2nd Annual

Shaping the Management of Parkinson’s Disease:
A Comprehensive Review of Discoveries and Clinical Trials
A Spe...
CoDirectors
CoDirectors
Hubert H. Fernandez, MD
Hubert H. Fernandez, MD

Co-Chair, PSG Executive Committee
Co-Chair, PSG E...
Shaping the Management of Parkinson’s Disease:
Shaping the Management of Parkinson’s Disease:
AAComprehensive Review of Di...
Registration

Course 021450 • Office Use Only

Shaping the Management of Parkinson’s Disease:
Hotel
Location
A Comprehensi...
Registration

Course 021450 • Office Use Only

Shaping the Management of Parkinson’s Disease:
A Comprehensive Review of Di...
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Shaping the Management of Parkinsons Disease: A Comprehensive Review of Discoveries and Clinical Trials

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Transcript of "Shaping the Management of Parkinsons Disease: A Comprehensive Review of Discoveries and Clinical Trials"

  1. 1. 2nd Annual Shaping the Management of Parkinson’s Disease: A Comprehensive Review of Discoveries and Clinical Trials A Special Weekend CME Program with Parkinson Study Group (PSG) Investigators in joint sponsorship with Cleveland Clinic February 8-9, 2014 Vdara Hotel & Spa | Las Vegas, Nevada Register Today! www.ccfcme.org/shapingPD14
  2. 2. CoDirectors CoDirectors Hubert H. Fernandez, MD Hubert H. Fernandez, MD Co-Chair, PSG Executive Committee Co-Chair, PSG Executive Committee Cleveland Clinic Cleveland Clinic Cleveland, Ohio Cleveland, Ohio Michael A.A. Schwarzschild, MD, PhD Michael Schwarzschild, MD, PhD Chair, PSG Executive Committee Chair, PSG Executive Committee Harvard Medical School Harvard Medical School Boston, Massachusetts Boston, Massachusetts Faculty Faculty Local Organizing Committee Local Organizing Committee Eric S.S. Farbman, MD Eric Farbman, MD Associate Professor of of Neurology Associate Professor Neurology Director of of Movement Disorders Center Director Movement Disorders Center University of of Nevada School of Medicine University Nevada School of Medicine Las Vegas, Nevada Las Vegas, Nevada Ryan R.R. Walsh MD, PhD Ryan Walsh MD, PhD Director, Parkinson’s Disease and Movement Director, Parkinson’s Disease and Movement Disorders Program Disorders Program Director, Huntington’s Disease Director, Huntington’s Disease Comprehensive Clinic Comprehensive Clinic Cleveland Clinic Lou Ruvo Center for Cleveland Clinic Lou Ruvo Center for Brain Health Brain Health Las Vegas, Nevada Las Vegas, Nevada Alberto J. J. Espay, MD, MSc, FAAN Alberto Espay, MD, MSc, FAAN Ronald F. F. Pfeiffer, MD Ronald Pfeiffer, MD Robert A.A. Hauser, MD, MBA Robert Hauser, MD, MBA Stephen G.G. Reich, MD Stephen Reich, MD Co-Chair of of the PSG Classic Motor Working Group Co-Chair the PSG Classic Motor Working Group Associate Professor of of Neurology Associate Professor Neurology Clinical Research Director of of the James J. and Clinical Research Director the James J. and Joan A.A. Gardner Center for Parkinson’s Disease Joan Gardner Center for Parkinson’s Disease and Movement Disorders and Movement Disorders University of of Cincinnati University Cincinnati Cincinnati, Ohio Cincinnati, Ohio Former PSG Executive Committee Member Former PSG Executive Committee Member Professor of of Neurology, Molecular Pharmacology Professor Neurology, Molecular Pharmacology and Physiology and Physiology Director, USF Byrd Parkinson’s Disease Director, USF Byrd Parkinson’s Disease and Movement Disorders Center and Movement Disorders Center University of of South Florida University South Florida Tampa, Florida Tampa, Florida Anthony E.E. Lang, OC, MD, FRCPC, FAAN, Anthony Lang, OC, MD, FRCPC, FAAN, FCAHS, FRSC FCAHS, FRSC Former Chair, PSG Classic Motor Working Group Former Chair, PSG Classic Motor Working Group Movement Disorders Centre Movement Disorders Centre Toronto Western Hospital Toronto Western Hospital Toronto, Ontario, Canada Toronto, Ontario, Canada Peter A.A. LeWitt, MD Peter LeWitt, MD Chair, PSG Biomarkers Working Group Chair, PSG Biomarkers Working Group Professor of of Neurology, Wayne State Professor Neurology, Wayne State University School of of Medicine University School Medicine Director, Parkinson’s Disease and Director, Parkinson’s Disease and Movement Disorders Program Movement Disorders Program Henry Ford West Bloomfield Hospital Henry Ford West Bloomfield Hospital West Bloomfield, Michigan West Bloomfield, Michigan Connie Marras, MD, PhD Connie Marras, MD, PhD Member, PSG Executive Committee Member, PSG Executive Committee Former Chair, PSG Genetics and Former Chair, PSG Genetics and Environmental Risk Factors Environmental Risk Factors Working Group Working Group Assistant Professor of of Neurology Assistant Professor Neurology University of of Toronto University Toronto Toronto, Ontario, Canada Toronto, Ontario, Canada William G.G. Ondo, MD William Ondo, MD Professor of of Neurology Professor Neurology University of of Texas Health Science Center University Texas Health Science Center at at Houston Houston Houston, Texas Houston, Texas Former Member, PSG Executive Former Member, PSG Executive Committee Committee Professor and Vice Chair Professor and Vice Chair Department of of Neurology Department Neurology University of of Tennessee Health University Tennessee Health Science Center Science Center Memphis, Tennessee Memphis, Tennessee Professor of of Neurology Professor Neurology The Frederick Henry Prince The Frederick Henry Prince Distinguished Professor in in Neurology Distinguished Professor Neurology Department of of Neurology Department Neurology University of of Maryland School of University Maryland School of Medicine Medicine Baltimore, Maryland Baltimore, Maryland Tanya Simuni, MD Tanya Simuni, MD Chair, PSG Classic Motor Working Group Chair, PSG Classic Motor Working Group Arthur C.C. Nielsen Professor of Neurology Arthur Nielsen Professor of Neurology Director, Parkinson’s Disease and Director, Parkinson’s Disease and Movement Disorders Center Movement Disorders Center Northwestern University Feinberg Northwestern University Feinberg School of of Medicine School Medicine Chicago, Illinois Chicago, Illinois Michele Tagliati, MD, FAAN Michele Tagliati, MD, FAAN Professor and Vice Chair Professor and Vice Chair Department of of Neurology Department Neurology Director of of Movement Disorders Director Movement Disorders Cedars-Sinai Medical Center Cedars-Sinai Medical Center Los Angeles, California Los Angeles, California Caroline M. Tanner, MD, PhD, FAAN Caroline M. Tanner, MD, PhD, FAAN Former Co-Chair, PSG Executive Former Co-Chair, PSG Executive Committee Committee Director, Clinical Research Director, Clinical Research Parkinson’s Institute Parkinson’s Institute Sunnyvale, California Sunnyvale, California Daniel Weintraub, MD Daniel Weintraub, MD Former Member, PSG Executive Former Member, PSG Executive Committee Committee Associate Professor of of Psychiatry Associate Professor Psychiatry and Neurology and Neurology Perelman School of of Medicine Perelman School Medicine University of of Pennsylvania University Pennsylvania Philadelphia, Pennsylvania Philadelphia, Pennsylvania
  3. 3. Shaping the Management of Parkinson’s Disease: Shaping the Management of Parkinson’s Disease: AAComprehensive Review of Discoveries and Clinical Trials Comprehensive Review of Discoveries and Clinical Trials The “modern clinician” is is practical and caring clinician who The “modern clinician” a a practical and caring clinician who realizes that therapeutic advancements inin Parkinson’s disease realizes that therapeutic advancements Parkinson’s disease are occurring atat an unprecedented pace. Much of today’s are occurring an unprecedented pace. Much of today’s treatment approach is is based on clinical trial findings. Therefore, treatment approach based on clinical trial findings. Therefore, it it is important for clinicians to not only be updated with the is important for clinicians to not only be updated with the clinical trial results, but also toto know the hypotheses behind clinical trial results, but also know the hypotheses behind them, the strengths, weaknesses and other findings outside them, the strengths, weaknesses and other findings outside the primary objectives ofof these clinical trials. This educational the primary objectives these clinical trials. This educational program is is unique because it intends to discuss the current program unique because it intends to discuss the current approaches toto the treatment of Parkinson’s disease in the approaches the treatment of Parkinson’s disease in the context ofof the “lessons learned” in clinical trials to date. The context the “lessons learned” in clinical trials to date. The program also intends toto provide sneak peak ofof the future in program also intends provide a a sneak peak the future in PD treatment based on planned and on-going clinical trials for PD treatment based on planned and on-going clinical trials for delaying disease progression and improving motor and nondelaying disease progression and improving motor and nonmotor symptoms ofof the disorder. motor symptoms the disorder. Learning Objectives Learning Objectives After completing this activity, the participant will be able toto do After completing this activity, the participant will be able do the following: the following: • • List the current and emerging treatment approaches for the List the current and emerging treatment approaches for the newly diagnosed Parkinson’s disease (PD) patient newly diagnosed Parkinson’s disease (PD) patient • • Describe the current and future treatment options for motor Describe the current and future treatment options for motor complications inin PD complications PD • • Recognize and treat the most common nonmotor problems Recognize and treat the most common nonmotor problems associated with PD associated with PD • • Explain the role of deep brain stimulation (DBS) surgery and Explain the role of deep brain stimulation (DBS) surgery and other advanced therapies for PD other advanced therapies for PD • • Analyze the strengths and weaknesses of clinical trials Analyze the strengths and weaknesses of clinical trials and their contribution toto today’s evidence-based treatment and their contribution today’s evidence-based treatment approach toto PD approach PD Session 2:2: Initiating Symptomatic Treatment inin Early PD: Session Initiating Symptomatic Treatment Early PD: ‘Pull your punches’ vs. ‘Come out swinging’ ‘Pull your punches’ vs. ‘Come out swinging’ Moderator: Ryan Walsh, MD, PhD Moderator: Ryan Walsh, MD, PhD 10:10 am 10:10 am Evidence Supporting Early Levodopa Monotherapy Evidence Supporting Early Levodopa Monotherapy Stephen Reich, MD Stephen Reich, MD 10:50 am 10:50 am The Advantages of of Delaying Levodopa Therapy The Advantages Delaying Levodopa Therapy Alberto Espay, MD Alberto Espay, MD 11:30 am Panel Discussion 11:30 am Panel Discussion 11:40 am 11:40 am Lunch and Exhibits Lunch and Exhibits Session 3:3: Selecting the Optimal Treatment for Motor Fluctuations Session Selecting the Optimal Treatment for Motor Fluctuations and Dyskinesias Moderator: Eric Farbman, MD and Dyskinesias Moderator: Eric Farbman, MD 12:40 pm 12:40 pm How Good Are Our Current Treatment Options? How Good Are Our Current Treatment Options? William Ondo, MD William Ondo, MD 1:20 pm 1:20 pm Promising Medical Therapies Promising Medical Therapies Robert Hauser, MD, MBA Robert Hauser, MD, MBA 2:00 pm 2:00 pm Panel Discussion Panel Discussion Session 4:4: When toto Consider ‘Advanced Therapies’ in Session When Consider ‘Advanced Therapies’ in Parkinson’s Disease Moderator: Eric Farbman, MD Parkinson’s Disease Moderator: Eric Farbman, MD 2:10 pm 2:10 pm The Role of of Deep Brain Stimulation Surgery and Gene Therapy The Role Deep Brain Stimulation Surgery and Gene Therapy Michele Tagliati, MD Michele Tagliati, MD The Value Pumps, Patches, Puffs, Infusions and Inhaled 2:50 pm 2:50 pm The Value of of Pumps, Patches, Puffs, Infusions and Inhaled Substances Substances Peter LeWitt, MD Peter LeWitt, MD 3:30 pm 3:30 pm Panel Discussion Panel Discussion 3:40 pm 3:40 pm Refreshment break and Exhibits Refreshment break and Exhibits Session 5:5: Autonomic and Sleep Dysfunction inin Parkinson’s Disease Session Autonomic and Sleep Dysfunction Parkinson’s Disease Moderator: Eric Farbman, MD Moderator: Eric Farbman, MD 4:00 pm 4:00 pm The Relevance of of Pre-Motor Autonomic and Sleep The Relevance Pre-Motor Autonomic and Sleep Dysfunction in in PD Dysfunction PD Connie Marras, MD, PhD Connie Marras, MD, PhD 4:40 pm 4:40 pm Recognition and Treatment of of Autonomic Disturbances in PD Recognition and Treatment Autonomic Disturbances in PD Ronald Pfeiffer, MD Ronald Pfeiffer, MD 5:20 pm 5:20 pm Panel Discussion Panel Discussion Target Audience Target Audience 5:30 pm 5:30 pm Adjourn Adjourn This educational activity is is intended for all clinicians who This educational activity intended for all clinicians who treat patients with Parkinson’s disease, including neurologists, treat patients with Parkinson’s disease, including neurologists, internists, family physicians, physician assistants, nurses, and internists, family physicians, physician assistants, nurses, and nurse practitioners. nurse practitioners. Meet the Faculty and Exhibitors: evening reception open toto all attendees Meet the Faculty and Exhibitors: evening reception open all attendees immediately following immediately following Sunday, February 9th, 2014 Sunday, February 9th, 2014 Session 6:6: Putting It It All Together: Lessons from Clinical Trials and Session Putting All Together: Lessons from Clinical Trials and Recent Discoveries Moderator: Hubert Fernandez, MD Recent Discoveries Moderator: Hubert Fernandez, MD Saturday, February 8th, 2014 Saturday, February 8th, 2014 7:30 am 7:30 am Continental Breakfast and Registration Continental Breakfast and Registration 8:15 am 8:15 am Welcome and Introduction Welcome and Introduction Hubert Fernandez, MD Hubert Fernandez, MD Michael Schwarzschild, MD, PhD Michael Schwarzschild, MD, PhD Session 1:1: Neuroprotection inin Parkinson’s Disease: Session Neuroprotection Parkinson’s Disease: Where Do We Stand? Where Do We Stand? Moderator: Ryan Walsh, MD, PhD Moderator: Ryan Walsh, MD, PhD 8:15 am 8:15 am Current Advancements That Have Altered Our Approach toto PD Current Advancements That Have Altered Our Approach PD Caroline Tanner, MD, PhD Caroline Tanner, MD, PhD 8:55 am 8:55 am Where We Are Headed? Where We Are Headed? Anthony Lang, MD Anthony Lang, MD 9:35 am 9:35 am Panel Discussion Panel Discussion 9:45 am 9:45 am Refreshment break and Exhibits Refreshment break and Exhibits Session 7:7: Behavioral and Cognitive Dysfunction inin Parkinson’s Session Behavioral and Cognitive Dysfunction Parkinson’s Disease Disease Moderator: Michael Schwarzschild, MD, PhD Moderator: Michael Schwarzschild, MD, PhD 8:20 am 8:20 am The Challenges We Currently Face The Challenges We Currently Face Tanya Simuni, MD Tanya Simuni, MD 10:05 am 10:05 am Current Challenges, Strategies and Treatment Options Current Challenges, Strategies and Treatment Options Hubert Fernandez, MD Hubert Fernandez, MD 9:00 am 9:00 am The Most Promising Leads The Most Promising Leads Michael Schwarzschild, MD, PhD Michael Schwarzschild, MD, PhD 10:45 am 10:45 am Promising Agents and Alternative Therapies and Approaches Promising Agents and Alternative Therapies and Approaches Daniel Weintraub, MD Daniel Weintraub, MD 9:40 am 9:40 am Panel Discussion Panel Discussion 11:25 am 11:25 am Panel Discussion Panel Discussion 9:50 am 9:50 am Refreshment break and Exhibits Refreshment break and Exhibits 11:40 am 11:40 am Adjourn Adjourn An interactive question and answer period is is included in each speaker’s allotted time. An interactive question and answer period included in each speaker’s allotted time.
  4. 4. Registration Course 021450 • Office Use Only Shaping the Management of Parkinson’s Disease: Hotel Location A Comprehensive Review of Discoveries and Clinical Trials Vdara Hotel & Spa 2600 W. Harmon Avenue February 8-9, 2014 Las Vegas, NV 89158 Fee ___________ Date ___________ M.O.P ________ CXL/Fee ________ . Designed by a world-class team of architects and designers, CityCenter™ is one of the most unique and ambitious projects in history. This unprecedented collection of talent, design, taste and style is located on 67 acres of the Las Vegas Strip and forever redefines the Las Vegas experience. Vdara Hotel & Spa Phone: 866.745.7111 or 702.590.2111 Las Vegas, Nevada Fee includes: Syllabus, continental breakfasts, refreshment breaks, and Saturday lunch. Vdara Hotel & Spa™, an internationally inspired all-suite hotel and spa designed for those who love PSG Member Non PSG Member the energy and excitement of Las Vegas but prefer to Investigator $100 Physician $200 enjoy it in an exclusive, non-gaming, smoke-free and sustainable environment. Ideally located between ARIA Coordinator $50 Resident/Fellow* $50 Resort & Casino™ and Bellagio®, Vdara combines Non-Physicianspaces with the very latest $100 contemporary interior *Letter from program director must be received in modern amenities and services. our office prior to the course to receive this fee. All memberships will be verified before the meeting. Hotel Accommodations Crystals at CityCenter™, is the premiere shopping destination in Las Vegas, where the world’s most elite names come together to create an unprecedented shopping A block of rooms has been reserved at experience. Crystals offers patrons an unparalleled tour through a high-end landscape the Vdara Hotel & Spa until January 16, of haute couture, modern dining, stunning architecture and contemporary art. The 2014. To make your reservations, contact unique collection of renowned retailers, including Louis Vuitton, Prada, Gucci, Tiffany the Hotel Reservations Department at & Co, Roberto Cavalli and TOM FORD, paired with one-of-kind galleries from artists 866.745.7767 and 702.590.2767. such as Richard MacDonald and Dale Chihuly combined with signature restaurants Please identify yourself as being with the CCF main campus, family health centers, andfrom Wolfgang Puckhospital employees (physiciansLongoria redefine the traditional CCHS community and celebrity restaurateur Eva and non-physicians) should CCN-PSG Meeting for a special rate of shopping experience. register online $174 plus tax. at the above web address. REGISTER ONLINE www.ccfcme.org/shapingPD14 Complete the Information Below if Registering by Mail or Fax (please print) General Information First Name: Faculty Disclosure MI: Last Accreditation Name: Company Name: This activity has been planned and The Cleveland Clinic Foundation Center implemented in accordance with the for Continuing Education has implemented Address: Essential Areas and policies of the a City: to comply with the current policy State: Accreditation Council for Continuing Medical Accreditation Council for Continuing Phone Education Fax Number: Education through the joint sponsorship Medical Number: Standards for of the Cleveland Clinic Foundation Center Commercial Support requiring resolution Specialty: Email Address: for Continuing Education and Parkinson ofTypefaculty conflicts ofOffice-Based all of Practice: o interest. Faculty Hospital Staff o o Resident/Fellow o Other Study Group. The Cleveland Clinic declaring a relevant commercial interest Foundation Center for Continuing Education will be require a vegetarianactivity syllabus. o I identified in the lunch. is accredited by the ACCME to provide continuing medical education for physicians. Registration and Cancellation: The Cleveland Clinic Foundation Center Total amount enclosed or to be charged: Register at www.ccfcme.org/shapingPD14. $___________ for Continuing Education designates this Deadline for registration for the symposium live activity for a maximum of 10.50 AMA Payment (EST), Tuesday, February 4, is 5:00 pm Options PRA Category 1 Credits™. Physicians 2014. A request for a refund must be o Check Enclosed (Made payable to:) should claim only the credit commensurate received in writing by February 4, 2014. No Foundation The Cleveland Clinic Educational with the extent of their participation in the refunds will be given after February 4, but activity. P Box 931653 .O. registration is transferable through February Cleveland, OH 44193-1082 Participants claiming CME credit from this 28. A $25 cancellation fee will be deducted activity may submit the credit hours from the refund – must register online youwww.ccfcme.org/shapingPD14 to pay by to for all cancellations. If at o Credit Card credit the American Osteopathic Association for card. register by mail, please allow up to three Category 2 credit. weeks for your registration to be processed. Parking: Degree: Free valet parking is available at the Vdara. Self parking is not available. Zip: Americans with Disabilities Act The Cleveland Clinic Foundation Center for Continuing Education fully intends to comply with the legal requirements of the Americans with Disabilities Act. If you need assistance, please notify Beth Viscomi at 216-444-7591 at least two weeks prior to the activity. For questions concerning registering, cmeregistration@ccf.org or call 216.448.0777. For questions about registration, please callemailFor the purposes of recertification, the 216-448-0777 or recognizes the importance of protecting the privacy and security of information provided to us. Therefore, we are no longer requesting email cmeregistration@ American Nurses Credentialing Center Cleveland Clinic ccf.org. card data in writing, including on registrationaccepts AMA PRA Category 1 to register using a credit card please log in to credit forms or faxes. If you would like Credit™ issued by organizations accredited a the www.ccfcme.org/shapingPD14 or call 216.448.0777 where it will be handled directly by bycertified processor. ACCME.
  5. 5. Registration Course 021450 • Office Use Only Shaping the Management of Parkinson’s Disease: A Comprehensive Review of Discoveries and Clinical Trials Fee ___________ Date ___________ M.O.P ________ CXL/Fee ________ . February 8-9, 2014 Vdara Hotel & Spa Las Vegas, Nevada Fee includes: Syllabus, continental breakfasts, refreshment breaks, and Saturday lunch. PSG Member Non PSG Member Investigator $100 Physician $200 Coordinator $50 Resident/Fellow* $50 Non-Physician $100 *Letter from program director must be received in our office prior to the course to receive this fee. All memberships will be verified before the meeting. REGISTER ONLINE www.ccfcme.org/shapingPD14 CCF main campus, family health centers, and CCHS community hospital employees (physicians and non-physicians) should register online at the above web address. Complete the Information Below if Registering by Mail or Fax (please print) First Name: MI: Last Name: Degree: Company Name: Address: City: State: Phone Number: Fax Number: Specialty: Email Address: Type of Practice: o Zip: o Office-Based o Hospital Staff o Resident/Fellow o Other I require a vegetarian lunch. Total amount enclosed or to be charged: $___________ Payment Options o Check Enclosed (Made payable to:) The Cleveland Clinic Educational Foundation P Box 931653 .O. Cleveland, OH 44193-1082 o Credit Card – must register online at www.ccfcme.org/shapingPD14 to pay by credit card. For questions concerning registering, email cmeregistration@ccf.org or call 216.448.0777. Cleveland Clinic recognizes the importance of protecting the privacy and security of information provided to us. Therefore, we are no longer requesting credit card data in writing, including on registration forms or faxes. If you would like to register using a credit card please log in to www.ccfcme.org/shapingPD14 or call 216.448.0777 where it will be handled directly by a certified processor.

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