-Louis Nomicos at Lasserre, Laurent Duchene and Pierre Hermé. Carissa was a featured contestant on season two of Food Network Star. She currently teaches local culinary classes and is in the process of writing her own cookbook. Carissa continues to pursue her ultimate dream of hosting her own television cooking show. Chef Patrick Dahms Patrick Dahms began his career in cuisine nearly 22 years ago. Chef Patrick was born in Luebeck, Germany and attended culinary school in Hamburg, Germany, during his apprenticeship at the world famous “Hotel Vier Jahreszeiten” where he became a certified chef and began his career. He has garnered several awards for his cooking including four bronze medals at the New Zealand Culinary Arts Festival. He is experienced in Mediterranean, Middle Eastern, Italian, German, Scandinavian, French, Thai and Japanese cuisines. Chef Patrick has worked in luxury properties the world over, including Germany, New Zealand, Bermuda and the United States. SLAS2014.org 27
  28. 28. SLAS Member Center Visit the SLAS Member Center where you can meet other attendees, such as SLAS leaders and representatives of SLAS’s scientific journals. The Member Center is also a great opportunity to view the SLAS Job Board, get a quick tour of the redesigned SLAS.org, sign up for one-on-one mentoring sessions, participate in the SLAS Passport for Prizes program, and to pick up a keepsake t-shirt or SLAS2014 lapel pin. SLAS professional team members are also on hand to answer questions and to offer advice on how to make the most of your SLAS membership. The SLAS Member Center serves as home base for The Lab Man throughout SLAS2014. Stop by to ask him questions or watch him interview Innovation and Poster award winners selected during the conference. The Lab Man Podcast Schedule (subject to change): Monday, January 20 4 pm – Interview Student Poster winners Tuesday, January 21 10:30 am – Interview with new SLAS Board members 1 pm – The Lab Man podcast 4 pm – Interview with the New Product Award winners Learn About JALA and JBS SLAS publishes two MEDLINE-indexed scientific journals in partnership with SAGE Publications - the Journal of Biomolecular Screening (JBS) and the Journal of Laboratory Automation (JALA). Visit the SLAS Member Center to meet members of the publishing team, learn more about the journals’ editorial scope and find out: • How to search, secure and manage information via JALA Online and JBS Online • How to submit an original scientific manuscript to JALA or JBS • How to increase awareness, discoverability and citations of your published manuscripts Eric Topol Book Signing Monday, January 20, 10 - 10:45 am The Creative Destruction of Medicine SLAS Author Meet & Greets Monday, January 20 and Tuesday, January 21 Visit the SLAS Member Center to get to know authors of some of JALA and JBS’s most innovative research. Enjoy face-to-face conversations about their work, your work and the new ideas shaping some of today’s most promising research. Authors scheduled to participate include: • Edward Chow, National University of Singapore • Thom Hughes, Montana Molecular • Joshua Kangas, Carnegie Mellon University and University of Pittsburgh • Peter Simpson, Astrazeneca • Pak Kin Wong, University of Arizona, Tucson • Yi-Chien Wu, University of California, Los Angeles JALA & JBS Author Workshop: How to Get Your Work Published Wednesday, January 22, 11:45 am - 1:15 pm There is no magic bullet, but there are important tips that every prospective author should know before submitting a scientific manuscript for consideration by a peer-reviewed journal. Edward Chow, National University of Singapore (an accomplished author and member of the JALA Editorial Board), shares step-by-step advice on how to design and write scientific research papers more clearly and effectively in order to improve their chances for successful publication. Attendees learn what editors want, what they don’t want, and how reviewers evaluate manuscripts. 28 SLAS2014 Preliminary Program
  29. 29. The Exhibition: LeadingEdge Innovation in Action The SLAS2014 Exhibition features more than 300 leading multinational providers of laboratory technology and related products and services. Unlike a traditional tradeshow, the SLAS2014 Exhibition encourages friendly, professional interaction among providers and practitioners, resulting in valuable insight on state-of-the-art technologies in a low-pressure environment. You leave the exhibition better prepared and positioned to recommend new products, services and tools for your organization. Stated simply, there is no better or bigger venue that showcases the latest in laboratory technologies. Exhibitor Tutorials Learn About the Science Behind the Technology As of press time, the following companies are presenting tutorials that offer an in-depth look at topics of ongoing practical interest: Monday, January 20 12:30 - 1:45 pm 12:30 - 1:15 pm 2 - 2:45 pm Beckman Coulter Agilent Technologies Genedata BioTek Instruments Artel Hamamatsu BMG Labtech PerkinElmer HighRes BioSolutions Brooks Automation TAP Biosystems Promega Labcyte TTP Labtech Tecan Thermo Scientific Wyatt Technology Tuesday, January 21 9:15 - 10 am Highlights of the SLAS2014 Exhibition include: • A host of exhibitor-led tutorials that further your education • The SLAS New Product Award (NPA) Designation that recognizes up to three new and especially innovative products and services being showcased in the exhibition • Innovation AveNEW, a dedicated area of the exhibition floor that hosts a collection of emerging and start-up companies offering promising new laboratory technologies. Past participants include start-ups from Singapore, Korea, Germany, the United Kingdom, and Switzerland to name a few. Read about Innovation AveNEW success stories in SLAS Electronic Laboratory Neighborhood View Here > 12:30 - 1:45 pm 12:30 - 1:15 pm 2 - 2:45 pm Nanion Technologies BMG Labtech Agilent Technologies Genedata Brooks Automation Beckman Coulter m2p-labs IntelliCyt MaxCyte Promega Labcyte PerkinElmer Tecan PerkinElmer TTP Labtech Qiagen See the latest schedule of Exhibitor Tutorials on SLAS2014.org SLAS is a strong supporter of FIRST (For Inspiration and Recognition of Science and Technology). Local FIRST Teams showcase their robots – not to mention ingenuity and enthusiasm for science – in the exhibition hall. Stop by to see the next generation of inventors and engineers. SLAS2014.org 29
  30. 30. Exhibitor List 3D Biomatrix ChemBridge Corporation Hamamatsu Corporation Microsonic Systems Inc. Seahorse Bioscience 4titude Ltd Chemspeed Technologies AG Hamilton Company Miltenyi Biotec GmbH SelectScience AAT Bioquest, Inc. Chieftek Precision Co., Ltd. HD Biosciences Co., Ltd Minarik Automation & Control SensiQ Technologies Inc. Accel Biotech, Inc. Cisbio Bioassays Hettich Instruments MiniFab (Aust) Pty Ltd Seyonic SA ACEA Biosciences, Inc. Cognex Corporation HighRes Biosolutions Minitubes Sias AG Active Motif Collaborative Drug Discovery HIWIN Corporation Moeller Medical Sigma-Aldrich Advantage Business Media Computype, Inc. Horizon Discovery Ltd Molecular Devices, LLC SiLA Consortium Agilent Technologies Inc. Conductive Technologies Inc. Hudson Robotics, Inc. Multispan, Inc. Silicon Kinetics AllMotion Confluence Discovery Technologies IDBS Nanion Technologies GmbH SilcoTek IDEA Bio-Medical Ltd NanoScreen, LLC SMC Corporation of America IDEX Health & Science New England Small Tube Corporation Solid State Cooling Systems Alpaqua Engineering LLC AMRI amsbio LLC Analytical Sales and Services, Inc. Core Informatics Corning Incorporated Covaris, Inc. CSEM SA Analyticon Discovery LLC CyBio AG Andrew Alliance S.A Cymatix, Inc. Apricot Designs Cyprotex Arise Biotech Corporation CYTOO Cell Architects Art Robbins Instruments DDNews ARTEL Diba Industries Inc. ASI / Applied Scientific Instrumentation Inc. DiscoveRx Corporation Astech Projects Ltd. Axxam SpA Bangs Laboratories, Inc. Beckhoff Automation Beckman Coulter, Inc. Biodirect, Inc. BioDot, Inc. BioFocus BioMedTech Laboratories, Inc. BioMicroLab, Inc. BioNex Solutions, Inc. BioSero, LLC BioTek Instruments, Inc. Biotix, Inc. Blue Sky BioServices BMG Labtech, Inc. BPS Bioscience Inc. BrandTech Scientific, Inc. Douglas Scientific Dynamic Biosensors GmbH Dynamic Devices E&K Scientific Products Inc. Elmo Motion Control, Inc. EMD Millipore Corporation Eppendorf EPSON Robots Essen BioScience Etaluma, Inc. Excel Scientific, Inc. Exquiron Biotech AG FalconUPS.com Festo Corporation Fluid Imaging Technologies, Inc. FluidX Fluotics, Ltd Formulatrix, Inc. Igus, Inc. IKO International, Inc. ILS infoteam Software AG INHECO Industrial Heating & Cooling GmbH Innovative Technologies in Biological Systems, S.L. (Innoprot) InSphero AG INTEGRA Biosciences IntelliCyt Corporation Intense Engineering IonField Systems LLC JSR Life Sciences JULABO USA, Inc. Kawator KBiosystems Ltd KMC Systems, Inc. KNF Neuberger Inc. Lab Services B.V. Labcon North America Labcyte, Inc. LABOMATIC Instruments AG LabSmith, Inc. LABVANTAGE Solutions, Inc. LabWare, Inc. LabX Media Group Lathrop Engineering Inc. LEAP Technologies Brooks Automation ForteBio - a Division of Pall Life Sciences BSSN Software Freeslate, Inc. LiCONiC US, Inc. Burkert Fluid Control Systems Frontier Scientific Services Life Chemicals, Inc. Cadence, Inc. GE Healthcare Lin Engineering, Inc. Cambridge Consultants Ltd Genalyte m2p-labs, Inc. Carl Zeiss Microscopy, LLC GenCell Biosystems Ltd Marin Scientific CCS Cell Culture Service, Inc. Genedata, Inc. Matrical Bioscience Cellular Dynamics International Gilson, Inc. MaxCyte, Inc. CETAC Automation Global Innovation Network Oy MeCour Temperature Control CG LifeSciences ChanTest Corporation ChemAxon LLC GNF Systems Greiner Bio-One 30 SLAS2014 Preliminary Program The Lee Company microfluidic ChipShop GmbH Micronic America Micronit Microfluidics BV Nippon Pulse Nova Biostorage Plus, LLC Novo Engineering Olympus America, inc. Omni International, Inc. Opticon, Inc. Orla Protein Technologies Ltd Pacific - iD Pall Life Sciences Parker Peak Analysis and Automation PerkinElmer PHENIX Research Products Piezosystem Jena, Inc. Planet Innovation Plastic Design Corporation Precise Automation Prestwick Chemical, Inc. Prior Scientific, Inc. Pro-Dex, Inc. ProGroup Instrument Corp. Promega Corporation PSS (Precision System Science) QIAGEN Sciences, Inc. Quantifoil Instruments GmbH QuantiScientifics Reaction Biology Corp Redd & Whyte Ltd Resonant Sensors Incorporated ReTiSoft Inc. Ritter GmbH Sophion Bioscience A/S Specs SPEX SamplePrep LLC STaCS DNA, Inc. STRATEC Biomedical AG SUMITOMO Bakelite Co, Ltd SurModics TAP Biosystems Tecan Technology Networks Ltd Tek-Matic, Inc. Thermo Scientific thinXXS Microtechnology AG Thorlabs Titian Software TOMTEC Torrey Pines Scientific, Inc. Trianja Technologies TriContinent Trinean TTP LabTech TubeWriter TWD TradeWinds, Inc. UNIConnect Union Biometrica, Inc. USA Scientific, Inc. V&P Scientific, Inc. Valcor Engineering VICI Valco Instruments VistaLab Technologies, Inc. Wako Automation Roche Weidmann Plastics Technology AG RURO, Inc. Wheaton SAMDI Tech, Inc. Wyatt Technology Corporation Sarstedt, Inc. Xavo Systems AG Schneider Electric Motion USA Zinsser Analytic SCIENION AG Scientific Device Laboratory, Inc. Scigilian Software, Inc. Scinomix, Inc.
  31. 31. Hotel and Travel Information SLAS2014 will take place at the San Diego Convention Center, 111 W. Harbor Drive, San Diego, CA, 92101. SLAS2014 has negotiated discounted lodging rates for conference attendees at two of San Diego’s premier convention hotels, the Hilton San Diego Bayfront [SLAS2014 Headquarters, located closest to the San Diego Convention Center] and the San Diego Marriott Marquis & Marina. Hilton San Diego Bayfront (Headquarters Hotel) One Park Boulevard, San Diego, CA 92101 Telephone Reservations: +1.800.445.8667 (Be sure to reference “SLAS2014” when booking via telephone.) Standard Nightly Rate: $242 + state and local tax • Cancellation Policy: 48 hours • No-shows will be charged one (1) night room and tax • Credit card # is required at the time of booking • Parking Fee: $27 self-parking, $36 valet per night San Diego Marriott Marquis & Marina 333 West Harbor Drive, San Diego, CA 92101 Telephone Reservations: +1.877.622.3056 (Be sure to reference “SLAS2014” when booking via telephone.) Standard Nightly Rate: $242 + state and local tax • Cancellation Policy: 48 hours Air Travel Information You may book your air travel directly with SLAS2014’s official travel agent, National Travel at: vipservices@nationaltravel.com; +1.800.557.0842 (toll free); +1.304.357.0808 (international) American Airlines is the official carrier of SLAS2014. Receive a 5% discount off the lowest applicable published fare on AA flights. If you use your own travel agency or book with American Airlines directly, please reference American Airlines Authorization Number 2714AH when booking to receive the discount. Rental Car Information National Travel can also assist you in adding a rental car to your existing reservation or in booking a rental car as a stand-alone reservation. Please contact National Travel at the e-mail or phone numbers listed above. Avis is the official rental car agency of SLAS2014. Receive up to a 25% discount off the lowest applicable published rate on Avis car rentals. If you use your own agency or book with Avis directly, please reference Avis Authorization Number B136001 when booking to receive the discount. Airport Transportation Information Travel from San Diego International Airport (SAN) and the two official SLAS Hotels and the San Diego Convention Center takes approximately 15 minutes. The following options are available in addition to rental car options: • No-shows will be charged one (1) night room and tax • Taxi: Approximately $15 per ride. • Credit card # is required at the time of booking • SuperShuttle: Approximately $8 per ride; $1 per ride discount for SLAS2014 attendees • Parking Fee: $28 self-parking, $40 valet per night • Telephone Reservations: 1.800.BLUE.VAN • Discount Code: SLAS • Significant discounts off standard guest room rates Why Book Your Hotel Room in the Official SLAS Housing Block? SLAS2014 has negotiated special rates and benefits for conference attendees at two of San Diego’s premier convention hotels, the Hilton San Diego Bayfront (SLAS2014 Headquarters) and the San Diego Marriott Marquis & Marina. Rates, details and online reservation links can be found at SLAS2014.org/travel. Not only are these hotels conveniently located near the San Diego Convention Center, but SLAS2014 attendees benefit in several other ways: • Complimentary guest room Internet service (value of up to $15 per night) • Complimentary guest access to hotel fitness center at Hilton or Marriott • Flexible booking policies • Simplified ability to make reservation changes, if required By staying in the SLAS block of guest rooms, SLAS is able to contract premier facilities such as the San Diego Convention Center. Additionally, you are helping the Society meet its contractual obligations to the hotels, avoid penalties and help to underwrite the cost of convention center rental, therefore keeping conference registration fees as affordable as possible. Your support of booking your room within the SLAS2014 guest room block is greatly appreciated. SLAS2014.org 31
  32. 32. SLAS2014 will offer limitless networking opportunities with thousands of practicing professionals. It will also provide you with a series of valuable resources to enhance your industry connections, set a plan for an accelerated career trajectory, and improve your ability to distinguish yourself in a challenging job market. Mentoring Members of American Chemical Society (ACS) San Diego Chapter will be on hand to provide complimentary mentoring and career advice. One-on-one sessions will be available in the morning and afternoon on Monday and Tuesday, January 20-21. Advance sign-up will be offered through SLAS2014.org. Give yourself a leg up in a tight job market – take advantage of SLAS Career Connections. Workshops The workshops include: “Networking–Not Networking 101–Building Relationships for Success” by Joanne Kamens, Executive Director, Addgene, and “Mock Interviews: Preparation and Practice for Getting the Jobs You Want” by Dan Eustace, University of Connecticut. Career Counseling A select number of one-onone career coaching sessions with Professor Eustace and Dr. Kamens will be available by appointment. For more information, visit SLAS2014.org. “I’ve utilized SLAS Career Connections to improve my resume and to connect with experts who have provided helpful guidance on job outlooks. Having these resources available at the SLAS conference is an excellent value-add for an early career professional like me.” - Tim Ruckh Postdoctoral Research Associate Northeastern University Read the SLAS ELN feature on personal self assessment by Dan Eustace. View Here >

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