Dr Martin Fried, Nutrition and Tic diseases


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Dr Martin Fried, Nutrition and Tic diseases

  1. 1. NUTRITION IN LYME and TICK INFECTIONS Martin D. Fried, MD, FAAP, ABPNSPhysician Nutrition Specialist 3200 Sunset Ave Suite 100 Ocean, NJ 07712 www.healthydays.info
  2. 2. Inflammed StomachNodularity Gastritis
  3. 3. Leaky Gut from Infection• Gastritis with foreign protein leaking into the blood stream• Examples of immune activation psoriasis, IBD, Celiac Neovascular rashes
  4. 4. Inflammation causes permeable gut Foreign proteins to immune system Crohn’s, Colitis, Celiac
  5. 5. Psoriasis
  6. 6. Immune/Autoimmune• Crohn’s, Celiac, Ulcerative Colitis• Lyme, Bartonella, Mycoplasma• Inflammatory mediators include: Tumor necrosis factor interleukins 2, 6, 10
  7. 7. Immune Activation Neovascular Rash
  9. 9. Nutritional Goals• Minimize Nutritional Risk• Provide Nutrition• enhance absorption and tolerance• Maintain intestinal integrity• Favorably alter intestinal flora• Regulate immune system favorably• Address fatigue and obesity
  10. 10. Nutritional Goals• Minimize nutritional risk by providing: adequate calories, protein, carbohydrates healthy fats, vitamins and minerals
  11. 11. Provide Nutrition to Enhance Absorption and Tolerance• Whey verses Casein properties of milk• Whey empties faster (reference 1)• Casein delays gastric emptying• In cases of Neurologic conditions affecting gut motility, whey protein is preferred• Mixture of protein sizes of varying length helps absorption due to dual transport of Proteins (reference 2)
  12. 12. Lyme and IBD, Celiac• Genetic predisposition• Environmental trigger (infection)• albumin, protein absorption, folate• Calcium and fat• Consider Zinc and Iron deficiencies (references 3-6)
  13. 13. Immune ActivationScalp Psoriasis to…….. Crohn’s Disease
  14. 14. Canker Sore
  15. 15. Inflammatory Ulcers
  16. 16. Colon Ulcers
  17. 17. Colitis
  18. 18. Celiac vs Food Intolerance• Celiac is Autoimmune to wheat, rye, barley• Gluten, Genetics and Environment• Allergy is IgE mediated• Celiac is non IgE mediated
  19. 19. Celiac DiseaseEnzymes lost in disease malabsorption affected:Lactase milk sugarSucrase table sugarMaltase Simple starchGlucoamylase Complex starch as rice
  20. 20. Maintain Intestinal Integrity• Iron, Zinc, Albumin• Fat soluble vitamins A,D,E,K (refer 4-7)• B12 malabsorption in ileum
  21. 21. Alter GI Flora Favorably• Minimize Clostridium difficile - colitis• Reduce Candida albicans – yeast overgrowth• Short chained Fructoligosaccharides (scFOS)• Promote growth of Bifidobacteria• Lactobacillus acidophillus
  22. 22. Clostridium difficile• C. difficile is normal bacterial flora• Antibiotics kill lactobacilli, bifidobacter• C. difficile overgrowth occurs• C. difficile elicits – Toxin A and Toxin B• Pseudomembranous colits• Treat with Metronidazole and pre/probiotics
  23. 23. Pseudomembranous Colitis
  24. 24. Candida Albicans• Normal Flora Yeast• Antibiotics kills Normal Flora• Yeast overgrowth occurs• Diet to produce lactobacillus, bifidobacteria• Short chained fructooligosaccharides (FOS)
  25. 25. Probiotics• > 90% killed by stomach acid• Lactobacillus• Bifidobacter
  26. 26. Prebiotics• Natural Carbohydrates not digested by : amylase, sucrase and maltase• scFOS• Sources include banana, garlic, onion, leeks, whole wheat, asparagus and tomato products
  27. 27. Keeps yeast and C difficile in checkLowers the pH in the colonAcidic environment is bifidogenic
  28. 28. Foods with sc FOS• Soluble Fiber in Fruits and Vegetables• Fermented in colon to short chain Fatty acids by normal colonic flora (refer 8,9)• banana onions• garlic asparagus• Barley wheat
  29. 29. Immune SupressionACNE progresses to….. THIRD DEGREE BURN
  30. 30. Down regulate Inflammation• Omega three oils are anti-inflammatory• Salmon, tuna, herring, walnuts, almonds• Omega six oils are inflammatory
  31. 31. Obesity• Inactivity, joint pains, malaise, fatigue• High caloric foods… leads to………….
  32. 32. Gallstones
  33. 33. Insulin Resistance
  34. 34. Fatty Liver
  35. 35. Sleep Apnea
  36. 36. Conclusions• Lyme, Bartonella, Mycoplasma cause inflammation and changes in the GI tract• Prevent yeast, c. difficile overgrowth with prebiotics and probiotics• Address specific nutritional deficiencies• Consider omega three foods to down
  37. 37. References• 1) J Pediatr 1992;120:569-572• 2)Ann Rev Physiol 2004; 66:361-384• 3) J Ped Gastroenterol Nutr 1985;4:45-51• 4) Am J Physiol 1995;268• 5) Am J Physiol 1999;277• 6) Ann Surg 1996; 223:316-333• 7) J Nutr 2001; 131:2157-2163• 8) Lancet 1993; 342:1266-1268• 9) Am J Gastroenterol 1990;85:1307-1312