67th Annual Meeting of the American Epilepsy Society (AES 2013)


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67th Annual Meeting of the American Epilepsy Society (AES 2013)

  1. 1. 67th Annual Meeting Brochure The place to be . . . for more research, networking, education, special interest groups, exhibitors & programs for junior members.
  4. 4. AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org3 SCHEDULE-AT-A-GLANCE 6:30 a.m. - 6:00 p.m. Registration 7:00 a.m. - 8:30 a.m. Special Interest Group Meetings 8:30 a.m. - 11:45 a.m. Presidential Symposium: The Changing Landscape of Epilepsy Surgery Noon - 6:00 p.m. Poster Session 1 Exhibit Hall 2:30 p.m. - 5:00 p.m. Professionals in Epilepsy Care Symposium: Access to Epilepsy Care Across the Spectrum 2:30 p.m. - 5:00 p.m. Translational Research Symposium: New Approaches in the Search for a Cure 5:00 p.m. - 6:00 p.m. Symposia Break 5:15 p.m. - 8:00 p.m. Antiepileptic Therapy Symposium: One Size Does Not Fit All: Personalized Medical Care 6:15 p.m. - 7:45 p.m. Special Interest Group Meetings 6:15 p.m. - 8:15 p.m. Translational Investigators’ Workshop 7:30 a.m. - 6:00 p.m. Registration 8:00 a.m. - 5:00 p.m. Scientific Exhibits Poster Session 2 8:45 a.m. - 4:45 p.m. Investigators’ Workshops IW Posters / Lunch: Noon - 1:30 p.m 8:45 a.m. - 5:15 p.m. Annual Course: An Algorithmic Approach to the Diagnosis and Treatment of Non-Lesional Epilepsy 10:00 a.m. - 6:00 p.m. Exhibit Hall (Reception: Suds for Scientists 5:00 p.m. - 6:00 p.m.) 6:00 p.m. - 7:30 p.m. Special Interest Group Meetings 8:00 p.m. - 10:00 p.m. Social Networking Groups SATURDAY December 7 SUNDAY December 8 MONDAY December 9 7:00 a.m. - 12:30 p.m. Registration 7:00 a.m. - 8:30 a.m. Special Interest Group Meetings 8:30 a.m. - 10:30 a.m. Scientific Symposium: Biomarkers for Epileptogenesis and Neurocognitive and Neurobehavioral Comorbidities 8:30 a.m. - 10:30 a.m. Hot Topics Symposium: New Insights into Basic Mechanisms, Diagnosis and Treatment of Epilepsy 10:45 a.m. - 12:15 p.m. Skills Workshops #1 (6 Concurrent) 12:30 p.m. - 2:00 p.m. Skills Workshops #2 (6 Concurrent) TUESDAY December 10 7:00 a.m. - 6:00 p.m. Registration 7:00 a.m. - 8:30 a.m. Special Interest Group Meetings 8:00 a.m. - 3:30 p.m. Poster Session 3 8:00 a.m. - 5:00 p.m. Scientific Exhibits 8:45 a.m. - Noon Merritt-Putnam Symposium: Future Therapies: How We Will Be Treating, Preventing and Curing Epilepsy in the Year 2025 9:00 a.m. - 10:30 a.m. Special Interest Group Meetings 10:00 a.m. - 3:30 p.m. Exhibit Hall 2:15 p.m. - 3:00 p.m. Lennox & Lombroso Lecture 3:45 p.m. - 5:15 p.m. Investigators’ Workshop Special Interest Group Meetings 3:45 p.m. - 6:00 p.m. Pediatric Epilepsy Highlights Session Platform Sessions: 3 Concurrent 5:15 p.m. - 6:15 p.m. Symposia Break 6:15 p.m. - 8:45 p.m. Pediatric State of the Art Symposium: Genetics of Catastrophic Infantile Epilepsies: From Gene Discovery to Practical Clinical Applications 7:00 a.m. - 6:00 p.m. Registration 8:30 a.m. - 11:30 a.m. Epilepsy Specialist Symposium: Treating the New Onset Epilepsy Patient 12:30 p.m. - 3:00 p.m. Annual Fundamentals of Epilepsy Symposium: Neuroimaging in Epilepsy: Focusing On the Focus and Outside the Focus 1:30 p.m. - 3:00 p.m. Professional Development in AES: A Program for Junior Members and Those in Transition Special Interest Group Meetings 3:30 p.m. - 5:30 p.m. Hoyer Lecture 3:30 p.m. - 6:00 p.m. Spanish Symposium: Treatment of Epilepsy: Algorithms for the Selection of Pharmacological and Non-Pharmacological Therapies 5:30 p.m. - 6:00 p.m. Symposia Break 6:00 p.m. - 7:30 p.m. Special Interest Group Meetings 6:00 p.m. - 8:00 p.m. North American Commission Symposium: Big Science: Global Collaborations Improving Epilepsy Care FRIDAY December 6 5:00 p.m. - 7:00 p.m. Registration THURSDAY December 5
  5. 5. 4AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org GENERAL INFORMATION AES 2013 Annual Meeting The American Epilepsy Society (AES) is one of 108 Chapters of the International League Against Epilepsy (ILAE). The Annual Meeting of the American Epilepsy Society is the largest meeting and exhibition in the world for those who share the common scientific and clinical interests of epilepsy and clinical neurophysiology. Each year over 4,000 attendees gather who are dedicated to improving the quality of life for those afflicted with epilepsy. This meeting will be the top forum to examine common concerns and to gain insight from leading authorities. Mission Statement The American Epilepsy Society promotes research and education for professionals dedicated to the prevention, treatment and cure of epilepsy. Target Audience Basic: Those new to epilepsy treatment or whose background is limited, e.g., students, residents, general physicians, general neurologists and neurosurgeons, other professionals in epilepsy care, administrators. Intermediate: Epilepsy fellows, epileptologists, epilepsy neurosurgeons, “mid-level” providers with experience in epilepsy care (e.g., advanced practice nurses, nurses, physician assistants), neuropsychologists, psychiatrists, basic and translational researchers. Advanced: Symposium will address highly technical or complex topics (e.g., neurophysiology, advanced imaging techniques, advanced treatment modalities, including surgery). Membership The American Epilepsy Society invites you to join one of the oldest neurological professional organizations in the United States. The American Epilepsy Society seeks to promote interdisciplinary communications, scientific investigation, and exchange of clinical information about epilepsy. Members include clinicians, scientists, and other professionals interested in seizure disorders, representing both pediatric and adult aspects of epilepsy. AES members receive benefits that include: Epilepsy Currents, the official journal of the AES, discounted fees for subscriptions to scientific journals and registration to the AES Annual Meeting; opportunities to apply for funding their research, participation in the Society through committee membership, and network with national and international colleagues. Join AES by Thursday, November 21, 2013 to qualify for the member registration discount. Policy on Commercial Support and Conflict of Interest The American Epilepsy Society maintains a policy on the use of commercial support, which ensures that all educational activities sponsored by the AES provide in-depth presentations that are fair, balanced, independent and scientifically rigorous. All faculty, planning committee members, editors, managers and other individuals who are in a position to control content are required to disclose any relevant relationships with any commercial interests related to the activity. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentations. All educational materials are reviewed for fair balance, scientific objectivity and levels of evidence. This information will also be made available through syllabus materials and faculty presentations. Disclosure of Unlabeled / Unapproved Uses This educational program may include references to the use of products for indications not approved by the FDA. These discussions are noted on the faculty’s disclosure forms as well as during their presentations. Opinions expressed with regard to unapproved uses of products are solely those of the faculty and are not endorsed by the American Epilepsy Society or any other manufacturers of pharmaceuticals. Abstracts Abstracts from the 2013 Annual Meeting will be available on the AES website and as an online supplement to Epilepsy Currents. Acknowledgment The Annual Meeting is supported in part by Pfizer Inc. Accreditation The American Epilepsy Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to offer continuing medical education for physicians. Credit Designation Physicians: The American Epilepsy Society designates this live activity for a maximum of 37.25 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physician Assistant: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 37.25 hours of Category 1 credit for completing this program. Nurses: EDUPRO Resources LLC is an approved provider of continuing nursing education by Pennsylvania State Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation, Provider number P208-8/08-11. EDUPRO is also an approved provider by the California Board of Registered Nursing, Provider number CEP-14387. Nurses who participate in selected AES programs can receive up to 37.25 contact hours. To successfully complete the activities, nurses will be required to complete evaluations for each session attended and to access the Medical Education Evaluator to claim credit. Disclaimer: Accreditation refers to educational content only and does not imply endorsement of products by PSNA, ANCC, CBRN, or EDUPRO Resources LLC. Pharmacists: Projects In Knowledge® is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. Selected AES programs are approved for a total of 35 contact hours (3.5 CEUs). To successfully complete the CPE activities, pharmacists will be required to complete evaluations for each program attended and to access the Medical Education Evaluator to claim credit. International Credits: The American Medical Association has determined that non-U.S. licensed physicians who participate in this CME activity are eligible for AMA PRA Category 1 Credits TM . CME / CE Certificates The Medical Education Evaluator® is an online system that allows any attendee to self-manage the process of completing course evaluations, tracking credits and printing out the appropriate certificate for either AMA PRA Category 1 CreditsTM , CNE or ACPE pharmacy statement of credits. Once you have accessed the Medical Education Evaluator® , you will be asked to enter your “myAES number” and password. The certificate(s) are saved to your personal account page which is cumulative. You may print the certificate(s) in PDF format at any time. To help support this process, attendees who want educational credits will be asked to pay: Member Fees: $50 through January 17, 2014 $75 January 18 – February 28, 2014 Non-member Fees: $75 through January 17, 2014 $100 January 18 – February 28, 2014 The online Evaluator will be left open through February 28, 2014, so you must complete the evaluations and credit tracking by that date. By completing this information online, attendees greatly assist the Council on Education and Annual Meeting Committee with important needs assessment data whereby the AES can further plan and address educational gaps to meet the needs of our learners. A meeting attendance certificate will be available at the registration desk for international meeting attendees.
  6. 6. 5AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org GENERAL INFORMATION Syllabus Syllabi for the educational symposia will be available via the virtual tote bag. Commercial Exhibits The Exhibit Hall is an integral part of the learning experience. Meeting participants will have an ideal opportunity to learn about the latest in pharmaceuticals, publications, scientific equipment, and technology relevant to the fields of epilepsy and neurophysiology. Please check the AES website for an updated listing of exhibiting companies and organizations. To ensure safety and security, no children, strollers, carriages, wheeled luggage or wheeled briefcases will be allowed in the Exhibit Hall during exhibit hours. Saturday, December 7 Noon - 6:00 p.m. Sunday, December 8 10:00 a.m. - 6:00 p.m. Monday, December 9 10:00 a.m. - 3:30 p.m. Scientific Exhibits AES has approved guidelines for industry-sponsored, Scientific Exhibits at the Annual Meeting. Scientific Exhibits differ from traditional poster presentations in that a broad range of material can be presented as a collection of topics, such as results of various clinical trials, or a thematic presentation of one aspect of drug development. Scientific Exhibits will be displayed on Sunday, December 8 and Monday, December 9. An application to register for a Scientific Exhibit was emailed to interested companies in May. Reservations will be reviewed and accepted on a first-come, first-served basis until space is sold out. Send inquiries of interest to JoLynn Amsden at jamsden@aesnet.org. Cyber Café The Cyber Café will be available at the Convention Center with email and Internet access. Check in with family members and colleagues, and conduct online research while attending the Meeting. You will also be able to complete the course evaluations and obtain your CME certificate online. Material presented at the AES Annual Meeting is not to be reproduced in any format without the express written consent of the AES. For your convenience, Wi-Fi will also be available in the Convention Center. Language The official language of the Annual Meeting is English. Photography and Recording of Programs AES strictly prohibits all photography (flash, digital, or otherwise), audio and / or videotaping during the Annual Meeting. Equipment will be confiscated. Attendees acknowledge and agree that commercial or promotional distribution, publishing or exploitation of speaker sessions, content, or materials from the AES Annual Meeting is strictly prohibited unless you have received the express prior written permission from AES or the otherwise applicable rights holder. When you attend an American Epilepsy Society (AES) event or program, you enter an area where photography, audio, and video recording may occur. By entering the event premises, you consent to photography and its release, publication, exhibition, or reproduction to be used for news, newsletters, promotional purposes, advertising, inclusion on websites, or any other purpose by AES and representatives. You release AES, its officers and employees, and each and all persons involved from any liability connected with the taking, digitizing, or publication of photographs and computer images. You have been fully informed of your consent, waiver of liability, and release before entering the event. Press Room AES offers meeting information kits and assistance for journalists reporting on epilepsy studies, educational presentations, and special reports at this meeting. The AES onsite Press Room staff works with journalists to develop stories, research facts and information, and connect with experts and presenters. The onsite Press Room is also available to sponsors and exhibitors for the display and distribution of relevant press releases and media kits. For more information, contact Peter Van Haverbeke at natalie@bigvoice.com. Program Changes AES cannot assume liability for any changes in the program due to external or unforeseen circumstances. Advanced Registration Once again, a registration discount of $50 is offered to all attendees who confirm a hotel room through Experient, the official AES Housing Bureau. This discount applies to all those who confirm a reservation and complete all registration and payment requirements by Tuesday, October 15. The discount code listed on your confirmation must be used at the time your registration is submitted. Please visit the AES website for updated information. Hotel Reservations AES continues to utilize Experient, Inc. for the online hotel reservation system allowing attendees to confirm, modify or cancel hotel reservations in real time, 24 / 7. Automated confirmations are sent immediately to your email address. Please contact Experient Housing at 800.974.9769 or 847.996.5892 if you have questions. Everyone is encouraged to use the discount hotel programs that have been arranged for you. Confirming your room through AES Housing allows AES to maintain consistent and competitive registration, exhibit space and other service fees from year to year. A portion of the room rate at each hotel will be used to offset meeting expenses. Did you know? Confirming your room using a preferred hotel allows AES to maintain consistent and competitive registration, exhibit space and other service fees from year to year. AES is financially liable if contractual obligations are not met. Therefore, everyone is encouraged to use the discounted hotel programs that have been arranged for you. A portion of the room rate at each hotel will be used to offset meeting expenses. Confirm your hotel room: 1. Book Online: (Credit cards only) PLEASE NOTE: Your email system or spam blocker may be preventing you from receiving important messages, including your hotel confirmation responses from Experient, Inc., the official AES Housing Bureau. Please remember to check your spam filter frequently. 2. Mail or Fax: 847.996.5401 (Credit Cards only) Experient, Inc., Housing 568 Atrium Drive Vernon Hills, IL 60061-1731 Important Information: • Credit card numbers are not accepted via email for security purposes. • Hotel Reservation Warning: Experient, Inc., the official AES Housing Bureau, will never contact you via the phone to solicit your business. They will only call if you request to speak with someone from their office. If you receive a call from anyone claiming to represent AES, be aware that this is not sanctioned and we strongly urge that you do not confirm a reservation. Questions: Call the Housing Customer Service Team at Experient, Inc. Monday – Friday, 9:00 a.m. – 5:00 p.m. (Central Time) Phone: 800.974.9769 (US & Canada) 847.996.5892 (International) Email Experient, Inc. – the official AES Housing Bureau Email: aes@experient-inc.com Housing Deadline The deadline for blocks of 10 or more rooms is Monday, October 7. The deadline for individual hotel reservations is Tuesday, November 12. You are encouraged to make your hotel reservations early, as rooms may sell out prior to these dates. Confirm your hotel room through Experient, the official AES Housing Bureau, and receive a $50 discount off your registration.
  7. 7. 6AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org GENERAL INFORMATION Room Deposit / Cancellation Policy A credit card is required to guarantee a reservation. After Monday, November 25, a one night, non-refundable deposit (room and tax) representing the first night of your reservation will be charged to your credit card. Changes can be made to your reservation online or with Experient, the official AES Housing Bureau, until Monday, November 25, based on availability. Please contact your hotel directly after this date. Early Departure Policy Guests who check out of the hotel prior to their scheduled departure date will be charged a penalty of one night’s room rate and tax. Renaissance Washington, D.C. Downtown Hotel (Headquarters Hotel) 999 Ninth Street, NW Washington, D.C. 20001 Rates: $234 Single / Double (plus tax) Check-in: 3:00 p.m. Check-out: Noon Courtyard by Marriot D.C. Convention Center 900 F Street, NW Washington, D.C. 20004 Rates: $179 Single / $189 Double (plus tax) Check-in: 3:00 p.m. Check-out: Noon Embassy Suites Washington D.C. – Convention Center 900 10th Street, NW Washington, D.C. 20001 Rates: $209 Single / Double (plus tax) Check-in: 3:00 p.m. Check-out: Noon Grand Hyatt Washington D.C. 1000 H Street, NW Washington, D.C. Rates: $249 Single / Double (plus tax) Check-in: 3:00 p.m. Check-out: Noon Hampton Inn Washington Downtown 901 6th Street, NW Washington, D.C. 20001 Rates: $189 Single / Double, plus tax Check-in: 4:00 p.m. Check-out: Noon Washington Marriott at Metro Center 775 12th Street, NW Washington, D.C. 20005 Rates: $228 Single / Double, plus tax Check-in: 4:00 p.m. Check-out: Noon Meeting Location Walter E. Washington Convention Center 801 Mt Vernon Pl NW Washington, D.C. 20001 Click here for Convention Center Parking Information Washington, D.C. Washington, D.C. is an exciting place, no matter your reason for visiting. Celebrity chefs, monuments, museums, shopping and more are all found here in D.C., the nation's capital. Whether you are looking for world class restaurants or want to put on your tennis shoes and hit the sidewalks as an urban explorer, the District of Columbia is a location that truly captures the excitement and bustle of a thriving metropolis. Additional visitor information may be accessed through the AES website. • AES Registration Level Two, L Street Bridge • Exhibit Hall and Posters Level Two, Hall D • Session Rooms Level Two and Three • General Sessions Level Three, Ballroom A / B Affiliate Meetings AES welcomes industry and other groups to participate in the Annual Meeting through support, Scientific Exhibits and exhibition opportunities. The AES also recognizes the need for meeting space during the Annual Meeting for events that may include Alumni Reunions / Receptions, Board Meetings, and Committee Meetings. All meetings must be approved and confirmed by AES in advance. Limited meeting space will be available at the Renaissance Washington, D.C. Downtown Hotel. Detailed guidelines and allowable times will be available on the AES website by the end of August. No Smoking Policy For the comfort and health of all attendees, smoking is not permitted at any AES functions. This includes educational sessions, meetings and all food functions. Both the Convention Center and the Hilton Baltimore are smoke- free facilities. Also, smoking is not permitted in public buildings, restaurants or bars. Meeting Attire AES promotes casual business attire for the duration of the Annual Meeting. Consider bringing a light jacket or sweater with you since meeting room temperatures and personal comfort levels vary. Getting to Washington, D.C. and Ground Transportation Washington, D.C. is serviced by three major airports (see below). Ronald Reagan Washington National Airport (DCA) DCA is located approximately five miles from the AES hotels and the Convention Center. • The Metro line is located in the airport. Follow the signs to the Metro station. Then, take the Yellow Line to Gallery Place (approximately $2.50 – one way). • SuperShuttle: (1.800.258.3826 or 800-BLUEVAN) is located in the Terminal B and C baggage claim area next to doors 4 and 9. • Taxi fare is estimated at $20 each way to the Convention Center and the AES hotels. Washington Dulles International Airport (IAD) IAD is roughly 28 miles from the AES hotels and the Convention Center. • Metrorail via the Metrobus. Please click here for details. • Shuttle Service: Available through SuperShuttle: (1.800.258.3826 or 800-BLUEVAN) or Supreme Airport Shuttle (800-590-0000). • Taxi fare is estimated at $75 each way to the Convention Center or AES hotels. Baltimore / Washington International Thurgood Marshall Airport (BWI) BWI is approximately 32 miles from the AES hotels and the Convention Center. • Amtrak to Metro: Take the Amtrak to Union Station and then take the Metro Red Line to Gallery Place; estimated fee is $35 one way. • SuperShuttle (1.800.258.3826 or 800-BLUEVAN) has two lower-level counters located near baggage claim areas 1 (Concourse A) and 10 (Concourse C). • Taxi fare is estimated at $75 each way to the Convention Center or AES hotels. Amtrak Union Station in Washington, D.C. is located at 50 Massachusetts Avenue NE. Details for discounted travel will be posted by the end of this summer.
  8. 8. 7AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org GENERAL INFORMATION Information for International Travelers Consulates and Embassies Please check with your local U.S. consulate or embassy to find out the earliest that you may apply for a visa at www.usembassy.gov/. The visa applications process can take as long as 8 weeks, especially for those countries that are on the State Sponsors of Terrorism List. Attendees from these countries should start the application process at least 6 to 8 months in advance of the Annual Meeting. Banking and Currency Exchange Banking hours in the United States are generally Monday to Friday, 9:00 a.m. - 4:00 p.m. A few banks are open on Saturdays. Several banking institutions are within walking distance of the Convention Center. Visa Application Information For information regarding important timelines and travel to the United States, you may access the AES Website: http://www.aesnet.org/go/meetings-and-events/annual-meeting/ travel-information/international-traveler#travelinfo • U.S. State Department • Canadian Citizens • U.S. Embassy Consular Section • Visa Waiver Program • Visa Wait Times • U.S. Visit Traveler Information • U.S. Visit Biometric Identification Services Disclaimer: Please note that this information is provided in good faith. Regulations may change and the only authoritative sources of information are the U.S. Government websites at www.unitedstatesvisas.us and www.travel.state.gov/visa/visa_1750.html. Letter of Invitation For security purposes, letters of invitation can only be sent to individuals registered for the Annual Meeting. Please check the appropriate box on the registration form. Once your payment has been processed a letter will be sent to you. Please send any questions to conferenceregistration@aesnet.org. Additional Information During the month of December, Washington, D.C. operates in the Eastern Standard Time Zone (GMT -5 hours). Gratuities are not automatically added to the bill, except in some cases for large groups. Waiters and waitresses are usually given 15% to 20% of the bill. Taxi drivers usually receive 15% of the fare and doormen and $2 per night for hotel housekeeping. Skycaps and porters are normally tipped $1 per bag. Voltage in the United States is 120 (60 HZ). Outlet sockets use either a Type A plug which is a Class II ungrounded plug with two flat parallel prongs, or a Type B plug which is a Class I plug with two flat parallel prongs and a grounding pin. European appliances will require a voltage transformer. Registration & Security AES is committed to providing a secure meeting environment. A formal security plan is being developed in consultation with the Security Department at the Convention Center. All meeting attendees will be required to produce government-issued photo identification prior to receiving their badge and registration materials. Appropriate badges must be worn at all times while in attendance at the Meeting and are required for admittance to all meeting activities. Security procedures will also be in place for exhibition materials and all deliveries to the AES Meeting. Additional security information will be available in the Program Book received at the onsite registration desk. Insurance / Liabilities AES cannot be held responsible for any personal injury, loss, damage, accident to private property or additional expenses incurred as a result of delays or changes in air, rail, sea, road, or other services, strikes, sickness, weather, acts of terrorism and any other cause. All participants are encouraged to make their own arrangements for health and travel insurance. Contact Information American Epilepsy Society Phone: 860.586.7505, ext. 512 342 North Main Street Meeting Fax: 860.586.7550 West Hartford, CT 06117-2507 Email: info@aesnet.org Website: www.AESNET.org Individuals who register prior to Wednesday, November 6 will receive their official annual meeting badge via postal mail. Please note that you will be charged $100 for badge and ticket reprints should you arrive without them. These items are required to access meeting and session areas and must be worn and visible at all times. If you register Thursday, November 7 or later, your badge and appropriate tickets will be printed onsite. Badge holders and lanyards will be available in the Registration Desk area onsite. Badge information: In order to receive your badge onsite, you must produce government-issued photo identification. Badges must be worn and visible at all times; they are non- transferable. Name badge replacement: A $100 fee will be issued for a replacement badge. Important Badge Information
  9. 9. 8AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org FRIDAY December 6, 2013 8:30 a.m. – 11:30 a.m. Epilepsy Specialist Symposium: Treating the New Onset Epilepsy Patient Overview While many epilepsy specialists spend much time seeing patients with long- standing disease, the group of new-onset epilepsy patients represents a distinct population with specific treatment concerns. This symposium will address the various issues involved in treating those with new-onset epilepsy, including considerations of when a patient should be treated, the evidentiary basis for drug choice, treatment prognosis, and specific factors relating to various subgroups (such as children and the elderly). Learning Objectives u Manage patients with new onset epilepsy across the age spectrum, based on preferred practices, peer reviewed literature, and published practice parameters u Recognize new-onset epilepsy syndromes and prescribe anti-seizure medications using published evidence regarding treatment of specific syndromes. Target Audience Basic (see page 4 for details) Program Co-Chairs: Gregory L. Krauss, M.D. and Scott Mintzer, M.D. Introduction Gregory L. Krauss, M.D. New Onset Epilepsy in the Elderly Ilo E. Leppik, M.D. Drug Choice in New-Onset Epilepsy Tracy A. Glauser, M.D. New-Onset Epilepsy in Children Dave F. Clarke, M.B.B.S. Treatment Prognosis for New-Onset Epilepsy Scott Mintzer, M.D. Population Study of First Seizures and Need for Treatment Bernd Pohlmann-Eden, M.D., Ph.D. Conclusions Gregory L. Krauss, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 3.0 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 3.0 contact hours for this session. 12:30 p.m. – 3:00 p.m. Annual Fundamentals of Epilepsy Symposium: Neuroimaging in Epilepsy: Focusing On the Focus and Outside the Focus Overview The Annual Fundamentals of Epilepsy Symposium will address standard and novel neuroimaging techniques used in the evaluation of epilepsy. Presentations will address recent advances in structural and functional MRI, tractography, PET, SPECT, and MRS. In addition, newer techniques of potential use in epilepsy will be presented. Two interactive sessions will allow the audience to read MRIs and submit their answers using Audience Response System. Learning Objectives u Use technical and interpretation key points to improve the quality and quantity of information extracted from neuroimaging studies in epilepsy u Use state of the art structural and functional imaging modalities in the diagnostic work-up of patients with epilepsy u Use new technologies such as fMRI and diffusion tensor imaging in presurgical evaluations. Target Audience Basic and Intermediate (see page 4 for details) Program Co-Chairs: Mohamad Z. Koubeissi, M.D. and Michael R. Sperling, M.D. Introduction Mohamad Z. Koubeissi, M.D. Diffusion Tensor Imaging Beate Diehl, M.D. Functional MRI in Epilepsy Matthias J. Koepp, M.D., Ph.D. New MRI Techniques in Epilepsy Graeme D. Jackson, M.D. Seizure Protocol MRI Barbara Dworetzky, M.D. PET & SPECT in Epilepsy William H. Theodore, M.D. Conclusions Michael R. Sperling, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.5 contact hours for this session. AES Fellows Program The American Epilepsy Society is committed to nurturing and supporting fellows in the field of epilepsy. The goal of the AES Fellows program is to encourage epilepsy fellows in training to attend the AES Annual Meeting where they will be exposed to the latest updates in clinical and basic science research. This year’s program will be held on Friday, December 6. A breakfast and lunch will be sponsored by the AES to allow fellows to meet and pair with mentors who can provide guidance regarding career planning, potential research paths, and clinical endeavors. Following the breakfast the fellows will attend the AES Epilepsy Specialist Symposium followed by the Annual Fundamentals of Epilepsy Symposium. Invitations will be sent out in July to epilepsy directors. Nominations are limited to one fellow per institution. This year, up to 85 fellows will be chosen, 10 of whom will be Ph.D.s doing epilepsy research. Priority will be given to first time attendees. Nominees should be neurology trainees in approved epilepsy fellowships; in rare instances other candidates may be considered if space permits. The 2013 AES Epilepsy Fellows program is supported by Lundbeck, Inc. and Upsher-Smith.
  10. 10. 9AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org FRIDAY December 6, 2013 9:00 a.m. – 4:00 p.m. 27th Annual Advances in the Management of Epilepsy and the Epilepsy Clinic (separate registration required — see below for instructions) This intensive one-day conference is designed for those professionals who participate in the care of persons with epilepsy. The overall purpose is to improve services to individuals and families affected by epilepsy. The conference is presented by the Department of Neurology of Wake Forest University School of Medicine, Winston-Salem, North Carolina, through an unrestricted grant committed to the education of health professionals, in an effort to promote the comprehensive care of those with epilepsy and their families. Registration for this program is done separately from the AES Annual Meeting and begins on September 1, 2013. You may register by calling Wake Forest School of Medicine at 800.642.0500. Up to 5.5 AMA Category 1 CME will be given. 1:30 p.m. – 3:00 p.m. Professional Development in AES: A Program for Junior Members and Those in Transition The American Epilepsy Society invites all interested meeting attendees to come to a special session on volunteer and leadership opportunities within the Society. The American Epilepsy Society has a variety of programs year round to improve the care and treatment of patients with epilepsy. These efforts include education for basic scientists and clinicians, research grant programs, leadership and organizational activities, community outreach and advocacy. Greater participation in the Society offers members extensive career development opportunities by providing a chance to hone leadership skills, to network with other AES members and outside funding organizations, and most importantly, to make significant contributions to improve the lives of patients with epilepsy. This session will be useful to trainees, basic scientists, clinicians and other health professionals (nurses, psychologists, Pharm.D.s) who want to know more about organizational structure or who want to become more involved. The session will provide an overview of the professional development and volunteering opportunities within the Society, followed by short presentations by members active in AES leadership. The session will end with a chance to meet with AES staff and committee leaders to learn more about available opportunities. 1:30 p.m. – 3:00 p.m. Special Interest Group Meetings Basic Neuroscience: Neurocircuitry of Lennox-Gastaut Syndrome: From Animal Models to Patients Coordinators: Martin J. Gallagher, M.D., Ph.D., Laura Jansen, M.D., Ph.D. Speakers: Aristea Galanopoulo, M.D., Ph.D., Carter O. Snead, M.D., John S. Archer, M.B.B.S., FRACP, Ph.D. Lennox-Gastaut Syndrome (LGS) is a common catastrophic epilepsy condition that is typically refractory to anticonvulsant drugs, and is usually associated with cognitive delay and regression. It is critical to identify the cortical and subcortical brain structures that participate in LGS seizures in order to facilitate the development of new pharmacological and neurosurgical treatments for this disease Therefore, the goal of this year’s basic neuroscience SIG is to review recent developments in elucidating the neurocircuitry involved in LGS seizures in both animal models and in human patients. First, Dr. Galanopoulou will discuss the developmental progression of seizures in rat models that starts with infantile spasms and then evolves into seizures more typical of LGS. Second, Dr. Sneed will review his recent work using stereotactic EEG in other rodent LGS models to identify the subcortical nuclei that participate in LGS seizures. Finally, Dr. Archer, of the Melbourne functional neuroimaging group will discuss their work using fMRI to localize brain regions involved in LGS seizures in human patients. Quality, Value and Safety Coordinator: Jeffrey W. Britton, M.D. Speakers: Jeffrey W. Britton, M.D., F. M. Cutrer, Erik K. St. Louis, M.D., Katherine Noe, Ph.D. This year’s Quality, Value and Safety SIG will discuss a number of topics of interest. First, a novel system using a data entry system to allow capture of epilepsy data points in clinic patients for future research purposes, and which allows automated note generation will be presented. Second, results of Quality of Life data obtained in the interictal state following reduction in medications in an EMU environment will be discussed. Third, an update on EMU Safety initiatives will be presented. Women with Epilepsy Across the Life Cycle: Impact of Genetics and Brain Physiology Coordinators: Danielle Andrade, M.D., M.Sc., Mona Sazgar, M.D. Speakers: Danielle Andrade, M.D., M.Sc., Mona Sazgar, M.D., Ingrid Scheffer, M.B.B.S., Ph.D., FRACP This program will be divided in two parts. In the first section the focus is on genetic causes of epilepsy in girls and how they are affected throughout their life cycle. The second part of this SIG will discuss our current knowledge about the physiologic changes in the brain during a menstrual period and the role it may play in pathogenesis of seizure exacerbation in women with catamenial epilepsy and its treatment implications. Some forms of epilepsy affect only or predominantly women. These conditions are mostly genetically determined. Given the recent advances in genetic technology and genetic testing, the epileptologist is now able to diagnose such patients more easily. However, most of us did not receive any training to manage these genetic epilepsies. Dr. Ingrid Scheffer and Dr. Danielle Andrade will discuss the clinical characteristics of genetically determined epilepsy affecting women only. When to think of these diagnoses? How are the seizures in these conditions? What other neurological, psychiatric and systemic problems are associated? What is the best treatment? These issues related to genetically determined epilepsy in women will be reviewed in the first part of the session. In up to 70% of women with epilepsy, seizures exacerbate with menstrual fluctuation of sex hormones. In the second half of this SIG, the speakers will discuss the role of sex hormones in pathogenesis of seizure exacerbation in catamenial epilepsy and whether the response to treatment can be predicted. They will also address the effects of antiepileptic drugs and seizures on reproductive function from puberty to menopause. There will be an interactive discussion regarding how we can use our knowledge of complex interactions between seizures, sex hormones, seizure medications and brain physiology to implement meaningful treatment approaches for women with epilepsy.
  11. 11. 10AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org FRIDAY December 6, 2013 3:30 p.m. – 5:30 p.m. 11th Judith Hoyer Lecture in Epilepsy Lecturer: Jack Pellock, M.D. Award Presentation: AES Service Award The 11th Judith Hoyer Lecture in Epilepsy, presented by invited Lecturer Dr. Jack Pellock, is sponsored by the National Institute of Neurological Disorders and Stroke. Dr. Pellock’s presentation is the eleventh in a series of lectures highlighting the promise of epilepsy research. This series is held in memory of Mrs. Judith Hoyer, an active member of the Board of Directors of the Epilepsy Foundation and the late wife of Representative Steny Hoyer (D-MD). Mrs. Hoyer spent her life both helping families to cope with epilepsy and promoting research into a cure and a better quality of life for those with the disorder. The purpose of the lecture is to raise awareness of epilepsy among researchers and the public and provide intellectual stimulation that will encourage continuing progress toward finding a cure for epilepsy. 3:30 p.m. – 6:00 p.m. Spanish Symposium: Treatment of Epilepsy: Algorithms for the Selection of Pharmacological and Non-Pharmacological Therapies Overview The symposium will present evidence-based information concerning the selection of pharmacological and non-pharmacological treatments for children and adults with recently diagnosed seizures and with refractory epilepsy. An algorithmic approach to treatment selection will be emphasized on the basis of available original data and published treatment guidelines. Learning Objectives u Develop a sequential, rational approach to drug selection in children and adults with newly diagnosed epilepsy u Knowledge and implementation of modern concepts of refractory epilepsy and treatment options to be considered. Target Audience Basic (see page 4 for details) Program Co-Chairs: Patricio E. Abad, M.D., Mario A. Alonso-Vanegas, M.D. Introduction Patricio E. Abad, M.D. Selection of Antiepileptic Drugs in Adults Carlos S. Acevedo, M.D. Selection of Antiepileptic Drugs in Children Roberto Caraballo, M.D. Refractory Epilepsy: Therapeutic Options Americo C. Sakamoto, M.D., Ph.D. Round Table Discussion Lilia Núñez-Orozco, M.D. and Arnoldo A. Soto, M.D. Conclusions Mario A. Alonso-Vanegas, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.5 contact hours for this session. 6:00 p.m. – 7:30 p.m. Special Interest Group Meetings Critical Care EEG Monitoring: Beyond Seizure Detection Coordinators: Evan Fertig, M.D., Suzette Laroche, M.D Speakers: Nicolas Abend, M.D., Peter W. Kaplan, MB, B.S., FRCP, M. Brandon Westover, M.D., Ph.D. The primary role of CEEG monitoring in the ICU setting is the detection of nonconvulsive seizures and Status Epilepticus. The purpose of this 2013 SIG is to discuss the potential added clinical value of CEEG for the critically ill population beyond seizure detection. Speakers will provide updates on new applications of CEEG monitoring. Topics to be covered are: EEG Monitoring for Prognostication in Neonates; The Prognostic Significance of EEG Patterns after Cardiac Arrest Treated with Therapeutic Hypothermia; and EEG Monitoring for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: Principles and Clinical Practice. Ample time will be allotted for speaker and audience interaction. Genetic Testing in the Epilepsy Clinic Coordinators: Melodie Winawer, M.D., M.S., Annapurna Poduri, M.D. Speakers: Ingrid Scheffer, M.B.B.S., Ph.D., FRACP, Beth Sheidley, M.S., CGC, Ruth Ottman, Ph.D., Tracy Dixon-Salazar, Ph.D. We will discuss the evolution of genetic testing for epilepsy in the clinic from the perspective of a parent of a child with epilepsy, an epileptologist with genetics expertise, a genetic counselor from an epilepsy genetics program, and researcher in epilepsy genetics studying the psychosocial impact of genetic testing. Neuroimaging: Imaging Epileptogenesis Coordinator: Matthias Koepp, M.D., Ph.D. Speakers: Andrea Bernasconi, M.D., Ph.D., Csaba Juhasz, M.D., Ph.D. Biomarkers in epilepsy are divided into those which reflect a particular stage of epileptogenesis, with a potential to predict the future development of epilepsy after a brain insult, and those which rather reflect ictogenicity, i.e., a state of cortical hyperexcitability sufficient to provoke seizures. In this year’s Neuroimaging SIG, we will discuss currently available imaging tools (e.g. MRI, fMRI, MEG, PET), which are predictors for the risk of future seizures, progression of the disease, the response to specific AEDs, or the need to continue such treatment after seizures being controlled for a period of time. SUDEP: Sudden Unexpected Death in Epilepsy Coordinators: Lawrence J. Hirsch, M.D., George B. Richerson, M.D., Ph.D. Speakers: Expert Panel We will have a panel of experts describe what they think have been the greatest SUDEP-related advances in the past five years, from the clinical, basic science, genetic, awareness, prevention and advocacy standpoints. The audience will then have a chance to provide their own opinions. The panel will then describe what they think are the top priorities for research and prevention in the near future, again followed by audience input. Lastly, a panel will provide tips on how and when to discuss SUDEP with patients and families. Tumor Induced Epilepsy Coordinators: Jeffrey Politsky, M.D., Theodore Schwartz, M.D. Speakers: TBD The 2013 program will again focus on novel data and research, but will also include a clinical session. The discussion points will include an expansion on pre-surgical evaluation, post-surgical follow-up, cognitive impact, and functional reorganization. We will also utilize the data toward the development of clinical recommendations, for patients of all ages. AES members will be invited to submit clinical cases/scenarios for discussion with the panel.
  12. 12. 11AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org FRIDAY December 6, 2013 6:00 p.m. – 8:00 p.m. North American Commission Symposium: Big Science: Global Collaborations Improving Epilepsy Care Overview With the emerging capabilities for global collaborations and enhanced data sharing, big science is playing an increasingly important role in epilepsy research. This symposium, sponsored jointly by the North American and European Commissions of the International League Against Epilepsy, will focus on four areas in which big science is playing an important role in epilepsy research. Areas of collaboration include epilepsy clinical and surgical trials, an international pregnancy registry, and EEG data sharing through an international web portal. Learning Objectives u Become familiar with and consider all surgical options for management of intractable childhood epilepsy, resulting in improved outcomes u Learners, familiar with limitations of epilepsy / pregnancy data bases, provide well informed counseling to women with epilepsy. Target Audience Basic, Intermediate and Advanced (see page 4 for details) Program Co-Chairs: Meir Bialer, M.B.A., Ph.D. and Sheryl Haut, M.D. Introduction Sheryl Haut, M.D. Setting Standards: International Collaboration for Pediatric Epilepsy Surgery Through the ILAE Gary W. Mathern, M.D. International Pregnancy Registries: A Global Approach to a Global Challenge Tobjorn Tomson, M.D., Ph.D. International Clinical Trials – Threats and Opportunities Eugen Trinka, M.D., M.Sc. Epilepsy, Big Data and International Research Brian Litt, M.D. Conclusions Meir Bialer, M.B.A., Ph.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.0 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.0 contact hours for this session.
  13. 13. 12AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org SATURDAY December 7, 2013 7:00 a.m. – 8:30 a.m. Special Interest Group Meetings Children’s Hour: Acute Treatment of Convulsive Seizures in Children Coordinator: Mary Connolly MB, BCh, FRCP(C), FRCP(I), FRCP(Edin) Speakers: Richard Chin, M.D., Ph.D., Mary Connolly, M.D., FRCP(C), Lieven Lagae, M.D., Ph.D. The 2013 SIG will cover the following topics: 1. Pre-hospital and emergency treatment of acute seizures; 2. Treatment of convulsive seizures in the ER after benzodiazepines; 3. Treatment of childhood epilepsy: Do we need 20 anti-seizure drugs or four broad spectrum drugs? Epidemiology Applied: Solving Problems in Epilepsy Care Through Research Coordinators: Anne Berg, Ph.D., Nathalie Jetté, M.D., FRCP(C) Speakers: Nathalie Jette, M.D., FRCP(C), Gigi Smith, M.S.N, APRN, CPNP, Christine Bower-Baca, M.D., Zachary M. Grinspan, M.D. This year’s Epidemiology SIG will consider the role that epidemiological and other studies play in epilepsy care from identifying gaps and needs to developing decision tools, performance indicators, and even guidelines. We will begin with an overview of how different levels and kinds of epidemiological and clinical research work together to provide the evidence needed to change practice. We will hear about the use of focus groups to identify research priorities, translating those findings to research studies, closing the gaps between treatment efficacy and implementation, and studying complex delivery of epilepsy care. Each of four speakers will give a brief presentation (10-15 minutes) and we will reserve 30-45 minutes for open discussion and comments from the attendees in the audience. Why Private Practice Epilepsy (vs. Traditional Academic Epilepsy)? and Update on Research Collaborations Coordinators: Marcelo Lancman, M.D., Pavel Klein, M.D. Speakers: Robert Leroy, M.D., Robert Wechsler, M.D., Ph.D., Marcelo Lancman, M.D., Pavel Klein, M.D. The “Epilepsy Care in Private Epilepsy Centers” SIG is a forum for epilepsy providers in private epilepsy centers as well as those interested in learning about it or considering transitioning. The group has monthly phone conferences in which business issues as well as research projects are discussed. We also communicate through our LinkedIn site. The goal of our group is to create a consortium of all epilepsy practitioners in the private setting. One of the main purposes of the SIG is to provide members with a resource for business questions, advice for providers who are starting in private practice (i.e. developing of a new epilepsy program) and expand our research possibilities through collaboration among groups. Treating Convulsive Status Epilepticus with the Right Medication At the Right Time Coordinators: Tobias Loddenkemper, M.D., Frank Drislane, M.D. Speakers: Robert Silbergleit, M.D., Jaideep Kapur, M.D., Ph.D., Iván Sánchez Fernández, M.D. Status epilepticus is a life-threatening condition necessitating immediate medical attention and treatment. Diagnosis, treatment and prognosis of patients with status epilepticus may be difficult depending on the duration, etiology and the underlying condition of the patient. One of the single most effective and modifiable factors in treating convulsive status epilepticus appears to be time to initiation of treatment and timely escalation of treatment. This year’s SIG will provide an overview of treatment timing including so called first line, second line and third line agents in adult and pediatric patients presenting with convulsive status epilepticus. Specifically, Dr. Robert Silbergleit will present first line treatment options and medication timing from the Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART), Dr. Jaideep Kapur will outline medication considerations and dose timing on second line agents based on the Established Status Epilepticus Treatment Trial (ESETT), and Dr. Iván Sánchez Fernández will illustrate treatment timing and third line treatment choices based on results from the pediatric Status Epilepticus Research Group (pSERG). Sleep in Epilepsy: The Borderland of Sleep and Epileptiform Neural Activity Coordinators: Mark Quigg, M.D., Erik K. St. Louis, M.D. Speakers: Iván Sánchez Fernández, M.D., Mark R. Bower, Ph.D, Mithri R. Junna, M.D. Recent evidence has defined the impact of structural thalamic brain lesions, cortical slow wave oscillations, and NREM sleep microarchitectural rhythms on the frequency of interictal EEG abnormalities and occurrence of seizures during sleep. This Sleep-Epilepsy SIG will highlight the work of three junior investigators in relation to the theme of the influence of sleep physiology and thalamic brain lesions on the frequency of epileptiform neural activity. 8:30 a.m. – 11:45 a.m. Presidential Symposium: The Changing Landscape of Epilepsy Surgery Award Presentation: Research Awards Overview Epilepsy surgery is a very effective intervention for patients with treatment resistant epilepsy. The most successful epilepsy surgery is temporal lobectomy, which traditionally has produced seizure freedom in approximately two-thirds of patients. An AAN / AES guideline recommended temporal lobectomy as the treatment of choice for treatment resistant temporal lobe epilepsy. Yet, in a survey of centers with large epilepsy surgery programs, the number of overall surgeries, as well as the number of temporal lobectomies had decreased almost universally from their peaks. Moreover, surgeries for mesial temporal sclerosis have declined by half, whereas non-lesional cases have increased by a third. This symposium will present the data from various sources that suggest a shift in epilepsy surgery type and possibly location (from established to emerging centers) and will provide available evidence for the theories that may account for these changes. Also, future directions related to these changes, including basic science considerations (should the neocortex receive as much attention as the hippocampus?) will be discussed. Learning Objectives u Recognize epilepsy syndromes other than temporal lobe epilepsy and evaluate such patients for epilepsy surgery u Evaluate all patients with refractory epilepsy syndromes including extra- temporal and non-lesional epilepsy to provide optimal treatment, identify surgical candidates, and perform epilepsy surgery for those with syndromes other than temporal lobe epilepsy when indicated. Target Audience Intermediate and Advanced (see page 4 for details) Program Chair: Jacqueline A. French, M.D. Introduction Jacqueline A. French, M.D. Who Was I Treating Then? Who am I Treating Now? Dennis D. Spencer, M.D. The Changing Surgical Landscape in Kids Howard L. Weiner, M.D. What Is the Evidence that the Landscape is Changing? Theories of Change Dale C. Hesdorffer, Ph.D.
  14. 14. 13AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org SATURDAY December 7, 2013 Perspective of Basic Science: Is There Life Outside the Hippocampus? Jeffrey A. Loeb, M.D., Ph.D. Conclusions Jacqueline A. French, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.25 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.25 contact hours for this session. 2:30 p.m. – 5:00 p.m. Professionals in Epilepsy Care Symposium: Access to Epilepsy Care Across the Spectrum Overview Despite progress in diagnosis of epilepsy and associated comorbidities, as well as an increase in treatment options for epilepsy, limitations to access have created barriers to appropriate care for persons with epilepsy. Barriers to access include availability of professionals skilled in treatment of epilepsy; accurate diagnosis, including identification of comorbidities; cultural and language barriers; and treatment for psychiatric comorbidities. This symposium will address these barriers; identify strategies and practical solutions to overcome the barriers, including those defined by Project Access and the Managing Epilepsy Well program; and examine the role of advocacy. A panel discussion will provide the opportunity to address these and other issues related to access to epilepsy care. Learning Objectives u Recognize and explicitly address cultural barriers to managing care for persons with epilepsy u Provide care for children and youth with epilepsy by utilizing medical home and telemedicine u Collaborate with patient in developing, utilizing, and maintaining self- management skills for psychiatric comorbidities and psychosocial challenges or recognizes the need to refer patient to mental health professional for such skills-based intervention. Target Audience Basic and Intermediate (see page 4 for details) Program Co-Chairs: Janelle Wagner, Ph.D., Paul M. Levisohn, M.D. Introduction Janelle Wagner, Ph.D. Epidemiologic Research into Access to Care for Epilelpsy David J. Thurman, M.D., M.P.H. Cultural and Associated Barriers to Epilepsy Care Lisa Andermann, M.Phil., MDCM Epilepsy Foundation's Role in Advocating for Access to Epilepsy Care Philip M. Gattone, M.Ed. Epilepsy Foundation and Access to Care: Overview of Project Access Janice M. Buelow, Ph.D., RN Project Access: Improved Access to Care Through Medical Home and Telemedicine Linda Fletcher, RN Managing Epilepsy Well: Addressing Access to Mental Healthcare Needs Nancy J. Thompson, Ph.D. Conclusions Paul M. Levisohn, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.5 contact hours for this session. 2:30 p.m. – 5:00 p.m. Translational Research Symposium: New Approaches in the Search for a Cure Overview Research: This symposium will inform the audience about recent advances in translational, basic research that directly bear on NIH benchmarks and that could potentially change / improve patient care. Advances in optogenetics (related to both epileptogenesis and the comorbidities of epilepsy), focal cooling and molecular targeting will be presented. Medical Treatment: Medical treatment will be advanced as new approaches are developed that can selectively target neuronal networks involved in epileptogenesis and the generation of seizures. These techniques have already been shown to have an impact in various models of epilepsy, and it is likely just a matter of time before they are translated into treatments for human epilepsy. Learning Objectives u Learn of new molecular and engineering approaches that may be useful in controlling epileptogenesis and seizurogenesis u Presentation of data concerning new molecular and device-based therapies for comorbidities of epilepsy will provide new knowledge about groundbreaking therapeutic approaches that are in development. Target Audience Intermediate (see page 4 for details) Program Co-Chairs: Daniel H. Lowenstein, M.D., Karen S. Wilcox, Ph.D. Introduction Daniel H. Lowenstein, M.D. Optical Deconstruction and Online Control of Corticothalamic Circuits Underlying Epilepsy Jeanne T. Paz, Ph.D. Optogenetic Dissection of Circuits Underlying Anxiety-related Behaviors Kay Tye, Ph.D. Focal Cooling for the Prevention and Treatment of Epilepsy: From Models to Patients Matthew D. Smyth, M.D. MicroRNAs as Treatment Targets in Epilepsy David C. Henshall, Ph.D. Conclusions Karen S. Wilcox, Ph.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.5 contact hours for this session.
  15. 15. 14AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org SATURDAY December 7, 2013 5:15 p.m. – 8:00 p.m. Antiepileptic Therapy Symposium: One Size Does Not Fit All: Personalized Medical Care Award Presentation: J. Kiffin Penry Award Overview The selection of the optimal therapy for a patient with seizures or epilepsy depends not only upon the specific epilepsy type but also upon a variety of individual characteristics of the patient. The goal of this AET symposium will be to discuss some of these factors and present treatment algorithms that would allow for a more personalized medical care for patients with seizures and maximize the efficacy and tolerability of the selected treatments. Specifically, this symposium will discuss how to use genetic tests to select appropriate therapies, select appropriate drug delivery methods to best serve each patient's needs, recognize and treat early allergic reactions to anti- seizure drugs as well as prevent cross-allergies with other drugs, select the optimal therapies for women with epilepsy to prevent teratogenic or other adverse effects on their reproductive system, and optimize epilepsy therapies in patients with HIV. A discussion of the future perspectives to overcome current barriers in AET implementation will also be presented. Learning Objectives u Develop an algorithmic approach for the selection of optimal antiepileptic therapy for each individual patient u Develop an algorithmic approach for the selection of the optimal antiepileptic formulation and delivery system for each individual patient with resulting increased adherence u Recognize early adverse drug reactions and the patient populations at risk for developing them and implement treatment protocols that minimize such adverse outcomes. Target Audience Intermediate (see page 4 for details) Programs Co-Chairs: Aristea Galanopoulou, M.D., Ph.D., Angus A. Wilfong, M.D. Introduction Aristea Galanopoulou, M.D., Ph.D. Genomic Approaches in Selecting AETs: Current State Norman Delanty, M.D. Personalizing Drug Delivery Emilio Perucca, M.D., Ph.D. Management of Allergic Reactions to AETs Bernard Cohen, M.D. Women Issues in AET Implementation Page B. Pennell, M.D. Management of Seizures in HIV Patients Gretchen L. Birbeck, M.D., M.P.H. Conclusions Angus A. Wilfong, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 2.5 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 2.5 contact hours for this session. Acknowledgment This program is supported by an educational grant from Eisai, Inc. 6:15 p.m. – 7:45 p.m. Special Interest Group Meetings AED Pregnancy Registry Outcomes Coordinators: Esther Bui, M.D., FRCP(C), Elizabeth Gerard, M.D. Speakers: John Craig, M.D., Lewis Holmes, M.D., Kimford Meador, M.D., Thomas McElrath, M.D., Ph.D., Terrence O’Brien, M.D., FRAC(P), Page Pennell, M.D., Sanjeev V. Thomas, M.D., Torbjörn Tomson, M.D., Ph.D. The AED Pregnancy Registry SIG will continue to present the latest updates from the six international registries, providing participants with the most recent and relevant information for counseling and managing women with epilepsy who are of childbearing age. In addition to presenting pivotal data on teratogenesis, pregnancy complications and fertility, the investigators will give their opinions on the management of several case examples demonstrating how they apply their data and experience to clinical care. This year’s SIG will pay special tribute to the late Autumn Klein, M.D., Ph.D. and her research on obstetrical and perinatal outcomes in women with epilepsy will be presented. Ictal Semiology Coordinators: Felix Rosenow, M.D., C. Akos Szabo, M.D. Speakers: Philip Kahane, M.D., Ph.D., C. Akos Szabo, M.D., Felix Rosenow, M.D., Hans Lüders, M.D., Ph.D. The moderator and members of the faculty will show ictal videos of epilepsy patients. This will include some typical seizures as also unusual cases. After showing each video, the presenter will give the audience an opportunity to discuss the case. Members of the audience will be invited to describe the ictal semiology and try to deduce the most likely symptomatogenic and epileptogenic zone. The moderator will then call on the other faculty members to give their opinion. The format of the conference is interactive, each presenter engaging the audience for their clinical opinions on the video and clinical findings in each patient. While the conferences are focused on semiology, the discussions also include evaluation of EEG, neuroimaging, and discussion of seizure and functional outcome in epilepsy surgery cases. Neuroendocrinology: Stress and Exercise in Epilepsy & Epileptogenesis Coordinators: D. Samba Reddy, Ph.D., R.Ph., Jana Veliskova, M.D., Ph.D. Speakers: TBD The Neuroendocrinology SIG will be focused on the impact of stress on epilepsy and the influence of exercise and environmental enrichment on the development of epilepsy in persons at risk. Stress is one of the major precipitating factors in seizures and could exert significant impact on neuronal plasticity. Stress, stress-induced neurohormones, and underlying molecular changes could play an important role in the susceptibility to epileptogenesis, whereby a brain becomes progressively epileptic due to an initial precipitating event of diverse origin such as brain injury, stroke, infections, or prolonged seizures. The molecular mechanisms underlying the acquired epilepsy are poorly understood. Neuroinflammation and neurodegeneration appear to trigger epileptogenesis following an initial injury. There is an intense search for drugs that truly prevent the development of epilepsy in people at risk. Exercise and stress-related hormonal factors may play an important role in adults with epilepsy. Corticosteroids and neurosteroids have been shown to affect seizure activity in animal models and in clinical studies. However, the impact of exercise and stress on epileptogenesis has not been investigated widely. The stress hormone cortisol or corticosterone has excitatory effects and triggers epileptogenesis in animal models. There is emerging interest on stress hormones and environmental enrichment-induced plasticity in regulating the epileptogenesis. Environmental enrichment and neurosteroids have promising disease-modifying potential in epileptogenesis. It is hoped that this SIG discussion may generate new insight on the stress, exercise and environmental enrichment on epileptic seizures and progression of epileptogenesis.
  16. 16. 15AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org SATURDAY December 7, 2013 Neurostimulation and Neuroengineering Coordinators: Erika E. Fanselow, Ph.D., Chrisopher DeGiorgio, M.D. Speakers: Marom Bikson, Tay Netoff This year’s program combines the Neurostimulation and Neuroengineering SIGs. Topics to be covered include: 1) TMS for control of refractory status and seizures, 2) DC stimulation for control of seizure activity, and 3) Sub-threshold stimulation methods for reduction of seizure activity. 6:15 p.m. – 8:15 p.m. Translational Investigators’ Workshop Translational Neurogenetics of Hemimegalencephaly Moderator: Peter Crino, M.D., Ph.D. Speakers: Annapurna Poduri, M.D., Laura Flores-Sarnat, M.D., Peter Crino, M.D., Ph.D. Easy, convenient, green . . . Lighten your load and receive AES Annual Meeting information electronically. Stay tuned for further details. The AES Annual Meeting Program Book will still be provided onsite as a hard copy book.
  17. 17. 16AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org SUNDAY December 8, 2013 8:45 a.m. – 4:45 p.m. Investigators’ Workshops Overview TThese Workshops, conducted informally and designed to encourage interaction, will address several important areas of rapidly-emerging knowledge in clinical and basic research in epilepsy. The workshops are intended to identify challenges in current research, propose methods to overcome those challenges, and encourage areas for future investigation. The Basic Science Investigator Workshops will highlight a number of research areas that have been developing rapidly over the last year. Participants include both established and junior epilepsy investigators as well as researchers outside the epilepsy community who have specialized expertise that may be applied to epilepsy basic science. In addition, one of the Workshops features presentations by Junior Investigators in cutting-edge areas of research. The Clinical Investigators’ Workshops provide a series of working seminars in matters of active clinical investigation and controversy. Speakers present results from their ongoing research and place their findings in the context of current understanding. One of these workshops has been selected as a Translational Investigators’ Workshop. This two-hour session will present a particularly broad overview of basic and clinical research on an important problem in epilepsy. Most of the workshops will run as concurrent sessions on Sunday, with the translational workshop Saturday afternoon and a single workshop on Monday afternoon. A separate Investigators’ Workshop Poster Session will occur starting at noon in close proximity to the IW Platform Sessions. Target Audience Basic scientists, neurologists, neuroscientists, pharmacologists, neuropsychologists and neurosurgeons who are performing research in epilepsy Program Investigators’ Workshop Chair: Michael Wong, M.D., Ph.D. Clinical Investigators’ Workshop Chair: Hal Blumenfeld, M.D., Ph.D. Morning Session I – 8:45 a.m. - 10:15 a.m. 1. Translating Clinical Research into Clinical Practice and Back Again Moderators: Anne Berg, Ph.D., Brandy Fureman, Ph.D. Speakers: Lorie Hamiwka, M.D., Tobias Loddenkemper, M.D., Russell Saneto, DO, Ph.D. 2. Dendritic Injury in Epilepsy: Mechanisms and Consequences Moderator: Michael Wong, M.D., Ph.D. Speakers: Joaquin Lugo, Ph.D., John Swann, Ph.D., Michael Wong, M.D., Ph.D. 3. Mitochondrial Abnormalities in Malformations of Cortical Development Moderator: Michael Miles, Pharm.D. Speakers: Hansel Greiner, M.D., Lili Miles, M.D., Michael Miles, Pharm.D. Break: 10:15 a.m. - 10:30 a.m. Morning Session II – 10:30 a.m. - Noon 4. The Big Picture: How Changes in Global Brain Connectivity Facilitate Epileptic Seizures and Cognitive Deficits Moderator: Jack J. Lin, M.D. Speakers: Leonardo Bonilha, M.D., Ph.D., Bruce Hermann, Ph.D., Marcus Kaiser, Ph.D. 5. Engaging Basic Scientists in the Early Stages of Drug Discovery Moderators: Manisha Patel, Ph.D., Helen Scharfman, Ph.D. Speakers: Ray Dingledine, Ph.D., Kevin Staley, M.D., Annamaria Vezzani, Ph.D. 6. What’s Next? A Young Investigators Workshop: A Series of Research Talks by Young Investigators in the Epilepsy Community Moderator: Chris Dulla, Ph.D. Speakers: Esther Krook-Magnuson, Ph.D. (UCI), Omar Ahmed, Ph.D. (Harvard), Jianxiong Jiang, Ph.D. (Emory), Robert Hunt, Ph.D. (UCSF) Noon - 1:30 p.m. Poster Session (Lunch) Afternoon Session I – 1:30 p.m. - 3:00 p.m. 7. Seizures Among Critically Ill Children: Epidemiology, Treatment and Outcomes Moderator: Cecil Hahn, M.D. Speakers: Nicholas Abend, M.D., Cecil Hahn, M.D., Michael Bell, M.D. 8. Controlling Seizures With Electrical Light Orchestra Moderators: Christophe Bernard, Ph.D., Ivan Soltesz, Ph.D. Speakers: Antal Berenyi, M.D., Ph.D., John Huguenard, Ph.D., Dimitri Kullmann, M.D., Ph.D. 9. The KCNQ2-Associated Epilepsy and Encephalopathy Spectrum: Bedside to Bench and Back Moderator: Ed Cooper, M.D., Ph.D. Speakers: John Millichap, M.D., Mala Shah, Ph.D., Mark Shapiro, Ph.D. Break: 3:00 p.m. - 3:15 p.m. Afternoon Session II – 3:15 p.m. - 4:45 p.m. 10. Translating Seizure Terminology and Modeling from Rodents to Humans: Is Consensus Possible? Moderators: Solomon Moshé, M.D., Alexis Arzimanoglou, M.D. Speakers: Aristea Galanopoulou, M.D., Ph.D., Karen Wilcox, Ph.D. 11. Neurocysticercosis-Related Epilepsy Moderator: Jorge G. Burneo, M.D. Speakers: David Millet, M.D., Ph.D., Alejandro L. Escalaya, M.D., Gagandeep Singh, M.D. 12. Astrocyte Control of the Extracellular Environment – Pathological and Therapeutic Implications Moderators: Chris Dulla, Ph.D., Alex Rotenberg, M.D., Ph.D. Speakers: Chris Dulla, Ph.D., Daniela Kaufer, Ph.D., Harald Sontheimer, Ph.D.
  18. 18. 17AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org SUNDAY December 8, 2013 8:45 a.m. – 5:15 p.m. Annual Course: An Algorithmic Approach to the Diagnosis and Treatment of Non-Lesional Epilepsy Overview Nonlesional epilepsy refers to the absence of a potentially epileptogenic lesion on magnetic resonance imaging (MRI). These cases are particularly challenging and time consuming to the epilepsy team as the apparent lack of a visual cue results in doubts regarding diagnostic validity of the diagnosis as well as whether surgery can even be considered due to the uncertainty of the extent of the epileptogenic zone. It is estimated that 20% to 30% of patients with medically refractory epilepsy will have a normal MRI. Moreover, most neurologists and comprehensive epilepsy centers report an increase in nonlesional epilepsy case referrals resulting in an increase in noninvasive and invasive diagnostic evaluations in order to verify the diagnosis and then to ultimately assess surgical candidacy. This year’s annual course will delve into the management of nonlesional epilepsy, a heterogeneous collection of complex epilepsies that most adult and pediatric clinicians face on a daily basis. The course is divided into two sessions with the morning session devoted to diagnostic issues and the afternoon to treatment. Each session will be framed by common clinical scenarios and will be used to discuss epileptogenic mechanisms, highlighting novel diagnostic and both medical and surgical treatment modalities. A multidisciplinary approach will be emphasized. The goal of the course is to highlight clinical management while illuminating basic science and practice gaps. Each session will end with a summary and offer an algorithm for the clinical management of nonlesional epilepsy. Learning Objectives u Develop an algorithmic approach for the diagnostic work-up of nonlesional patients presenting with “spells” with improved diagnosis and better treatment outcomes u Apply state of the art imaging and electrophysiological modalities in both the diagnostic work-up and pre-surgical evaluations of nonlesional epilepsies u Understand the pathophysiology of epilepsy in patients with normal imaging and effectively manage their care u Utilize recent developments in pharmacological and non-surgical treatment approaches to non-lesional epilepsy u Develop and utilize an algorithmic approach for the process of pre-surgical evaluation of patients with non-lesional drug-resistant epilepsy with improved seizure control and quality of life. Target Audience Basic, Intermediate and Advanced (see page 4 for details) Program Chair: Joseph I. Sirven, M.D. Diagnostic Challenges 8:45 a.m. Introduction Joseph Sirven, M.D. 8:55 a.m. Case Presentation Jennifer DeWolfe, D.O. 9:00 a.m. Lecture: Advanced Imaging Techniques – PET, MRI, MRS, MSI, SPECT, DTI Ruben Kuzniecky, M.D. 9:25 a.m. Flash Panel: Ictal Semiology and Diagnosis Selim Benbadis, M.D., Jeffrey Buchhalter, M.D., Ph.D., Prakash Kotagal, M.D. 9:40 a.m. Lecture: Advanced EEG Techniques – HFOs and EEG fMRI Jean Gotman, Ph.D. 10:05 a.m. Break 10:20 a.m. Case Presentation Randa Jarrar, M.D. 10:25 a.m. Lecture: Genomic testing in the Setting of Non-Lesional Epilepsy Alica Goldman, M.D., Ph.D. 10:50 a.m. Lecture: Understanding Epilepsy Networks William Stacey, M.D., Ph.D. 11:15 a.m. Case Presentation David Spencer, M.D. 11:20 a.m. Debate: Extent of Diagnostic Evaluations for Non-Lesional Epilepsy – Case Management Practice vs.Economic Considerations Richard Zimmerman, M.D., Charles Begley, Ph.D. 11:50 a.m. Algorithm for Diagnosis of Nonlesional Epilepsy Jorge Burneo, M.D. Noon - 2:00 pm. Lunch Break Treatment Challenges 2:00 p.m. Case Presentation Daniel Friedman, M.D. 2:05 p.m. Lecture: Pharmacologic Management of Non-Lesional Epilepsy Michael Privitera, M.D. 2:25 p.m. Flash Panel: Presurgical Evaluation in Nonlesional Epilepsy Gregory Cascino, M.D. – SPECT, Terrence O’Brien M.D. – PET, Robert Knowlton, M.D. – MEG 2:40 p.m. Case Presentation Oliver Jeffery, M.B., Ch.B. 2:45 p.m. Lecture: Intracranial Evaluation and Outcomes in Nonlesional Epilepsy William Bingaman, M.D. 3:10 p.m. Debate: How Far Do You Go in the Treatment of Nonlesional Epilepsy? – Case Management Orrin Devinsky, M.D., Greg Krauss, M.D. 3:40 p.m. Break 3:55 p.m. Case Presentation Christi Heck, M.D. 4:00 p.m. Lecture: Devices for Nonlesional Epilepsy Andrew Cole, M.D. 4:25 p.m. Lecture: Dietary Approaches to Non-Lesional Epilepsy Eric Kossoff, M.D. 4:40 p.m. Lecture: The Future for Patients with Non-Lesional Epilepsy Robert Fisher, M.D., Ph.D. 5:00 p.m. Algorithm for Treatment of Non-Lesional Epilepsy Lara Jehi, M.D. 5:15 p.m. Course Ends Credit Designation The American Epilepsy Society designates this live activity for a maximum of 6.0 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 6.0 contact hours for this session. Acknowledgment This program is supported by an educational grant from Eisai, Inc.
  19. 19. 18AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org SUNDAY December 8, 2013 5:00 p.m. – 6:00 p.m. Reception: Suds for Scientists Join your colleagues in the Exhibit Hall for complimentary appetizers and a cash bar. A portion of the sale of each beverage will support the Lennox & Lombroso Trust. The Trust supports fellowships and early career grants for postgraduates and newly independent faculty. A fundraising drawing is also being planned by the Development Committee. 6:00 p.m. – 7:30 p.m. Special Interest Group Meetings Basic Mechanisms Underlying Cognitive and Behavioral Deficits Associated with Epilepsy Coordinators: Amy L. Brewster, Ph.D., Dane Chetkovich, M.D., Ph.D. Speakers: Eric Klann, Ph.D., Farah Lubin, Ph.D., Mauro Costa-Mattioli, Ph.D. Cognitive and behavioral deficits are often seen in individuals with epilepsy. This session will cover molecular mechanisms at the epigenetic and protein translation level that are associated with the regulation of memory and behavior under physiological conditions and in epilepsy. Research in this area provides insight into potential novel mechanisms that can be targeted for treatment of comorbidities in epilepsy. Cognitive / Behavioral Approaches for Treatment of Epileptic Seizures and PNES Coordinators: Steve Schachter, M.D., Siegward Elsas, M.D., Rosa Michaelis, M.D., Lauren Frey, M.D., Marcio Sotero De Menezes, M.D. Speakers: W. Curt LaFrance, Jr., M.D., M.P.H. To date, about one third of individuals with epilepsy continue to have medically intractable epileptic seizures despite high-dose polytherapy; even the new generation of anticonvulsive drugs has failed to bring significant change to this situation. Uncertainty about when a seizure might occur may be more disabling than the actual number of seizures if it decreases the individual’s sense of self-control. Treatment options for psychogenic non- epileptic seizures are few, despite the high prevalence and disabling nature of the disorder. Although basic principles of behavioral approaches to epileptic and psychogenic nonepileptic seizures have been discussed in the literature for many years, specialty clinics have not integrated behavioral therapy into their treatment programs. Literature suggests that adjunctive behavioral treatment approaches that investigate multiple factors underlying seizure activity can lead to proactive strategies for avoiding seizure triggers which may also facilitate the transition of an individual’s sense of self-identity from “chronically ill” to “normal” and “being in control.” This group session aims at offering a platform which gives practitioners an opportunity to exchange tools that will allow them to implement elements of cognitive behavioral interventions in their clinical practice. In expectation of the publication of the workbook “Taking Control of Your Seizures”, authored by the Andrews / Reiter Epilepsy Treatment Program in collaboration with Dr. Curt LaFrance, Dr. LaFrance will review this standardized workbook as an on-going step by step guideline of a systematic, multi-modal counseling intervention that aims at assisting the individual in improving seizure frequency and overall self-defined quality of life. NIH SIG: Funding Opportunities in the NINDS Phase II Clinical Trial Network, NeuroNEXT Coordinators: Brandy Fureman, Ph.D., Deborah G. Hirtz, M.D. Speakers: Elizabeth McNeil, Shanta Rajaram, Tracy Glauser, M.D. The NINDS recently launched the “Network for Excellence in Neuroscience Clinical Trials” known as NeuroNEXT. NeuroNEXT provides a robust, standardized, and accessible infrastructure to facilitate rapid development and implementation of protocols in neurological disorders affecting adult and / or pediatric populations. The network includes multiple Clinical Sites, one Clinical Coordinating Center (CCC) and one Data Coordinating Center (DCC). The Network website is www.neuronext.org. A unique feature of this network is that you DO NOT need to be part of the NeuroNEXT infrastructure to apply to conduct a study within the network. Applications from academic investigators, advocacy groups / foundations, small businesses and the pharmaceutical industry are welcomed. This NIH SIG session will feature brief talks about applying for NeuroNEXT funding from the NINDS Scientific Program Director, the Scientific Review Officer coordinating NeuroNEXT application reviews, and a member of the NeuroNEXT Executive Committee. The session will include ample time for questions and discussion. Temporal Lobe Club: Surgical Referrals for Epilepsy – Too Little Too late Coordinator: Jerome Engel, M.D., Ph.D. Speakers: Edward Chang, M.D., Jerome Engel, Jr., M.D., Ph.D., Jacqueline A. French, M.D., David Millett, M.D., Ph.D. This year’s session will address the possible reasons for the treatment gap in epilepsy surgery, and approaches to correct this. Eddie Chang will present data from his study published in Neurology last year (Englot et al., Neurology2012;78:1200-1206) indicating an increase in hospital admissions for epilepsy but no change in number of surgeries between 1990 and 2008. More patients were referred to smaller hospitals without surgical facilities. Pete Engel will present data indicating that the delay from diagnosis to referral to an epilepsy surgery program for MTLE has not changed as a result of the Wiebe RCT, and the AAN practice parameter recommending surgery as the treatment of choice for temporal lobe epilepsy. (Haneef et al., Neurology 2010;75:699-704). Jackie French is collecting data indicating a reduction in referrals of MTLE with hippocampal sclerosis and will argue that this represents a decrease in the prevalence of surgical candidates. 8:00 p.m. – 10:00 p.m. Social Networking Groups (registration is not required) Informal gathering and networking for SIG participants. Space is limited so participants are welcome on a first-come, first-served basis. Roundtable topics to be covered this year will be announced soon.
  20. 20. 19AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org MONDAY December 9, 2013 7:00 a.m. – 8:30 a.m. Special Interest Group Meetings Ketogenic Diet: Supplements and Alternatives Coordinators: Elizabeth A. Thiele, M.D., Ph.D., Susan A. Masino, Ph.D., Christina Bergqvist, M.D. Speakers: Richard L. Veech, Dominic D’Agostino, Robin S. B. Williams, Karin Borges, Ph.D. The 2013 Ketogenic Diet Special Interest Group (KD-SIG) will focus on supplements and alternative to ketogenic diet therapy. There has been intense interest in supplements that might make a dietary approach more effective or more palatable, and in alternatives which may avert the need for an extremely strict diet. This year’s session will feature four speakers who are focusing on ketone esters and alternative oils (triheptanoin and medium chain triglyceride (MCT) variants): Richard L. Veech, National Institutes of Health, Dominic D’Agostino, University of South Florida, Robin S. B. Williams, Royal Holloway, University of London, and Karin Borges, University of Queensland. Each speaker will offer a short 10-12 minute talk to briefly outline basic science to mechanisms and metabolism, the potential use for epilepsy with or without dietary treatments, and any data on current clinical use (unrelated to epilepsy), as appropriate. After the presentations, there will be ample time to discuss what further basic science knowledge and potential clinical trials are needed to establish effectiveness and bring these compounds to patients and for questions and answers. With attendees representing all the major centers worldwide, the KD-SIG has the potential to become a launching board for a multicenter trial and collaborative laboratory work. Neuropharmacology: Clinical Relevance of Mechanisms of Action Coordinators: Jeannine Conway, Pharm.D., Scott Mintzer, M.D. Speakers: Nathan Fountain, M.D., Mikiko Yamada, Pharm.D., John Kehne, Ph.D. Please join our SIG for a spirited discussion about the role of mechanisms of action play in determining efficacy, side effects, and developing new agents for the treatment of epilepsy. Each speaker will provide a short presentation and audience members are encouraged to engage in the discussion. Time will also be allocated for addressing SIG business and networking. Posttraumatic Epilepsy – NEW Coordinators: Enrique A. Feoli, M.D., Joseph Drazkowski, M.D. Speakers: Asla Pitkanen, M.D., Joseph Drazkowski, M.D., Enrique A. Feoli, M.D. The primary point of this SIG is to bring together specialists who care for patients with TBI and PTE and in so doing, to improve our understanding of the underlying causes and our approach to the care of these patients. Multiple questions about TBI and PTE remain unanswered and deserve coordinated focus and discussion, including but not limited to antiseizure drug prophylaxis, the value of electroencephalography, novel treatments in the acute setting such as hypothermia, epileptogenicity of various forms of TBI, prevalence and impact of early seizures and Status Epilepticus, interplay between AEDs, seizures, and cognitive function. Topics will include the following discussion points: a. Consensus on AED prophylaxis and benefit of early (first week) AED therapy b. Prevalence of Status Epilepticus and utility of continuous EEG in early TBI c. Existing animal models of PTE d. Case presentations Tuberous Sclerosis: Utility and Application of mTOR Inhibitors in Tuberous Sclerosis Complex: How and When to Start Treatment Coordinator: Peter Crino, M.D., Ph.D. Speakers: Peter Crino, M.D., Ph.D., Darcy A. Krueger, M.D., Ph.D., Tanjala Gipson The SIG would cover the current indications for mTOR inhibitor therapy, how to start sirolimus / everolimus (dose), what to follow (labs, EEG), potential risks and serious adverse events (SAE), what to do in the setting of SAEs, dealing with insurance and cost issues, when to stop therapy, and special cases and clinical scenarios (renal failure, organ transplant, cancer history, prenatal use, interactions with AEDs). The SIG would end with a panel discussion of specific cases or uses, comparing sirolimus versus everolimus, and then an information sheet that can be emailed to all SIG participants that ask for it. 8:45 a.m. – Noon Merritt-Putnam Symposium: Future Therapies: How We Will Be Treating, Preventing and Curing Epilepsy in the Year 2025 Award Presentation: Lennox Award Overview Multiple strategies are being forwarded for prevention and treatment of epilepsy, some of which raise the possibility of providing an eventual cure for the disorder. Signaling pathways and inflammatory processes offer promising targets for novel treatment strategies, some of which use existing medications. As stem cell research progresses, cell replacement therapy is considered a potential option to replace lost or dysfunctional neurons in the epileptic brain. Optogenetics may provide unique strategies for potential treatment of brain diseases, particularly epilepsy. Seizure detection and prediction devices suggest possible non-medication related approaches for treatment of epilepsy. This symposium will review these topics and provide insight into emerging treatment options. Learning Objectives u Utilize novel therapies for treatment of patients with difficult to control epilepsy with resulting improved seizure controls u Assess patients for inflammatory processes which are causing uncontrolled seizures and treat with anti-inflammatory and immune therapies when appropriate. Target Audience Intermediate and Advanced (see page 4 for details) Program Chair: Amy Brooks-Kayal, M.D. Introduction Amy Brooks-Kayal, M.D. Cell Signaling Modulators as Novel Disease Modifying Therapies Anne Anderson, M.D. Anti-Inflammatory Therapy Annamaria Vezzani, Ph.D. Cellular Therapies Scott C. Baraban, Ph.D. Optogenetic Therapy Ivan Soltesz, Ph.D. Seizure Detection / Prediction Devices and Therapies Gregory A. Worrell, M.D., Ph.D. Conclusions Amy Brooks-Kayal, M.D. Credit Designation The American Epilepsy Society designates this live activity for a maximum of 3.0 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses may claim up to 3.0 contact hours for this session.
  21. 21. 20AES 2013 ANNUAL MEETING | WASHINGTON, D.C. www.AESNET.org MONDAY December 9, 2013 9:00 a.m. – 10:30 a.m. Special Interest Group Meetings EEG: What’s a Hell Conductor in Thalamus? Coordinator: Hiroshi Otsubo, M.D. Speakers: O. Carter Snead, M.D., Pete Alasz, Hiroshi Otsubo, M.D. We focus on a role of thalamus in epilepsy. Epileptic discharges of continuous spike and wave during sleep and 3 Hz spike and waves in children are well known as abnormal discharges with thalamo-cortical epileptic network. Sleep spindles and awake alpha rhythm are also thalamo-cortical functional network. We discuss these EEG and clinical findings of abnormal and normal thalmo-cortical network to explore the mechanism of thalamus in conducting cortex in epilepsy. Junior Investigators Workshop: Finding and Starting Your First Academic Job Coordinator: William Stacey, M.D., Ph.D. Speakers: Brian Litt, M.D., John Huguenard, Ph.D., John Greenfield, M.D., Ph.D. Making the leap into your first faculty position is a daunting task, but there are many opportunities available. Our panel, comprised of both senior and recently-hired faculty, will discuss how to approach this process, from initial contact to negotiating a contract to getting started once you are there. This informal discussion will allow junior investigators to ask questions and get advice about finding and starting your first job. In addition, a list of current academic job openings will be available for all attendees. Neonatal Seizures: Do Neonatal Seizures Harm the Brain? Coordinators: Adam Hartman, M.D., Renee Shellhass, M.D. Speakers: Maria Roberta Cilio, M.D., Ph.D., Carl Stafstrom, M.D., Ph.D. For 2013 we are modifying the format a bit to make this SIG even more interactive. In addition to our traditional debate, we are including a “data blitz” segment. The organizers will select several of the best neonatal seizure- related abstracts accepted for presentation at AES. The authors of these papers will be invited to briefly present their work and respond to questions from the audience. Following the data blitz, we will again employ a debate format, highlighting the question “Do neonatal seizures harm the brain?”. Our debaters, Dr. Roberta Cilio (UCSF) and Dr. Carl Stafstrom (University of Wisconsin, Madison), are both known for their eloquence and rational approaches to the literature. We anticipate this thought-provoking debate will engender spirited discussion from the audience! Neuropsychology: Epilepsy and the Aging Brain — Neuropsychological Perspectives Coordinator: Philip Fastenau, Ph.D. Speakers: Gail L. Risse, Ph.D., Marilyn Jones-Gotman, Ph.D., Michael Seidenberg, Ph.D. Three renowned neuropsychologists will present recent and emerging data examining changes in cognitive functioning, psychiatric comorbidities, and brain imaging associated with aging in people with epilepsy. Dr. Gail L. Risse will introduce the topic with a brief review of the latest research on neuroanatomic and cognitive changes in the brain during normal aging and will consider how these changes may be affected by chronic seizures, epilepsy surgery and the longitudinal effects of AEDs. Dr. Marilyn Jones- Gotman will share preliminary data from her longitudinal study comparing people with temporal lobe epilepsy (TLE) who had undergone surgical management of their seizures, a comparison group of people with chronic TLE who had not undergone surgery, and a control group of healthy adults who were matched to the patients on age and years of education. They investigated whether cognitive changes with aging are greater after surgery versus long-term medical management alone versus normal aging. Dr. Michael Seidenberg will summarize a series of studies from his group, including a four-year longitudinal study that examined MRI volumetrics, cognition, and psychiatric status in adults with TLE compared to healthy individuals. This collection of presentations will summarize what is known, set the stage for discussion with the audience about implications for patient education, assessment, and management and will highlight the gaps in knowledge to direct future research with our aging epilepsy populations. Nursing: Highlighting Current Research Coordinators: Madona D. Plueger, APRN, ANCS-BC, Georgette Smith, M.S.N., APRN, CPNP Speakers: TBD The 2013 Nursing SIG will highlight nursing awardee poster presentations. We continue to choose this approach for the third year to provide further opportunities for nurses to share current quality improvement and research projects with one another. This forum fosters the development of ongoing nursing participation and collaboration in the field of epilepsy. The experience provides the nurses and participants more time to discuss posters than time allotted in the conference hall. In addition, a discussion on education and competency will be led by the moderator. 2:15 p.m. – 3:00 p.m. Lennox & Lombroso Lecture Lecturer: Andres Kanner, M.D. 3:45 p.m. – 5:15 p.m. Investigators’ Workshop Antiepileptic Drug and Device Development – What Does the Future Hold? Moderators: H. Steve White, Ph.D., Nicholas Poolos, M.D., Ph.D. Speakers: Henrik Klitgaard, Ph.D., Martha Morrell, M.D., Stephen Collins, M.D., Ph.D. 3:45 p.m. – 5:15 p.m. Special Interest Group Meetings MEG Navigates to Neurosurgeons: A Trajectory of Success Coordinator: Anto Bagić, M.D., Ph.D. Speakers: Andreas Alexopoulos, M.D., M.P.H., Stefan Rampp, M.D., Jorge Gonzalez Martinez, M.D., Ph.D. Clinical MEG has evolved dramatically from its beginnings as an exotic research tool to a practical workhorse for epilepsy localization and for mapping of functional areas. Practice guidelines have been developed by ACMEGS, then endorsed and published by ACNS. Nevertheless, there is still diversity in the way that MEG is interpreted and reported, as well as variability among neurosurgeons in the way that they perceive and use the results of these reports. And the effect on patient care of even the most polished report will not be maximized unless properly integrated into the surgical planning. The speakers in this Special Interest Group will address the continuum of MEG care from optimal indications through clinically informative and technologically versatile reporting to advanced incorporation into preoperative planning and neuronavigation. This dynamic exchange between medical and surgical specialties is expected to help clarify the best possible use of MEG in the care of epilepsy patients. Military Epileptologists: VA Telehealth Initiative and How It May Relate to Epilepsy Care, Sleep Medicine / Epilepsy Comorbility, and Epilepsy Care in the Elderly Coordinators: Jonathan Halford, M.D., Hamada Hamid, M.D. Speakers: Martin Salinsky, M.D., Glen Graham, William Curt LaFrance, Jr., M.D., M.P.H., Stephanie Chen The VA Healthcare System has traditionally served as a leader in healthcare service technology and innovation. In the last three years, the VA Epilepsy Centers of Excellence (ECOE) has incorporated and developed video telehealth