2012.09.13 peto hiit_glucosetolerance_gluauc

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Slides to accompany Max Peto's talk about high-intensity interval training ("HIIT") and its dramatic, positive effect on insulin sensitivity at the Health Extension Salon in September 2012. You can …

Slides to accompany Max Peto's talk about high-intensity interval training ("HIIT") and its dramatic, positive effect on insulin sensitivity at the Health Extension Salon in September 2012. You can see the video here: https://vimeo.com/50895380

In this video, Max also presents a modified (shorter, easier, effective) version of a published HIIT protocol which he developed. Slides are not visible in video - use these slides to follow the video

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  • 1. Short-Duration, High-IntensityInterval Training DramaticallyImproves Insulin Sensitivity Health Extension Salon, 2012.09.13 Paper: Babraj, Timmons et al., 2009 Presented by: Maximus Peto
  • 2. Format of This Presentation1. Review the aspects of disease that insulin is involved in (e.g. athero, cancer)2. Mention a paper (Timmons, 2009) showing HIIT improves insulin sensitivity3. Discuss an exercise intervention I developed to replicate Timmons’ insulin sensitivity enhancements, but with much less time/effort
  • 3. Why talk about insulin sensitivity? Insulin signaling relates to many aspects of health and longevity, including: 1. Cholesterol synthesis 2. Cell division 3. Substrate utilization (oxidation (“burning”) of fat or carbs, depending on insulin status, among other things). This will then strongly influence body fatness, which influences inflammation and other disease factors  Others (not discussed today)
  • 4. [Insulin] and Cholesterol Synthesis Insulin + insulin sensitivity enables glucose to enter cells; insulin resistance prevents it High glucose (e.g. via insulin resistance) activates HMG-CoA Reductase HMG-CoA Reductase is the rate-limiting enzyme involved in cholesterol biosynthesis, and the target of cholesterol lowering drugs like statins I.e. Statins are largely prescribed for people with insulin resistance – DON’T BE!
  • 5. [Insulin] and Cell Division (Specifically:Cancer Proliferation) Insulin is an anabolic hormone – required for cell growth and division Type 1 diabetics, despite high glucose, have metabolic and wasting problems due to lack of insulin production (glucose can’t get used) Many (most? all?) cancers need insulin signaling for cell division – this is one big reason why calorie restriction has been shown to inhibit cancer (CR enhances insulin sensitivity
  • 6. [Insulin] and Substrate Utilization (WhatMacronutrients are Used as Fuel) Low insulin = burn fat; high insulin = NOT Insulin decreases autophagy (i.e. its lack enhances it!) Insulin increases lipid esterification (preparation for storage of lipids in fat cells – i.e. you get fatter) Insulin decreases proteolysis (which is why many bodybuilders eat high-glycemic diets – to retain muscle mass)
  • 7. Measuring [Insulin] Indirectly – TheOGTT OGTT = “Oral Glucose Tolerance Test” 75 g glucose, dissolved in water Fast for 12 hours, drink glucose water Measure blood glucose every 30 mins for 2 hours (5 data points: 0, 30, 60, 90, 120 mins)
  • 8. Measuring [Insulin] Indirectly – TheOGTT High glucose during OGTT most likely illustrates poor insulin action (e.g. secretion, sensitivity) Low glucose during OGTT suggests poor digestion (e.g. high fiber/low glycemic) or excellent insulin sensitivity, or both
  • 9. Max’s Personal Experiments – Loweringthe OGTT and Postprandial Glucose I have tried many, many, many things to enhance insulin sensitivity (as measured by both OGTT, and fasting insulin), for all the reasons I’ve described before E.g. intermittent fasting, calorie restriction, low-carb diet, low-glycemic diet, exercise (low, moderate, and high-intensity), combining fat w/ meals (lowers glycemic index) among others. Lost 65 lbs back in 2007 (effective, yay!)
  • 10. Max’s Personal Experiments – Loweringthe OGTT and Postprandial Glucose Achieved much better body fat and fasting insulin, but OGTT won’t change much (damn it!) Tried many things to change it Only found a single way to improve OGTT reliably – HIIT, the topic of today’s paper
  • 11. Experimental Parameters in Timmons,et. al 2009 Take a group of healthy people, test OGTT before experiment Do exercise protocol: HIIT: bicycle sprint 30 sec, rest 4 min, repeat 4-6x in one session. Do 3 sessions/week for 2 weeks Wait 2 or 3 days (washout acute effects) Take OGTT again
  • 12. Max Developed His Own Protocol Fast 12+ hours (e.g. overnight) Before breakfast, sprint as long as possible (15-30 sec), rest 60 seconds, sprint as long as possible (10-20 seconds) Rest until you feel like eating (~2-4 mins; you’ll be really out of breath, and maybe nauseous) Have breakfast; go about your day as normal Perform 3-5x per week
  • 13. Max, Pre-HIIT 180 Postprandial OGTTGlucose (mg/dL) 160 140 120 100 80 60 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 Time (hours)
  • 14. Max, Post-HIIT 180 Postprandial OGTTGlucose (mg/dL) 160 140 120 100 80 60 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 Time (hours)
  • 15. A Few Notes I measured glucose, NOT insulin. So this is actually representative of enhanced GLUCOSE DISPOSAL, which is related to, but not identical to, insulin sensitivity My glucose AUC findings were similar to what Timmons et. al found, so Im ASSUMING my insulin sensitivity is ALSO enhanced (I will be testing soon) I would like to do actual scientific study
  • 16. Disclaimers! If you are trying this... Be sure you are in decent cardiac/vascular health. This is very strenuous, and you could give yourself a stroke or heart attack if you have current cardiac/vascular issues Jog 30 mins/day, 3x/week for 2 weeks before doing this, to get muscles ready EXPECT to be sore the next few days when starting (this goes away with training). I was sore in abs & hip flexors, but not now
  • 17. QUESTIONS?