American Epilepsy Society's (AES) Annual Meeting 2012

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American Epilepsy Society's (AES) Annual Meeting 2012

  1. 1. 66TH ANNUAL MEETING
  2. 2. SCHEDULE November 30FRIDAYSATURDAY December 1 December 2SUNDAY AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 1 www.AESNET.org
  3. 3. MONDAY SCHEDULE December 3TUESDAY December 4 AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 2 www.AESNET.org
  4. 4. SCHEDULE-AT-A-GLANCE FRIDAY November 30 7:00 a.m. - 6:00 p.m. Registration 1:30 p.m. - 3:00 p.m. Special Interest Group Meetings 8:30 a.m. - 11:30 a.m. Epilepsy Specialist Symposium: 3:30 p.m. - 6:00 p.m. Spanish Symposium: Algorithms in the Diagnosis and Extratemporal Epilepsies Treatment of Epilepsy 4:15 p.m. - 5:45 p.m. Hoyer Lecture 12:30 p.m. - 3:00 p.m. Annual Fundamentals of Epilepsy 5:45 p.m. - 6:30 p.m. Symposia Break Symposium: Optimal Use of the Newest AEDs and Generics 6:30 p.m. - 8:00 p.m. Special Interest Group Meetings 1:30 p.m. - 3:00 p.m. Professional Development in AES: 6:30 p.m. - 9:00 p.m. Hot Topics Symposium: A Program for Junior Members and Those Modulators of Epilepsy: The Influence of in Transition Lifestyle and Environmental Factors SATURDAY December 1 6:30 a.m. - 6:00 p.m. Registration 2:00 p.m. - 4:30 p.m. Translational Research Symposium: 7:00 a.m. - 8:30 a.m. Special Interest Group Meetings Epilepsy Benchmarks: Major Advances 8:30 a.m. - 11:30 a.m. Presidential Symposium: IOM Report 2012: Clinical and Basic Science Keynotes Epilepsy Across the Spectrum: Promoting (2:00 p.m. - 2:30 p.m.) Health and Understanding 6:15 p.m. - 7:45 p.m. Special Interest Group Meetings 11:45 a.m. - 6:00 p.m. Poster Session 1 6:15 p.m. - 8:15 p.m. Investigators’ Workshops Exhibit Hall 6:15 p.m. - 8:45 p.m. Antiepileptic Therapy Symposium: (Reception: 4:30 p.m. - 6:00 p.m.) Management of Refractory Status Epilepticus 2:00 p.m. - 4:30 p.m. Professionals in Epilepsy Care Symposium: Current Issues in Clinical Practice: Transitioning from Adolescent to Adult Epilepsy Care SUNDAY December 2 7:30 a.m. - 6:00 p.m. Registration 8:45 a.m. - 5:15 p.m. Investigators’ Workshops 8:00 a.m. - 5:00 p.m. Scientific Exhibits IW Posters / Boxed Lunch: Noon - 2:00 p.m. 8:00 a.m. - 6:00 p.m. Poster Session 2 10:00 a.m. - 4:00 p.m. Exhibit Hall 8:45 a.m. - 5:15 p.m. Annual Course: Managing Common Complex 7:30 p.m. - 9:00 p.m. Special Interest Group Meetings Symptomatic Epilepsies: Tumors and Trauma 8:00 p.m. - 10:00 p.m. Social Networking Groups MONDAY December 3 7:30 a.m. - 6:00 p.m. Registration 2:15 p.m. - 3:00 p.m. Lennox & Lombroso Lecture 7:00 a.m. - 8:30 a.m. Special Interest Group Meetings 3:45 p.m. - 5:15 p.m. Investigators’ Workshop 8:00 a.m. - 3:00 p.m. Poster Session 3 Special Interest Group Meetings 8:00 a.m. - 5:00 p.m. Scientific Exhibits 4:00 p.m. - 5:30 p.m. Pediatric Epilepsy Highlights Session 9:00 a.m. - 10:30 a.m. Special Interest Group Meetings 4:00 p.m. - 6:15 p.m. Platform Sessions: 3 Concurrent Sessions 9:00 a.m. - Noon Merritt-Putnam Symposium: 5:45 p.m. - 6:30 p.m. Symposia Break From Molecules to Cells, Networks and 6:30 p.m. - 9:00 p.m. Pediatric State of the Art Symposium: Seizures: How Does a Gene Cause Epilepsy? Prolonged Febrile Seizures and TLE: 10:00 a.m. - 3:00 p.m. Exhibit Hall Hot New Information TUESDAY December 4 8:30 a.m. - 12:30 p.m. Registration 8:30 a.m. - 10:00 a.m. North American Commission Symposium: Epilepsy Classification: Hot Controversies 7:00 a.m. - 8:30 a.m. Special Interest Group Meetings in 2012 8:30 a.m. - 10:00 a.m. Scientific Symposium: Stereotactic 10:00 a.m. - 11:30 a.m. Skills Workshops #1 (3 Concurrent) Electroencephalography (sEEG) in the Pre-surgical Investigation of Refractory Focal 11:45 a.m. - 1:15 p.m. Skills Workshops #2 (3 Concurrent) EpilepsyAES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 3 www.AESNET.org
  5. 5. GENERAL INFORMATION AES 2012 Annual Meeting Accreditation The American Epilepsy Society (AES) is one of 108 Chapters of the The American Epilepsy Society is accredited by the Accreditation Council for International League Against Epilepsy (ILAE). The Annual Meeting of the Continuing Medical Education (ACCME) to offer continuing medical education American Epilepsy Society is the largest meeting and exhibition in the world for physicians. of those who share the common scientific and clinical interests of epilepsy and clinical neurophysiology. Each year over 4,000 attendees gather who are Credit Designation dedicated to improving the quality of life for those afflicted with epilepsy. This Physicians: The American Epilepsy Society designates this live activity for a meeting will be the top forum to examine common concerns and to gain maximum of 35.0 AMA PRA Category 1 CreditsTM. Physicians should claim only insight from leading authorities. the credit commensurate with the extent of their participation in the activity. Physician Assistant: AAPA accepts certificates of participation for Mission Statement educational activities certified for AMA PRA Category 1 Credit™ from The American Epilepsy Society promotes research and education for organizations accredited by ACCME or a recognized state medical society. professionals dedicated to the prevention, treatment and cure of epilepsy. Physician assistants may receive a maximum of 35.0 hours of Category 1 Target Audience credit for completing this program. Basic: Those new to epilepsy treatment or whose background is limited, e.g., Nurses: EDUPRO Resources LLC is an approved provider of continuing nursing students, residents, general physicians, general neurologists and education by Pennsylvania State Nurses Association, an accredited approver neurosurgeons, other professionals in epilepsy care, administrators. by the American Nurses Credentialing Center’s Commission on Accreditation, Intermediate: Epilepsy fellows, epileptologists, epilepsy neurosurgeons, Provider number P208-8/08-11. “mid-level” providers with experience in epilepsy care (e.g., advanced practice EDUPRO is also an approved provider by the California Board of Registered nurses, nurses, physician assistants), neuropsychologists, psychiatrists, basic Nursing, Provider number CEP-14387. and translational researchers. Nurses who participate in selected AES programs can receive up to 35 Advanced: Symposium will address highly technical or complex topics contact hours. To successfully complete the activities, nurses will be required (e.g., neurophysiology, advanced imaging techniques, advanced treatment to complete evaluations for each session attended and to access the Medical modalities, including surgery). Education Evaluator to claim credit. Membership Disclaimer: Accreditation refers to educational content only and does not The American Epilepsy Society invites you to join one of the oldest imply endorsement of products by PSNA, ANCC, CBRN, or EDUPRO neurological professional organizations in the United States. The American Resources LLC. Epilepsy Society seeks to promote interdisciplinary communications, scientific Pharmacists: Projects In Knowledge® is accredited by the investigation, and exchange of clinical information about epilepsy. Members Accreditation Council for Pharmacy Education (ACPE) as a provider of include clinicians, scientists, and other professionals interested in seizure continuing pharmacy education. disorders, representing both pediatric and adult aspects of epilepsy. Selected AES programs are approved for a total of 35 contact hours (3.5 AES members receive benefits that include: Epilepsy Currents, the official CEUs). To successfully complete the CPE activities, pharmacists will be journal of the AES, discounted fees for subscriptions to scientific journals and required to complete evaluations for each program attended and to access registration to the AES Annual Meeting; opportunities to apply for funding the Medical Education Evaluator to claim credit. their research, participation in the Society through committee membership, International Credits: The American Medical Association has determined that and network with national and international colleagues. non-U.S. licensed physicians who participate in this CME activity are eligible Join AES by Monday, November 19, 2012 to qualify for the member for AMA PRA Category 1 Credits TM. registration discount. CME / CE Certificates Policy on Commercial Support and Conflict The Medical Education Evaluator® is an online system that allows any of Interest attendee to self-manage the process of completing course evaluations, The American Epilepsy Society maintains a policy on the use of commercial tracking credits and printing out the appropriate certificate for either AMA support, which ensures that all educational activities sponsored by the AES PRA Category 1 CreditsTM, CNE or ACPE pharmacy statement of credits. provide in-depth presentations that are fair, balanced, independent and Once you have accessed the Medical Education Evaluator®, you will be asked scientifically rigorous. All faculty, planning committee members, editors, to enter your “myAES number” and password. The certificate(s) are saved to managers and other individuals who are in a position to control content are your personal account page which is cumulative. You may print the required to disclose any relevant relationships with any commercial interests certificate(s) in PDF format at any time. related to the activity. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentations. All To help support this process, attendees who want educational credits will be educational materials are reviewed for fair balance, scientific objectivity and asked to pay: levels of evidence. This information will also be made available through Member Fees: $35 through January 18, 2013 syllabus materials and faculty presentations. $50 January 19 – February 28, 2013 Non-member Fees: $50 through January 18, 2013 Disclosure of Unlabeled / Unapproved Uses $75 January 19 – February 28, 2013 This educational program may include references to the use of products for indications not approved by the FDA. These discussions are noted on the The online Evaluator will be left open through February 28, 2013, so you must faculty’s disclosure forms as well as during their presentations. Opinions complete the evaluations and credit tracking by that date. expressed with regard to unapproved uses of products are solely those of the By completing this information online, attendees greatly assist the Council on faculty and are not endorsed by the American Epilepsy Society or any other Education and Annual Meeting Committee with important needs assessment manufacturers of pharmaceuticals. data whereby the AES can further plan and address educational gaps to meet the needs of our learners. Abstracts Abstracts from the 2012 Annual Meeting will be available on the AES website A meeting attendance certificate will be available at the registration desk for and as an online supplement to Epilepsy Currents. international meeting attendees . Syllabus Syllabi for the educational symposia will be available via the virtual tote bag.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 4 www.AESNET.org
  6. 6. GENERAL INFORMATION Commercial Exhibits Advanced Registration The Exhibit Hall is an integral part of the learning experience. Meeting Once again, a registration discount of $50 is offered to all attendees who participants will have an ideal opportunity to learn about the latest in confirm a hotel room through Experient, the official AES Housing Bureau. This pharmaceuticals, publications, scientific equipment, and technology relevant discount applies to all those who confirm a reservation and complete all to the fields of epilepsy and neurophysiology. Please check the AES website registration and payment requirements by Friday, October 26. The discount for an updated listing of exhibiting companies and organizations. To ensure code listed on your confirmation must be used at the time your registration is safety and security, no children, strollers, carriages, wheeled luggage or submitted. Please visit the AES website for updated information. wheeled briefcases will be allowed in the Exhibit Hall during exhibit hours. Hotel Reservations Saturday, December 1 11:45 a.m. - 6:00 p.m. AES continues to utilize Passkey as the online hotel reservation system allowing Sunday, December 2 10:00 a.m. - 4:00 p.m. attendees to confirm, modify or cancel hotel reservations in real time, 24 / 7. Monday, December 3 10:00 a.m. - 3:00 p.m. Automated confirmations are sent immediately to your e-mail address. Please Scientific Exhibits contact Experient Housing at 800.974.9769 or 847.996.5892 if you have questions. AES has approved guidelines for industry-sponsored, scientific exhibits at the Everyone is encouraged to use the discount hotel programs that have been Annual Meeting. Scientific Exhibits differ from traditional poster presentations arranged for you. Confirming your room through AES Housing allows AES to in that a broad range of material can be presented as a collection of topics, maintain consistent and competitive registration, exhibit space and other such as results of various clinical trials, or a thematic presentation of one service fees from year to year. A portion of the room rate at each hotel will be aspect of drug development. Scientific Exhibits will be displayed on Sunday, used to offset meeting expenses. December 2 and Monday, December 3. An application to register for a Three ways to confirm your hotel room: Scientific Exhibit was e-mailed to interested companies in May. Reservations will be reviewed and accepted on a first-come, first-served basis until space 1. Book Online (credit cards only) is sold out. Send inquiries of interest to JoLynn Amsden at PLEASE NOTE: Your e-mail system or spam blocker may be preventing jamsden@aesnet.org. you from receiving important messages, including your hotel confirmation responses from Experient, the official AES Housing Bureau. Please Cyber Café remember to check your spam filter frequently. The Cyber Café will be available at the Convention Center with e-mail and Internet access. Check in with family members and colleagues, and conduct 2. Mail or Fax: 847.996.5401 (credit cards only) online research while attending the Meeting. You will also be able to complete Experient Housing the course evaluations and obtain your CME certificate online. Material presented 568 Atrium Drive at the AES Annual Meeting is not to be reproduced in any format without the Vernon Hills, IL 60061-1731 express written consent of the AES. 3. Contact the Housing Customer Service Team at Experient Monday – Friday, 9:00 a.m. - 5:00 p.m. (Central Time) Language Phone: 800.974.9769 (U.S. & Canada) The official language of the Annual Meeting is English. Simultaneous 847.996.5892 (International) translation will be available in the Annual Course and NAC Symposium. E-mail Experient at AES@experient-inc.com Photography and Recording of Programs AES strictly prohibits all photography (flash, digital, or otherwise), audio and / Housing Deadline or videotaping during the Annual Meeting. Equipment will be confiscated. The deadline for blocks of 10 or more rooms is Monday, October 8. The deadline for individual hotel reservations is Monday, November 5. You are Attendees acknowledge and agree that commercial or promotional encouraged to make your hotel reservations early, as rooms may sell out prior distribution, publishing or exploitation of speaker sessions, content, or to these dates. materials from the AES Annual Meeting is strictly prohibited unless you have received the express prior written permission from AES or the otherwise Confirm your hotel room through Experient, the official AES Housing Bureau, applicable rights holder. and receive a $50 discount off your registration. When you attend an American Epilepsy Society (AES) event or program, Room Deposit / Cancellation Policy you enter an area where photography, audio, and video recording may occur. A credit card is required to guarantee a reservation. After Monday, By entering the event premises, you consent to photography and its release, November 19, a one night, non-refundable deposit (room and tax) publication, exhibition, or reproduction to be used for news, newsletters, representing the first night of your reservation will be charged to your credit promotional purposes, advertising, inclusion on websites, or any other card. Changes can be made to your reservation online or with Experient, the purpose by AES and representatives. You release AES, its officers and official AES Housing Bureau, until Monday, November 19, based on employees, and each and all persons involved from any liability connected availability. After Monday, November 19, please contact your hotel directly. with the taking, digitizing, or publication of photographs and computer images. You have been fully informed of your consent, waiver of liability, and release Early Departure Policy Guests who check out of the hotel prior to their scheduled departure date will before entering the event. be charged a penalty of one night’s room rate and tax. Press Room San Diego Marriott Marquis and Marina (Headquarters Hotel) AES offers meeting information kits and assistance for journalists reporting on 333 West Harbor Drive epilepsy studies, educational presentations, and special reports at this San Diego, CA 92101 meeting. The AES on-site Press Room staff works with journalists to develop Rates: $253 Single / Double (Cityview) stories, research facts and information, and connect with experts and $273 Single / Double (Bayview) presenters. The on-site Press Room is also available to sponsors and exhibitors for the display and distribution of relevant press releases and media kits. For Check-in: 4:00 p.m. Check-out: Noon more information, contact Peter Van Haverbeke at pvanhaverbeke@gmail.com. Hilton San Diego Bayfront Program Changes One Park Boulevard AES cannot assume liability for any changes in the program due to external or San Diego, CA 92101 unforeseen circumstances. Rates: $250 Single / Double Check-in: 3:00 p.m. Check-out: NoonAES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 5 www.AESNET.org
  7. 7. GENERAL INFORMATION Manchester Grand Hyatt San Diego Amtrak One Market Place The San Diego train station, located at 1050 Kettner Boulevard, is minutes San Diego, CA 92101 from the San Diego Convention Center. Amtrak offers a 10% discount off the Rates: $253 Single / Double lowest available rail fare to San Diego, CA (SAN) between November 28, Check-in: 4:00 p.m. Check-out: Noon 2012 and December 8, 2012. To confirm a reservation, please call Amtrak at 1.800.872.7245 or contact your travel professional. Refer to Fare Code X43K- Residence Inn Gaslamp San Diego 949 to receive the 10% discount. The discounted fare cannot be booked via 356 6th Avenue Amtrak.com. This offer is not valid on Acela Express service. Offer is valid San Diego, CA 92101 with Sleeper accommodations, Business Class or First Class seating with Rates: $167 Single / Double payment of the full applicable accommodation charges. Fare is valid on Check-in: 4:00 p.m. Check-out: Noon Amtrak Northeast Regional service for all departures seven days a week, except during holiday blackout dates. Meeting Location Airport Shuttles The San Diego Convention Center Shuttle Service is available at the transportation plazas across from San Diego 111 W. Harbor Drive Airport Terminals 1 and 2, and curbside at the Commuter Terminal. Several San Diego, CA 92101 shuttles companies with vans and buses are also available for hire from the Reminiscent of a grand cruise ship, the San Diego Convention Center is one of airport. the world’s most modern and technologically sophisticated meeting facilities. Car Rental Lobby services include ATM, restaurant information and reservation booth and San Diegos airport is served by all major car rental agencies. Car rental a full service business center. Ample areas are available for meeting reservation boards are located near the baggage claim areas of Terminal 1 attendees to meet and network with colleagues. and 2. Visitors can request shuttle transportation to the car rental company of • AES Registration Upper Level, Ballroom 6 Lobby their choice by using convenient courtesy phones. • Exhibit Hall and Posters Ground Level, Hall B Taxis Many companies provide taxicab service at the San Diego International • Session Rooms Upper Level and Mezzanine Level Airport. Signage leads visitors from the gate to the transportation plazas, • General Sessions Upper Level, Ballroom 6C where a transportation coordinator places visitors with the first available taxi. Affiliate Meetings Information for International Travelers AES welcomes industry and other groups to participate in the Annual Meeting through support, Scientific Exhibits and exhibition opportunities. The AES also Consulates and Embassies recognizes the need for meeting space during the Annual Meeting for events Please check with your local U.S. consulate or embassy to find out the earliest that may include Alumni Reunions / Receptions, Board Meetings, and that you may apply for a visa at www.usembassy.gov/. The visa applications Committee Meetings. All meetings must be approved and confirmed by AES process can take as long as 8 weeks, especially for those countries that are in advance. Limited meeting space will be available at the San Diego Marriott on the State Sponsors of Terrorism List. Attendees from these countries Marquis and Marina. Detailed guidelines and allowable times will be available should start the application process at least 6 to 8 months in advance of the on the AES website in August. Annual Meeting. No Smoking Policy Banking and Currency Exchange For the comfort and health of all attendees, smoking is not permitted at any Banking hours in the United States are generally Monday to Friday, AES functions. This includes educational sessions, meetings and all food 9:00 a.m. - 5:00 p.m. A few banks are open on Saturdays. Several banking functions. Both the Convention Center and the Hilton Baltimore are smoke- institutions are within walking distance of the Convention Center. free facilities. Also, smoking is not permitted in public buildings, restaurants Visa Application Information or bars. For information regarding important timelines and travel to the United States, you may access the following websites: Meeting Attire AES promotes casual business attire for the duration of the Annual Meeting. • U.S. State Department Consider bringing a light jacket or sweater with you since meeting room • Canadian Citizens temperatures and personal comfort levels vary. • U.S. Embassy Consular Section City Information • Visa Waiver Program As California’s second largest city, and the United States’ eighth largest, San Diego boasts a citywide population of 1.3 million residents. The city includes • Visa Wait Times many popular areas such as the downtown historic Gaslamp Quarter, Little • U.S. Visit Traveler Information Italy, Coronado Island, La Jolla and Del Mar, to name a few. The area is • U.S. Visit Biometric Identification Services renowned for its idyllic climate and an average daily temperature of 70 degrees F year round (21.4 degrees Celsius). Winters are sunny and mild, Disclaimer: Please note that this information is provided in good faith. while nights can be cool. San Diego offers an expansive variety of things to do Regulations may change and the only authoritative sources of information are and see, appealing to guests of all ages from around the world. For additional the U.S. Government websites at www.unitedstatesvisas.us and information, access the visitor information through the AES website. www.travel.state.gov/visa/visa_1750.html. Letter of Invitation Getting to San Diego and Ground Transportation For security purposes, letters of invitation can only be sent to individuals The San Diego International Airport is ideally located three miles from registered for the Annual Meeting. Please check the appropriate box on the downtown San Diego and 10 minutes away from the San Diego Convention registration form. Once your payment has been processed a letter will be sent Center. All major airlines, and many other domestic and international carriers, to you. Please send any questions to conferenceregistration@aesnet.org. provide daily service to the airport and bring more than 18 million visitors to America’s Finest City. For a complete list of all airlines that offer service to San Diego, please visit www.san.org.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 6 www.AESNET.org
  8. 8. GENERAL INFORMATION Additional Information in During the month of December, San Diego, California operates in the Pacific Standard Time Zone (GMT -8 hours). New 2 Gratuities are not automatically added to the bill, except in some cases for 201 large groups. Waiters and waitresses are usually given 15 - 20% of the bill. Taxi drivers usually receive 15% of the fare and doormen and $2 per night for Important Badge Information hotel housekeeping. Skycaps and porters are normally tipped $1 per bag. Voltage in the United States is 120 (60 HZ). Outlet sockets use either a Type Individuals who register prior to Wednesday, A plug which is a class II ungrounded plug with two flat parallel prongs, or a Type B plug which is a class I plug with two flat parallel prongs and a November 7 will receive their official annual meeting grounding pin. European appliances will require a voltage transformer. badge via postal mail. Please note that you will be charged $100 for badge and ticket reprints should Registration & Security AES is committed to providing a secure meeting environment. A formal you arrive without them. These items are required security plan is being developed in consultation with the Security Department to access meeting and session areas and must be at the Convention Center. All meeting attendees will be required to produce worn at all times. If you register November 8 or later, government-issued photo identification prior to receiving their badge and registration materials. Appropriate badges must be worn at all times while in your badge and appropriate tickets will be printed on- attendance at the Meeting and are required for admittance to all meeting site. Badge holders and lanyards will be available in activities. Security procedures will also be in place for exhibition materials and the Registration Desk area on-site. all deliveries to the AES meeting. Additional security information will be available in the Program Book received at the on-site registration desk. Badge information: In order to receive your badge on- Insurance / Liabilities site, you must produce government-issued photo AES cannot be held responsible for any personal injury, loss, damage, accident to private property or additional expenses incurred as a result of identification. Badges must be worn at all times and delays or changes in air, rail, sea, road, or other services, strikes, sickness, are non-transferable. weather, acts of terrorism and any other cause. All participants are encouraged to make their own arrangements for health and travel insurance. Name badge replacement: A $100 fee will be charged Contact Information for a replacement badge. American Epilepsy Society Phone: 860.586.7505, ext. 512 342 North Main Street Meeting Fax: 860.586.7550 West Hartford, CT 06117-2507 E-mail: info@aesnet.org Additional information available when registration Website: www.AESNET.org opens in August. AES Fellows Program The American Epilepsy Society is committed to nurturing and supporting fellows in the field of epilepsy. The goal of the AES Fellows program is to encourage epilepsy fellows in training to attend the AES Annual Meeting where they will be exposed to the latest updates in clinical and basic science research. This year’s program will be held on Friday, November 30. A breakfast and lunch will be sponsored by the AES to allow fellows to meet and pair with mentors who can provide guidance regarding career planning, potential research paths, and clinical endeavors. Following the breakfast the fellows will attend the AES Epilepsy Specialist Symposium: Algorithms in the Diagnosis and Treatment of Epilepsy followed by the Annual Fundamentals of Epilepsy Symposium: Optimal Use of the Newest AEDs and Genetics. The afternoon programs consist of a lecture with Robert Fisher, M.D., Ph.D., followed by the Hoyer Lecture and the Hot Topics Symposium in the evening. Invitations were recently sent to epilepsy directors. Nominations are limited to one fellow per institution. This year, 85 fellows will be chosen, 10 of which will be new M.D.’s. Priority will be given to first time attendees. Nominees should be neurology trainees in approved epilepsy fellowships; in rare instances other candidates may be considered if space permits. The 2012 AES Epilepsy Fellows program is supported by Lundbeck, Inc., UCB, Inc, and Eisai Inc.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 7 www.AESNET.org
  9. 9. FRIDAY November 30, 2012 8:30 a.m. – 11:30 a.m. 9:00 a.m. – 4:00 p.m. Epilepsy Specialist Symposium: 26th Annual Advances in the Management of Algorithms in the Diagnosis and Treatment Epilepsy and the Epilepsy Clinic of Epilepsy (separate registration required — see below for instructions) Overview This intensive one-day conference is designed for those professionals who This symposium will discuss common problems encountered in caring for participate in the care of persons with epilepsy. The overall purpose is to patients with new onset or difficult to control seizures. The topics will include: improve services to individuals and families affected by epilepsy. The (i) The diagnosis and treatment of a first seizure – who is at risk of conference is presented by the Department of Neurology of Wake Forest recurrence, the risks and benefit balance of starting treatment, and how long University School of Medicine, Winston-Salem, North Carolina, through an to treat. (ii) How to approach the pre-operative evaluation to localize the epileptic onset zone non-invasively and how to plan invasive recordings to unrestricted grant committed to the education of health professionals, in an localize the seizure onset zone. (iii) Patient selection for treatment by effort to promote the comprehensive care of those with epilepsy and their neurostimulator devices (VNS, DBS) to palliate seizures and optimization of families. stimulation parameters. (iv) Discussing SUDEP – when to have the discussion, Registration for this program is done separately from the AES Annual Meeting with which patients, and how to approach the topic with patients at risk. The and begins on September 1, 2012. You may register online at speakers will present the audience with algorithms that identify key decisions www.nwahec.org/?34929 or you may call Pat Gibson of Wake Forest School in the evaluation and treatment of seizures. of Medicine at 800.642.0500 with any questions. Learning Objectives u Manage patients with first seizure by applying risk/benefit analysis using prediction of seizure recurrence based on presentation and ancillary tests 12:30 p.m. – 3:00 p.m. Annual Fundamentals of Epilepsy u Evaluate patients for epilepsy surgery weighing the advantages / disadvantages of different approaches and understanding the rationale for Symposium: Optimal Use of the Newest selecting a specific approach AEDs and Generics u Appropriately refer patients for implantation of and will successfully treat Overview them with neurostimulator devices. The Annual Fundamentals Symposium will address both the newer u Recognize when and how to initiate discussion of SUDEP in patients antiepileptic medications (AEDs) and current understanding regarding use of who are at risk generic medications. Presentations will address pharmacology and mechanism of action of new AEDs, their clinical pharmacokinetics and drug Target Audience interactions. Efficacy and adverse effects of newer AEDs in approved Basic and Intermediate (see page 4 for details) indications plus alternative uses of newer AEDs in epilepsy syndromes and status epilepticus will also be reviewed. There will be discussion of current Program data regarding the use of generic AEDs. Chair: Fred A. Lado, M.D., Ph.D. Introduction and Overview Learning Objectives u Use newer AEDs to treat patients with refractory epilepsy Fred A. Lado, M.D., Ph.D. First Seizure: Diagnosis, Treatment and Prognosis u Match newest AEDs to the epileptic syndrome when appropriate Sheryl Haut, M.D. u Anticipate and recognize adverse effects related to use of newer AEDs Debate: Surgical Planning for Extratemporal Non-lesional Surgery? u Use generic medications and advocate for their use based on Ashesh Mehta, M.D. and Francois Dubeau, M.D. understanding on available scientific data. Treatment of Epilepsy with Implanted Devices: What Are Indications and Target Audience Benefits? Basic and Intermediate (see page 4 for details) Barbara C. Jobst, M.D. Program Discussing SUDEP: If, When, How Co-Chairs: James C. Cloyd, Pharm.D. and Michael D. Privitera, M.D. Jeffrey Buchhalter, M.D., Ph.D. Introduction and Overview Conclusions James C. Cloyd, Pharm.D. Fred Lado, M.D., Ph.D. Mechanism of Action of the New AEDs Credit Designation Misty Smith, Ph.D. The American Epilepsy Society designates this live activity for a maximum of 3.0 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit Clinical Pharmacokinetics and Drug Interactions commensurate with the extent of their participation in the activity. Cecile Johannessen Landmark, Ph.D. Efficacy and Adverse Effects of Newer AEDs in Approved Indications Nurses may claim up to 3.0 contact hours for this session. R. Edward Faught, Jr., M.D. The Emerging Uses of the Newer Antiseizure Medications in Status Epilepticus and Epilepsy Howard Goodkin, M.D., Ph.D.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 8 www.AESNET.org
  10. 10. FRIDAY November 30, 2012 Generic AEDs: Facts and Fiction the luxury of being in a monitoring unit, is essential in surgical work-ups, and Michael D. Privitera, M.D. is often critical in accurate recognition of rare syndromes. It is less manageable in the office setting and often impossible in epidemiological Case Presentations contexts. How can we develop a hierarchical, consistent lexicon that allows All faculty meaningful communication and translation across these diverse settings Conclusions without losing essential detail where it is needed and without imposing it in Michael D. Privitera, M.D. settings where it is not available? We will have a face-off with epidemiologists and tertiary center epileptologists presenting their Credit Designation perspectives and lexicological needs. Videos will be used to illustrate the The American Epilepsy Society designates this live activity for a maximum of debacle with everyone invited to participate in a pre- and a post-self test. 2.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit There will be ample time for discussion. commensurate with the extent of their participation in the activity. Psychiatry in Epilepsy – Interictal Dysphoric Disorder: Nurses may claim up to 2.5 contact hours for this session. Fact or Fiction Coordinators: Rochelle Caplan, M.D., John J. Barry, M.D. Speakers: The SIG speakers supporting IDD will be Andres M. Kanner, M.D. 1:30 p.m. – 3:00 p.m. and Marco Mula, M.D. and those against will be Alan B. Ettinger, M.D. and Professional Development in AES: A Program John J. Barry, M.D. David W. Dunn, M.D. will discuss its absence in pediatric epilepsy. for Junior Members and Those in Transition Interictal Dysphoric Disorder is a form of depression that has been described The American Epilepsy Society invites all interested meeting attendees to come in people with epilepsy, but it has yet to be accepted universally. The aim of to a special session on volunteer and leadership opportunities within the Society. this SIG is to review the evidence for and against the presence of this The American Epilepsy Society has a variety of programs year round to improve condition. This debate addresses important theoretical and clinical the care and treatment of patients with epilepsy. These efforts include education implications of this diagnosis. From the theoretical perspective, a similar for basic scientists and clinicians, research grant programs, leadership and condition in migraine, and the wide range of psychiatric diagnoses in organizational activities, community outreach and advocacy. Greater participation individuals with this diagnosis question the specificity of this condition and its in the Society offers members extensive career development opportunities by underlying mechanisms to epilepsy. From the clinical perspective, how does providing a chance to hone leadership skills, to network with other AES members this diagnosis benefit patients in terms of their treatment and long-term and outside funding organizations, and most importantly, to make significant outcome? contributions to improve the lives of patients with epilepsy. This session will be useful to trainees, basic scientists, clinicians and other health 3:30 p.m. – 6:00 p.m. professionals (nurses, psychologists, Pharm.D.s) who want to know more about Spanish Symposium: Extratemporal Epilepsies organizational structure or who want to become more involved. The session will provide an overview of the professional development and volunteering Overview opportunities within the Society, followed by short presentations by members The symposium will present evidence-based information concerning the active in AES leadership. The session will end with a chance to meet with AES scientific and clinical fundamentals of extratemporal epilepsy that are relevant staff and committee leaders to learn more about available opportunities. for the diagnosis and management of adult and pediatric patients. The semiology of seizures originating in frontal, parietal and occipital neocortex will present and contrast with symptoms of temporal lobe seizures. The 1:30 p.m. – 3:00 p.m. diagnosis and outcomes of pediatric and adult epilepsy syndromes and the Special Interest Group Meetings criteria for determination of refractoriness will be emphasized. Presurgical evaluation and the selection of surgical or other non-pharmacologic EEG - Spotlight on Slow Waves treatments will be critically reviewed. Coordinator: Hiroshi Otsubo, M.D. Speakers: Akio Ikeda, M.D., Ph.D., Marco de Curtis, M.D., Learning Objectives Hal Blumenfeld, M.D., Ph.D. u Knowledge of diagnosis, treatment and outcome of pediatric and adult extratemporal epilepsy syndromes Slow waves represent diverse pathophysiological mechanisms in epilepsy. The spikes and high frequency oscillations (HFOs) are highlighted for u Knowledge and implementation of modern concepts of refractory epilepsy. epileptogenesis. However, the combination of spike and slow wave is a key Target Audience element of interictal epileptic discharges. Ictal HFOs are frequently Basic, Intermediate (see page 4 for details) superimposed on very slow waves, called slow shift, to start seizures. Toward the end of seizures the spike and slow waves reappear to stop the seizures. Program This SIG EEG session invites three speakers to present mechanisms of Co-Chairs: Alvaro Hernando Izquierdo Bello, M.D. and Patricio Abad, M.D. interictal and ictal slow waves for understanding the role of epileptic slow waves. Introduction and Overview Alvaro Hernando Izquierdo Bello, M.D. Epidemiology – Simple, Generalized and Complex? The Words We Use to Communicate About the Central Extratemporal Epilepsies in Children and Adolescents Manifestations of Epilepsy Ignacio Valencia, M.D. Coordinator: Anne T. Berg, Ph.D. Speakers: Samden Lhatoo, M.D., FRCP, Jeffrey Buchhalter, M.D., Ph.D. Extratemporal Epilepsies in the Adult and the Elderly José F. Tellez-Centeno, M.D., Ph.D. A recent report recommended major restructuring of terminology for seizures and abandoning the terms simple and complex partial in favor of describing Surgical Treatment of Extratemporal Epilepsies: Indications, Procedure ictal semiology instead. The impetus is to encourage precise, accurate Selection, Outcome diagnosis and, one would hope, improve treatment. This is feasible if one has Carlos Barzallo, M.D.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 9 www.AESNET.org
  11. 11. FRIDAY November 30, 2012 Round Table: Case Presentations and Discussion Botanicals and Alternative Therapies for Epilepsy – Lilia Nuñez-Orozco, M.D. and Alcy R. Torres, M.D. (moderators) Behavioral Interventions for Epilepsy Coordinators: Siegward M. Elsas, M.D., Steven C. Schachter, M.D. Conclusions Speakers: Peter Wolf, M.D., Ph.D., Joanne Dahl, Ph.D., Donna J. Andrews, Ph.D., Patricio E. Abad, M.D. Rosa Michaelis Credit Designation This year, we plan to discuss the rationale of comprehensive behavioral The American Epilepsy Society designates this live activity for a maximum of interventions for improving seizure control in epilepsy patients, as described 2.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit by representatives of several centers which have experience in using different commensurate with the extent of their participation in the activity. methods to accomplish similar goals. Is it possible for patients to accomplish a change in attitude from a passive role, receiving external treatment to an Nurses may claim up to 2.5 contact hours for this session. active role of taking charge of their own epilepsy condition? Is it possible to identify early seizure warning signs or triggers for the average epilepsy patient to allow for a timely countermeasure? We hope that by comparing different 4:15 p.m. – 5:45 p.m. approaches, critical features of behavioral interventions for seizures will 10th Judith Hoyer Lecture in Epilepsy become apparent in the discussion. In addition, we will consider methodological issues in the conduct of clinical trials of behavioral Lecturer: John M. Pellock, M.D. interventions by reviewing recently published pilot studies. For example, what are the characteristics of suitable control conditions for a study of behavioral The 10th Judith Hoyer Lecture in Epilepsy, presented by invited Lecturer interventions? Dr. Jack Pellock, is sponsored by the National Institute of Neurological Disorders Ictal Semiology and Stroke. Dr. Pellock’s presentation is the tenth in a series of lectures Coordinator: Felix Rosenow, M.D. highlighting the promise of epilepsy research. This series is held in memory of Speakers: Hans O. Lüders, M.D., Ph.D., Philippe Kahane, M.D., Ph.D., Mrs. Judith Hoyer, an active member of the Board of Directors of the Epilepsy Akos C. Szabo, M.D., Felix Rosenow, M.D. Foundation and the late wife of Representative Steny Hoyer (D-MD). Mrs. Hoyer spent her life both helping families to cope with epilepsy and promoting The moderator and members of the faculty will show ictal videos of epileptic research into a cure and a better quality of life for those with the disorder. The patients. This will include some typical seizures as well as unusual cases. purpose of the lecture is to raise awareness of epilepsy among researchers and After showing the video the moderator will give the audience an opportunity the public and provide intellectual stimulation that will encourage continuing to discuss the case. The discussant should describe the ictal semiology and progress toward finding a cure for epilepsy. try to deduce the most likely symptomatogenic and epileptogenic zone. The moderator will then call on his faculty to give their opinion. At the end neurophysiological, neuroimaging or other evidence will be presented that 6:30 p.m. – 8:00 p.m. elucidates the symptomatogenic and / or epileptogenic zone. Special Interest Group Meetings Nursing Coordinators: Madona D. Plueger, M.S.N., RN, CNRN, ACNS-BC, Basic Neuroscience – Mechanisms of Juvenile Myoclonic Georgette Smith, M.S.N., M.D.N, APRN, CPNP Epilepsy: From Molecules to Networks Speakers: TBA Coordinators: Martin J. Gallagher, M.D., Ph.D., Michael Wong, M.D., Ph.D. Speakers: Martin J. Gallagher, M.D., Ph.D., Antonio B. Delgado-Escueta, M.D., Ph.D., The Nursing SIG will focus the 2012 session on enhancement of nursing Matthias J. Koepp, M.D., Ph.D. knowledge in the field of epilepsy regarding current practice inquiry and research. The SIG will highlight nursing awardee posters allowing author Juvenile Myoclonic Epilepsy (JME) is a common Idiopathic Generalized presentation and sharing of information. In addition, the Managing Well with Epilepsy (IGE) syndrome that differs from the more-frequently-studied IGE Epilepsy Network will provide an update regarding current research projects syndrome, Childhood Absence Epilepsy (CAE), in several domains. Clinically, and clinical applicability. This forum fosters the development of ongoing JME patients exhibit myoclonic and generalized tonic-clonic seizures as well nursing participation and collaboration in the field. as, occasionally, absence seizures. Moreover, JME patients experience substantially greater rates of pharmacodependence and pharmacoresistance Supported by Eisai, Inc. than CAE patients. Electrographically, epileptiform discharges in JME patients occur at faster frequencies and with a different morphology than CAE SUDEP: Explaining the Unexplained discharges. Finally, neurophysiological studies revealed that patients with JME Coordinators: Elizabeth J. Donner, M.D., FRCP(C), George B. Richerson, M.D., Ph.D., demonstrate a particular diurnal variability of cortical excitability. These Lawrence J. Hirsch, M.D. observations suggest that JME is produced by different pathophysiological Speakers: Edward Glasscock, Ph.D., Rainer Surges, M.D., Anne E. Anderson, M.D., mechanisms affecting different brain networks than those involved in CAE. Gordon F. Buchanan, M.D., Daniel Mulkey, Ph.D. While several animal models suggested that CAE results from disruption of Sudden Unexpected Death in Epilepsy (SUDEP) remains a mysterious tragedy. thalamocortical oscillations, we still need good models of JME to understand While the causes of death are thought to ultimately involve cardiac, the molecular and network mechanisms that cause this disease and to autonomic or respiratory dysfunction, there is much less known about the identify new targets to treat pharmacologically. This Basic Neuroscience SIG CNS mechanisms that lead from a seizure to cardiorespiratory failure. In this will discuss the recent developments in the identification of novel genes session, speakers will present their own personal theories about the specific involved in JME, the elucidation of molecular consequences of JME mutations pathophysiological mechanisms involved, at the molecular, cellular and in vitro and in vivo, and the determination of brain regions involved in JME in network levels within the CNS or heart, that lead from a seizure to SUDEP. An human patients. emphasis will be placed on which groups of neurons, axonal pathways, neurotransmitters, or molecules are involved, and not simply whether death is due to a cardiac or respiratory mechanism. A substantial amount of conjecture will be allowed, as long as speakers remain constrained by actual data. Following five to six short presentations, ample time will be used for a panel discussion with questions and comments from the audience.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 10 www.AESNET.org
  12. 12. FRIDAY November 30, 2012 Translational Research Programs at the NINDS and NIH Neurosteroids as Neuromodulators of Epileptogenesis in Animals Coordinators: Brandy E. Fureman, Ph.D., William Benzing, Ph.D., Istvan Mody, Ph.D. Randall Stewart, Ph.D. Speakers: William Benzing Ph.D., Rajesh Ranganathan, Ph.D., Brian Litt, M.D., How Neurosteroids Modulate Seizures in Children and Adults H. Steve White, Ph.D., Gregory A. Worrell, M.D., Ph.D. Page B. Pennell, M.D. Conclusions NIH and NINDS speakers will provide overviews of currently available programs for funding translational research projects (including changes to the R. Edward Hogan, M.D. Anticonvulsant Screening Program), the application process, and review Credit Designation considerations. Current translational award grantees will provide experiences The American Epilepsy Society designates this live activity for a maximum of from the applicant point of view. 2.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 6:30 p.m. – 9:00 p.m. Hot Topics Symposium: Modulators of Nurses may claim up to 2.5 contact hours for this session. Epilepsy: The Influence of Lifestyle and Environmental Factors Overview Exercise is a neglected area when evaluating epilepsy patients. Exercise is often considered as a disease modulating factor in other conditions, but not epilepsy. We will discuss whether cardiovascular fitness can influence the development of epilepsy and its prognosis. Stress is a negative modulator of epilepsy and the aim of this section will be to elucidate how stress can change the course of epilepsy and what can be done about it. Are there environmental or emotional factors that positively influence epilepsy, or are they all negative? Endogeneous factors, such as circulating and CNS hormones, are important modulators of epileptogenesis, seizure severity and frequency. In this section hormonal factors, and how to influence them will be discussed. The mechanism of action, and disease modulating effect of neurosteroids remains an understudied area. Learning Objectives u Recommend the type of exercise which is most advantageous for patients with epilepsy and advise patients regarding the factors involved in performing exercise that can have a positive influence on epilepsy u Counsel patients regarding different stress in life and management of stress, including those stresses which can aid in managing epilepsy u Implement therapies that can positively influence the neurosteroid environment to decrease seizure activity. Target Audience Basic and Intermediate (see page 4 for details) Program Co-Chairs: Elinor Ben-Menachem, M.D., Ph.D. and R. Edward Hogan, M.D. Introduction and Overview Elinor Ben-Menachem, M.D., Ph.D. Exercise as a Neuromodulator of Cognition and Epilepsy: What Do We Know from Animal Studies? Georg Kuhn, Ph.D. Effects of Exercise (Cardiovascular Function) on the Development of Epilepsy in Adults Elinor Ben-Menachem, M.D., Ph.D. Stressors/Environmental Enhancement as a Mediator of Epileptogenesis – Animal Models Nigel Jones, Ph.D. Stressors/Environmental Enhancement as a Mediator of Epileptogenesis –Translational Aspects Terence J. OBrien, M.D.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 11 www.AESNET.org
  13. 13. SATURDAY December 1, 2012 7:00 a.m. – 8:30 a.m. 8:30 a.m. – 11:30 a.m. Special Interest Group Meetings Presidential Symposium: IOM Report 2012: Epilepsy Across the Spectrum: Basic Mechanisms Coordinators: Howard Goodkin, M.D., Ph.D., Timothy Benke, M.D., Ph.D., Promoting Health and Understanding Sanjay Rakhade, Ph.D., M.B.B.S. Speakers: Nicholas P. Poolos, M.D., Ph.D., Helen E. Scharfman, Ph.D., Overview This symposium will describe the process that led to the development of the Steve Danzer, Ph.D. 2012 IOM. There will be a report on the potential impact of IOM report on Epilepsy-induced changes in axonal and dendritic cytoarchitecture have both the AES community and the health care community in general . There started attracting attention again in the last few years with new studies about will be a review of the major elements of the report and how it will be their role in comorbidties of epilepsy. Human pathological studies and studies implemented to change professional education, certification of epilepsy in animal models of epilepsy have shown structural abnormalities in the centers and specialists, and patient access to care. Actionable elements of dendrites of neurons. Several hypotheses suggest that these abnormalities the IOM report that will require coordinated participation of federal and non- may be contributing to neuronal dysfunction, epileptogenesis and cognitive / federal entities will be addressed. The relationship of the IOM report to the neurological dysfunction in epilepsy. expanded NINDS and inter-institute funding programs for epilepsy research as well as how the IOM report can support the NINDS Epilepsy Benchmarks will This basic mechanism SIG will be focused on updating the attendees about be described. Finally, the response of patient advocacy and nongovernmental the current knowledge about the cytoarchitecture and arborization of organizations will be presented, including implementation of the report dendrites observed in the human subject and animal models of epilepsy. The recommendations and coordination with the community of professionals in featured talks will provide an overview of the dendritic pathologies observed epilepsy care. in different models of epilepsy, dendritic channelopathies observed in models of epilepsy (Dr. Poolos); the structural abnormalities in mature granule cells in Learning Objectives temporal lobe epilepsy (Dr. Danzer) and abnormalities in the ectopic granule u Recognize the impact of current gaps in diagnosis and treatment, as well cells in the hippocampus in pilocarpine model of epilepsy (Dr. Scharfman). as quality of life issues for patients with epilepsy Targeted mechanisms for preventing seizure-related structural changes in dendrites may represent a novel therapeutic strategy for treating epilepsy and u Utilize information from emerging surveillance efforts to assess incidence its complications. and prevalence of epilepsy in the population across all age ranges to define clinical needs in their communities Critical Care Monitoring – ICU EEG Monitoring Coordinators: Evan Fertig M.D., Suzette M. Laroche, M.D. u Understand significant areas of need for clinical, basic, and Speakers: Susan T. Herman, M.D., Suzette M. Laroche, M.D., epidemiological research related to epilepsy and its comorbidities and Puneet Gupta, M.D., MSE, Cecil Hahn, M.D. their relationship to NINDS Epilepsy Benchmarks in order to define their research goals 1) Review of the new guidelines for Critical Care EEG Monitoring developed by the ICU EEG monitoring consortium. Recommendations will be presented for u Identify and engage others devoted to provision of care in order to equipment, personnel, review, coding, billing, etc. 2) Case presentations by coordinate management of patients with epilepsy expert speakers followed by audience comment and debate. Cases will u Manage care of patients based on established quality measures and highlight the utility of quantitative EEG methods and new terminology for desired improvement strategies in order to optimize patient outcomes. quasi-periodic patterns developed by the ICU EEG monitoring consortium. Target Audience Junior Investigators Workshop – Opportunities for Funding Basic, Intermediate and Advanced (see page 4 for details) and Career Development for Junior Investigators Coordinator: Andre Lagrange, M.D., Ph.D. Program Speakers: TBA Chair: Frances E. Jensen, M.D. Join us for an exciting Junior Investigators Workshop on how to get funded to Introduction and Overview support your research career. This will be an interactive session in which our Frances E. Jensen, M.D. renowned panelists will share their pearls of wisdom. We will open the floor for discussion, so bring your questions and topics of discussion. This is sure to The IOM Process and Committee Discussion be a lively and informative interchange! Joseph I. Sirven, M.D. Pediatric Epilepsy Diagnosis and Treatment Opportunities – The Context of the IOM Report: A View from HHS Leadership Case-based Discussions Howard Koh, M.D., M.P.H. Coordinator: Elaine Wyllie, M.D. Speakers: TBA What the IOM Report Means for Basic and Clinical Research Story Landis, Ph.D. Six dynamic faculty will each present an exciting case from his or her clinical experience that teaches an important clinical point and advances our field of How the IOM Report Will Impact the Lives of Patients with Epilepsy pediatric epilepsy. Topics will be diverse and touch on controversies in EEG, Susan Axelrod seizure semiology, genetics, neurometabolism, neuroimaging, antiepileptic drug therapy, and epilepsy surgery. Audience interaction is encouraged! Conclusions Frances E. Jensen, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.5 contact hours for this session.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 12 www.AESNET.org
  14. 14. SATURDAY December 1, 2012 2:00 p.m. – 4:30 p.m. 2:00 p.m. – 4:30 p.m. Professionals in Epilepsy Care Symposium: Translational Research Symposium: Epilepsy Current Issues in Clinical Practice: Benchmarks: Major Advances Transitioning from Adolescent to Adult Overview Epilepsy Care Research. This symposium will inform the audience about recent advances in translational, basic research that directly bear on NIH benchmarks and that Overview could potentially change / improve patient care. Advances in genetics, EEG Clinical care guidelines for the transition of adolescents to adult epilepsy care recordings and analysis, potential cell based therapies, and understanding the currently are not available. Therefore, most common clinical issues associated relationship between epilepsy and autism will be presented. with transition of care and practical strategies to address them are identified as an educational need for epilepsy healthcare professionals. Theoretical Relationship to the Epilepsy Benchmarks. The presentations are aligned with models, multidisciplinary and multicultural clinical experience, and current the following benchmarks: Identify new treatments or therapies to prevent, strategies for clinical practice of transition of care will be discussed. In interrupt, or reverse the development of epilepsy; Develop and test at least addition, special topics in transition of care such as intellectual disability and one animal model of epilepsy and an associated condition; Develop and test ILAE task force activities will be presented. biological and other markers that pinpoint the locations of brain networks associated with the development of epilepsy. Learning Objectives u When counseling patients and care providers, learner will address Medical Treatment. Medical treatment will be advanced as genetic challenges and offer suggestions for transitioning youth with intellectual underpinnings of epilepsy are understood and new treatment modalities, such disabilities and epilepsy to adult health care as cell transplants and diet therapies, are explored. Furthermore, identification and characterization of electrical biomarkers via advances in EEG technologies u Establish procedures to support patient transition from pediatric to adult will lead to better understanding of epilepsy phenotypes and improved care. care providers Learning Objectives u Define specific practical issues and the role of pediatric neurologists in the u Recognize genetic epilepsies and understand the presumptive transition and transfer of care within their clinical setting utilizing ILAE task mechanisms that underlie conditions such as astatic myoclonic epilepsy force activities related to the transition of adolescents with epilepsy and that may contribute to comorbidies such as autism. When managing Target Audience such patients, address both the mechanism of the epilepsy and the Basic and Intermediate (see page 4 for details) expected comorbidities. Program u Review data concerning cell based therapies in models of intractable Co-Chairs: Sigita Plioplys, M.D. and Janelle Wagner, Ph.D. epilepsy that may provide new insights into novel approaches for correcting network dysfunction in epilepsy Introduction and Overview Sigita Plioplys, M.D. u Participants will utilize state-of-the-art EEG technologies to improve seizure classification and localization. How Can Transition Best be Orchestrated? Models and Personal Experience Peter R. Camfield, M.D., FRCP(C) Target Audience Intermediate and Advanced (see page 4 for details) Global Issues in the Transition of Adolescents with Epilepsy – A Child Neurologist’s Perspective Program Jaime Carriroza, M.D. Co-Chairs: Daniel H. Lowenstein, M.D. and Karen S. Wilcox, Ph.D. Challenges in Transitioning Adolescents with Intellectual Disabilities and Introduction and Overview Epilepsy Daniel H. Lowenstein, M.D. Rebecca Schultz, Ph.D., RN, CPNP Role of CNTNAP2 in Epilepsy, Neuronal Migration Abnormalities, and Core Adolescent Epilepsy Transition and the Role of Nursing Autism-related Deficits Laura Jurasek, PNP, M.N. Olga Peñagarikano, Ph.D. Conclusions Using Multi-electrode Array Recordings to Detect Unrecognized Electrical Janelle Wagner, Ph.D. Events in Epilepsy Credit Designation Catherine Schevon, M.D., Ph.D. The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit Embryonic MGE Cells as a Treatment for Epilepsy commensurate with the extent of their participation in the activity. Scott C. Baraban, Ph.D. Glucose Transporter 1 Deficiency as a Treatable Cause of Myoclonic Astatic Nurses may claim up to 2.5 contact hours for this session. Epilepsy Saul Mullen, M.D. 2:00 p.m. – 2:30 p.m. Clinical and Basic Science Keynotes Conclusions Karen S. Wilcox, Ph.D. Basic and Clinical Science Research Recognition Award Recipients each give a 15-minute keynote. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.25 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.25 contact hours for this session.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 13 www.AESNET.org
  15. 15. SATURDAY December 1, 2012 6:15 p.m. – 7:45 p.m. 6:15 p.m. – 8:45 p.m. Special Interest Group Meetings Antiepileptic Therapy Symposium: Management of Refractory Status Epilepticus PNES Coordinators: John J. Barry, M.D. and Markus Reuber, M.D., Ph.D. Speakers: Nicole Roberts, Sigita Plioplys, M.D., Julia Doss, Psy.D. Overview Refractory Status Epilepticus is associated with high morbidity and special The PNES SIG will be separated into two parts. In the first section, the focus challenges in its management, that differ in special populations of patients. In will be on recent findings from a series of studies exploring the this symposium, we will combine clinical and translational lectures to critically neurobiological and cognitive underpinnings of PNES. This will be discussed by update current practice and progress in the management of Refractory Status Dr. Nicole Roberts. In the second segment, Drs. Sigita Plioplys and Julia Doss Epilepticus in adults and children. The mechanisms underlying the will discuss important clinical questions and difficulties in managing children management of Refractory Status Epilepticus, based on recent basic science with PNES and their families. They will also provide new research evidence and translational research, will be discussed. The presentations will address from an ongoing prospective multi site study on risk factors in pediatric PNES. the role of autoimmunity in the pathogenesis and treatment and the role of Active input from the audience will be welcome. inflammation and immune system in the pathogenesis of Refractory Status Epilepticus. Also presented will be a critical evaluation and update on the Sleep in Epilepsy – Mechanisms and Consequences of emerging therapies for Refractory Status Epilepticus. Interrupted Sleep by Epilepsy Coordinator: Mark S. Quigg, M.D. Learning Objectives Speakers: Carl Bazil, M.D., Ph,D., Erik S. Louis, M.D., Rama Maganti, M.D., u Promptly recognize and initiate appropriate treatment algorithms for Selim R. Benbadis, M.D. refractory status epilepticus, adapting these practices to the needs of special populations, including adults and pediatric patient populations. This year’s SIG will concentrate on impact of interrupted sleep of the patient with epilepsy and talks will include: (1) The effects of epilepsy on underlying u Optimize management of patients with refractory status epilepticus genetic mechanisms of the biological clock. Evidence of seizures effects on utilizing current theories on the basic mechanisms of refractory status basic clock mechanisms will be presented. (2) The effects of anticonvulsant epilepticus and applying this information in patient care. medications on sleep parameters. Patients with epilepsy have disturbed sleep, u Recognize autoimmune and inflammatory pathogenesis of refractory and certain anticonvulsant medications have particular effects on sleep status epilepticus and implement etiology-specific treatment protocols regulation. (3) The effects of the epileptic state and accompanying seizures on sleep. Recent studies in patients after VNS placement and after epilepsy u Manage patients with refractory status epilepticus utilizing emerging surgery show that physiologic lesions that affect epilepsy also affect sleep. treatment options based on specific treatment indications and reported outcomes. Target Audience 6:15 p.m. – 7:45 p.m. Intermediate and Advanced (see page 4 for details) Investigators’ Workshop Programs fMRI Task Selection for Presurgical Mapping in Children: Goals Co-Chairs: Aristea S. Galanopoulou, M.D., Ph.D. and Angus A. Wilforg, M.D. and Challenges Introduction Moderator: Madison Berl, Ph.D. Aristea S. Galanopoulou, M.D., Ph.D. Speakers: Louise J. Croft, M.S., Leigh Sepeta, Ph.D., Simona Ghetti, Ph.D. Management of Refractory SE in Adults Andrea Rossetti, M.D. 6:15 p.m. – 8:15 p.m. Management of Refractory SE in the Pediatric Population Translational Investigators’ Workshop Tobias Loddenkemper, M.D. What Do Interictal Spikes Mean – Do They Have Pathophysiology and Treatment of Refractory SE: Lessons from Animal Models Predictive Value? Claude G. Wasterlain, M.D. Moderator: Christophe Bernard, Ph.D. Speakers: Massimo Avoli, M.D., Ph.D., Kevin J. Staley, M.D., Inflammation and Autoimmune Cases of Refractory SE: Clinical Perspective Christophe Bernard, Ph.D., Elaine C. Wirrell, M.D. Josep Dalmau, M.D., Ph.D. The Role of Immune System in Refractory SE: Preclinical Perspectives Annamaria Vezzani, Ph.D. Future Perspectives in the Management of Refractory SE Eugen Trinka, M.D., M.Sc. Conclusions Angus A. Wilfong, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.5 contact hours for this session.AES 2012 ANNUAL MEETING | SAN DIEGO, CALIFORNIA 14 www.AESNET.org

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