anti microbial resistances challenges and solutions
ANTIMICROBIAL RESISTANCE -CHALLENGES AND SOLUTIONS
The strength of trillions upon trillions ofmicro-organism , combined with ancient force of evolution will inevitably over power our drugs
The evolution ofmicroorganism isDarwinian : in the faceof change , THEFITTEST SURVIVES
It is the ability of micro-organism to surviveconcentration of antibiotic that is sensitive tocells of same strain.When a sensitive strain gain the ability towithstand an antibiotic, its an antibioticresistant
Failure of response to standard treatment Hampers the control of infectious diseases Increase in cost of health care Threatens a return to pre- antibiotic era Jeopardizes health care gains to society
QUORUM SENSING- confers virulence, conjugation,sporulation & biofilm formation. Q.S. can acts as potential target for antimicrobial resistance bacteria Vaccination Use of narrow spectrum antibiotics Rapid diagnostic tests Antibiotic susceptibility test Rational usage of antibiotics
There is a need to extendthe capabilities ofantimicrobialtherapies, to developdrugs that destroypathogens and alsoundermine resistancemechanism in moreeffective way.