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Pathology-driven Approach to Epilepsy Surgery: Current State and Future Directions
 

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    Pathology-driven Approach to Epilepsy Surgery: Current State and Future Directions Pathology-driven Approach to Epilepsy Surgery: Current State and Future Directions Document Transcript

    • 21st Annual InternationalEpilepsy SymposiaMarriott Cleveland Downtown at Key CenterCleveland, OHClinical Epileptology Review and UpdateOctober 19-20, 2012Pathology-driven Approach to Epilepsy Surgery:Current State and Future DirectionsOctober 21-24, 2012International Neuroethics Conference: Brain Matters 3October 24-25, 2012 www.ccfcme.org/epilepsy12 In Collaboration With:
    • General InformationTarget AudienceThe symposia are designed for adult and pediatric neurologists andepileptologists, neurosurgeons with an interest in epilepsy surgery inadults and children, psychiatrists, clinical neuropsychologists, socialworkers and other expert caretakers of patients with epilepsy acrossall age groups.LocationCleveland Marriott Downtown at Key Center127 Public SquareCleveland, OH 44114216-696-9200A block of rooms has been reserved at the Cleveland MarriottDowntown at Key Center at the special group rate of $169 per nightplus tax. Reservations must be made by Tuesday, September 4,2012, in order to quality for this rate.Information AccreditationFor further information about this activity, contact Martha Tobin atLocal: 216-445-3449 The Cleveland Clinic Foundation Center for Continuing EducationToll Free: 800-223-2273 x53449 is accredited by the Accreditation Council for Continuing MedicalEmail: tobinm@ccf.org Education to provide continuing medical education for physicians. The Cleveland Clinic Foundation Center for Continuing EducationDeadline for Registration and Cancellation designates this live activity for a maximum of 59.75 AMA PRARegister at www.ccfcme.org/epilepsy12. Deadline for registration Category 1 Credits™. Physicians should claim only the creditfor the symposium is 5:00 pm (EST), Monday, October 15, commensurate with the extent of their participation in the activity.2012. A request for a refund must be received in writing by October Participants claiming CME credit from this activity may submit the5, 2012. No refunds will be given after October 5, but registration is credit hours to the American Osteopathic Association for Categorytransferable through October 15, 2012. A $50 cancellation fee will be 2 credit.deducted from the refund for all cancellations. The American Board of Psychiatry and Neurology has reviewedIf you register by mail, please allow up to three weeks for your the Clinical Epileptology Review and Update and has approvedregistration to be processed. this program as part of a comprehensive Self AssessmentFor questions about registration, please call 216-448-0777 or email Activity Program, which is mandated by the ABMS as a necessarycmeregistration@ccf.org. component of maintenance of certification. 15 Category-1 CME credits from the education activity and 4 Self Assessment CME credits. Faculty Disclosure Statement The Cleveland Clinic Foundation Center for Continuing Education has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education Standards for Commercial Support requiring resolution of all faculty conflicts of interest. Faculty declaring a relevant commercial interest will be identified in the activity syllabus. Americans with Disabilities Act The Cleveland Clinic Foundation Center for Continuing Education fully intends to comply with the legal requirements of the Americans with Disabilities Act. If you need assistance, please notify Monet Smith at 216-444-9380 at least two weeks prior to the activity.
    • Review and Update on Clinical EpileptologyOctober 19-20, 2012Course Overview Learning ObjectivesThis course will focus on updated knowledge that has directimpact on the practice and treatment of patients with epilepsy. 1. Recognize molecular and genetic mechanisms of epilepsyTopics will cover the latest understanding of mechanisms, 2. Review the spectrum of epilepsy in neurocutaneous disorderssyndromes, antiepileptic drugs, EEG techniques, psychiatric 3. Discuss the use of antiepileptic drugsissues, and patient management involving medications, 4. Review the treatment of status epilepticusneurostimulators, and surgery. 5. Describe the recognition and management of psychiatricThe format of the course will be structured with daily self- comorbidities in patients with epilepsyassessment examinations, to qualify for self-assessment 6. Discuss the management of non-epileptic seizuresexamination credits that fulfill the Neurology Maintenance of 7. Discuss the management of seizures in special populations:Certification Part II requirements for continued certification as in the elderly and in pregnancygranted by the ABPN. Test questions will be answered in talks 8. Review the application of neurostimulation in epilepsywith feedback using an audience response system. 9. Discuss successes and failures in epilepsy surgery 10. Illustrate the use of EEG and imaging in epilepsy Course Schedule Friday, October 19, 2012 Saturday, October 20, 2012 8:00-9:00 am Self-Assessment Examination (SA CME) 8:00-9:00 am Self-Assessment Examination (SA CME) 9:00 am–12:15 pm Morning Session 9:00 am–12:15 pm Morning Session Pathogenesis of Epilepsy – Imad Najm Practice Guidelines and Parameters in Epilepsy – Paul Van Ness Neurocutaneous Syndromes and Epilepsy – Ajay Gupta Management of Non-Epileptic Seizures – Selim Benbadis Genetics in Epilepsy – Jocelyn Bautista Evaluation and Treatment of Psychiatric Co-morbidities – George Tesar Pharmaco-kinetics, -dynamics, and -genomics of drugs – Ilo Leppick Pregnancy and Epilepsy – Nancy Foldvary 1:15–6:00 pm Afternoon Session 1:15–6:00 pm Afternoon Session EEG Pearls – Deepak Lachhwani (presenter), Neuroimaging Pearls in Epilepsy – Stephen Jones Panel: Paul Van Ness, Selim Benbadis Epilepsy in the Elderly – Andrey Stojic Newer Antiepileptic Drugs – Ilo Leppick MEG and EEG Source Modeling – Richard Burgess Changing and Adding Antiepileptic Drugs – Norman So Epilepsy Surgery: Successes and Failures – Lara Jehi Treatment of Acute Repetitive Seizures and Status Epilepticus – Andreas Alexopoulos Neurostimulation in Epilepsy – Dileep Nair EEG in the ICU and Hospital – Stephen Hantus Epilepsy Case Management Case discussion – Dileep Nair, Elaine Wyllie (presenters); Focal Epilepsy from the Operculum, Insula, Parietal Lobe Panel: Jocelyn Bautista, Zhong Ying, Ilo Leppick, Paul Van Ness Case discussion – Andreas Alexopoulos, Prakash Kotagal (presenters); Panel: Selim Benbadis, Paul Van Ness 6:00 pm Adjourn 6:00 pm AdjournApplication for Self-Assessment CME (4 credits) has been made to the American Board of Psychiatry and Neurology. Approval is pending.
    • Pathology-driven Approach to Epilepsy Surgery: Current State and Future DirectionsOctober 21-24, 2012Conference Overview Learning ObjectivesThese unique epilepsy symposia will provide a comprehensive 1. Define each of the major pathological substratesand at the same time refreshing approach to the evaluation underlying surgically-remediable epilepsiesand surgical management of adult and pediatric patients with 2. Review the histopathological identification of eachuncontrolled seizures. Specifically, the symposia will focus on substratethe current state and future directions of presurgical evaluations 3. Review the neuroimaging features and advancements inand epilepsy surgery guided by our renewed understanding of the identification of each pathologyunderlying pathology in each individual. With the widespread use 4. Review the current role of EEG, video-EEG and semiologyof noninvasive and invasive evaluations and epilepsy neurosurgery tailored to presurgical evaluationthe need arises to better define the pathological substrate 5. Review advanced techniques in clinical neurophysiology, and structural as well as functional neuroimaging thatand tailor our investigations, and expectations accordingly. may enhance identification and understanding of eachThis goal will be accomplished by detailing the structural and pathologyhistopathological identification of each epileptic substrate. We 6. Review indications, techniques and complications ofwill then review neuroimaging, electro-clinical and anatomo- different methods of invasive monitoring as these relatefunctional, typical and atypical, presentations of each pathological to the underlying pathological substratesubstrate in adult and pediatric patients with medically-intractable 7. Review tailored surgical decision-making and managementepilepsies. We will then review the process of individualized of each individual patientsurgical decision-making based on illustrative case discussions. 8. Discuss our understanding of successes and failures of epilepsy surgeryConference ScheduleSunday, October 21 The Fourth Dudley S. Dinner Distinguished Epileptologist’s Luncheon Lecture 12:00–1:00 pmI. Introduction/Overview 7:30–9:30 am • Pathology-based epilepsy surgery or epilepsy surgeries? IIb. Electro-functional 1:30–4:00 pm – William Bingaman • The “classical” electroclinical presentation of hippocampal • Contribution of pathological studies to Epilepsy Surgery: sclerosis (are there specific historical, EEG and imaging Past, present and future – Roberto Spreafico features)? Significance of distribution of interictal spikes in adults and children – Americo Sakamoto • Contribution of Imaging to Epilepsy Surgery: Past, present and future – Steve Jones • Red flags and diagnostic approach – when do you need more data? How can HS exhibit itself as HS, and non-HS asII. Hippocampal Sclerosis HS, and how to address these issues? – Norman So Moderators: Fernando Cendes and Mario Alonso • The cognitive impact of hippocampal sclerosis, early versus late surgical intervention, and impact of epilepsy surgery –IIa. Structural 10:00–11:30 am how do we identify at-risk patients for memory decline and • Anatomy of the temporal lobe and its connections: what does memory decline mean for the patient? implications for EEG/semiology/management; epileptogenic – Robyn Busch network in HS – Imad Najm • How can we use other technologies to assess cognitive and • Histology and histopathology of the hippocampus: what memory function? Current & future directions – Jeff Binder is hippocampal sclerosis? Is HS a single pathological • Can early intervention prevent bilateral HS or disease diagnosis? How many types of HS do we have? What is progression? – Robert Elwes beyond the histology? Are there molecular markers? – Richard Prayson IIc. Pediatric 4:30–5:00 pm • Typical and atypical MRI findings. How normal is a normal Hippocampal sclerosis in children; age-based differences MRI in hippocampal sclerosis? (The role of post-processing in imaging, semiology, comorbid conditions and surgical techniques in optimizing the diagnosis/evaluation strategies management – Prakash Kotagal of mesial temporal lobe epilepsies) – Fernando Cendes
    • IId. Surgical Case-based Discussion 5:00–7:00 pm Monday, October 22 Moderators: William Bingaman and Eliseu Paglioli III. Focal Cortical Dysplasia Faculty: Guy McKhann II; Deepak Lachhwani; Nancy Foldvary; Moderators: Roberto Spreafico and Imad Najm Americo Sakamoto; Norman So; Tonicarlo Velasco; Silvia Neme; Paul Shkurovich; Carlos Carlotti IIIa. Structural 8:00–9:30 am Case #1: Dominant mesial temporal lobe epilepsy with • Neuropathology of Brain Damage in the Embryogenesis of preserved material specific memory – Carlos Carlotti Epilepsy – Marin Padilla Case #2: Pediatric case of intractable hippocampal sclerosis – • Histopathology of Cortical Dysplasia – Ingmar Blümcke Ahsan Moosa Naduvil Valappil • MRI in Cortical Dysplasia: What do we see? What we do not Case #3: Bilateral hippocampal sclerosis on MRI; discussion of see and why? How can we see what we do not see? MRI nonresective approaches – Norman So techniques structural imaging (post-processing & high field strength); how can we get better? – Irene Wang IIIb. Electro-functional 9:30–11:30 pm BYOCD Dinner 7:30-9:30 pm • EEG and imaging correlates of focal cortical dysplasia Bring Your Own Case Discussion – Laura Tassi This year the Cleveland Clinic Epilepsy Surgery Symposium • Functional correlates of Cortical Dysplasia – Prasanna organizing committee invites meeting attendees to submit Jayakar interesting or challenging surgical cases that have been • Choice of invasive technique(s) – Andreas Alexopoulos evaluated and managed at their home institutions. The IIIc. Pediatric 11:30–12:00 pm cases should highlight a particular clinical, EEG, imaging or histopathological presentation that would be of considerable Cortical dysplasia in the very young: age-based differences in interest to the audience. imaging, electroclinical presentation and surgical management – Michael Duchowny Each case should include a brief description of IIId. Surgical Case-based discussion 1:00–3:00 pm demographics, epilepsy history and electroclinical Moderators: Steven Roper and Giorgio LoRusso presentation, without any patient identifiable information, Faculty: Imad Najm; Giorgio LoRusso; Aleksandar J Ristic ; lasting for 5 minutes or less and limited to a total of 5 Michael Duchowny; Jocelyn Bautista; Francesco Cardinale; slides. Meeting participants will have the opportunity to Zhong Ying present their case, which will be followed by an interactive discussion with faculty and meeting attendees. Case #1: Focal Cortical Dysplasia (FCD) in eloquent cortex – Juan Bulacio A total of 10 cases will be selected by the organizing Case #2: Pediatric case of intractable FCD – Deepak Lachhwani committee to be reviewed in this format. Case #3: Reoperation in FCD – Mario Alonso Cases may be submitted at IIIe. Special considerations in MRI-negative patients www.ccfcme.org/Epilepsy12 (A) Structural 3:15–3:45 pm Deadline for submission is September 1, 2012. What are the pathologies of nonlesional epilepsy? Does it exist? Markers of nonlesional epilepsies? – Richard Prayson (B) Electro-functional 3:45–6:30 pm • Neurophysiology: Noninvasive EEG (including high density arrays / HFOs), and MEG: contributions & limitations in nonlesional epilepsies – Richard Wennberg • EEG-triggered functional-MRI: contributions & limitations in nonlesional epilepsies – Ana Carolina Coan • Nuclear/molecular imaging: contributions & limitations in nonlesional epilepsies – Matthias Koepp • Post-processing neuroimaging techniques – Andrea Bernasconi • Approach to nonlesional epilepsies of elusive/genetic etiology: are focal features a clue to surgical candidacy? – Hans Holthausen
    • Pathology-driven Approach to Epilepsy Surgery: Current State and Future DirectionsOctober 21-24, 2012Tuesday, October 23 Vd. Special Considerations – Vascular Malformations 4:30–5:00 pmIV. Brain Tumors Cavernous angiomas imaging findings, electroclinical Moderators: Eleonora Aronica and Guy McKhann II presentation and management: when a lesionectomy isIVa. Structural 8:00–9:00 am enough and when not – Lara Jehi • Histopathology of tumoral epilepsies: what makes tumors Ve. Surgical Case-based Discussion 5:00–6:30 pm epileptic? – Eleonora Aronica Moderators: Eliseu Paglioli and Hans Holthausen Faculty: André Palmini; Lara Jehi; Prakash Kotagal; • Imaging: Can we see the “epileptic” part of the tumor? Helio Machado; Hans Holthausen; Jocelyn Bautista; – Horst Urbach Aleksandar J RisticIVb. Electro-functional 9:00–10:15 am Case #1: Presurgical evaluation and surgical approach to • The approach to a patient with tumor and intractable patient with temporal lobe epilepsy in the setting of temporo- epilepsy: How complete or thorough should the evaluation polar cavernous angioma in the dominant hemisphere – be? Is VEEG monitoring needed? – Gregory D. Cascino Jocelyn Bautista • Where is the epileptogenicity in tumors? How to define it? Case #2: Presurgical evaluation and surgical approach to a – Dileep Nair patient with lateral temporoparietal encephalomalacia andIVc. Pediatric 10:15–10:45 am possible hippocampal sclerosis – André Palmini Brain tumors unique to children: electroclinical presentation, Case #3: Epilepsy in a child with large hemispheric imaging findings and management – Deepak Lachhwani encephalomalacia but preserved sensorimotor function – Prakash KotagalIVd. Surgical Case-based Discussion 10:45–12:15 pm Moderators: Guy McKhann II and Jorge Gonzalez-Martinez Special Combined Epilepsy and Ethics Lecture Faculty: Zhong Ying; Deepak Lachhwani; Michael Duchowny; Cross-cultural Understanding of Seizures 6:45–7:45 pm Guy McKhann II; Francesco Cardinale; Andrey Stojic; Dileep Nair; Stephen Hantus Case #1: Patient with epilepsy in the setting of an infiltrative or Wednesday, October 24 non-resectable tumor: Can surgery be helpful? What is the best VI. Preferential Pediatric Pathologies 8:00–11:30 am surgical approach and management? – Stephen Hantus Moderators: Ajay Gupta and Elaine Wyllie Case #2: Pediatric case of intractable tumoral epilepsy • Hemispheric dysplasia & hemimegalencephaly: pathological – Hans Holthausen and imaging findings, electroclinical presentation and Case #3: Case of epilepsy surgery versus tumor surgery surgical management – Elaine Wyllie – Zhong Ying and Dileep Nair • Sturge Weber syndrome: pathological and imaging findings; focal versus radical surgery – Eric KossoffSpecial Luncheon Lecture 12:15-1:30 pm • Tuberous Sclerosis: pathological and imaging findings, Lessons Learned From Surgery in Epilepsy Associated with electroclinical presentation and surgical management – Neurocysticercosis: A Model of Acquired Epilepsy? Howard Weiner – Kurupath Radhakrishnan • Rasmussen Encephalitis: pathological and imaging findings,V. Vascular Destructive Lesions & Vascular Malformations electroclinical presentation and surgical management – Moderators: André Palmini and Eliseu Paglioli Christian Bien • Hemispherectomy: surgical techniques, indications forVa. Structural 1:30–2:30 pm disconnections and choice of the technique – William • Imaging-histopathological correlations of vascular/hypoxic Bingaman destructive lesions associated with epilepsy: Ulegyria, major • Outcomes and their determinants following hemispheric telencephalic destructions and the transition to normal disconnections – Ajay Gupta tissue – Charles Raybaud • Coping with early destruction: How the brain reorganizes Surgical Case-based Discussion 11:30–1:30 pm function and why it matters for epilepsy surgery? Moderators: Howard Weiner and Helio Machado – Martin Staudt Faculty: William Bingaman; Hans Holthausen; Deepak Lachhwani; Helio Machado; Eric Kossoff; Prakash Kotagal, Christian BienVb. Electro-functional 2:30–3:30 pm Case #1: Tuberous Sclerosis with invasive recordings • Clinical and electrographic hallmarks of the neurological and – Ajay Gupta epileptic pictures – André Palmini Case #2: Sturge Weber syndrome with focal resection • Delineating the relevant epileptogenic and functional cortex – Helio Machado associated with encephalomalacia – Stefano Francione Case #3: Rasmussen encephalitis with initial medicalVc. Pediatric Considerations 4:00–4:30 pm management – Eric Kossoff Inducing favorable plasticity through seizure control and resection of epileptogenic abnormalities – Eliseu Paglioli Adjourn 1:30 pm
    • International Neuroethics ConferenceBrain Matters 3: Values at the Crossroads of Neurology, Psychiatry and PsychologyOctober 24-25, 2012Conference Overview Learning ObjectivesThis conference addresses ethical dilemmas in the treatment and research inconditions with neurological symptomatology but that are without identifiable 1. Create neuroethics research collaborations on conditions with neurological symptomatology,biological correlates/causes. The conditions of interest are often framed as but that have medically unexplained symptomsmedically unexplained symptoms (MUS), non-specific etiologies (NoS), or or are believed to have psychogenicpurely psychological. These diagnoses include, but are not limited to, chronic components.pain disorders, psychogenic movement disorders, conversion disorders, posttraumatic stress disorder, and fibromyalgia. The complexities of suffering 2. Disseminate new synthesis of ideas andand disability experienced by individuals with these conditions are significant; reflections from leading researchers.including exposure to dangerous and futile treatments. Among clinicians, 3. Bring together a unique, diversedisagreement continues over which aspects of these conditions are “all in multidisciplinary group of researchers,one’s head,” either literally or figuratively. Hidden value assumptions about clinicians, and ethicists to foster greatercausation permeate research studies and clinical decisions, and effect collaboration in developing this field.underlying treatment and care of patients. These assumptions have significantinfluence on the obligations, roles, and entitlements for patients and health 4. Create an analysis of ethics in the research andcare providers. Patients who suffer from these conditions are “orphaned” by treatment of Non-Epileptic Seizures, in bothspecialties and largely ignored in bioethics discussions. The plenary speakers pediatric and adult contexts.of this conference will address ethical challenges from a variety of academicdisciplines and medical subspecialties. Presentations will be given by patients,physicians, neuroscientists, and ethicists. Research abstracts will be solicitedboth for oral presentations as well as poster presentations. Conference Schedule Tuesday, October 23 Thursday, October 25 6:45-7:45 pm Evening Pre-conference Lecture: Cross- 8:00 am Plenary 4: Ethical Challenges Relating to Cultural Understandings of Seizures – Lisa Andermann Understanding the Physiology of Volition. What is Free About Free Will? – Mark Hallett Wednesday, October 24 9:30 am Breakout Sessions III 8:00 am Plenary 1: Patients’ Perspectives on Medically A. “Parent-ectomy”/“Child-ectomy” Panel Unexplained Symptoms – Siri Hustvedt and Carmen Paradis B. Accepted Paper C. Accepted Papers 9:30 am Breakout Sessions I A. Adult Psychogenic Nonepileptic Seizures Ethics 11:15 am Plenary 5: Ethical Challenges in Post Traumatic Working Session Stress Disorder and Traumatic Brain Injury in the Military B. Accepted Paper Context – Elspeth Ritchie C. Accepted Papers 1:30 pm Breakout Sessions IV 11:15 am Plenary 2: The Cultural Brain and the A. DSM-V Redefinitions Panel Construction of Self – Grant Gillett B. Accepted Paper C. Accepted Papers 1:30 pm Breakout Sessions II A. Pediatric Psychogenic Nonepileptic Seizures 3:45 pm Plenary 6: Partial Truths, Labels, and Ethics Working Group Responsibilities in Medically Unexplained Symptoms B. Accepted Paper – Richard Kanaan C. Accepted Papers 5:00 pm Adjourn 3:45 pm Plenary 3: Non-Epileptic Seizures, Communication and Ethics – Markus Reuber 5:00 pm Adjourn
    • Call for AbstractsThe Cleveland Clinic Epilepsy Surgery Symposium organizing as well as the opportunity to present their data in a dedicatedcommittee invites meeting attendees to submit abstracts session and ceremony.describing original epilepsy-related research. Our goal is to encourage young researchers in the field of epilepsyThe committee is also happy to announce the institution of the by providing them with an opportunity to showcase and discussCleveland Clinic Epilepsy Research Award. This award is offered to their results with experts in the field, and provide ground for furthermeeting attendees from within the United States and abroad whose investigations.abstracts provide a significant contribution to the Symposium’sgeneral theme and the understanding of epilepsy mechanisms and All other accepted abstracts will be shown in a poster session.treatments. Abstracts may be submitted atFive winners will be selected by the organizing committee. The www.ccfcme.org/EpilSurg12abstracts.winners will have their meeting registration fee waived and will be Deadline for submission is September 1, 2012.provided free accommodation in the meeting hotel’s headquarters,The Fourth Dudley S. DinnerDistinguished Epileptologist’s Lecture Patrick Chauvel, MD of paroxysmal events sources. He has also regarded his work in epilepsy as an opportunity to study normal human cortical Patrick Chauvel is Professor of Physiology physiology: the new Institute includes research teams working on at the Medical School of Aix-Marseille language and memory processing and higher cognitive functions. University (AMU), and Head of Department of Clinical Neurophysiology at the His main contributions have been to develop the concept of Assistance Publique des Hôpitaux de epileptogenic zone as a neural network with peculiar properties of Marseille. He trained in epileptology under synchronization, to make major advances in the pathophysiology of Jean Bancaud, working in Paris, at Hôpital déjà vu and dreamy state, and to decipher the complex patterns of Sainte-Anne and INSERM, with Bancaud frontal lobe seizures.and Talairach at a time when they were laying the foundation formuch of what we know of the dynamics of onset and propagationof focal seizures. Continuing to work in the field of epilepsy Dudley Dinner, MD (1947-2007) camesurgery, he moved to Rennes in the early nineties, then to Marseille to the Cleveland Clinic in 1979 as thein 1997, founding in the town of Henri Gastaut a major Epilepsy first fellow in clinical neurophysiologyCenter oriented towards presurgical investigation of drug-resistant and epilepsy and then joined theepilepsies. He has always devoted his time to developing research Epilepsy Section as staff neurologist andon partial epilepsy pathophysiological mechanisms and treatment, epileptologist. He played a leading role inin close relation with cerebral cortex physiology. He has paid establishing the epilepsy surgery program, evoked potentials and intraoperativemuch attention to interfacing his research field with Cognitive monitoring. Dr. Dinner made manyNeuroscience on the one hand, Biophysics, Signal Processing and valuable contributions to understandingComputational Neuroscience on the other hand. He is currently the the usefulness of the intra-carotid amytalDirector of a new INSERM-AMU Research Unit, named “Institute (WADA) test and the functional anatomy of the supplementary motorof Systems Neuroscience” (U1106), where all these domains are area cortex. He established and directed the sleep disorders center.cooperating through modeling of the clinical reality (http://ins. Dr. Dinner published numerous scientific papers, invited reviews,medecine.univmed.fr). editorials and chapters and also edited the book Sleep and Epilepsy. His vast knowledge and experience was a source of strength for both the epilepsy surgery and sleep programs at the Cleveland Clinic. HeHe is the author or the co-author of more than 270 publications. was very active in the American Clinical Neurophysiology Society andBesides many studies on the clinical semiology of seizures was Associate Editor of the Journal of Clinical Neurophysiology. Hisand its correlation with intracerebral recording (SEEG), he has wisdom and kind, gentle spirit provided guidance and encouragementused EEG signal processing for unraveling the epileptogenic to patients, colleagues, epilepsy fellows and neurology residents.zone organization, and for non-invasive EEG/MEG localization www.ccfcme.org/epilepsy12
    • FacultyCleveland Clinic Conference Invited Guest FacultyDirector Mario Alonso, MD Eric Kossoff, MD México City, Mexico Baltimore, MDImad Najm, MD Lisa Andermann, MD, MA W. Curt LaFrance Jr., MD, MPH Toronto, Canada Providence, RICleveland Clinic Planning Eleonora Aronica, MD, PhD Ilo Leppick, MDCommittee Amsterdam, The Netherlands Minneapolis, MNAndreas Alexopoulos, MD, MPH Selim Benbadis, MD Giorgio LoRusso, MDPaul Ford, PhD Tampa, FL Milan, ItalyStephen Jones, PhD, MD Andrea Bernasconi, MD Helio Machado, MD Montreal, Canada Ribeirão Preto, BrazilNorman So, MD Christian Bien, MD Miguel Marin-Padilla, MD Bielefeld, Germany Hanover, NHCleveland Clinic Faculty Jeff Binder, MD Guy McKhann II, MD, PhDJocelyn Bautista, MD Milwaukee, WI New York, NYWilliam Bingaman, MD Ingmar Blümcke, MD Eliseu Paglioli, MDJuan Bulacio, MD Erlangen, Germany Porto Alegre, BrazilRichard Burgess, MD Francesco Cardinale, MD André Palmini, MD, PhDRobyn Busch, PhD Milan, Italy Porto Alegre, BrazilTatiana Falcone, MD Carlos Carlotti, MD Kurupath Radhakrishnan, MD Campinas, Brazil Trivandrum, IndiaNancy Foldvary, DO Gregory Cascino, MD Charles Raybaud, MDJorge Gonzalez-Martinez, MD, PhD Rochester, MN Toronto, OntarioAjay Gupta, MD Fernando Cendes, MD, PhD Markus Reuber, MD, PhD, FRCPStephen Hantus, MD Campinas, Brazil Sheffield, United KingdomLara Jehi, MD Patrick Chauvel, MD ´ Aleksandar Ristic , MDPrakash Kotagal, MD Marseilles, France Belgrade, SerbiaDeepak Lachhwani, MD Ana Carolina Coan, MD Ret. Col. Elspeth Ritchie, MD, MPHAhsan Moosa Naduvil Valappil, MD Campinas, Brazil Washington, DCDileep Nair, MD Michael Duchowny, MD Steven Roper, MD Miami, FL Gainesville, FLSilvia Neme-Mercante, MD Robert Elwes Esq. Americo Sakamoto, MDCarmen Paradis, MD, MA London, United Kingdom Ribeirão Preto, BrazilRichard Prayson, MD Stefano Francione, MD, PhD Paul Shkurovich, MDAndrey Stojic, MD, PhD Milan, Italy México City, MexicoGeorge Tesar, MD Grant Gillett, MD, PhD Roberto Spreafico, MD, PhDIrene Z. Wang, PhD Dunedin, New Zealand Milan, ItalyDylan Wint, MD Mark Hallett, MD Martin Staudt, MD Bethesda, MD Vogtareuth, GermanyElanie Wyllie, MDZhong Ying, MD, PhD Bruce Hermann, PhD Laura Tassi, MD Madison, WI Milan, Italy Hans Holthausen, MD Horst Urbach, MD Vogtareuth, Germany Bonn, Germany Siri Hustvedt, PhD Paul Van Ness, MD New York, NY Dallas, TX Prasanna Jayakar, MD Tonicarlo Velasco, MD Miami, FL Ribeirão Preto, Brazil Richard Kanaan, MD Howard Weiner, MD London, United Kingdom New York, NY Matthias Koepp, MD, PhD Richard Wennberg, MD, FRCP(C) London, United Kingdom Toronto, Ontario
    • Registration 2012 Epilepsy Symposia Course 020900 Office Use Only October 19-25, 2012 Fee___________ Date___________ Go to: www.ccfcme.org/epilepsy12 M.O.P._________ Once you register online, please do not mail or fax in a registration form. CXL/Fee_______ Complete the information below if registering by mail or fax: PLEASE PRINT First Name Last Name Ml Degree Company Address City State Zip Phone Fax Specialty E-Mail q I require a vegetarian meal Clinical Epileptology Update* and Pathology-driven Pathology-driven International Neuroethics Clinical Epileptology Approach to Approach to Epilepsy Conference: Update* Epilepsy Surgery Surgery Combined Brain Matters 3 Oct 19-20 Oct 21-24 Oct 19-24 Oct 24-25 Check one: A B C D Professional Physicians $295.00 $525.00 $695.00 $195.00 No charge if registering Residents, Fellows, PhD, Nurses, PAs, APNs $149.00 $295.00 $395.00 for A, B or C Student Comprecare #__________________________ $191.75 $342.00 $452.00 $95.00 No charge if registering Cleveland Clinic Alumnus $177.00 $315.00 $417.00 for A, B or C *Application for Self-Assessment CME (4 credits) has been made to the American Board of Psychiatry and Neurology. Approval is pending. Fee includes: registration materials, self-assessment CME (part A), AM & PM break refreshments, and box lunches. Payment must be received prior to admittance to the symposium. Purchase orders are not accepted. Total amount enclosed or to be charged: $___________________________________ PAYMENT Make check payable to: Cleveland Clinic Educational Foundation or charge the following account: q Visa q MasterCard q American Express q Discover Card Number Exp. Date Signature (not valid without signature) If paying by check, registration should be MAILED to: Cleveland Clinic Educational Foundation P.O. Box 931653 • Cleveland, OH 44193-1082 Any questions regarding registrations should be e-mailed to cmeregistration@ccf.org or call 216-448-0777.
    • 21st Annual International Epilepsy Symposia Marriott Cleveland Downtown at Key Center Cleveland, OH Clinical Epileptology Review and Update October 19-20, 2012 Pathology-driven Approach to Epilepsy Surgery: Current State and Future Directions October 21-24, 2012 International Neuroethics Conference: Brain Matters 3 October 24-25, 2012The Cleveland Clinic Foundation 90 Years Logo 4 color process Blue: 100/34/0/2 Green: 100/0/85/24 Neurological Institute, S-40 Cleveland, OH 44195 9500 Euclid Avenue www.ccfcme.org/epilepsy12 No charge if registering In Collaboration With: for A, B or C