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  • 1. The Effect of Physical Activity on Alzheimer’s Disease
    Belinda Brown
  • 2. Benefits of Physical Activity
    Benefits of regular physical activity;
    Prevents cardiovascular disease
    Increases independence
    Reduces body weight
    Alleviation of depression
  • 3. Physical Activity Levels in Australia
  • 4.
  • 5. Physical Activity and Cognition/Memory
    Physical Activity and Dementia/Alzheimer’s Disease
    How Physical Activity May Delay AD
  • 6. Physical Activity and Memory
    French Study
    Physical and Mental Activity improved cognition
    Eight people per group
    Only outcome was cognition
    Source: Fabre et al, 2002
  • 7. Physical Exercise and Cognitive Stimulation (PEACS)
    200 participants; 50 allocated to each trial group
    Control Group
    Physical Activity
    Cognitive Stimulation (2 programmes from POSIT Science)
    Combined PA+CS
    Each individual undertakes;
    Memory tests
    Blood testing
    Activity Monitor Assessment
    Sub-groups;
    PET brain imaging
    CSF collection (Lumbar Puncture)
    DEXA Scanning (Body Composition)
    Physical Fitness Assessments
  • 8. Our Research....
    Highest intensity activity = Highest memory score
    0
    Lowest intensity activity = Lowest memory score
  • 9. Physical Activity and Cognition/Memory
    Physical Activity and Dementia/Alzheimer’s Disease
    How Physical Activity May Prevent AD
  • 10. Risk Factors
    Life Habits (eg smoking), hypertension, occupation, depression, head trauma
    Genetic Risk Factors
    Socio-Economic Status Factors
    0 20 40 60 80
    DietRich social networks
    Mental Activities
    Physical Activity
    High Education
    Diet
    Protective Factors
    Protective factor at mid-life and late-life
  • 11. Physical Activity and Onset Delay of AD
    Those exercising more than three times a week, are more likely to be dementia free as they age
    Dementia Risk
    Source: Larson et al 2006
    More Exercise = Less Dementia Risk
  • 12. Our Research....
    Collecting longitudinal data every 18 months to find out;
    Do individuals that exercise, have a less chance of developing Alzheimer’s in the future?
    Do individuals that go from being sedentary to physically active, still receive the benefit of reduce AD risk?
  • 13. Physical Activity and Cognition/Memory
    Physical Activity and Dementia/Alzheimer’s Disease
    How Physical Activity May Prevent AD
  • 14. Decrease in Amyloid – Mouse Model
    Source: Adlard, P. A. et al
    The effect of exercise on Amyloid-β load inthree different brain regions of transgenic mice
  • 15. Decrease in Amyloid – Our Research...
    Lowest activity = highest Aβ
    Highest activity = lowest Aβ
    0
  • 16. Some other ideas....
    Increase in brain-derived neurotrophic factor (BDNF)
    Stimulates growth of new brain cells
    Improves learning and mental performance
    Increase in synaptic plasticity (ability of brain to learn and remember)
    Reduces risk of Cardiovascular Disease and Type II Diabetes
  • 17. You don’t have to be an elite athlete
    Benefits can be gained from 30 minutes exercise daily
    More pronounced benefit when intensity is higher
  • 18. No matter what age you are, your life-style choices may contribute to the risk of AD
    Beyond increases to cognition, physical activity can aid in many aspects of health and increase function and independence