Pathogenic Processes in Asthma and COPD
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    Pathogenic Processes in Asthma and COPD Pathogenic Processes in Asthma and COPD Document Transcript

    • Keystone Symposia is pleased to present  Pathogenic Processes in Asthma and COPD Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston joint with the meeting on Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology January 10–15, 2013 | Santa Fe Community Convention Center | Santa Fe, New Mexico | USA hronic obstructive pulmonary disease (COPD) and asthma continue to be important causes of morbidity, mortality and C healthcare costs worldwide. However, their underlying causes remain poorly understood, even as their incidence of continues to increase. Recent discoveries have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent asthma and chronic airway obstruction in adulthood. The meeting’s overall goal is to draw together investigators from multiple disciplines doing work relevant to understanding the genetic, epigenetic and environmental factors and mechanisms that affect the development of asthma and COPD. Specific goals include: > Explore recent insights into the genetic and epigenetic origins of asthma and COPD; > Understand the relationship between early life environmental exposures and impaired lung function throughout life; > Dissect the relationship between lung infections as well as changes in the intestinal microbiome and the development of chronic lung diseases; > Understand the role of newly described innate immune cell populations and pathways in the development of lung inflammation; > Elucidate recent insights into the mechanisms of lung development, repair and remodeling; > Explore unique pathways of resolution of lung inflammation. By bringing together a critical mass of multidisciplinary researchers, the symposium should provide an ideal forum for exploring novel prevention and treatment strategies for these chronic respiratory diseases based on the identification of the genetic and environmental factors that interactively cause them. > New Insights into the Pathogenesis of Lung Diseases Session Topics: > Infectious Origins of Lung Disease > Innate Helper Cells in Type 2 Immunity > Role of Th17 Cells in the Regulation of Lung Immunity > Lung Development, Repair and Remodeling > Mechanisms of Chronic Obstructive Pulmonary Disease > Initiating Type 2 Immunity > Therapeutic Opportunities in Asthma and COPD Abstract & Scholarship Deadline: September 10, 2012 Late-Breaking Abstract Deadline: October 10, 2012 1.970.262.1230 | 1.800.253.0685 (US & Canada) Early Registration Deadline: November 8, 2012 Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization Note: Scholarships are available to students and postdoctoral fellows and requireheadquartered in Colorado, USA directed and supported by the scientific community. a brief application and submission of an abstract. Short talk speakers will also be selected from abstracts. Early registration saves US$150 on later fee. Information shown is subject to possible change. Please visit meeting website for the most up-to-date program information. www.keystonesymposia.org/13J2 Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.
    • KEYSTONE SYMPOSIA on Molecular and Cellular Biology Pathogenic Processes in Asthma and COPD (J2) Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston Supported by the Directors Fund Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) Scientific Organizers: Richard M. Locksley and Judith E. Allen January 10-15, 2013 •  Santa Fe Community Convention Center •  Santa Fe, New Mexico, USA Supported by an educational donation provided by Amgen Abstract & Scholarship Deadline: September 10, 2012 / Late-Breaking Abstract Deadline: October 10, 2012 / Early Registration Deadline: November 8, 2012THURSDAY, JANUARY 10 Gabriela Wlasiuk, University of Arizona, USA Short Talk: Epigenetic Predictors of Childhood Asthma are DetectableArrival and Registration in the Methylome at BirthWelcome and Keynote Address (Joint) Regulating the Type 2 Cytokines (J1)Bart N. Lambrecht, VIB - UGent, BelgiumThe Lung Dendritic Cell Network and the Response to Allergens *Fred D. Finkelman, University of Cincinnati, USA Dirk E. Smith, Amgen, Inc., USAFRIDAY, JANUARY 11 The Role of IL-33 in Regulating Innate Airway Inflammation Steven F. Ziegler, Benaroya Research Institute, University ofAdaptations to Chronic Helminth Infection (J1) Washington School of Medicine, USA *Judith E. Allen, University of Edinburgh, UK TSLP in the Regulation of Type 2 Immunity Fred D. Finkelman, University of Cincinnati, USA Richard M. Maizels, University of Edinburgh, UK Overview of Adaptations to Intestinal Helminthes Modulation of the Host Immune Response by Parasitic Helminths Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands Toshinori Nakayama, Chiba University, Japan Human Helminth Infections, Immune Responses and their Short Talk: Sox4 Acts as a Downstream Target of TGFbeta and Consequence Suppresses GATA3-Induced Th2 Cell Differentiation Ajay Chawla, University of California, San Francisco, USA Barbara Platzer, Boston Childrens Hospital, USA Metabolic Consequences of Type 2 Immunity Short Talk: Dendritic Cells use IgE as an Antigen Sensor for Andrew S. MacDonald, University of Edinburgh, UK Regulating Th2 Immunity Short Talk: Epigenetic Control of Th2 Induction by Dendritic Cells Infectious Origins of Lung Disease (J2) Ilaria Mosconi, Global Health Institute, Switzerland Short Talk: Differential Role of Peyer’s Patches and Mesenteric *Jay K. Kolls, University of Pittsburgh School of Medicine, USA Lymph Nodes during Helminth Infection James E. Gern, University of Wisconsin, USA Hermelijn H. Smits, Leiden University Center, Netherlands Virus Infections and Asthma Inception and Exacerbation Short Talk: Human Schistosome-Induced IL-10 Producing CD1dhi B Sebastian L. Johnston, Imperial College London, UK Cells Regulate Effector T Cell Responses Mechanisms of Rhinovirus-Induced Exacerbations in Asthma and Mark A. Travis, University of Manchester, UK COPD Short Talk: The TGFbeta-Activating Integrin alphavbeta8 on Dendritic Michael J. Holtzman, Washington University, USA Cells Regulates Type 2 Immunity in the Intestine to Promote Chronic Epithelial-Immune Cell Collaboration for Chronic Airway Disease Parasitic Infection Derek E. Byers, Washington University, USA Short Talk: Predominant Role of IL-33 as the Upstream Inducer ofNew Insights into the Pathogenesis of Lung Diseases (J2) IL-13-Mediated Chronic Airway Disease *Donata Vercelli, University of Arizona, USA Sally E. Wenzel, University of Pittsburgh, USA Poster Session 1 Emerging Concepts on Asthma Heterogeneity SATURDAY, JANUARY 12 Fernando D. Martinez, University of Arizona, USA Early-Life Origins of Chronic Obstructive Pulmonary Disease Innate Helper Cells in Type 2 Immunity (Joint) Avrum Spira, Boston University, USA *David Voehringer, University Hospital of Erlangen, Germany Molecular Insights into COPD via Transcriptomic Profiling Andrew N.J. McKenzie, Medical Research Council, UK Ian M. Adcock, Imperial College London, UK IL-25 and IL-33 Regulation of ILC2 in Protective Immunity and Allergy Epigenetic Regulation of Lung Disease Hergen Spits, University of Amsterdam, Netherlands Peter McErlean, Northwestern University, USA The Spectrum of Human Innate Lymphoid Cells Short Talk: Asthma Exacerbations during Acute Respiratory Illness Richard M. Locksley, University of California, San Francisco, USA are Characterized by Distinct Expression Profiles of Immunoregulatory Function-Marking Innate Helper Type 2 Cells and Cellular Repair Genes in the Nasal Mucosa Shigeo Koyasu, Keio University School of Medicine, Japan Critical Role of GATA3 in Natural Helper Cell Differentiation and Function* Session Chair  † Invited but not yet accepted     Program current as of December 14, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13J2 and www.keystonesymposia.org/13J1.
    • KEYSTONE SYMPOSIA on Molecular and Cellular Biology Pathogenic Processes in Asthma and COPD (J2) Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston Supported by the Directors Fund Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) Scientific Organizers: Richard M. Locksley and Judith E. Allen January 10-15, 2013 •  Santa Fe Community Convention Center •  Santa Fe, New Mexico, USA Supported by an educational donation provided by Amgen Abstract & Scholarship Deadline: September 10, 2012 / Late-Breaking Abstract Deadline: October 10, 2012 / Early Registration Deadline: November 8, 2012 Laurel A. Monticelli, University of Pennsylvania, USA Nicholas van Panhuys †, NIAID, National Institutes of Health, USA Short Talk: Innate Lymphoid Cells Promote Airway Epithelial Repair Short Talk: TCR Strength of Signal is Upstream of and Dominates through the Amphiregulin-EGFR Pathway Over Cytokine Effects in Controlling CD4+ T Cell Polarization in Vivo Christopher D.C. Allen, University of California, San Francisco, USAPoster Session 2 Short Talk: Regulation of IgE+ B Cell Responses Revealed by NovelWorkshop 1: Molecular Regulation of Allergic Responses (J2) Fluorescent Reporter Mice *Clare M. Lloyd, Imperial College London, UK Role of Th17 Cells in the Regulation of Lung Immunity (J2) Jennifer L. Ather, University of Vermont, USA *Hergen Spits, University of Amsterdam, Netherlands Serum Amyloid A Downregulates Bim Expression and Caspase-3 Activation in Serum-Starved Bone Marrow Derived Dendritic Cells Jay K. Kolls, University of Pittsburgh School of Medicine, USA and Induces Glucocorticoid Resistance in CD4+ T Cells Th17 Cells in the Regulation of Lung Immunity Sofia Tousa, Biomedical Research Foundation of the Academy of Susan V. Lynch, University of California, San Francisco, USA Athens, Greece Airway Microbiota and Lung Disease Activin-A-Induced Human Regulatory T Cells: Novel Controllers of Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Allergic Asthma Health, USA Elizabeth A. Jacobsen, Mayo Clinic, USA Colonization with Segmented Filamentous Bacteria Drives Severe Activated Pulmonary Eosinophils Are Necessary for Th2 Pulmonary Asthma through an IL-17A-Dependent Mechanism Inflammation Saheli Chowdhury, Academic Medical Center, Netherlands Hiromasa Inoue, Kagoshima University, Japan Short Talk: Exposure to IL-17 Reveals Defective mRNA Degradation Role of Leukotriene B4 Receptor BLT2 in Allergic Airway Inflammation by Bronchial Epithelial Cells in 70% of Patients with Asthma Purvi Mehrotra, Indiana University School of Medicine, USA PARP-14 and its Enzyme Activity Regulates Th2 Differentiation and SUNDAY, JANUARY 13 Allergic Airway Disease Commensals, Immunity and Epithelial Homeostasis (J1) David J. Cousins, Kings College London, UK *Hajime Karasuyama, Tokyo Medical and Dental University, In vitro Differentiation and Transcriptome Profiling of Human Th9 Cells Graduate School, Japan Tao Liu, Brigham and Women’s Hospital, Harvard Medical School, Wenjun Ouyang, Genentech, Inc., USA USA Regulation and Function of IL-22 on Epithelial Cells Deficiency of Inducible PGE2 is Sufficient to Cause Aspirin Sensitivity Yasmine Belkaid, NIAID, National Institutes of Health, USA in the Setting of Pulmonary Inflammation Commensal-Pathogen Interactions at Barrier SitesAdaptive Th2 and TFH Cells (J1) Sabine Eming, University of Cologne, Germany *Richard M. Locksley, University of California, San Francisco, USA Tissue Repair and Type 2 Immunity K. Mark Ansel, University of California San Francisco DeBroski R. Herbert, University of California, San Francisco, USA MicroRNA Regulation of TFH and Th2 Cell Development Short Talk: Trefoil Factor 2 Initiates IL-33 Production for Non-Canonical Type 2 Immunity against Murine Hookworm Infection Shane Crotty, La Jolla Institute for Allergy and Immunology, USA The Relationship between Th2 and Tfh Cells: Defining Characteristics Soichiro Yoshikawa, Tokyo Medical and Dental University, Japan of Tfh Cell Differentiation and Function Short Talk: Mechanisms Underlying the Recruitment, Accumulation and Activation of Basophils at Tick-Feeding Sites for Protective Matthew D. Taylor, University of Edinburgh, Scotland Immunity to Tick Re-Infestation Short Talk: Th2 Cell Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection via the PD-1/PD-L2 Pathway Png Loke, NYU School of Medicine Short Talk: Type 2 Immunity in Helminth Treatment for Inflammatory Fabienne Andris, Université Libre de Bruxelles, Belgium Bowel Diseases Short Talk: The Capacity of Th2 Lymphocytes to Deliver B Cell Help Requires Expression of the Transcription Factor STAT3 Lung Development, Repair and Remodeling (J2) *Fernando D. Martinez, University of Arizona, USA* Session Chair  † Invited but not yet accepted     Program current as of December 14, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13J2 and www.keystonesymposia.org/13J1.
    • KEYSTONE SYMPOSIA on Molecular and Cellular Biology Pathogenic Processes in Asthma and COPD (J2) Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston Supported by the Directors Fund Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) Scientific Organizers: Richard M. Locksley and Judith E. Allen January 10-15, 2013 •  Santa Fe Community Convention Center •  Santa Fe, New Mexico, USA Supported by an educational donation provided by Amgen Abstract & Scholarship Deadline: September 10, 2012 / Late-Breaking Abstract Deadline: October 10, 2012 / Early Registration Deadline: November 8, 2012 Jeffrey A. Whitsett, Cincinnati Childrens Hospital Medical Center, Initiating Type 2 Immunity (Joint) USA Epigenetic and Genetic Regulation of Goblet Cell Metaplasia and *Andrew N.J. McKenzie, Medical Research Council, UK Antiviral Innate Immunity by FOXA3 Jean-Philippe Girard, CNRS, France Paul W. Noble, Duke University, USA IL-33 Processing and Activation by Inflammatory Proteases Matrix Regulation of Lung Injury, Inflammation and Repair Jenny P.-Y. Ting, University of North Carolina at Chapel Hill, USA Stephanie C. Eisenbarth, Yale University, USA NLRs and Type 2 Immunity NOD-Like Receptors and the Regulation of Lung Inflammation Marco Idzko, University Hospital Freiburg, Germany Joanne L. Wright, University of British Columbia, Canada ATP and P2X Receptors in Type 2 Immunity Cigarette Smoke Induced COPD - Use of Animal Models Jack A. Elias, Yale School of Medicine, USA Hesam Movassagh, University of Manitoba, Canada Chitinase-like Moieties in Lung Inflammation, Injury and Repair Short Talk: Semaphorin 3E Inhibits Human Airway Smooth Muscle Laura J. Simpson, University of California, San Francisco, USA Cell Proliferation and Migration Short Talk: miRNA Expression in CD4 T Cells from Asthmatic Airways Sejal Saglani, Imperial College London, UK Takehiko Shibata, University of Michigan Medical School, USA Short Talk: Interleukin-33 Promotes Airway Remodelling in Paediatric Short Talk: Gas6/TAM Signaling Differentially Modulates Chronic Severe Steroid Resistant Asthma Fungal Asthma with the Expansion of Myeloid Regulatory Cell Subsets in MiceMyeloid Cells in Tissue Homeostasis (J1) *Richard M. Maizels, University of Edinburgh, UK Workshop 2: Viral Infections and Exacerbations of Lung Disease (J2) Judith E. Allen, University of Edinburgh, UK Macrophages in Helminth Infection: Where Inflammation is *Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Anti-Inflammatory Health, USA David Voehringer, University Hospital of Erlangen, Germany Charles S. Dela Cruz, Yale University, USA Eosinophil and Basophil Responses to Allergens and Helminths Cigarette Smoke Exposure Enhances Interleukin-15, NK and CD8 T Hajime Karasuyama, Tokyo Medical and Dental University, Graduate Cell Responses during Influenza Virus Infection in Models of COPD School, Japan Jenny Calvén, Lund University, Sweden Basophil as a Crucial Player in Acquired Immune Responses Viral Stimuli and Epithelium-Derived Mediators Trigger Cytokine Carla V. Rothlin, Yale University, USA Expression in Bronchial Smooth Muscle Cells Short Talk: TAMing Type 2 Immunity Sumit Ghosh, North Dakota State University, USA Hyaluronic Acid Impacts B Lymphocyte Recruitment and Function in aMechanisms of Chronic Obstructive Pulmonary Disease (J2) Murine Fungal Allergic Asthma Model *Sebastian L. Johnston, Imperial College London, UK Amali E. Samarasinghe, St. Jude Childrens Research Hospital, USA Shyam Biswal, Johns Hopkins School of Public Health, USA Allergic Eosinophils Enhance Anti-Viral Defenses in a Murine Oxidative Stress Regulation of Lung Inflammation in COPD Co-Morbidity Model of Asthma and Influenza Augustine Choi, Harvard Medical School, USA Tamlyn Peel, Imperial College London, UK Regulation and Function of Autophagy in COPD IL-17 Modulation of Rhinovirus-Induced Allergic Airways Disease Farrah Kheradmand, Baylor College of Medicine, USA Lara Ravanetti, Academic Medical Center Autoreactive T Cells in The Pathophysiology of Human and Mouse Influenza-Induced Exacerbation in a Murine Chronic House Dust Mite Emphysema (HDM) Asthma Model Chandran Nagaraj †, Ludwig Boltzmann Institute for Lung Vascular Kristen N. Kindrachuk, National Institutes of Health, USA Research, Austria Muc5ac-Deficiency Exacerbates Bleomycin-Induced Airway Short Talk: p22phox Regulates House Dust Mite (HDM) Induced Inflammation Allergic Airway Inflammation Pathologic Syndromes (J1)Poster Session 3 *Jack A. Elias, Yale School of Medicine, USA Stuart G. Tangye, Garvan Institute of Medical Research, AustraliaMONDAY, JANUARY 14 Lymphocyte Defects in Hyper-IgE Syndromes* Session Chair  † Invited but not yet accepted     Program current as of December 14, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13J2 and www.keystonesymposia.org/13J1.
    • KEYSTONE SYMPOSIA on Molecular and Cellular Biology Pathogenic Processes in Asthma and COPD (J2) Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston Supported by the Directors Fund Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) Scientific Organizers: Richard M. Locksley and Judith E. Allen January 10-15, 2013 •  Santa Fe Community Convention Center •  Santa Fe, New Mexico, USA Supported by an educational donation provided by Amgen Abstract & Scholarship Deadline: September 10, 2012 / Late-Breaking Abstract Deadline: October 10, 2012 / Early Registration Deadline: November 8, 2012 Thomas A. Wynn, NIAID, National Institutes of Health, USA Macrophages and Mucins in the Pathogenesis of Type 2 Immunity Lawren C. Wu, Genentech, Inc., USA Therapeutic Targeting of IgE-Switched Cells in Asthma Mark S. Wilson, National Institute for Medical Research, Medical Research Council, UK Short Talk: miR-182 and miR-10a Are Key Regulators of Treg Specialisation and Stability during Th2 and Th1-Associated Inflammation Adam Matson, University of Connecticut Health Center, USA Short Talk: Maternal Allergy Is Associated with Surface-Bound IgE on Cord Blood BasophilsTherapeutic Opportunities in Asthma and COPD (J2) *Sally E. Wenzel, University of Pittsburgh, USA Aili Lazaar, GlaxoSmithKline, USA Challenges and Opportunities in COPD Drug Development John G. Matthews, Genentech, Inc., USA Treatment of Adult Asthmatics with the Anti-IL-13 Lebrikizumab Alison L. Budelsky, Amgen Inc., USA Blockade of IL-17RA in Asthma Sofie Lock Johansson, Institut for Molecular Medicine, Denmark Short Talk: Microfibril Associated Protein 4 (MFAP4) Is Associated to Dyspnea and the Composite BODE Index in COPDTUESDAY, JANUARY 15Departure* Session Chair  † Invited but not yet accepted     Program current as of December 14, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13J2 and www.keystonesymposia.org/13J1.