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One of the morning repor reviews which I did during my rotation and Allergan, Inc.

One of the morning repor reviews which I did during my rotation and Allergan, Inc.

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  • 1. A CHIP-PILL?!! Maryana Arsanious CPQS weekly review December 3 rd , 2010
  • 2. Chip in a pill ??!!!
    • A “smart-pill”, is a new technology which has been developed by Proteus Biomedical of Redwood City, California
    • It is a “pill” which contains a chip inside and upon ingestion, the chip gets activated by stomach acid
    • The chip goes into the patient’s skin, where there’s an activating system in a patch on the patient’s shoulder
    • When it’s activated, the chip sends data to a receiver which could be located at the patient’s cell phone or at the doctor’s office (through the internet)
  • 3.  
  • 4. Smart-pill vs. Raisin vs. ChipSkin??!!!
    • Smart-pill : A tablet which contains a chip that is ingested by patient
    • Raisin : A smart pill, which also releases medications while holding the chip inside
    • ChipSkin : A smart pill, which contains an implantable device that does not get deactivated by body fluids. Similar to the one in pacemakers.
  • 5. What does it do?
    • Physician:
    • Gives the physician access to patient’s chip instantly at any given time to help him stay updated with patient’s health status
    • Patient:
    • Sends a text message to the patient in case:
    • Patient forget to take medication
    • Patient is not taking medication as directed
  • 6. Where is it now?
    • In January, Norvartis spent ~$24 million to ensure its access to the device made by Proteus Biomedical.
    • “ Joe Jimenez, head of pharmaceuticals at Novartis, said tests using the system – which broadcasts from the “chip in the pill” to a receiver on the shoulder – on 20 patients using Diovan, a drug to lower blood pressure, had boosted “compliance” with prescriptions from 30 per cent to 80 per cent after six months ”
    • (Jack, A. Financial Times . Novartis chip to help ensure bitter pills are swallowed, 2010 00144feabdc0.html#axzz15OLuY0CD )
  • 7. Where is it now? (cont.)
    • Novartis is not planning to carry out full-scale clinical trials or test for safety since the chip will be added to currently existing medications
    • Novartis’s plan is to carry out a “bio-equivalency” study to test for effectiveness of the device
    • The first “chip-in-pill” is expected to be available in a pharmacy by 2012
  • 8. Purpose??!!
    • To make sure patient takes the right medication, the right dose at the right time
    • To insure better compliance of patients, which saves millions of dollars of unnecessary costs
    • To help monitor physiological signs of patients
    • To help study the true efficacy of drugs
    • To eliminate the claim made by some pharmaceutical companies that lack of efficacy is due to lack of compliance.
  • 9. Where will it go next?!!
    • The chip will be used to collect internal physiological information such as heart rate, body temperature, blood pressure… in the real time.
    • Novartis is looking into using the chip as a means of identifying whether the medications are working properly
    • By using this property, doctors will be more able to identify a problem at the exact moment, and the pharmacodynamics of the drug at the moment.
  • 10. Current Concerns
    • Privacy: Patient’s personal information is transmitted through wireless connections
    • Safety, especially with no clinical trials conducted
    • Higher medication price
    • One physician vs. multiple patients with multiple conditions requiring multiple medications for each
  • 11. References
    • Hirschler, B. Reuters, Look out, your medicine is watching you, 2009 .
    • Proteus Biometrics, Proteus Ingestible Microchip Hits Clinical Trials, 2009 .
    • Jack, A. Financial Times . Novartis chip to help ensure bitter pills are swallowed, 2010