Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The French Paradox, which states that even though the French drink, smoke and eat high-fat foods they have some of the lowest incidences of poor cardiovascular and cellular health. Scientists attribute this to the large amounts of red wine that the French consume, or more importantly, an extract found in red wine, resveratrol.
1. Mark Lange, Ph. D. Market America Director of Quality Control The Science of Resveratrol
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5. Resveratrol is naturally produced by plants as a defense system against infection and oxidative stress due to external attacks. UV Fungi Copper Ozone time Resveratrol level
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15. Increased frequency of apoptosis in two tumor cell lines induced by polyphenolic extracts (Japanese knotweed) Cells death rate (%) Cells death rate (%)
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23. A study of mechanisms involved in vasodilation by Resveratrol Li etal. A Study of Mechanisms Involved in Vasodilation Induced by Resveratrol in Isolated Porcine Coronary Artery. Physiol. Res . 55:365-72, 200 6. 1 5 50 100 0 20 40 60 80 100 Control E-NOS Inhibitor (L-NNA) Endothelium Removed Endothelium Intact Arterial Relaxation (%) 1 55 10 10 50 100 Red Wine Extract Concentration (μM)
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25. Resveravine protects LDL from oxidation better than synthetic resveratrol, catechin and vitamin E
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33. Protection against oxidative stress Influence of three related polyphenols on the oxidative stress of lymphocytes infected by the Epstein-Barr virus (EBV) Peroxidation rate (%)
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40. BioVin ® Advanced vs. Wine Amount of Resveratrol in 200mg BioVin ® Advanced Amount required to be equivalent to 200 mg BioVin® Advanced Red Wine White Wine 10 mg 10 glasses (1500 ml) 40 glasses (6000 ml)
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46. Hypoxia-Inducible Factor (HIF) – Why Antioxidants May Help to Prevent Cancer NORMAL CONDITIONS OXYGEN Hypoxia OXYGEN Nat Rev Cancer. 2003 Oct;3(10):721-32
47. HIF Helps Cells Survive, But Free Radicals Must Be Present OXYGEN Hypoxia HIF FREE RADICALS "HIF-1 helps an oxygen- starved cell convert sugar to energy without using oxygen and also initiates the construction of new blood vessels to bring in a fresh oxygen supply."
49. But HIF Can’t Help the Cancer Cells Survive When Antioxidants Have Neutralized All The Free Radicals . OXYGEN Hypoxia HIF FREE RADICALS Antioxidants
Cancer is caused by genetic mutations. Sometimes the mutations are inherited and there is a predisposition to cancer. But most of the time, the mutations slowly accumulate over time. Cancer is caused by multiple genetic mutations. Resveratrol tells cells with genetic mutations to shut down and die, thus preventing cancer from developing.
Resveratrol supresses tumor development and its progression. In other words, it stops cancer in its tracks.
Rheumatoid arthritis and bronchial asthma.
Platelets are particles circulating in the blood that are necessary for blood clots to form. Blood clotting is important because it stops us from bleeding when we get cut. However, if a blood clot forms inside an artery, it blocks the flow of blood to the tissue that the artery supplies, and that can damage the tissue. For example, a blood clot in a coronary artery causes a heart attack and a blood clot that forms in an artery supplying blood to the brain causes a stroke.
The endothelium is a single layer of cells which line the internal wall of blood vessels. It enables blood to flow smoothly inside the blood vessels. The endothelium has many different biological actions, but the one we’re focusing on is controlling blood pressure. Nitroglycerine patches or taking pills?
Resveratrol’s antioxidant capability has been demonstrated in numerous studies. READ SLIDE .
Let’s move on to another berrry extract—this one called BioVin® Advanced. READ SLIDE . It’s still being isolated from French red grapes like Resveravine®, but in this extract contains oligomeric proanthocyanidins (OPCs), anthocyanins, other phenolic acids and 5% naturally occurring resveratrol. Here we are looking at the possibility of more beneficial interactions among these compounds.
We move on to another potent berry extract, called Vita Blue™ Blueberry Extract , which concentrates anthocyanins, other polyphenolic acids, and another interesting compound pterostilbene —a close chemical cousin of resveratrol.