anti microbial resistances challenges and solutions

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anti microbial resistances challenges and solutions

  1. 1. ANTIMICROBIAL RESISTANCE -CHALLENGES AND SOLUTIONS
  2. 2. The strength of trillions upon trillions ofmicro-organism , combined with ancient force of evolution will inevitably over power our drugs
  3. 3. The evolution ofmicroorganism isDarwinian : in the faceof change , THEFITTEST SURVIVES
  4. 4. It is the ability of micro-organism to surviveconcentration of antibiotic that is sensitive tocells of same strain.When a sensitive strain gain the ability towithstand an antibiotic, its an antibioticresistant
  5. 5.  MDR-TB & XDR –TB MRSA Vancomycin resistant Enterococci Beta lactamase NDM-I Antibiotic resistant E.coli
  6. 6. Causes of development of antimicrobial resistance
  7. 7. INAPPROPRIATE AND IRRATIONAL USE OF ANTIBIOTICS
  8. 8. Inappropriate useof antibiotics inlivestock asgrowth promoters
  9. 9. DiagnosticsVaccines
  10. 10.  Failure of response to standard treatment Hampers the control of infectious diseases Increase in cost of health care Threatens a return to pre- antibiotic era Jeopardizes health care gains to society
  11. 11.  QUORUM SENSING- confers virulence, conjugation,sporulation & biofilm formation. Q.S. can acts as potential target for antimicrobial resistance bacteria Vaccination Use of narrow spectrum antibiotics Rapid diagnostic tests Antibiotic susceptibility test Rational usage of antibiotics
  12. 12. There is a need to extendthe capabilities ofantimicrobialtherapies, to developdrugs that destroypathogens and alsoundermine resistancemechanism in moreeffective way.
  13. 13. Thank you

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