Chip In A Pill


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One of the morning repor reviews which I did during my rotation and Allergan, Inc.

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Chip In A Pill

  1. 1. A CHIP-PILL?!! Maryana Arsanious CPQS weekly review December 3 rd , 2010
  2. 2. Chip in a pill ??!!! <ul><li>A “smart-pill”, is a new technology which has been developed by Proteus Biomedical of Redwood City, California </li></ul><ul><li>It is a “pill” which contains a chip inside and upon ingestion, the chip gets activated by stomach acid </li></ul><ul><li>The chip goes into the patient’s skin, where there’s an activating system in a patch on the patient’s shoulder </li></ul><ul><li>When it’s activated, the chip sends data to a receiver which could be located at the patient’s cell phone or at the doctor’s office (through the internet) </li></ul>
  3. 4. Smart-pill vs. Raisin vs. ChipSkin??!!! <ul><li>Smart-pill : A tablet which contains a chip that is ingested by patient </li></ul><ul><li>Raisin : A smart pill, which also releases medications while holding the chip inside </li></ul><ul><li>ChipSkin : A smart pill, which contains an implantable device that does not get deactivated by body fluids. Similar to the one in pacemakers. </li></ul>
  4. 5. What does it do? <ul><li>Physician: </li></ul><ul><li>Gives the physician access to patient’s chip instantly at any given time to help him stay updated with patient’s health status </li></ul><ul><li>Patient: </li></ul><ul><li> Sends a text message to the patient in case: </li></ul><ul><li>Patient forget to take medication </li></ul><ul><li>Patient is not taking medication as directed </li></ul>
  5. 6. Where is it now? <ul><li>In January, Norvartis spent ~$24 million to ensure its access to the device made by Proteus Biomedical. </li></ul><ul><li>“ Joe Jimenez, head of pharmaceuticals at Novartis, said tests using the system – which broadcasts from the “chip in the pill” to a receiver on the shoulder – on 20 patients using Diovan, a drug to lower blood pressure, had boosted “compliance” with prescriptions from 30 per cent to 80 per cent after six months ” </li></ul><ul><li>(Jack, A. Financial Times . Novartis chip to help ensure bitter pills are swallowed, 2010 00144feabdc0.html#axzz15OLuY0CD ) </li></ul>
  6. 7. Where is it now? (cont.) <ul><li>Novartis is not planning to carry out full-scale clinical trials or test for safety since the chip will be added to currently existing medications </li></ul><ul><li>Novartis’s plan is to carry out a “bio-equivalency” study to test for effectiveness of the device </li></ul><ul><li>The first “chip-in-pill” is expected to be available in a pharmacy by 2012 </li></ul>
  7. 8. Purpose??!! <ul><li>To make sure patient takes the right medication, the right dose at the right time </li></ul><ul><li>To insure better compliance of patients, which saves millions of dollars of unnecessary costs </li></ul><ul><li>To help monitor physiological signs of patients </li></ul><ul><li>To help study the true efficacy of drugs </li></ul><ul><li>To eliminate the claim made by some pharmaceutical companies that lack of efficacy is due to lack of compliance. </li></ul>
  8. 9. Where will it go next?!! <ul><li>The chip will be used to collect internal physiological information such as heart rate, body temperature, blood pressure… in the real time. </li></ul><ul><li>Novartis is looking into using the chip as a means of identifying whether the medications are working properly </li></ul><ul><li>By using this property, doctors will be more able to identify a problem at the exact moment, and the pharmacodynamics of the drug at the moment. </li></ul><ul><li> </li></ul>
  9. 10. Current Concerns <ul><li>Privacy: Patient’s personal information is transmitted through wireless connections </li></ul><ul><li>Safety, especially with no clinical trials conducted </li></ul><ul><li>Higher medication price </li></ul><ul><li>One physician vs. multiple patients with multiple conditions requiring multiple medications for each </li></ul>
  10. 11. References <ul><li>Hirschler, B. Reuters, Look out, your medicine is watching you, 2009 . </li></ul><ul><li>Proteus Biometrics, Proteus Ingestible Microchip Hits Clinical Trials, 2009 . </li></ul><ul><li>Jack, A. Financial Times . Novartis chip to help ensure bitter pills are swallowed, 2010 </li></ul>